{"id":"https://openalex.org/W2609965556","doi":"https://doi.org/10.1248/bpb.b16-00832","title":"Hydrogen Rich Water Attenuates Renal Injury and Fibrosis by Regulation Transforming Growth Factor-\u03b2 Induced Sirt1","display_name":"Hydrogen Rich Water Attenuates Renal Injury and Fibrosis by Regulation Transforming Growth Factor-\u03b2 Induced Sirt1","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2609965556","doi":"https://doi.org/10.1248/bpb.b16-00832","mag":"2609965556","pmid":"https://pubmed.ncbi.nlm.nih.gov/28458345"},"language":"en","primary_location":{"id":"doi:10.1248/bpb.b16-00832","doi":"https://doi.org/10.1248/bpb.b16-00832","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.b16-00832","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/40/5/40_b16-00832/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological &amp; Pharmaceutical Bulletin","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/bpb/40/5/40_b16-00832/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101078225","display_name":"Zhaoyu Xing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhaoyu Xing","raw_affiliation_strings":["Department of Urology, The Third Affiliated Hospital of Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The Third Affiliated Hospital of Soochow University","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024069945","display_name":"Wanma Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wanma Pan","raw_affiliation_strings":["Department of Pharmacology, School of Pharmacy, Fudan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, Fudan University","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100345489","display_name":"Jing Zhang","orcid":"https://orcid.org/0000-0003-2966-9149","observed_orcids":["https://orcid.org/0000-0003-2966-9149","https://orcid.org/0000-0002-2407-5352"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Zhang","raw_affiliation_strings":["Department of Pharmacology, School of Pharmacy, Fudan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, Fudan University","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101073551","display_name":"Xu Xianlin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianlin Xu","raw_affiliation_strings":["Department of Urology, The Third Affiliated Hospital of Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The Third Affiliated Hospital of Soochow University","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100358954","display_name":"Xuemei Zhang","orcid":"https://orcid.org/0000-0002-4979-6965","observed_orcids":["https://orcid.org/0000-0002-4979-6965"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuemei Zhang","raw_affiliation_strings":["Department of Pharmacology, School of Pharmacy, Fudan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, Fudan University","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100697533","display_name":"Xiaozhou He","orcid":"https://orcid.org/0000-0001-9292-5788","observed_orcids":["https://orcid.org/0000-0001-9292-5788"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaozhou He","raw_affiliation_strings":["Department of Urology, The Third Affiliated Hospital of Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The Third Affiliated Hospital of Soochow University","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086621430","display_name":"Min Fan","orcid":"https://orcid.org/0000-0002-1787-4287","observed_orcids":["https://orcid.org/0000-0002-1787-4287"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Fan","raw_affiliation_strings":["Department of Urology, The Third Affiliated Hospital of Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The Third Affiliated Hospital of Soochow University","institution_ids":["https://openalex.org/I3923682"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.52,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.88827849,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"40","issue":"5","first_page":"610","last_page":"615"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrogen-rich-water","display_name":"hydrogen-rich water","score":0.9549999833106995},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/kidney-injury","display_name":"kidney injury","score":0.7459999918937683},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9810000061988831},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9110000133514404},{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/sirtinol","display_name":"sirtinol","score":0.8289999961853027},{"id":"https://openalex.org/keywords/unilateral-ureteral-obstruction","display_name":"unilateral ureteral obstruction","score":0.8949999809265137},{"id":"https://openalex.org/keywords/hk-2-cells","display_name":"HK-2 cells","score":0.9290000200271606},{"id":"https://openalex.org/keywords/proximal-tubular-epithelial-cells","display_name":"proximal tubular epithelial cells","score":0.8889999985694885},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.8730000257492065},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.6159999966621399},{"id":"https://openalex.org/keywords/smad2","display_name":"Smad2","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.6652077436447144},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6038811802864075},{"id":"https://openalex.org/C2778176769","wikidata":"https://www.wikidata.org/wiki/Q764079","display_name":"Blood urea nitrogen","level":3,"score":0.5952104330062866},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5840096473693848},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.5838198661804199},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.5471476912498474},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.4968562424182892},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.4928288757801056},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4459635317325592},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.419904887676239},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.410783052444458},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3689422011375427},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35259920358657837},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.18777063488960266},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08671656250953674},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001806","descriptor_name":"Blood Urea Nitrogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006859","descriptor_name":"Hydrogen","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007677","descriptor_name":"Kidney Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009395","descriptor_name":"Nephritis, Interstitial","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014517","descriptor_name":"Ureteral Obstruction","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D014517","descriptor_name":"Ureteral Obstruction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056564","descriptor_name":"Sirtuin 1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D056564","descriptor_name":"Sirtuin 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1248/bpb.b16-00832","doi":"https://doi.org/10.1248/bpb.b16-00832","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.b16-00832","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/40/5/40_b16-00832/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological &amp; Pharmaceutical Bulletin","raw_type":"journal-article"},{"id":"pmid:28458345","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28458345","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological & pharmaceutical bulletin","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1248/bpb.b16-00832","doi":"https://doi.org/10.1248/bpb.b16-00832","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.b16-00832","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/40/5/40_b16-00832/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological &amp; Pharmaceutical Bulletin","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2609965556.pdf","grobid_xml":"https://content.openalex.org/works/W2609965556.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1598113198","https://openalex.org/W1601570879","https://openalex.org/W1963789809","https://openalex.org/W1964169659","https://openalex.org/W1969070593","https://openalex.org/W1974339335","https://openalex.org/W1991719590","https://openalex.org/W2003202139","https://openalex.org/W2021988350","https://openalex.org/W2035543709","https://openalex.org/W2041959419","https://openalex.org/W2042064949","https://openalex.org/W2044069347","https://openalex.org/W2053094449","https://openalex.org/W2055900062","https://openalex.org/W2056783874","https://openalex.org/W2066344747","https://openalex.org/W2091214272","https://openalex.org/W2114633799","https://openalex.org/W2119037401","https://openalex.org/W2138620116","https://openalex.org/W2140339497","https://openalex.org/W2156934560","https://openalex.org/W2211001601","https://openalex.org/W2237448578","https://openalex.org/W2515036868"],"related_works":["https://openalex.org/W3191381569","https://openalex.org/W2340790095","https://openalex.org/W4406847524","https://openalex.org/W1968976383","https://openalex.org/W2597773248","https://openalex.org/W2237448578","https://openalex.org/W3004274337","https://openalex.org/W4394809121","https://openalex.org/W2043266996","https://openalex.org/W2734496067"],"abstract_inverted_index":{"The":[0,109,166,195],"current":[1],"research":[2],"was":[3,32,44,102,131,152,205],"designed":[4],"to":[5,18,34,49,71,84,104,154],"study":[6],"the":[7,15,106,135,156,171,186,197,208,217,229],"role":[8],"of":[9,53,95,117,121,126,143,158,173,177,188,199,219,231,250],"hydrogen":[10],"in":[11,88,134,147,180,233],"renal":[12,16,54,86,118,178],"fibrosis":[13,116,174,232],"and":[14,37,77,92,123,145,163,175,235],"epithelial":[17,60],"mesenchymal":[19],"transition":[20],"(EMT)":[21],"induced":[22,113,192,201,223],"by":[23,193,202,207,224],"transforming":[24],"growth":[25],"factor-\u03b21":[26],"(TGF-\u03b21).":[27],"Hydrogen":[28],"rich":[29],"water":[30],"(HW)":[31],"used":[33],"treat":[35],"animal":[36],"cell":[38],"models.":[39],"Unilateral":[40],"ureteral":[41],"obstruction":[42],"(UUO)":[43],"performed":[45,103,153],"on":[46,221],"Balb/c":[47],"mice":[48],"create":[50],"a":[51,114,213,247],"model":[52],"fibrosis.":[55],"Human":[56],"kidney":[57,90,234],"proximal":[58],"tubular":[59],"cells":[61,101,238],"(HK-2":[62],"cells)":[63],"were":[64,82],"treated":[65],"with":[66,111,138,140,168,210],"TGF-\u03b21":[67,203],"for":[68],"36":[69],"h":[70],"induce":[72],"EMT.":[73],"Serum":[74],"creatinine":[75],"(Scr)":[76],"blood":[78],"urea":[79],"nitrogen":[80],"(BUN)":[81],"measured":[83],"test":[85],"function,":[87],"addition,":[89],"histology":[91],"immunohistochemical":[93],"staining":[94],"alpha-smooth":[96],"muscle":[97],"actin":[98],"(\u03b1-SMA)":[99],"positive":[100],"examine":[105,155],"morphological":[107],"changes.":[108],"treatment":[110,167,209],"UUO":[112,181],"robust":[115],"interstitium,":[119],"shrink":[120],"glomerulus":[122],"partial":[124],"fracture":[125],"basement":[127],"membrane.":[128],"Renal":[129],"function":[130,179],"also":[132],"impaired":[133],"experimental":[136],"group":[137],"UUO,":[139],"an":[141],"increase":[142],"Scr":[144],"BUN":[146],"serum.":[148],"After":[149],"that,":[150],"Western-blot":[151],"expression":[157,198],"\u03b1-SMA,":[159],"fibronectin,":[160],"E-cadherin,":[161],"Smad2":[162],"Sirtuin-1":[164],"(Sirt1).":[165],"HW":[169,189,220,226],"attenuated":[170],"development":[172,230],"deterioration":[176],"model.":[182],"In":[183],"HK-2":[184,237],"cells,":[185],"pretreatment":[187],"abolished":[190],"EMT":[191,222,241],"TGF-\u03b21.":[194,225,251],"down-regulation":[196],"Sirt1":[200,214],"which":[204,242],"dampened":[206],"HW.":[211],"Sirtinol,":[212],"inhibitor,":[215],"reversed":[216],"effect":[218],"can":[227],"inhibit":[228],"prevents":[236],"from":[239],"undergoing":[240],"is":[243],"mediated":[244],"through":[245],"Sirt1,":[246],"downstream":[248],"molecule":[249]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-05-05T00:00:00"}
