{"id":"https://openalex.org/W2609730561","doi":null,"title":"A study on the effect of \u03b2-adrenergic stimulation on the electrophysiology of the isolated heart","display_name":"A study on the effect of \u03b2-adrenergic stimulation on the electrophysiology of the isolated heart","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2609730561","mag":"2609730561"},"language":"en","primary_location":{"id":"pmh:oai:theses.gla.ac.uk:8001","doi":null,"is_oa":true,"landing_page_url":"https://theses.gla.ac.uk/8001/1/2017Campbellphd.pdf","pdf_url":"https://theses.gla.ac.uk/8001/1/2017Campbellphd.pdf","source":{"id":"https://openalex.org/S4306401724","display_name":"Enlighten: Theses (The University of Glasgow)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I7882870","host_organization_name":"University of Glasgow","host_organization_lineage":["https://openalex.org/I7882870"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://theses.gla.ac.uk/8001/1/2017Campbellphd.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111797020","display_name":"Annabel S. Campbell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"A. Campbell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5111797020"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-adrenergic-stimulation","display_name":"beta-adrenergic stimulation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/ventricular-conduction-velocity","display_name":"ventricular conduction velocity","score":0.8510000109672546},{"id":"https://openalex.org/keywords/isoproterenol","display_name":"isoproterenol","score":0.8510000109672546},{"id":"https://openalex.org/keywords/forskolin","display_name":"forskolin","score":0.8859999775886536},{"id":"https://openalex.org/keywords/3-isobutyl-1-methylxanthine","display_name":"3-isobutyl-1-methylxanthine","score":0.7200000286102295},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.9340000152587891},{"id":"https://openalex.org/keywords/beta1-adrenergic-receptor","display_name":"beta1-adrenergic receptor","score":0.8149999976158142},{"id":"https://openalex.org/keywords/gap-junction-conductance","display_name":"gap junction conductance","score":0.8889999985694885},{"id":"https://openalex.org/keywords/sodium-channels","display_name":"sodium channels","score":0.49399998784065247},{"id":"https://openalex.org/keywords/action-potential-amplitude","display_name":"action potential amplitude","score":0.7979999780654907},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.9390000104904175},{"id":"https://openalex.org/keywords/langendorff-preparation","display_name":"isolated perfused heart","score":0.578000009059906},{"id":"https://openalex.org/keywords/cardiac-electrophysiology","display_name":"cardiac electrophysiology","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.8068545460700989},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.6886653900146484},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5769463181495667},{"id":"https://openalex.org/C2779276759","wikidata":"https://www.wikidata.org/wiki/Q412747","display_name":"Forskolin","level":3,"score":0.5534388422966003},{"id":"https://openalex.org/C2781298581","wikidata":"https://www.wikidata.org/wiki/Q223093","display_name":"IBMX","level":4,"score":0.5516595840454102},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5025873184204102},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.49781274795532227},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4553069472312927},{"id":"https://openalex.org/C2776090920","wikidata":"https://www.wikidata.org/wiki/Q415550","display_name":"Isoprenaline","level":3,"score":0.4538808763027191},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3298507332801819}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:theses.gla.ac.uk:8001","doi":null,"is_oa":true,"landing_page_url":"https://theses.gla.ac.uk/8001/1/2017Campbellphd.pdf","pdf_url":"https://theses.gla.ac.uk/8001/1/2017Campbellphd.pdf","source":{"id":"https://openalex.org/S4306401724","display_name":"Enlighten: Theses (The University of Glasgow)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I7882870","host_organization_name":"University of Glasgow","host_organization_lineage":["https://openalex.org/I7882870"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2609730561","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.712628","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:theses.gla.ac.uk:8001","doi":null,"is_oa":true,"landing_page_url":"https://theses.gla.ac.uk/8001/1/2017Campbellphd.pdf","pdf_url":"https://theses.gla.ac.uk/8001/1/2017Campbellphd.pdf","source":{"id":"https://openalex.org/S4306401724","display_name":"Enlighten: Theses (The University of Glasgow)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I7882870","host_organization_name":"University of Glasgow","host_organization_lineage":["https://openalex.org/I7882870"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2609730561.pdf","grobid_xml":"https://content.openalex.org/works/W2609730561.grobid-xml"},"referenced_works_count":149,"referenced_works":["https://openalex.org/W27796146","https://openalex.org/W71098528","https://openalex.org/W155182420","https://openalex.org/W172699719","https://openalex.org/W207527558","https://openalex.org/W1492344127","https://openalex.org/W1521606503","https://openalex.org/W1547589333","https://openalex.org/W1550053345","https://openalex.org/W1561915708","https://openalex.org/W1592811135","https://openalex.org/W1604209299","https://openalex.org/W1617602615","https://openalex.org/W1716758067","https://openalex.org/W1853529274","https://openalex.org/W1937474708","https://openalex.org/W1952008325","https://openalex.org/W1967086072","https://openalex.org/W1967182435","https://openalex.org/W1969618035","https://openalex.org/W1977845454","https://openalex.org/W1979411530","https://openalex.org/W1980056833","https://openalex.org/W1980832554","https://openalex.org/W1981613914","https://openalex.org/W1985376688","https://openalex.org/W1985575095","https://openalex.org/W1986061022","https://openalex.org/W1986189584","https://openalex.org/W1988085802","https://openalex.org/W1988478280","https://openalex.org/W1990405521","https://openalex.org/W1991288228","https://openalex.org/W1991914992","https://openalex.org/W1996798884","https://openalex.org/W2002833810","https://openalex.org/W2003918316","https://openalex.org/W2003946902","https://openalex.org/W2004205861","https://openalex.org/W2004353555","https://openalex.org/W2005784286","https://openalex.org/W2014694363","https://openalex.org/W2015162683","https://openalex.org/W2015164655","https://openalex.org/W2018372068","https://openalex.org/W2018773000","https://openalex.org/W2020701492","https://openalex.org/W2023201524","https://openalex.org/W2027148833","https://openalex.org/W2028163040","https://openalex.org/W2031025602","https://openalex.org/W2031422633","https://openalex.org/W2036395998","https://openalex.org/W2038250633","https://openalex.org/W2039841202","https://openalex.org/W2044586443","https://openalex.org/W2046148503","https://openalex.org/W2047134130","https://openalex.org/W2050584736","https://openalex.org/W2050824263","https://openalex.org/W2050844532","https://openalex.org/W2052446388","https://openalex.org/W2052675651","https://openalex.org/W2053751445","https://openalex.org/W2055936125","https://openalex.org/W2056550364","https://openalex.org/W2057334944","https://openalex.org/W2058893216","https://openalex.org/W2059297663","https://openalex.org/W2060080141","https://openalex.org/W2062887543","https://openalex.org/W2063637335","https://openalex.org/W2063650232","https://openalex.org/W2063716341","https://openalex.org/W2065858432","https://openalex.org/W2067584517","https://openalex.org/W2068487087","https://openalex.org/W2069466450","https://openalex.org/W2070349643","https://openalex.org/W2073097600","https://openalex.org/W2075003787","https://openalex.org/W2075209232","https://openalex.org/W2075270893","https://openalex.org/W2075947666","https://openalex.org/W2075977132","https://openalex.org/W2079957777","https://openalex.org/W2083358058","https://openalex.org/W2083786873","https://openalex.org/W2084282904","https://openalex.org/W2084817526","https://openalex.org/W2087126362","https://openalex.org/W2087198217","https://openalex.org/W2090043621","https://openalex.org/W2090079352","https://openalex.org/W2093637056","https://openalex.org/W2095587732","https://openalex.org/W2097158209","https://openalex.org/W2097718589","https://openalex.org/W2098276166","https://openalex.org/W2098623005","https://openalex.org/W2104838758","https://openalex.org/W2109249622","https://openalex.org/W2109422805","https://openalex.org/W2110183948","https://openalex.org/W2111355903","https://openalex.org/W2111880897","https://openalex.org/W2112091653","https://openalex.org/W2113153848","https://openalex.org/W2116691755","https://openalex.org/W2117689702","https://openalex.org/W2121902159","https://openalex.org/W2123572047","https://openalex.org/W2123929920","https://openalex.org/W2128180407","https://openalex.org/W2128296661","https://openalex.org/W2128824332","https://openalex.org/W2129529218","https://openalex.org/W2132691682","https://openalex.org/W2136290454","https://openalex.org/W2138354938","https://openalex.org/W2138688828","https://openalex.org/W2140313980","https://openalex.org/W2140417243","https://openalex.org/W2141260882","https://openalex.org/W2142067945","https://openalex.org/W2142100237","https://openalex.org/W2143018211","https://openalex.org/W2146516838","https://openalex.org/W2147337108","https://openalex.org/W2147857057","https://openalex.org/W2148936486","https://openalex.org/W2149239576","https://openalex.org/W2151641082","https://openalex.org/W2153624323","https://openalex.org/W2153855760","https://openalex.org/W2155347215","https://openalex.org/W2159726502","https://openalex.org/W2163151214","https://openalex.org/W2163946213","https://openalex.org/W2165286550","https://openalex.org/W2167525963","https://openalex.org/W2167708918","https://openalex.org/W2168217298","https://openalex.org/W2168760561","https://openalex.org/W2171409673","https://openalex.org/W2184156660","https://openalex.org/W2418779321","https://openalex.org/W2423815963","https://openalex.org/W2430085908"],"related_works":["https://openalex.org/W2085716671","https://openalex.org/W2046148503","https://openalex.org/W7096343377","https://openalex.org/W2022773366","https://openalex.org/W1980720980","https://openalex.org/W7005975224","https://openalex.org/W2027702162","https://openalex.org/W15754148","https://openalex.org/W2006909118","https://openalex.org/W3203096537"],"abstract_inverted_index":{"Background:":[0],"A":[1],"coordinated":[2],"heart":[3,440],"beat":[4],"relies":[5],"on":[6,92,133,177],"the":[7,15,20,82,93,102,107,115,137,146,155,172,181,185,230,233,255,304,311,337,340,407,425,439,448,458],"propagation":[8],"of":[9,23,39,52,81,101,109,126,148,174,220,232,249,339,382,392,427,438,447],"a":[10,28,216,242,317,364,419],"rapid":[11],"depolarising":[12],"event":[13],"throughout":[14],"atria":[16],"and":[17,19,34,55,153,163,202,223,251,259,291,370,441,454],"ventricles":[18],"subsequent":[21],"coupling":[22],"this":[24,158,422],"electrical":[25],"signal":[26],"to":[27,144,150,170,188,276,285,309,361,403,434,444],"transient":[29],"contraction":[30],"in":[31,136,272,287,295,313,325,375,399,421,457],"every":[32],"atrial":[33],"ventricular":[35,134],"cardiomyocyte.":[36],"The":[37,141,237,397],"rate":[38],"propagation,":[40],"known":[41],"as":[42,184],"conduction":[43,349],"velocity":[44],"(CV)":[45],"is":[46,62,432],"mainly":[47],"determined":[48],"by":[49,72,120,199,267,333,380,395,429],"cellular":[50,178],"expression":[51],"Na":[53],"channels":[54],"gap":[56,321],"junctional":[57],"proteins":[58,67],"(connexins),":[59],"however":[60],"there":[61],"emerging":[63],"evidence":[64],"that":[65,79,300],"both":[66],"may":[68,442],"be":[69,277,404],"functionally":[70],"regulated":[71],"intrinsic":[73],"signaling":[74,453],"processes.":[75],"Previous":[76],"studies":[77],"indicate":[78],"stimulation":[80,111,152,176,262,358,431],"\u03b2-adrenergic":[83],"pathway":[84],"increases":[85],"CV,":[86,363],"but":[87],"little":[88],"consistent":[89],"data":[90,335],"exists":[91],"magnitude,":[94],"associated":[95],"adrenoreceptor":[96],"pharmacology":[97],"or":[98,119,389],"time":[99],"course":[100],"effect.":[103],"This":[104,270,280,315,329],"study":[105],"investigates":[106],"effect":[108,173,281],"\u03b2-AR":[110,151,175,189,261,357,430,452],"\u2013":[112],"using":[113,215],"either":[114],"\u03b2-agonist":[116],"isoproterenol":[117],"(ISO)":[118],"directly":[121],"raising":[122],"cAMP":[123,278,377,408,413],"via":[124,367],"addition":[125],"Forskolin":[127],"(Fsk)":[128,388],"and/or":[129],"3-Isobutyl-1-methylxanthine":[130],"(IBMX)":[131],"-":[132],"CV":[135,149,186,211,238,266,273,327,400,428],"intact":[138],"rat":[139],"heart.":[140,460],"aim":[142],"was":[143,274,282,302,306,331,342,359,378,401],"measure":[145],"response":[147,187,341,365],"investigate":[154],"mechanisms":[156],"behind":[157],"response.":[159],"Action":[160],"potential":[161,318],"(AP)":[162],"intracellular":[164,252],"Ca2+":[165,253,288],"measurements":[166,212,248],"were":[167,197,213],"also":[168,240],"made":[169],"determine":[171],"electrophysiology":[179],"over":[180],"same":[182],"time-course":[183],"stimulation.":[190],"Methods:":[191],"Adult":[192],"male":[193],"Wistar":[194],"rats":[195],"(250-350g)":[196],"euthanized":[198],"cervical":[200],"dislocation":[201],"excised":[203],"hearts":[204],"retrogradely":[205],"perfused":[206],"with":[207,386],"modified":[208],"Tyrode's":[209],"solution.":[210],"taken":[214],"custom-built":[217],"probe,":[218],"consisting":[219],"bipolar":[221],"stimulating":[222],"recording":[224],"electrode":[225],"pairs":[226],"placed":[227],"flat":[228],"against":[229],"epicardium":[231],"left":[234],"ventricle":[235],"(LV).":[236],"probe":[239],"incorporated":[241],"fibre-optic":[243],"light":[244],"guide,":[245],"allowing":[246],"ratiometric":[247],"voltage":[250],"from":[254],"LV":[256,264],"epicardium.":[257],"Results":[258],"Conclusions:":[260],"increased":[263,379],"longitudinal":[265,355],"approximately":[268],"10%.":[269],"increase":[271,294,362,374,398],"found":[275],"mediated.":[279],"not":[283,417],"due":[284],"changes":[286],"handling":[289],"alone":[290],"although":[292],"an":[293,373],"AP":[296],"amplitude":[297],"(APA)":[298],"suggested":[299,316],"INa":[301],"increased,":[303],"magnitude":[305,338],"thought":[307],"insufficient":[308],"explain":[310],"change":[312],"CV.":[314],"role":[319,420],"for":[320],"junction":[322],"conductance":[323],"(GJC)":[324],"mediating":[326],"changes.":[328],"view":[330],"supported":[332],"preliminary":[334],"indicating":[336],"larger":[343],"when":[344],"measuring":[345],"transverse":[346,348],"CV:":[347],"involves":[350],"proportionally":[351],"more":[352],"GJC":[353],"than":[354],"conduction.":[356],"confirmed":[360],"mediated":[366,405],"\u03b21AR":[368],"subtype,":[369],"which":[371],"required":[372],"cAMP:":[376],"activation":[381],"adenylyl":[383],"cyclase":[384],"(AC)":[385],"forskolin":[387],"through":[390,406],"inhibition":[391],"phosphodiesterases":[393],"(PDEs)":[394],"IBMX.":[396],"shown":[402],"sensitive":[409],"kinase,":[410],"PKA;":[411],"another":[412],"target,":[414],"Epac,":[415],"appeared":[416],"have":[418],"pathway.":[423],"Understanding":[424],"regulation":[426,437],"crucial":[433],"understanding":[435,446],"sympathetic":[436],"lead":[443],"further":[445],"interplay":[449],"between":[450],"downregulated":[451],"arrhythmia":[455],"generation":[456],"diseased":[459]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-05-05T00:00:00"}