{"id":"https://openalex.org/W2609727992","doi":"https://doi.org/10.1186/s12885-017-3284-7","title":"Effect of genetic variants and traits related to glucose metabolism and their interaction with obesity on breast and colorectal cancer risk among postmenopausal women","display_name":"Effect of genetic variants and traits related to glucose metabolism and their interaction with obesity on breast and colorectal cancer risk among postmenopausal women","publication_year":2017,"publication_date":"2017-04-26","ids":{"openalex":"https://openalex.org/W2609727992","doi":"https://doi.org/10.1186/s12885-017-3284-7","mag":"2609727992","pmid":"https://pubmed.ncbi.nlm.nih.gov/28446149","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5405540"},"language":"en","primary_location":{"id":"doi:10.1186/s12885-017-3284-7","doi":"https://doi.org/10.1186/s12885-017-3284-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-017-3284-7","pdf_url":"https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-017-3284-7","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-017-3284-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012046553","display_name":"Su Yon Jung","orcid":"https://orcid.org/0000-0002-0513-1830","observed_orcids":["https://orcid.org/0000-0002-0513-1830"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4390039293","display_name":"UCLA Jonsson Comprehensive Cancer Center","ror":"https://ror.org/0599cs764","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I4390039293"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Su Yon Jung","raw_affiliation_strings":["Translational Sciences Section, Jonsson Comprehensive Cancer Center, School of Nursing, University of California Los Angeles, 700 Tiverton Ave, 3-264 Factor Building, Los Angeles, CA, 90095, USA. sjung@sonnet.ucla.edu","Translational Sciences Section, Jonsson Comprehensive Cancer Center, School of Nursing, University of California Los Angeles, 700 Tiverton Ave, 3-264 Factor Building, Los Angeles, CA, 90095, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Sciences Section, Jonsson Comprehensive Cancer Center, School of Nursing, University of California Los Angeles, 700 Tiverton Ave, 3-264 Factor Building, Los Angeles, CA, 90095, USA. sjung@sonnet.ucla.edu","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"]},{"raw_affiliation_string":"Translational Sciences Section, Jonsson Comprehensive Cancer Center, School of Nursing, University of California Los Angeles, 700 Tiverton Ave, 3-264 Factor Building, Los Angeles, CA, 90095, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061772385","display_name":"Eric M. Sobel","orcid":"https://orcid.org/0000-0002-1718-0031","observed_orcids":["https://orcid.org/0000-0002-1718-0031"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric M. Sobel","raw_affiliation_strings":["Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067468133","display_name":"Jeanette C. Papp","orcid":"https://orcid.org/0000-0001-9561-7860","observed_orcids":["https://orcid.org/0000-0001-9561-7860"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeanette C. Papp","raw_affiliation_strings":["Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100661022","display_name":"Zuo\u2010Feng Zhang","orcid":"https://orcid.org/0000-0002-4669-3995","observed_orcids":["https://orcid.org/0000-0002-4669-3995"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zuo-Feng Zhang","raw_affiliation_strings":["Department of Epidemiology, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5012046553"],"corresponding_institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":0.9053,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.7373264,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"17","issue":"1","first_page":"290","last_page":"290"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.8438000082969666,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.8438000082969666,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.07050000131130219,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.03999999910593033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.734000027179718},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.8790000081062317},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7749999761581421},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7480000257492065},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":1.0},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.996999979019165},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.777999997138977},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.925000011920929},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.9539999961853027},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.6859999895095825},{"id":"https://openalex.org/keywords/mediation-analysis","display_name":"mediation analysis","score":0.6230000257492065},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9079999923706055},{"id":"https://openalex.org/keywords/gckr","display_name":"GCKR","score":0.972000002861023},{"id":"https://openalex.org/keywords/women-s-health-initiative","display_name":"Women's Health Initiative","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7174785733222961},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7116599082946777},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.6811965703964233},{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.6771002411842346},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6258267760276794},{"id":"https://openalex.org/C3018603563","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Postmenopausal women","level":2,"score":0.5980786085128784},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5059410929679871},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5036973357200623},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41488519310951233},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36216604709625244},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18370869755744934}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D017698","descriptor_name":"Postmenopause","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/s12885-017-3284-7","doi":"https://doi.org/10.1186/s12885-017-3284-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-017-3284-7","pdf_url":"https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-017-3284-7","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4252842","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5405540","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5405540","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5405540","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"Text"},{"id":"pmid:28446149","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28446149","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC cancer","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d1f12f8e2f3846d9a353ab27695c39fe","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d1f12f8e2f3846d9a353ab27695c39fe","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Cancer, Vol 17, Iss 1, Pp 1-14 (2017)","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt3vz1178d","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/3vz1178d","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Cancer, vol 17, iss 1","raw_type":"article"},{"id":"pmh:qt3vz1178d","doi":null,"is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/3vz1178d","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Jung, SY; Sobel, EM; Papp, JC; &amp; Zhang, ZF. (2017). Effect of genetic variants and traits related to glucose metabolism and their interaction with obesity on breast and colorectal cancer risk among postmenopausal women. BMC Cancer, 17(1), 290. doi: 10.1186/s12885-017-3284-7. UCLA: Retrieved from: http://www.escholarship.org/uc/item/3vz1178d","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12885-017-3284-7","doi":"https://doi.org/10.1186/s12885-017-3284-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-017-3284-7","pdf_url":"https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-017-3284-7","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2609727992.pdf","grobid_xml":"https://content.openalex.org/works/W2609727992.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W243350443","https://openalex.org/W1580610162","https://openalex.org/W1971383683","https://openalex.org/W1976926066","https://openalex.org/W1981642992","https://openalex.org/W1987318711","https://openalex.org/W1995532066","https://openalex.org/W1995962039","https://openalex.org/W1996633881","https://openalex.org/W2000811716","https://openalex.org/W2008697716","https://openalex.org/W2014979078","https://openalex.org/W2019020805","https://openalex.org/W2025740950","https://openalex.org/W2027586254","https://openalex.org/W2041776447","https://openalex.org/W2042560956","https://openalex.org/W2042650991","https://openalex.org/W2045965772","https://openalex.org/W2048383138","https://openalex.org/W2063398467","https://openalex.org/W2065417819","https://openalex.org/W2066802671","https://openalex.org/W2069115947","https://openalex.org/W2073737592","https://openalex.org/W2077296319","https://openalex.org/W2080825863","https://openalex.org/W2087370105","https://openalex.org/W2089575987","https://openalex.org/W2093678620","https://openalex.org/W2097819965","https://openalex.org/W2098392939","https://openalex.org/W2101449835","https://openalex.org/W2104057213","https://openalex.org/W2109402196","https://openalex.org/W2118356108","https://openalex.org/W2119362678","https://openalex.org/W2128037741","https://openalex.org/W2138412263","https://openalex.org/W2139291585","https://openalex.org/W2150746786","https://openalex.org/W2157957715","https://openalex.org/W2159422401","https://openalex.org/W2160234571","https://openalex.org/W2163470362","https://openalex.org/W2164822601","https://openalex.org/W2171750333","https://openalex.org/W2234675074","https://openalex.org/W2244175081","https://openalex.org/W2290627980","https://openalex.org/W2607031541","https://openalex.org/W4212838134"],"related_works":["https://openalex.org/W6958991814","https://openalex.org/W6977096008","https://openalex.org/W7136081928","https://openalex.org/W7136058778","https://openalex.org/W2763406009","https://openalex.org/W2740609900","https://openalex.org/W4392691015","https://openalex.org/W2895989264","https://openalex.org/W2911046959","https://openalex.org/W2611903691"],"abstract_inverted_index":{"BACKGROUND:":[0],"Impaired":[1],"glucose":[2,43,57,63,70,78,90,118,196,229,259,278],"metabolism-related":[3],"genetic":[4,45,59,72,261],"variants":[5,46,60,73,262],"and":[6,12,19,35,66,92,104,114,123,141,144,151,212,245],"traits":[7],"likely":[8],"interact":[9,263],"with":[10,89,138,164,178,264],"obesity":[11,34],"related":[13],"lifestyle":[14],"factors,":[15],"influencing":[16],"postmenopausal":[17,96],"breast":[18,139,237],"colorectal":[20],"cancer":[21,48,140,161,182,224,269],"(CRC),":[22],"but":[23],"their":[24],"interconnected":[25],"pathways":[26,75,272],"are":[27],"not":[28],"fully":[29],"understood.":[30],"By":[31],"stratifying":[32],"via":[33,228],"lifestyles,":[36],"we":[37,109],"partitioned":[38],"the":[39,99,112,157,165,169,172,186,203],"total":[40,173],"effect":[41,159,174,193],"of":[42,117,160,171,181,223],"metabolism":[44,58,64,71,79,91,197,230,260,279],"on":[47],"risk":[49,162,183,225,270],"into":[50],"two":[51,130,234],"putative":[52],"mechanisms:":[53],"1)":[54],"indirect":[55,113,192,204],"(risk-associated":[56,69],"mediated":[61,194,227,276],"by":[62,195,277],"traits)":[65,80],"2)":[67],"direct":[68,115,158],"through":[74,243,252,271],"other":[76,273],"than":[77,274],"effects.":[81],"METHOD:":[82],"Using":[83],"16":[84],"single-nucleotide":[85],"polymorphisms":[86],"(SNPs)":[87],"associated":[88,137,163],"data":[93],"from":[94,190],"5379":[95],"women":[97],"in":[98,202,236,239,246,248,267],"Women's":[100],"Health":[101],"Initiative":[102],"Harmonized":[103],"Imputed":[105],"Genome-Wide":[106],"Association":[107],"Studies,":[108],"retrospectively":[110],"assessed":[111],"effects":[116,207],"metabolism-traits":[119],"(fasting":[120],"glucose,":[121,244],"insulin,":[122],"homeostatic":[124],"model":[125],"assessment-insulin":[126],"resistance":[127],"[HOMA-IR])":[128],"using":[129],"quantitative":[131],"tests.":[132],"RESULTS:":[133],"Several":[134],"SNPs":[135],"were":[136,208],"CRC":[142],"risk,":[143],"these":[145],"SNP-cancer":[146],"associations":[147],"differed":[148],"between":[149,210],"non-obese":[150,211],"obese":[152,213,220],"women.":[153,214],"In":[154],"both":[155],"strata,":[156],"SNP":[166,187],"accounted":[167],"for":[168,175],"majority":[170],"most":[176],"SNPs,":[177],"roughly":[179],"10%":[180],"due":[184],"to":[185,233,241,250],"that":[188,218,258],"was":[189,226],"an":[191],"traits.":[198,280],"No":[199],"apparent":[200],"differences":[201],"(glucose":[205],"metabolism-mediated)":[206],"seen":[209],"It":[215],"is":[216],"notable":[217],"among":[219],"women,":[221],"50%":[222],"trait,":[231],"owing":[232],"SNPs:":[235],"cancer,":[238],"relation":[240,249],"GCKR":[242],"CRC,":[247],"DGKB/TMEM195":[251],"HOMA-IR.":[253],"CONCLUSIONS:":[254],"Our":[255],"findings":[256],"suggest":[257],"obesity,":[265],"resulting":[266],"altered":[268],"those":[275]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-05-05T00:00:00"}
