{"id":"https://openalex.org/W2609301554","doi":null,"title":"Novel functional roles for CRH -binding protein at the pituitary.","display_name":"Novel functional roles for CRH -binding protein at the pituitary.","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2609301554","mag":"2609301554"},"language":"en","primary_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/123954","doi":null,"is_oa":false,"landing_page_url":"https://deepblue.lib.umich.edu/bitstreams/61b21e41-1286-4ed7-871e-d9bd3569dbc9/download","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062951881","display_name":"Debra B. Speert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Debra Speert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5062951881"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.8407999873161316,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.8407999873161316,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.05649999901652336,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.055399999022483826,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crh-binding-protein","display_name":"CRH-binding protein","score":0.8939999938011169},{"id":"https://openalex.org/keywords/corticotropin-releasing-factor","display_name":"corticotropin-releasing factor","score":0.9769999980926514},{"id":"https://openalex.org/keywords/pituitary-gland","display_name":"pituitary gland","score":0.8429999947547913},{"id":"https://openalex.org/keywords/lactotrophs","display_name":"lactotrophs","score":0.8669999837875366},{"id":"https://openalex.org/keywords/corticotrophs","display_name":"corticotrophs","score":0.9670000076293945},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.8529999852180481},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.6980000138282776},{"id":"https://openalex.org/keywords/sexual-dimorphism","display_name":"sexual dimorphism","score":0.7639999985694885},{"id":"https://openalex.org/keywords/estrogen-regulation","display_name":"estrogen regulation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.7820000052452087},{"id":"https://openalex.org/keywords/ovariectomy","display_name":"ovariectomy","score":0.8740000128746033},{"id":"https://openalex.org/keywords/prolactin-secretion","display_name":"prolactin secretion","score":0.9169999957084656},{"id":"https://openalex.org/keywords/acth-secretion","display_name":"ACTH secretion","score":0.8830000162124634},{"id":"https://openalex.org/keywords/restraint-stress","display_name":"restraint stress","score":0.7820000052452087},{"id":"https://openalex.org/keywords/proestrus","display_name":"proestrus","score":0.8740000128746033}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3923322856426239},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3511630892753601},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3015475869178772}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/123954","doi":null,"is_oa":false,"landing_page_url":"https://deepblue.lib.umich.edu/bitstreams/61b21e41-1286-4ed7-871e-d9bd3569dbc9/download","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2609301554","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2027.42/123954","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Deep Blue (University of Michigan)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3199070677","https://openalex.org/W2085518231","https://openalex.org/W2004954728","https://openalex.org/W2624402403","https://openalex.org/W1522975530","https://openalex.org/W3153878485","https://openalex.org/W4296740463","https://openalex.org/W2390328414","https://openalex.org/W2162181411","https://openalex.org/W2073282022"],"abstract_inverted_index":{"Corticotropin-releasing":[0],"hormone":[1],"(CRH)":[2],"is":[3,20,31],"the":[4,8,23,37,61,78,85,104,110,121,125,159,186,202,233,237,245,275,281,328,334,341],"key":[5],"regulator":[6],"of":[7,14,57,97,124,132,178,208,236,242,300,336],"mammalian":[9],"stress":[10,160,267],"response.":[11],"The":[12],"bioactivity":[13],"CRH":[15,59],"and":[16,40,101,144,161,217,240,251],"other":[17],"CRH-like":[18],"peptides":[19],"modulated":[21],"by":[22],"CRH-binding":[24],"protein":[25,102],"(CRH-BP),":[26],"a":[27,287],"secreted":[28],"glycoprotein":[29],"that":[30,168,309,321],"expressed":[32],"at":[33,120,211,225],"multiple":[34,337],"sites":[35,177,191],"in":[36,49,60,64,74,79,84,103,109,147,184,201,220,244,248,279,315,327,340],"rodent":[38],"brain":[39],"pituitary.":[41,122,205,342],"Behavioral":[42],"studies":[43,166,231,319],"have":[44,67],"demonstrated":[45,68,296],"elevated":[46,55,107,224,260],"anxiogenic":[47],"behavior":[48],"CRH-BP-deficient":[50],"(BPKO)":[51],"mice,":[52],"consistent":[53],"with":[54,106],"levels":[56,299],"free":[58],"brain.":[62],"Studies":[63],"cell":[65],"culture":[66],"an":[69],"inhibitory":[70],"role":[71,81,174,276],"for":[72,82,118,192,277],"CRH-BP":[73,83,99,119,133,141,153,169,181,200,209,218,243,278,310,322],"pituitary":[75,86,98,140,187,247],"cells.":[76],"However,":[77],"vivo":[80],"has":[87,92],"remained":[88],"unclear.":[89],"Recent":[90],"examination":[91],"revealed":[93,167],"sexually":[94],"dimorphic":[95],"expression":[96,108,210,219],"mRNA":[100,142],"mouse,":[105],"female.":[111],"These":[112,272,306],"data":[113,273,307],"suggest":[114,308,320],"potentially":[115],"novel":[116,173,238],"roles":[117,325],"Characterization":[123],"sexual":[126],"dimorphism":[127],"reveals":[128],"positive":[129],"estrogen":[130],"regulation":[131,239],"expression.":[134,179],"Ovariectomy":[135],"dramatically":[136],"reduced":[137],"steady":[138],"state":[139],"levels,":[143],"estradiol":[145],"treatment":[146],"ovariectomized":[148],"mice":[149,258,294],"reinstated":[150],"control":[151],"levels.":[152],"may":[154,170,311],"therefore":[155],"facilitate":[156],"interactions":[157,335],"between":[158],"reproductive":[162],"axes.":[163],"Cellular":[164],"localization":[165,241],"mediate":[171,331],"this":[172],"from":[175,265],"additional":[176],"While":[180],"was":[182,213,222],"observed":[183],"corticotropes,":[185],"HPA":[188,282],"axis":[189,283],"target":[190],"CRH,":[193],"lactotropes":[194,221],"were":[195],"also":[196,295],"found":[197],"to":[198,215,228,269,284,303,330],"express":[199],"female":[203,246,329],"mouse":[204],"Eighty":[206],"percent":[207],"proestrus":[212,226],"localized":[214],"lactotropes,":[216],"significantly":[223],"compared":[227,268,302],"metestrus.":[229],"Functional":[230],"demonstrate":[232],"physiological":[234],"importance":[235],"both":[249],"corticotropes":[250],"lactotropes.":[252],"Female":[253,289],"but":[254,290],"not":[255,291],"male":[256,292],"BPKO":[257,293],"exhibited":[259],"ACTH":[261],"secretion":[262,314],"during":[263],"recovery":[264],"restraint":[266],"wildtype":[270,304],"controls.":[271],"illuminate":[274],"returning":[280],"homeostasis":[285],"following":[286],"stressor.":[288],"diminished":[297],"serum":[298],"prolactin":[301,313],"mice.":[305],"modulate":[312,333],"vivo.":[316],"Together,":[317],"these":[318],"performs":[323],"important":[324],"specifically":[326],"or":[332],"endocrine":[338],"systems":[339]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2017-05-05T00:00:00"}