{"id":"https://openalex.org/W2609239341","doi":"https://doi.org/10.1093/sleepj/zsx050.136","title":"0137 AMYGDALAR REGULATION OF PONTINE REM REGULATORY REGIONS: EFFECTS OF SLEEP","display_name":"0137 AMYGDALAR REGULATION OF PONTINE REM REGULATORY REGIONS: EFFECTS OF SLEEP","publication_year":2017,"publication_date":"2017-04-28","ids":{"openalex":"https://openalex.org/W2609239341","doi":"https://doi.org/10.1093/sleepj/zsx050.136","mag":"2609239341"},"language":"en","primary_location":{"id":"doi:10.1093/sleepj/zsx050.136","doi":"https://doi.org/10.1093/sleepj/zsx050.136","is_oa":false,"landing_page_url":"https://doi.org/10.1093/sleepj/zsx050.136","pdf_url":null,"source":{"id":"https://openalex.org/S42921845","display_name":"SLEEP","issn_l":"0161-8105","issn":["0161-8105","1550-9109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sleep","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019612542","display_name":"BL Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"BL Williams","raw_affiliation_strings":["Eastern Virginia Medical School, Norfolk, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eastern Virginia Medical School, Norfolk, VA","institution_ids":["https://openalex.org/I156802259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016075429","display_name":"AM Sutton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"AM Sutton","raw_affiliation_strings":["Eastern Virginia Medical School, Norfolk, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eastern Virginia Medical School, Norfolk, VA","institution_ids":["https://openalex.org/I156802259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108629167","display_name":"ME Fitzpatrick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ME Fitzpatrick","raw_affiliation_strings":["Eastern Virginia Medical School, Norfolk, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eastern Virginia Medical School, Norfolk, VA","institution_ids":["https://openalex.org/I156802259"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Machida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Machida","raw_affiliation_strings":["Eastern Virginia Medical School, Norfolk, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eastern Virginia Medical School, Norfolk, VA","institution_ids":["https://openalex.org/I156802259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079202106","display_name":"Laurie L. Wellman","orcid":"https://orcid.org/0000-0001-9195-2063","observed_orcids":["https://orcid.org/0000-0001-9195-2063"]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LL Wellman","raw_affiliation_strings":["Eastern Virginia Medical School, Norfolk, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eastern Virginia Medical School, Norfolk, VA","institution_ids":["https://openalex.org/I156802259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075821432","display_name":"Gy\u00f6rgy L\u00f3n\u00e1rt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G Lonart","raw_affiliation_strings":["Eastern Virginia Medical School, Norfolk, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eastern Virginia Medical School, Norfolk, VA","institution_ids":["https://openalex.org/I156802259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112273576","display_name":"LD Sanford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LD Sanford","raw_affiliation_strings":["Eastern Virginia Medical School, Norfolk, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eastern Virginia Medical School, Norfolk, VA","institution_ids":["https://openalex.org/I156802259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I156802259"],"apc_list":{"value":4388,"currency":"USD","value_usd":4388},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"suppl_1","first_page":"A51","last_page":"A51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/central-nucleus-of-the-amygdala","display_name":"central amygdala","score":0.8360000252723694},{"id":"https://openalex.org/keywords/rem-sleep","display_name":"REM sleep","score":0.7720000147819519},{"id":"https://openalex.org/keywords/pedunculopontine-nucleus","display_name":"pedunculopontine nucleus","score":0.9779999852180481},{"id":"https://openalex.org/keywords/subcoeruleus","display_name":"subcoeruleus","score":0.9599999785423279},{"id":"https://openalex.org/keywords/brainstem-circuits","display_name":"brainstem circuits","score":0.5189999938011169},{"id":"https://openalex.org/keywords/optogenetics","display_name":"optogenetics","score":0.6830000281333923},{"id":"https://openalex.org/keywords/rem-sleep-regulation","display_name":"REM sleep regulation","score":0.5139999985694885},{"id":"https://openalex.org/keywords/sleep-architecture","display_name":"sleep architecture","score":0.3160000145435333},{"id":"https://openalex.org/keywords/nrem-sleep","display_name":"NREM sleep","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C50738837","wikidata":"https://www.wikidata.org/wiki/Q781492","display_name":"Optogenetics","level":2,"score":0.813916802406311},{"id":"https://openalex.org/C24566897","wikidata":"https://www.wikidata.org/wiki/Q943621","display_name":"Tegmentum","level":4,"score":0.6628133058547974},{"id":"https://openalex.org/C2778897929","wikidata":"https://www.wikidata.org/wiki/Q192570","display_name":"Pons","level":2,"score":0.6620423793792725},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6555750370025635},{"id":"https://openalex.org/C2777426569","wikidata":"https://www.wikidata.org/wiki/Q5062126","display_name":"Central nucleus of the amygdala","level":3,"score":0.5608864426612854},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5011417865753174},{"id":"https://openalex.org/C2778655484","wikidata":"https://www.wikidata.org/wiki/Q750588","display_name":"Reticular formation","level":3,"score":0.4879891276359558},{"id":"https://openalex.org/C551621295","wikidata":"https://www.wikidata.org/wiki/Q182228","display_name":"Brainstem","level":2,"score":0.4770585596561432},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.4765380322933197},{"id":"https://openalex.org/C2779213384","wikidata":"https://www.wikidata.org/wiki/Q211402","display_name":"Rapid eye movement sleep","level":3,"score":0.44235605001449585},{"id":"https://openalex.org/C20566671","wikidata":"https://www.wikidata.org/wiki/Q1752878","display_name":"Non-rapid eye movement sleep","level":3,"score":0.4105711877346039},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33294469118118286},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.306511253118515},{"id":"https://openalex.org/C552161191","wikidata":"https://www.wikidata.org/wiki/Q185080","display_name":"Midbrain","level":3,"score":0.28999435901641846},{"id":"https://openalex.org/C153050134","wikidata":"https://www.wikidata.org/wiki/Q760256","display_name":"Eye movement","level":2,"score":0.24989712238311768},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.14894062280654907}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/sleepj/zsx050.136","doi":"https://doi.org/10.1093/sleepj/zsx050.136","is_oa":false,"landing_page_url":"https://doi.org/10.1093/sleepj/zsx050.136","pdf_url":null,"source":{"id":"https://openalex.org/S42921845","display_name":"SLEEP","issn_l":"0161-8105","issn":["0161-8105","1550-9109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sleep","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4210488917","https://openalex.org/W2608793742","https://openalex.org/W2066867569","https://openalex.org/W2057940958","https://openalex.org/W2021905125","https://openalex.org/W2608984126","https://openalex.org/W1966035657","https://openalex.org/W3032724029","https://openalex.org/W2940120670","https://openalex.org/W3029465907"],"abstract_inverted_index":{"The":[0,123],"central":[1],"nucleus":[2,55,63],"of":[3,19,26,47,150,164,203,236,259,281,287],"the":[4,20,23,27,45,51,57,62,84,112,118,134,141,176,282,285,288],"amygdala":[5,289],"(CNA)":[6],"projects":[7],"to":[8,43,111,147,199,267],"brainstem":[9,114],"regions":[10,31],"that":[11,102,107,234,243,272],"generate":[12],"and":[13,22,61,86,136,144,159,185,196,212,216,241],"regulate":[14],"REM.":[15,67,291],"However,":[16],"synaptic":[17],"mapping":[18],"circuitry":[21,283],"actual":[24],"influence":[25,46,239,286],"CNA":[28,48,85,105,167,174,195,204,211,215,237,257],"on":[29,66,254,290],"these":[30],"has":[32],"not":[33,219,226,265],"been":[34],"determined.":[35],"In":[36],"this":[37],"study,":[38],"we":[39],"used":[40],"optogenetic":[41,79],"methods":[42],"assess":[44],"inputs":[49],"into":[50,83,89,133,173,194,210],"oral":[52],"pontine":[53],"reticular":[54],"(PnO),":[56],"pedunculo-pontine":[58],"tegmentum":[59],"(PPT)":[60],"subcoeruleus":[64],"(SubC)":[65],"Twelve":[68],"male":[69],"Wistar":[70],"strain":[71],"rats":[72],"were":[73,99,108,125],"stereotaxically":[74],"injected":[75,193],"with":[76,87,127,137,170,190,207],"an":[77,246],"excitatory":[78],"construct":[80],"(AAV5-EF1a-DIO":[81],"-hChR2(H134R)-EYFP)":[82],"AAV5-EF1a-mCherry-IRES-WGA-Cre":[88],"PnO":[90,244],"(n=4),":[91,93],"PPT":[92,213,260],"or":[94,214,261],"SubC":[95,217,262],"(n=4).":[96],"These":[97,231],"constructs":[98,192],"designed":[100],"such":[101],"only":[103],"those":[104],"neurons":[106],"synaptically":[109],"connected":[110],"specific":[113],"region":[115],"would":[116],"express":[117],"light":[119,131,162,172],"sensitive":[120],"opsin,":[121],"hChR2-EYFP.":[122],"animals":[124,189,206],"implanted":[126],"bilateral":[128],"optrodes":[129],"for":[130,139,277],"delivery":[132],"CNA,":[135],"electrodes":[138],"recording":[140],"electroencephalogram":[142],"(EEG)":[143],"electromyogram":[145],"(EMG)":[146],"allow":[148],"determination":[149],"sleep.":[151,201,256],"After":[152],"recovery,":[153],"sleep":[154,222],"was":[155,264],"recorded":[156],"under":[157,160],"non-stimulated":[158],"blue":[161,171],"stimulation":[163],"opsin":[165],"expressing":[166],"neurons.":[168],"Stimulation":[169,202],"during":[175],"dark":[177],"period":[178],"resulted":[179],"in":[180,188,205,250],"significantly":[181,220,228],"higher":[182],"REM":[183,186,240,255,269],"amounts":[184],"episodes":[187],"paired":[191,208],"PnO,":[197],"compared":[198],"baseline":[200],"injections":[209],"did":[218,225],"affect":[221],"parameters.":[223],"NREM":[224],"differ":[227],"between":[229],"groups.":[230],"data":[232],"demonstrate":[233,242],"activation":[235],"can":[238,274],"is":[245],"important":[247],"projection":[248],"area":[249],"mediating":[251],"CNA\u2019s":[252],"effects":[253],"modulation":[258],"alone":[263],"sufficient":[266],"alter":[268],"thereby":[270],"indicating":[271],"optogenetics":[273],"be":[275],"useful":[276],"delineating":[278],"functional":[279],"components":[280],"underlying":[284],"MH1057701,":[292],"MH64827.":[293]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2017-05-05T00:00:00"}