{"id":"https://openalex.org/W2609027640","doi":null,"title":"Exploring the Hypersensitivity of PTEN Deleted Prostate Cancer Stem Cells to WEE1 Tyrosine Kinase Inhibitors","display_name":"Exploring the Hypersensitivity of PTEN Deleted Prostate Cancer Stem Cells to WEE1 Tyrosine Kinase Inhibitors","publication_year":2015,"publication_date":"2015-12-01","ids":{"openalex":"https://openalex.org/W2609027640","mag":"2609027640"},"language":"en","primary_location":{"id":"mag:2609027640","doi":null,"is_oa":false,"landing_page_url":"https://apps.dtic.mil/dtic/tr/fulltext/u2/1031407.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082062478","display_name":"Kiran N. Mahajan","orcid":"https://orcid.org/0000-0001-7192-396X","observed_orcids":["https://orcid.org/0000-0001-7192-396X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kiran Mahajan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5082062478"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.7836999893188477,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.7836999893188477,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.08380000293254852,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.057100001722574234,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pten-deletion","display_name":"PTEN deletion","score":0.7850000262260437},{"id":"https://openalex.org/keywords/prostate-cancer-stem-cells","display_name":"prostate cancer stem cells","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mk-1775","display_name":"MK-1775","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mitotic-catastrophe","display_name":"mitotic catastrophe","score":0.675000011920929},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.6309999823570251},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.7049999833106995},{"id":"https://openalex.org/keywords/chromatin-replication","display_name":"chromatin replication","score":0.6990000009536743},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.6890000104904175},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7469713687896729},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.742388129234314},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.698909342288971},{"id":"https://openalex.org/C2781252693","wikidata":"https://www.wikidata.org/wiki/Q7979264","display_name":"Wee1","level":5,"score":0.6884258985519409},{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.675333559513092},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5924805402755737},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.4764145612716675},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.4565775394439697},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4028361737728119},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3913532495498657},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.36057546734809875},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.2959153652191162},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2510063946247101},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.21328994631767273},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1727319061756134},{"id":"https://openalex.org/C120504264","wikidata":"https://www.wikidata.org/wiki/Q1147372","display_name":"Cyclin-dependent kinase 1","level":4,"score":0.12181299924850464}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2609027640","doi":null,"is_oa":false,"landing_page_url":"https://apps.dtic.mil/dtic/tr/fulltext/u2/1031407.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1963844762","https://openalex.org/W1970891016","https://openalex.org/W2008720155","https://openalex.org/W2012099961","https://openalex.org/W2013338142","https://openalex.org/W2034203606","https://openalex.org/W2034718433","https://openalex.org/W2041615416","https://openalex.org/W2056946030","https://openalex.org/W2077496230","https://openalex.org/W2123241821","https://openalex.org/W2148864927","https://openalex.org/W2148999957","https://openalex.org/W2153023562","https://openalex.org/W2159656070","https://openalex.org/W2162309096","https://openalex.org/W2168396953","https://openalex.org/W3026082319","https://openalex.org/W4300506829"],"related_works":["https://openalex.org/W4415444661","https://openalex.org/W7148731087","https://openalex.org/W2974873440","https://openalex.org/W2081650736","https://openalex.org/W2088702072","https://openalex.org/W4362592686","https://openalex.org/W2013653563","https://openalex.org/W1976720798","https://openalex.org/W2077495735","https://openalex.org/W2113866772"],"abstract_inverted_index":{"Abstract":[0],":":[1],"Central":[2],"to":[3,28,83,92,123,138,150,158,171,201,235],"all":[4],"cycling":[5],"cells-including":[6],"prostate":[7,51,68,104,195,212,217,227,254],"cancer":[8,69,105,213,218,228],"stem":[9,219,229],"cells-":[10],"is":[11,41,54,112],"the":[12,22,44,86,101,124,128,178],"expression":[13],"of":[14,21,49,127,246,251],"WEE1":[15,18,87,137,145,172,185,204,236,241],"tyrosine":[16],"kinase.":[17],"monitors":[19],"duplication":[20],"chromatin":[23,141,156],"during":[24],"each":[25],"cell":[26,71,79,107,214,220],"cycle":[27],"preserve":[29],"genome":[30],"stability":[31],"and":[32,38,53,63,76,133,210,216,248],"prevent":[33,243],"mitotic":[34,159],"catastrophe.":[35,160],"PTEN":[36,66,102,114,193,225,252],"(phosphatase":[37],"tensin":[39],"homolog)":[40],"deleted":[42],"at":[43,177],"10q23.3":[45],"locus":[46],"in":[47,81,100,117,120,192,207],"40%":[48],"human":[50],"cancers":[52],"associated":[55],"with":[56,60,85,153,165],"aggressive":[57],"metastatic":[58],"disease":[59],"poor":[61],"prognosis":[62],"androgen-independence.":[64],"A":[65],"null":[67,253],"derived":[70,106],"line,":[72,108],"LNCaP,":[73,93],"displays":[74],"hypersensitivity":[75],"undergoes":[77],"significant":[78],"death":[80],"response":[82],"treatment":[84],"inhibitor,":[88],"MK1775.":[89],"In":[90,161],"contrast":[91],"MK1775":[94],"induces":[95],"a":[96,188],"differentiation":[97],"like":[98],"phenotype":[99,119],"wildtype":[103],"LAPC4.":[109],"Our":[110],"hypothesis":[111],"that":[113],"deletion":[115],"results":[116],"hyper-proliferation":[118],"part":[121],"due":[122],"constitutive":[125],"activation":[126,168],"oncogenic":[129],"AKT":[130,167],"survival":[131],"kinase":[132,186],"these":[134],"cells":[135,149,230],"require":[136],"ensure":[139],"proper":[140],"duplication.":[142],"However,":[143],"blocking":[144],"function,":[146],"will":[147,169,183],"force":[148],"enter":[151],"mitosis":[152],"incompletely":[154],"replicated":[155],"leading":[157],"contrast,":[162],"LAPC4":[163],"cells,":[164],"regulated":[166],"respond":[170],"inhibition":[173],"by":[174],"undergoing":[175],"arrest":[176],"G2/M":[179],"border.":[180],"This":[181],"proposal":[182],"explore":[184],"as":[187],"novel":[189],"therapeutic":[190],"target":[191],"mutated":[194],"cancer.":[196],"The":[197],"main":[198],"objectives":[199],"are":[200],"first":[202],"examine":[203],"nuclear":[205],"signaling":[206],"isogenic":[208],"PTEN-deficient":[209],"proficient":[211],"lines":[215],"population.":[221],"Second,":[222],"interrogate":[223],"whether":[224,240],"depleted":[226],"(PCSC)":[231],"display":[232],"enhanced":[233],"sensitivity":[234],"inhibitors.":[237],"Finally,":[238],"determine":[239],"inhibitors":[242],"tumorigenic":[244],"potential":[245],"PCSC":[247],"block":[249],"metastasis":[250],"xenograft":[255],"tumors.":[256]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-05-05T00:00:00"}