{"id":"https://openalex.org/W2608918396","doi":"https://doi.org/10.1017/cbo9780511544699.004","title":"The conceptual basis for the developmental origins of health and disease","display_name":"The conceptual basis for the developmental origins of health and disease","publication_year":2006,"publication_date":"2006-04-20","ids":{"openalex":"https://openalex.org/W2608918396","doi":"https://doi.org/10.1017/cbo9780511544699.004","mag":"2608918396"},"language":"en","primary_location":{"id":"doi:10.1017/cbo9780511544699.004","doi":"https://doi.org/10.1017/cbo9780511544699.004","is_oa":false,"landing_page_url":"https://doi.org/10.1017/cbo9780511544699.004","pdf_url":null,"source":{"id":"https://openalex.org/S4306462995","display_name":"Cambridge University Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Origins of Health and Disease","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W1420275956","display_name":"Developmental Origins of Health and Disease"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058979039","display_name":"Peter David Gluckman","orcid":"https://orcid.org/0000-0002-5711-1655","observed_orcids":["https://orcid.org/0000-0002-5711-1655"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Peter D. Gluckman","raw_affiliation_strings":["University of Auckland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Auckland","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100695706","display_name":"Mark A. Hanson","orcid":"https://orcid.org/0000-0002-6907-613X","observed_orcids":["https://orcid.org/0000-0002-6907-613X","https://orcid.org/0000-0002-0820-4521","https://orcid.org/0000-0002-7967-0730"]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark A. Hanson","raw_affiliation_strings":["University of Southampton"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Southampton","institution_ids":["https://openalex.org/I43439940"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":20.6729,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.99797776,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"33","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14393","display_name":"Health, Environment, Cognitive Aging","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10174","display_name":"Animal Behavior and Reproduction","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/developmental-origins-of-health-and-disease","display_name":"developmental origins of health and disease","score":0.9919999837875366},{"id":"https://openalex.org/keywords/developmental-plasticity","display_name":"developmental plasticity","score":0.9679999947547913},{"id":"https://openalex.org/keywords/reaction-norms","display_name":"reaction norms","score":0.8130000233650208},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.9190000295639038},{"id":"https://openalex.org/keywords/early-life-exposure","display_name":"early life exposure","score":0.6600000262260437},{"id":"https://openalex.org/keywords/disease-risk","display_name":"disease risk","score":0.6629999876022339},{"id":"https://openalex.org/keywords/phenotypic-plasticity","display_name":"phenotypic plasticity","score":0.7739999890327454},{"id":"https://openalex.org/keywords/desert-locust","display_name":"Schistocerca gregaria","score":0.8349999785423279},{"id":"https://openalex.org/keywords/barker-hypothesis","display_name":"Barker hypothesis","score":0.6830000281333923},{"id":"https://openalex.org/keywords/birth-size","display_name":"birth size","score":0.6830000281333923},{"id":"https://openalex.org/keywords/human-disease","display_name":"human disease","score":0.37700000405311584}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5794424414634705},{"id":"https://openalex.org/C46355384","wikidata":"https://www.wikidata.org/wiki/Q726686","display_name":"Compromise","level":2,"score":0.5707725286483765},{"id":"https://openalex.org/C62277055","wikidata":"https://www.wikidata.org/wiki/Q295130","display_name":"Phenotypic plasticity","level":2,"score":0.5492968559265137},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5231006145477295},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5230161547660828},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.5127154588699341},{"id":"https://openalex.org/C2779670156","wikidata":"https://www.wikidata.org/wiki/Q281634","display_name":"Desert locust","level":4,"score":0.48519495129585266},{"id":"https://openalex.org/C86878447","wikidata":"https://www.wikidata.org/wiki/Q5266812","display_name":"Developmental plasticity","level":3,"score":0.4787166118621826},{"id":"https://openalex.org/C143098186","wikidata":"https://www.wikidata.org/wiki/Q178694","display_name":"Heredity","level":2,"score":0.4493081569671631},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3802783489227295},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.36965638399124146},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3464953303337097},{"id":"https://openalex.org/C2781335186","wikidata":"https://www.wikidata.org/wiki/Q1313710","display_name":"Schistocerca","level":3,"score":0.31574547290802},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.19829723238945007},{"id":"https://openalex.org/C2776041477","wikidata":"https://www.wikidata.org/wiki/Q83931","display_name":"Locust","level":2,"score":0.16281747817993164},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1536489725112915},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14466643333435059},{"id":"https://openalex.org/C79186407","wikidata":"https://www.wikidata.org/wiki/Q472074","display_name":"Plasticity","level":2,"score":0.13430342078208923},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.10657954216003418},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C36289849","wikidata":"https://www.wikidata.org/wiki/Q34749","display_name":"Social science","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1017/cbo9780511544699.004","doi":"https://doi.org/10.1017/cbo9780511544699.004","is_oa":false,"landing_page_url":"https://doi.org/10.1017/cbo9780511544699.004","pdf_url":null,"source":{"id":"https://openalex.org/S4306462995","display_name":"Cambridge University Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Origins of Health and Disease","raw_type":"book-chapter"},{"id":"pmh:oai:eprints.soton.ac.uk:61148","doi":null,"is_oa":false,"landing_page_url":"https://eprints.soton.ac.uk/61148/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Book Section"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":96,"referenced_works":["https://openalex.org/W191734444","https://openalex.org/W647488638","https://openalex.org/W1487395029","https://openalex.org/W1505430213","https://openalex.org/W1531334610","https://openalex.org/W1540898082","https://openalex.org/W1541471661","https://openalex.org/W1548068272","https://openalex.org/W1549046555","https://openalex.org/W1591423336","https://openalex.org/W1602975631","https://openalex.org/W1614548752","https://openalex.org/W1616982859","https://openalex.org/W1633496227","https://openalex.org/W1894533129","https://openalex.org/W1949591994","https://openalex.org/W1960454382","https://openalex.org/W1964304628","https://openalex.org/W1968807355","https://openalex.org/W1969235931","https://openalex.org/W1978450788","https://openalex.org/W1979462236","https://openalex.org/W1980326749","https://openalex.org/W1986171491","https://openalex.org/W1987171082","https://openalex.org/W2002508149","https://openalex.org/W2002763203","https://openalex.org/W2011576149","https://openalex.org/W2014176926","https://openalex.org/W2015007412","https://openalex.org/W2016962970","https://openalex.org/W2025550433","https://openalex.org/W2034900729","https://openalex.org/W2035122767","https://openalex.org/W2035616843","https://openalex.org/W2036442486","https://openalex.org/W2041299409","https://openalex.org/W2043837995","https://openalex.org/W2049590417","https://openalex.org/W2054899442","https://openalex.org/W2059632047","https://openalex.org/W2063319087","https://openalex.org/W2063959211","https://openalex.org/W2070225563","https://openalex.org/W2072171169","https://openalex.org/W2077208583","https://openalex.org/W2082948887","https://openalex.org/W2083661633","https://openalex.org/W2085352214","https://openalex.org/W2088346988","https://openalex.org/W2088616483","https://openalex.org/W2090489384","https://openalex.org/W2093948271","https://openalex.org/W2094707609","https://openalex.org/W2101961001","https://openalex.org/W2102703502","https://openalex.org/W2104536988","https://openalex.org/W2106735268","https://openalex.org/W2109183846","https://openalex.org/W2110952210","https://openalex.org/W2113850661","https://openalex.org/W2115116599","https://openalex.org/W2120788691","https://openalex.org/W2121804122","https://openalex.org/W2121917420","https://openalex.org/W2125089843","https://openalex.org/W2126082773","https://openalex.org/W2128029386","https://openalex.org/W2135550286","https://openalex.org/W2136742557","https://openalex.org/W2139764169","https://openalex.org/W2140599655","https://openalex.org/W2140734898","https://openalex.org/W2140942460","https://openalex.org/W2151172803","https://openalex.org/W2153121423","https://openalex.org/W2159735990","https://openalex.org/W2162057258","https://openalex.org/W2162107991","https://openalex.org/W2164404896","https://openalex.org/W2166194564","https://openalex.org/W2169265983","https://openalex.org/W2170505333","https://openalex.org/W2170760271","https://openalex.org/W2171059041","https://openalex.org/W2183392041","https://openalex.org/W2320137365","https://openalex.org/W2398436375","https://openalex.org/W2403633580","https://openalex.org/W2481624751","https://openalex.org/W2611732352","https://openalex.org/W2970701603","https://openalex.org/W4243658082","https://openalex.org/W4254476900","https://openalex.org/W4404342747","https://openalex.org/W6632376585"],"related_works":["https://openalex.org/W2171890429","https://openalex.org/W2050014967","https://openalex.org/W4410204989","https://openalex.org/W2038333280","https://openalex.org/W2387589578","https://openalex.org/W2519530369","https://openalex.org/W2010084879","https://openalex.org/W2079609453","https://openalex.org/W7099327913","https://openalex.org/W2489537178"],"abstract_inverted_index":{"Introduction":[0],"The":[1,29],"fundamental":[2],"assumption":[3],"underlying":[4],"the":[5,53,56,67,77,83,111,138,148,180,194,224,230],"DOHaD":[6],"model":[7],"is":[8,44,75,127],"that":[9,31,71],"environmental":[10],"factors":[11,145],"acting":[12,146],"in":[13,26,63,120,147,182,191,234],"early":[14,231],"life":[15],"have":[16],"consequences":[17],"which":[18],"become":[19],"manifest":[20,95],"as":[21,96],"an":[22],"altered":[23],"disease":[24,98,211,241],"risk":[25,99,242],"later":[27,240],"life.":[28],"concept":[30,195],"multiple":[32],"phenotypes":[33,49,70],"can":[34,72],"arise":[35],"during":[36],"development":[37],"from":[38,137],"a":[39,59,106,131,152,170,175,183],"single":[40],"genotype":[41],"(\u2018developmental":[42],"plasticity\u2019)":[43],"not":[45],"new:":[46],"these":[47],"different":[48,132],"are":[50],"based":[51],"on":[52,206,222],"nature":[54],"of":[55,69,85,90,110,123,185,196,209],"gene\u2013environment":[57],"interactions,":[58],"feature":[60],"well":[61],"recognised":[62],"developmental":[64,86,199],"biology":[65,193],"and":[66,161,187,246],"range":[68],"be":[73,94,115,216],"induced":[74],"termed":[76],"reaction":[78,112],"norm":[79,113],"(Gilbert":[80],"2001).":[81],"Given":[82],"universality":[84],"plasticity,":[87],"particular":[88],"sets":[89],"phenotypic":[91],"outcomes":[92],"may":[93,114],"variable":[97],"(Bateson":[100],"et":[101,165],"al":[102,166],".":[103],"2004).":[104],"As":[105],"result,":[107],"one":[108,121],"part":[109],"associated":[116],"with":[117],"better":[118,128],"survival":[119],"type":[122],"environment,":[124],"while":[125],"another":[126],"suited":[129],"to":[130,215,239],"environment.":[133],"One":[134],"example":[135],"comes":[136],"desert":[139],"locust":[140,181],"Schistocerca":[141],"gregaria":[142],",":[143],"where":[144],"larval":[149],"stage":[150],"induce":[151],"phenotype":[153],"appropriate":[154,173],"for":[155,174],"migratory":[156],"or":[157],"non-migratory":[158,176],"situations":[159],"(Applebaum":[160],"Heifetz":[162],"1999,":[163],"Simpson":[164],".,":[167],"2002).":[168],"Having":[169],"wing":[171],"shape":[172],"lifestyle":[177],"will":[178],"compromise":[179],"situation":[184],"overcrowding":[186],"nutritional":[188],"compromise.":[189],"While":[190],"comparative":[192],"environmentally":[197],"influenced":[198],"trajectories":[200],"has":[201,212,220,227],"been":[202],"accepted,":[203],"its":[204],"influence":[205],"our":[207],"understanding":[208],"human":[210],"taken":[213],"time":[214],"accepted.":[217],"This":[218],"delay":[219],"impacted":[221],"how":[223],"developmental-origins":[225],"field":[226],"developed":[228],"since":[229],"epidemiological":[232],"observations":[233],"humans":[235],"relating":[236],"birth":[237],"size":[238],"(Forsdahl":[243],"1977,":[244],"Barker":[245],"Osmond":[247],"1986).":[248]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-05-05T00:00:00"}