{"id":"https://openalex.org/W2608548299","doi":"https://doi.org/10.7912/c2/2111","title":"Glucocorticoid induced osteoporosis and mechanisms of intervention","display_name":"Glucocorticoid induced osteoporosis and mechanisms of intervention","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2608548299","doi":"https://doi.org/10.7912/c2/2111","mag":"2608548299"},"language":"en","primary_location":{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/12303","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1805/12303","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.7912/c2/2111","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035327351","display_name":"Amy Y. Sato","orcid":"https://orcid.org/0000-0001-5061-1369","observed_orcids":["https://orcid.org/0000-0001-5061-1369"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sato, Amy Yoshiko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5035327351"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucocorticoid-induced-osteoporosis","display_name":"glucocorticoid-induced osteoporosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.8899999856948853},{"id":"https://openalex.org/keywords/bone-loss","display_name":"bone loss","score":0.8619999885559082},{"id":"https://openalex.org/keywords/osteoporosis-prevention","display_name":"osteoporosis prevention","score":0.8109999895095825},{"id":"https://openalex.org/keywords/bone-metabolism","display_name":"bone metabolism","score":0.47200000286102295},{"id":"https://openalex.org/keywords/drug-induced-bone-disease","display_name":"drug-induced bone disease","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.7681988477706909},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.7427500486373901},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.5069077610969543},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5064061880111694},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3423084616661072},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.301037073135376},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.1337304413318634}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/12303","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1805/12303","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:2608548299","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.iupui.edu/bitstream/1805/12303/1/Sato_iupui_0104D_10175.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"doi:10.7912/c2/2111","doi":"https://doi.org/10.7912/c2/2111","is_oa":true,"landing_page_url":"https://doi.org/10.7912/c2/2111","pdf_url":null,"source":{"id":"https://openalex.org/S7407051850","display_name":"IU Indianapolis University Library","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"doi:10.7912/c2jk55","doi":"https://doi.org/10.7912/c2jk55","is_oa":true,"landing_page_url":"https://doi.org/10.7912/c2jk55","pdf_url":null,"source":{"id":"https://openalex.org/S7407051850","display_name":"IU Indianapolis University Library","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Other"}],"best_oa_location":{"id":"doi:10.7912/c2/2111","doi":"https://doi.org/10.7912/c2/2111","is_oa":true,"landing_page_url":"https://doi.org/10.7912/c2/2111","pdf_url":null,"source":{"id":"https://openalex.org/S7407051850","display_name":"IU Indianapolis University Library","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":146,"referenced_works":["https://openalex.org/W5697116","https://openalex.org/W13182415","https://openalex.org/W132137022","https://openalex.org/W1502345896","https://openalex.org/W1505761263","https://openalex.org/W1505991918","https://openalex.org/W1590930560","https://openalex.org/W1644079882","https://openalex.org/W1945322507","https://openalex.org/W1960633973","https://openalex.org/W1965169554","https://openalex.org/W1968677875","https://openalex.org/W1977548231","https://openalex.org/W1977603207","https://openalex.org/W1978136096","https://openalex.org/W1978630977","https://openalex.org/W1979035516","https://openalex.org/W1979193732","https://openalex.org/W1980073120","https://openalex.org/W1980718679","https://openalex.org/W1980904837","https://openalex.org/W1981280480","https://openalex.org/W1981465641","https://openalex.org/W1983660080","https://openalex.org/W1983738559","https://openalex.org/W1984126393","https://openalex.org/W1988982864","https://openalex.org/W1991999080","https://openalex.org/W1992310701","https://openalex.org/W1993044623","https://openalex.org/W1993542424","https://openalex.org/W1994518372","https://openalex.org/W1994744000","https://openalex.org/W1997014674","https://openalex.org/W1998779640","https://openalex.org/W1999199849","https://openalex.org/W2002315967","https://openalex.org/W2003092614","https://openalex.org/W2007478852","https://openalex.org/W2008765983","https://openalex.org/W2009794434","https://openalex.org/W2010040669","https://openalex.org/W2010657508","https://openalex.org/W2011203192","https://openalex.org/W2012256930","https://openalex.org/W2013293643","https://openalex.org/W2013791944","https://openalex.org/W2016125985","https://openalex.org/W2016712537","https://openalex.org/W2017969831","https://openalex.org/W2019196925","https://openalex.org/W2019268093","https://openalex.org/W2019772919","https://openalex.org/W2021917408","https://openalex.org/W2024601193","https://openalex.org/W2024717330","https://openalex.org/W2029190152","https://openalex.org/W2030397489","https://openalex.org/W2030914871","https://openalex.org/W2033797333","https://openalex.org/W2034826045","https://openalex.org/W2035409850","https://openalex.org/W2038965450","https://openalex.org/W2039234402","https://openalex.org/W2039244397","https://openalex.org/W2042007405","https://openalex.org/W2042087486","https://openalex.org/W2043779824","https://openalex.org/W2057472181","https://openalex.org/W2058072946","https://openalex.org/W2059600999","https://openalex.org/W2060940729","https://openalex.org/W2062056760","https://openalex.org/W2062447638","https://openalex.org/W2062473455","https://openalex.org/W2062859034","https://openalex.org/W2064538665","https://openalex.org/W2065414831","https://openalex.org/W2068916684","https://openalex.org/W2072611479","https://openalex.org/W2074506352","https://openalex.org/W2074898328","https://openalex.org/W2080089180","https://openalex.org/W2080121305","https://openalex.org/W2081071444","https://openalex.org/W2081432593","https://openalex.org/W2084395631","https://openalex.org/W2088767951","https://openalex.org/W2089139414","https://openalex.org/W2090197092","https://openalex.org/W2092885411","https://openalex.org/W2093849986","https://openalex.org/W2096263722","https://openalex.org/W2096324771","https://openalex.org/W2096689446","https://openalex.org/W2099531123","https://openalex.org/W2099925679","https://openalex.org/W2100688137","https://openalex.org/W2105695548","https://openalex.org/W2105885232","https://openalex.org/W2107310628","https://openalex.org/W2111274663","https://openalex.org/W2115271834","https://openalex.org/W2116190639","https://openalex.org/W2116359902","https://openalex.org/W2116751183","https://openalex.org/W2117332077","https://openalex.org/W2119902047","https://openalex.org/W2119934014","https://openalex.org/W2124011858","https://openalex.org/W2128261464","https://openalex.org/W2130264839","https://openalex.org/W2131632095","https://openalex.org/W2131721093","https://openalex.org/W2133493898","https://openalex.org/W2137579759","https://openalex.org/W2140470606","https://openalex.org/W2140487984","https://openalex.org/W2142008186","https://openalex.org/W2143214738","https://openalex.org/W2145340416","https://openalex.org/W2146138547","https://openalex.org/W2146527833","https://openalex.org/W2150691073","https://openalex.org/W2151917785","https://openalex.org/W2152774804","https://openalex.org/W2153101639","https://openalex.org/W2157644862","https://openalex.org/W2159406891","https://openalex.org/W2159879792","https://openalex.org/W2163341100","https://openalex.org/W2163748946","https://openalex.org/W2167033587","https://openalex.org/W2167048916","https://openalex.org/W2167512318","https://openalex.org/W2169251377","https://openalex.org/W2170680219","https://openalex.org/W2171105433","https://openalex.org/W2190005528","https://openalex.org/W2256342783","https://openalex.org/W2269013044","https://openalex.org/W2314674563","https://openalex.org/W2376677157","https://openalex.org/W2619897119","https://openalex.org/W2776961186","https://openalex.org/W3203441888"],"related_works":["https://openalex.org/W2400098452","https://openalex.org/W115663059","https://openalex.org/W1995956739","https://openalex.org/W2106504012","https://openalex.org/W2034009153","https://openalex.org/W2376677157","https://openalex.org/W2325374101","https://openalex.org/W2121606354","https://openalex.org/W1979370401","https://openalex.org/W2962097991"],"abstract_inverted_index":{"Glucocorticoid":[0],"excess":[1,223],"is":[2,64,85,230],"a":[3],"leading":[4],"cause":[5],"of":[6,10,25,34,54,60,98,132,146,155,161,184,195,218,241,252,286,296],"osteoporosis.":[7],"The":[8,57,96],"loss":[9,51,143,181,212],"bone":[11,31,36,44,50,55,72,111,142,147,170,180,198,211,264,297],"mass":[12],"and":[13,41,52,74,77,127,149,159,175,203,265,298],"strength":[14],"corresponds":[15],"to":[16,102,115,207,282],"the":[17,30,123,192,208,215,237,249,284,292],"increase":[18,75],"in":[19,48,169,186,197,205,262,291],"fractures":[20],"exhibited":[21,213],"after":[22],"three":[23],"months":[24],"glucocorticoid":[26,94,219,222,294],"therapy.":[27,95,220],"Glucocorticoids":[28],"induce":[29,259],"cellular":[32],"responses":[33],"deceased":[35],"formation,":[37,199],"increased":[38,43,200,253],"osteoblast/osteocyte":[39,150,201],"apoptosis,":[40,202],"transient":[42],"resorption,":[45],"which":[46,229],"result":[47],"rapid":[49,209],"degradation":[53],"microarchitecture.":[56],"current":[58],"standard":[59],"care":[61],"for":[62,89,273],"osteoporosis":[63],"bisphosphonate":[65,234],"treatment;":[66],"however,":[67,172],"these":[68,99,189],"agents":[69],"further":[70],"suppress":[71],"formation":[73,148],"osteonecrosis":[76],"low":[78],"energy":[79],"atypical":[80],"fracture":[81],"risks.":[82],"Thus,":[83,277],"there":[84],"an":[86],"unmet":[87],"need":[88],"interventions":[90,238],"that":[91,106,118],"protect":[92],"from":[93],"purpose":[97],"studies":[100,190,279],"was":[101],"investigate":[103,283],"novel":[104,250],"mechanisms":[105],"potentially":[107],"interfere":[108],"with":[109],"glucocorticoid-induced":[110,141,167],"loss.":[112],"We":[113],"chose":[114],"explore":[116],"pathways":[117],"regulate":[119],"endoplasmic":[120,133],"reticulum":[121,134],"stress,":[122],"canonical":[124],"Wnt":[125,156],"pathway,":[126],"Pyk2":[128,162,176,246],"activity.":[129],"Pharmacologic":[130],"reduction":[131],"stress":[135],"through":[136,182],"salubrinal":[137],"administration":[138],"protected":[139,178],"against":[140,179],"by":[144,233,260,267],"preservation":[145],"viability.":[151],"In":[152],"contrast,":[153],"inhibition":[154,160,183],"antagonist":[157],"Sost/sclerostin":[158,174,243],"signaling":[163,258,290],"did":[164],"not":[165,231],"prevent":[166],"reductions":[168,196],"formation;":[171],"both":[173,263],"deficiency":[177],"increases":[185],"resorption.":[187],"Overall,":[188],"demonstrate":[191],"significant":[193],"contributions":[194],"elevations":[204],"resorption":[206],"6-12%":[210],"during":[214],"first":[216],"year":[217],"However,":[221],"also":[224],"induces":[225],"skeletal":[226],"muscle":[227],"weakness,":[228],"reversed":[232],"treatment":[235],"or":[236,245],"reported":[239],"here":[240],"salubrinal,":[242],"inhibition,":[244],"deficiency.":[247],"Further,":[248],"finding":[251],"E3":[254,287],"ubiquitin":[255,288],"ligase":[256,289],"atrophy":[257],"glucocorticoids":[261],"muscle,":[266],"tissue-specific":[268],"upstream":[269],"mechanisms,":[270],"provides":[271],"opportunities":[272],"therapeutic":[274],"combination":[275],"strategies.":[276],"future":[278],"are":[280],"warranted":[281],"role":[285],"deleterious":[293],"effects":[295],"muscle.":[299]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2017-05-05T00:00:00"}
