{"id":"https://openalex.org/W2608464015","doi":"https://doi.org/10.1182/blood.v128.22.1629.1629","title":"A Pediatric-Inspired Regimen Containing Multiple Doses of Intravenous Pegylated Asparaginase Appears Safe and Effective in Newly Diagnosed Adult Patients with Ph-Negative Acute Lymphoblastic Leukemia in Adults up to Age 60: Results of a Multi-Center Phase II Clinical Trial","display_name":"A Pediatric-Inspired Regimen Containing Multiple Doses of Intravenous Pegylated Asparaginase Appears Safe and Effective in Newly Diagnosed Adult Patients with Ph-Negative Acute Lymphoblastic Leukemia in Adults up to Age 60: Results of a Multi-Center Phase II Clinical Trial","publication_year":2016,"publication_date":"2016-12-02","ids":{"openalex":"https://openalex.org/W2608464015","doi":"https://doi.org/10.1182/blood.v128.22.1629.1629","mag":"2608464015"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v128.22.1629.1629","doi":"https://doi.org/10.1182/blood.v128.22.1629.1629","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v128.22.1629.1629","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101838284","display_name":"Jae H. Park","orcid":"https://orcid.org/0000-0002-2903-5130","observed_orcids":["https://orcid.org/0000-0002-2903-5130","https://orcid.org/0009-0003-2678-9513"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jae H. Park","raw_affiliation_strings":["Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078887304","display_name":"Ellen Kelly Ritchie","orcid":"https://orcid.org/0000-0001-8150-5542","observed_orcids":["https://orcid.org/0000-0001-8150-5542"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellen K. Ritchie","raw_affiliation_strings":["Weill Cornell Medical College, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medical College, New York, NY","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056698355","display_name":"Arati V. Rao","orcid":"https://orcid.org/0009-0004-2922-710X","observed_orcids":["https://orcid.org/0009-0004-2922-710X"]},"institutions":[{"id":"https://openalex.org/I4210140816","display_name":"Gilead Sciences (United States)","ror":"https://ror.org/056546b03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140816"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arati V. Rao","raw_affiliation_strings":["Gilead Sciences, Inc., Foster City, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gilead Sciences, Inc., Foster City, CA","institution_ids":["https://openalex.org/I4210140816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044552886","display_name":"Sean M. Devlin","orcid":"https://orcid.org/0000-0002-6801-720X","observed_orcids":["https://orcid.org/0000-0002-6801-720X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean Devlin","raw_affiliation_strings":["Department of Biostatistics and Epidemiology, Memorial Sloan Kettering Cancer Center, New York,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Epidemiology, Memorial Sloan Kettering Cancer Center, New York,","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081019088","display_name":"Meier Hsu","orcid":"https://orcid.org/0000-0002-9519-8560","observed_orcids":["https://orcid.org/0000-0002-9519-8560"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meier Hsu","raw_affiliation_strings":["Department of Biostatistics and Epidemiology, Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Epidemiology, Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085886046","display_name":"Talal T Khawaja","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Talal T Khawaja","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bridget A O'Donnell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bridget A O'Donnell","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015214048","display_name":"M. Isabella Cazacu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria I Cazacu","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039866413","display_name":"Diane M Stopka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diane M Stopka","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001124933","display_name":"Martin S. Tallman","orcid":"https://orcid.org/0000-0002-4367-6102","observed_orcids":["https://orcid.org/0000-0002-4367-6102"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin S. Tallman","raw_affiliation_strings":["Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111663910","display_name":"Dan Douer","orcid":"https://orcid.org/0000-0002-3693-8864","observed_orcids":["https://orcid.org/0000-0002-3693-8864"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan Douer","raw_affiliation_strings":["Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":1.9898,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.88579414,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"128","issue":"22","first_page":"1629","last_page":"1629"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pediatric-inspired-regimens","display_name":"pediatric-inspired regimens","score":0.7160000205039978},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9259999990463257},{"id":"https://openalex.org/keywords/pegylated-asparaginase","display_name":"pegylated asparaginase","score":0.9089999794960022},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.6069999933242798},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.6570000052452087},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.9929999709129333},{"id":"https://openalex.org/keywords/anti-asparaginase-antibodies","display_name":"anti-asparaginase antibodies","score":0.8450000286102295},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.49399998784065247},{"id":"https://openalex.org/keywords/induction-chemotherapy","display_name":"induction chemotherapy","score":0.3370000123977661},{"id":"https://openalex.org/keywords/relapse-free-survival","display_name":"relapse-free survival","score":0.4970000088214874},{"id":"https://openalex.org/keywords/event-free-survival","display_name":"event-free survival","score":0.6940000057220459},{"id":"https://openalex.org/keywords/t-cell-acute-lymphoblastic-leukemia","display_name":"T-cell acute lymphoblastic leukemia","score":0.45500001311302185},{"id":"https://openalex.org/keywords/b-cell-acute-lymphoblastic-leukemia","display_name":"B-cell acute lymphoblastic leukemia","score":0.9179999828338623}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8222723603248596},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.7034774422645569},{"id":"https://openalex.org/C2779823535","wikidata":"https://www.wikidata.org/wiki/Q6865356","display_name":"Minimal residual disease","level":3,"score":0.5778429508209229},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5505537986755371},{"id":"https://openalex.org/C2778904437","wikidata":"https://www.wikidata.org/wiki/Q105296036","display_name":"Asparaginase","level":4,"score":0.5218117237091064},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4879891276359558},{"id":"https://openalex.org/C2781107101","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Acute lymphocytic leukemia","level":4,"score":0.430306077003479},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.42247533798217773},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.39538541436195374},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3428151607513428},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.3023844361305237},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.30197039246559143},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.2792810797691345}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v128.22.1629.1629","doi":"https://doi.org/10.1182/blood.v128.22.1629.1629","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v128.22.1629.1629","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3093090760","https://openalex.org/W2589503004","https://openalex.org/W2979507353","https://openalex.org/W2588629388","https://openalex.org/W2980143174","https://openalex.org/W2570374628","https://openalex.org/W2553390276","https://openalex.org/W3157531318","https://openalex.org/W2973492021","https://openalex.org/W2236930807"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"The":[2,110,135,212,226,588],"U.S.":[3],"Intergroup":[4],"C10403":[5],"trial":[6],"has":[7],"demonstrated":[8],"that":[9,531],"treating":[10],"acute":[11],"lymphoblastic":[12],"leukemia":[13],"(ALL)":[14],"in":[15,48,52,77,263,434,549,631],"adolescents":[16],"and":[17,30,46,105,127,129,178,188,210,232,268,278,313,316,364,395,402,422,428,453,465,517,547,571,577,598,616,626],"young":[18],"adults":[19,54,551],"up":[20,85,557],"to":[21,86,97,285,393,417,441,558,586],"age":[22,56,87,214,559],"39":[23],"using":[24],"a":[25,69,138,289,443,532],"pediatric":[26,50],"regimen":[27,76,112,534],"improves":[28],"event-free":[29],"overall":[31],"survival":[32],"compared":[33],"with":[34,83,99,475,490,552],"adult":[35,80,93,633],"regimens":[36,51],"(Stock":[37],"W":[38],"et":[39,166],"al.":[40,167],"ASH":[41],"2014).":[42],"However,":[43],"the":[44,66,248,304,320,339,404,476,621],"safety":[45],"efficacy":[47],"implementing":[49],"older":[53,550],"above":[55],"40":[57],"have":[58,566],"not":[59,385],"been":[60],"well":[61],"studied.":[62],"Herein,":[63],"we":[64,565],"report":[65],"results":[67,611],"from":[68,332,500],"phase":[70,527],"II":[71],"multicenter":[72],"study":[73,529],"of":[74,114,125,132,140,143,154,190,292,370,379,408,461,513,540,590,593,612,624,628],"pediatric-inspired":[75,533],"newly":[78,553],"diagnosed":[79,92,554],"patients":[81,298],"(pts)":[82],"ALL":[84,100,107,556,634],"60":[88,98],"(NCT01920737).":[89],"Methods:":[90],"Newly":[91],"pts":[94,205,236,252,271,283,388,412,438,489,504,520,601],"aged":[95],"18":[96],"were":[101,108,194,206,223,432],"eligible.":[102],"Burkitt":[103],"type":[104],"Ph+":[106],"excluded.":[109],"treatment":[111,136,584],"consisted":[113],"induction":[115,118],"1":[116,317],"(I1),":[117],"2":[119,301,528],"(I2)":[120],"followed":[121],"by":[122,180],"several":[123],"cycles":[124],"intensifications":[126],"re-inductions":[128],"3":[130,297,488],"years":[131],"maintenance":[133],"therapy.":[134],"contained":[137],"total":[139],"6":[141,340,538],"doses":[142,407,539],"2,000":[144,541],"IU/m2":[145,542],"pegylated":[146],"asparaginase":[147,185,399,445,594,613],"(Peg-ASP),":[148],"administered":[149],"IV":[150,543],"at":[151,215,311,329,510],"various":[152],"intervals":[153],"\u00b34":[155],"weeks":[156],"based":[157],"on":[158,196,347,458,607],"our":[159],"previous":[160],"pharmacokinetics":[161],"(PK)":[162],"data":[163,431],"(Douer":[164],"D":[165],"Blood":[168],"2007).":[169],"Minimal":[170],"residual":[171],"disease":[172,240],"(MRD)":[173],"was":[174,217,261,448,515,595],"assessed":[175,195,262],"after":[176,199,258,276,279,309,327,473],"I1":[177,277,310,328,333,374,464,474],"I2":[179,482],"multiparameter":[181],"flow":[182],"cytometry.":[183],"Serum":[184],"enzymatic":[186,446,523],"activity":[187,447,477,497,606],"presence":[189],"anti-asparaginase":[191],"antibody":[192],"(Ab)":[193],"day":[197,459,608],"7":[198,330,460],"each":[200],"Peg-ASP":[201,394,415,462,544,625],"dose.":[202],"Results:":[203],"27":[204,249],"enrolled":[207],"between":[208],"4/2014":[209],"4/2016.":[211],"median":[213,290,444],"diagnosis":[216],"43.6":[218],"(range,":[219,295,451,456],"20-60)":[220],"years:":[221],"52%":[222],"40-60":[224],"years.":[225],"majority":[227],"had":[228,238,493,506,521,604],"precursor":[229],"B-ALL":[230],"(70%)":[231],"rest":[233],"T-ALL.":[234],"Four":[235,387,503],"(15%)":[237,389,505],"extramedullary":[239],"only":[241],"(mediastinal":[242],"mass,":[243],"lymph":[244],"nodes,":[245],"bone).":[246],"Of":[247],"pts,":[250],"26":[251],"(96%)":[253],"achieved":[254,272],"complete":[255],"remission":[256],"(CR)":[257],"I1.":[259],"MRD":[260,273,322,341],"20":[264],"pts;":[265],"8":[266,321],"(40%)":[267],"15":[269],"(75%)":[270],"neg":[274],"CR":[275,324,569],"I2,":[280,466],"respectively.":[281,467],"Six":[282],"proceed":[284],"allogeneic":[286],"HSCT.":[287],"With":[288],"follow-up":[291,562],"7.8":[293],"months":[294,331],"0.9-22.5),":[296],"(12%)":[299],"relapsed:":[300],"occurred":[302,318,337,372,579],"among":[303,319,338],"12":[305],"MRD+CR":[306],"group":[307,325],"(17%)":[308],"4.5":[312],"8.8":[314],"months,":[315],"negative":[323],"(13%)":[326],"completion.":[334],"No":[335,344],"relapses":[336],"unknown":[342],"pts.":[343,436],"pt":[345,469],"died":[346],"study.":[348],"Grade":[349],"3-4":[350,382],"Peg-ASP-related":[351],"toxicities":[352],"(Table":[353],"1)":[354],"included":[355],"hypertriglyceridemia":[356],"(59%),":[357],"transaminitis":[358,576],"(52%),":[359],"hyperglycemia":[360],"(41%),":[361],"hyperbilirubinemia":[362,371,383,578],"(30%),":[363],"pancreatitis":[365],"(4%).":[366],"Notably,":[367],"all":[368,518,600],"cases":[369],"during":[373,463,481],"but":[375,483,581],"despite":[376],"continued":[377],"use":[378],"Peg-ASP,":[380,442],"grade":[381],"did":[384],"recur.":[386],"developed":[390,470],"hypersensitivity":[391,440,491,603],"reactions":[392,492],"subsequently":[396],"received":[397],"Erwinia":[398],"without":[400,439,484,602],"reaction":[401],"completed":[403],"full":[405],"intended":[406],"Peg-Asp":[409],"treatments.":[410],"Three":[411],"(11%)":[413],"discontinued":[414,583],"due":[416,585],"toxicity":[418],"(n=2;":[419],"hyperbilirubinemia,":[420],"transaminitis)":[421],"physician":[423],"preference":[424],"(n=1).":[425],"Asparaginase":[426],"PK":[427,614],"anti-ASP":[429,486,508],"Ab":[430,509],"available":[433],"16":[435],"In":[437],"0.58":[449],"IU/ml":[450,455,480],"0.30-0.88)":[452],"0.73":[454],"0.53-0.88)":[457],"One":[468],"silent":[471,591,617],"inactivation":[472,592,618],"level":[478],"<0.01":[479],"detectable":[485],"Ab;":[487],"no":[494],"or":[495],"lowest":[496],"levels,":[498],"ranging":[499],"<0.01-0.1":[501],"IU/ml.":[502],"pre-existing":[507],"pre-treatment;":[511],"none":[512],"these":[514],"neutralizing":[516],"4":[519],"adequate":[522,605],"activity.":[524],"Conclusions:":[525],"This":[526],"suggests":[530],"containing":[535],"rationally":[536],"synchronized":[537],"is":[545],"safe":[546],"effective":[548],"Ph-negative":[555],"60.":[560],"Although":[561],"remains":[563],"short,":[564],"observed":[567],"high":[568],"rates":[570],"few":[572,582],"relapses.":[573],"Hypertriglyceridemia,":[574],"hyperglycemia,":[575],"frequently":[580],"toxicities.":[587],"rate":[589],"low":[596],"(6%),":[597],"almost":[599],"7.":[609],"Further":[610],"analysis":[615],"will":[619],"inform":[620],"appropriate":[622],"dosing":[623],"utility":[627],"PK/Ab":[629],"tests":[630],"future":[632],"trials.":[635],"Disclosures":[636],"Park:":[637],"Amgen:":[638],"Consultancy;":[639,672,678],"Genentech/Roche:":[640],"Research":[641,646],"Funding;":[642],"Juno":[643],"Therapeutics:":[644],"Consultancy,":[645,674],"Funding.":[647],"Ritchie:Arian:":[648],"Speakers":[649,656,659,675],"Bureau;":[650,657,676],"Novartis:":[651],"Honoraria;":[652,654,668],"Pfizer:":[653,677],"Celgene:":[655],"Incyte:":[658],"Bureau.":[660],"Rao:Gilead":[661],"Sciences:":[662],"Employment,":[663],"Equity":[664],"Ownership.":[665],"Douer:Jazz":[666],"Pharmaceuticals:":[667],"Gilled":[669],"Sciences,":[670],"Inc:":[671],"Shire:":[673],"Spectrum:":[679],"Consultancy.":[680]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3}],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2017-05-05T00:00:00"}