{"id":"https://openalex.org/W2608251297","doi":"https://doi.org/10.1212/wnl.0000000000003969","title":"Preventing Parkinson disease by vagotomy","display_name":"Preventing Parkinson disease by vagotomy","publication_year":2017,"publication_date":"2017-04-27","ids":{"openalex":"https://openalex.org/W2608251297","doi":"https://doi.org/10.1212/wnl.0000000000003969","mag":"2608251297","pmid":"https://pubmed.ncbi.nlm.nih.gov/28446643"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.0000000000003969","doi":"https://doi.org/10.1212/wnl.0000000000003969","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.0000000000003969","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005853815","display_name":"Per Borghammer","orcid":"https://orcid.org/0000-0001-6391-8052","observed_orcids":["https://orcid.org/0000-0001-6391-8052"]},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2799337515","display_name":"Toronto Western Hospital","ror":"https://ror.org/03qv8yq19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]},{"id":"https://openalex.org/I4405280014","display_name":"Campbell Family Mental Health Research Institute","ror":"https://ror.org/02ab2j218","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1338135719","https://openalex.org/I4405280014"]}],"countries":["CA","DK"],"is_corresponding":false,"raw_author_name":"Per Borghammer","raw_affiliation_strings":["From the Department of Nuclear Medicine and PET Centre (P.B.), Aarhus University Hospital, Denmark; Division of Neurosurgery (C.H.), Toronto Western Hospital, University of Toronto; and Department of Neuroimaging (C.H.), Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, Ontario, Canada","Division of Neurosurgery (C.H.), Toronto Western Hospital, University of Toronto","From the Department of Nuclear Medicine and PET Centre (P.B.), Aarhus University Hospital, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Nuclear Medicine and PET Centre (P.B.), Aarhus University Hospital, Denmark; Division of Neurosurgery (C.H.), Toronto Western Hospital, University of Toronto; and Department of Neuroimaging (C.H.), Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1338135719","https://openalex.org/I185261750","https://openalex.org/I2799337515","https://openalex.org/I2802335433","https://openalex.org/I4405280014"]},{"raw_affiliation_string":"Division of Neurosurgery (C.H.), Toronto Western Hospital, University of Toronto","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2799337515"]},{"raw_affiliation_string":"From the Department of Nuclear Medicine and PET Centre (P.B.), Aarhus University Hospital, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058507775","display_name":"Clement Hamani","orcid":"https://orcid.org/0000-0002-7586-2487","observed_orcids":["https://orcid.org/0000-0002-7586-2487"]},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2799337515","display_name":"Toronto Western Hospital","ror":"https://ror.org/03qv8yq19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]},{"id":"https://openalex.org/I4405280014","display_name":"Campbell Family Mental Health Research Institute","ror":"https://ror.org/02ab2j218","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1338135719","https://openalex.org/I4405280014"]}],"countries":["CA","DK"],"is_corresponding":false,"raw_author_name":"Clement Hamani","raw_affiliation_strings":["From the Department of Nuclear Medicine and PET Centre (P.B.), Aarhus University Hospital, Denmark; Division of Neurosurgery (C.H.), Toronto Western Hospital, University of Toronto; and Department of Neuroimaging (C.H.), Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, Ontario, Canada","Division of Neurosurgery (C.H.), Toronto Western Hospital, University of Toronto","From the Department of Nuclear Medicine and PET Centre (P.B.), Aarhus University Hospital, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Nuclear Medicine and PET Centre (P.B.), Aarhus University Hospital, Denmark; Division of Neurosurgery (C.H.), Toronto Western Hospital, University of Toronto; and Department of Neuroimaging (C.H.), Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1338135719","https://openalex.org/I185261750","https://openalex.org/I2799337515","https://openalex.org/I2802335433","https://openalex.org/I4405280014"]},{"raw_affiliation_string":"Division of Neurosurgery (C.H.), Toronto Western Hospital, University of Toronto","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2799337515"]},{"raw_affiliation_string":"From the Department of Nuclear Medicine and PET Centre (P.B.), Aarhus University Hospital, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"88","issue":"21","first_page":"1982","last_page":"1983"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9610000252723694},{"id":"https://openalex.org/keywords/vagotomy","display_name":"vagotomy","score":0.9819999933242798},{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.8610000014305115},{"id":"https://openalex.org/keywords/prion-like-propagation","display_name":"prion-like propagation","score":0.7049999833106995},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.6579999923706055},{"id":"https://openalex.org/keywords/neurodegeneration-prevention","display_name":"neurodegeneration prevention","score":0.6769999861717224},{"id":"https://openalex.org/keywords/cell-to-cell-spread","display_name":"cell-to-cell transmission","score":0.6399999856948853},{"id":"https://openalex.org/keywords/protein-misfolding","display_name":"protein misfolding","score":0.8289999961853027}],"concepts":[{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.7068799138069153},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5924609899520874},{"id":"https://openalex.org/C2781449126","wikidata":"https://www.wikidata.org/wiki/Q288591","display_name":"Alpha-synuclein","level":4,"score":0.5842345952987671},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4342797100543976},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4320727586746216},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3934328258037567},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38434308767318726},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.353249728679657},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.083036869764328}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013548","descriptor_name":"Sweden","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014628","descriptor_name":"Vagotomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1212/wnl.0000000000003969","doi":"https://doi.org/10.1212/wnl.0000000000003969","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.0000000000003969","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},{"id":"pmid:28446643","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28446643","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Editorial"},{"id":"pmh:oai:pure.atira.dk:publications/35ddadb3-fbb9-4213-8734-40c7a527e226","doi":null,"is_oa":false,"landing_page_url":"https://pure.au.dk/portal/en/publications/35ddadb3-fbb9-4213-8734-40c7a527e226","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Borghammer, P & Hamani, C 2017, 'Preventing Parkinson disease by vagotomy : Fact or fiction?', Neurology, vol. 88, no. 21, pp. 1982-1983. https://doi.org/10.1212/WNL.0000000000003969","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G640838616","display_name":null,"funder_award_id":"R190-2014-4183","funder_id":"https://openalex.org/F4320321999","funder_display_name":"Lundbeckfonden"}],"funders":[{"id":"https://openalex.org/F4320321999","display_name":"Lundbeckfonden","ror":"https://ror.org/03hz8wd80"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1564387586","https://openalex.org/W1920030402","https://openalex.org/W2073449985","https://openalex.org/W2104419318","https://openalex.org/W2105047187","https://openalex.org/W2309910088","https://openalex.org/W2338538733","https://openalex.org/W2490803709","https://openalex.org/W2521817318","https://openalex.org/W2607991581","https://openalex.org/W2743212537"],"related_works":["https://openalex.org/W3168754484","https://openalex.org/W2159340140","https://openalex.org/W1591395701","https://openalex.org/W3189977438","https://openalex.org/W2763748630","https://openalex.org/W2057541416","https://openalex.org/W4361803167","https://openalex.org/W2805466047","https://openalex.org/W2062837668","https://openalex.org/W4365515191"],"abstract_inverted_index":{"Aggregation":[0],"of":[1,18,51],"the":[2,16,36,46],"neuronal":[3],"protein":[4],"\u03b1-synuclein":[5,27,41],"into":[6],"insoluble":[7],"filamentous":[8],"inclusions":[9,28],"may":[10],"be":[11],"a":[12],"determining":[13],"factor":[14],"in":[15],"development":[17],"Parkinson":[19],"disease":[20],"(PD).":[21],"Converging":[22],"evidence":[23],"has":[24],"demonstrated":[25],"that":[26],"have":[29],"prion-like":[30],"properties,":[31],"including":[32],"cell-to-cell":[33],"transmission":[34],"and":[35],"ability":[37],"to":[38,42],"induce":[39],"native":[40],"misfold,":[43],"thus":[44],"setting":[45],"stage":[47],"for":[48],"domino-like":[49],"spreading":[50],"cellular":[52],"pathology.1":[53]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-05-05T00:00:00"}