{"id":"https://openalex.org/W2608110367","doi":"https://doi.org/10.1016/j.tips.2017.03.011","title":"A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies","display_name":"A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies","publication_year":2017,"publication_date":"2017-04-25","ids":{"openalex":"https://openalex.org/W2608110367","doi":"https://doi.org/10.1016/j.tips.2017.03.011","mag":"2608110367","pmid":"https://pubmed.ncbi.nlm.nih.gov/28455089","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5476494"},"language":"en","primary_location":{"id":"doi:10.1016/j.tips.2017.03.011","doi":"https://doi.org/10.1016/j.tips.2017.03.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tips.2017.03.011","pdf_url":null,"source":{"id":"https://openalex.org/S31167473","display_name":"Trends in Pharmacological Sciences","issn_l":"0165-6147","issn":["0165-6147","1873-3735"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Pharmacological Sciences","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5476494","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045770248","display_name":"Miranda E. Orr","orcid":"https://orcid.org/0000-0002-0418-2724","observed_orcids":["https://orcid.org/0000-0002-0418-2724"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miranda E. Orr","raw_affiliation_strings":["Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX 78229, USA; Department of Pharmacology, University of Texas Health San Antonio, San Antonio, TX 78229, USA","Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX 78229, USA","Department of Pharmacology, University of Texas Health San Antonio, San Antonio, TX 78229, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX 78229, USA; Department of Pharmacology, University of Texas Health San Antonio, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Pharmacology, University of Texas Health San Antonio, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060173315","display_name":"Anna Campbell Sullivan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Campbell Sullivan","raw_affiliation_strings":["Department of Neurology, University of Texas Health San Antonio, San Antonio, TX 78229, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Texas Health San Antonio, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044174930","display_name":"Bess E Frost","orcid":"https://orcid.org/0000-0002-1212-8138","observed_orcids":["https://orcid.org/0000-0002-1212-8138"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bess Frost","raw_affiliation_strings":["Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX 78229, USA; Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX 78229, USA. Electronic address: bfrost@uthscsa.edu","Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX 78229, USA","Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX 78229, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX 78229, USA; Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX 78229, USA. Electronic address: bfrost@uthscsa.edu","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5044174930"],"corresponding_institution_ids":["https://openalex.org/I165951966"],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":null,"fwci":1.7783,"has_fulltext":false,"cited_by_count":236,"citation_normalized_percentile":{"value":0.86182744,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"38","issue":"7","first_page":"637","last_page":"648"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tauopathy","display_name":"tauopathy","score":0.8529999852180481},{"id":"https://openalex.org/keywords/tau-aggregation","display_name":"tau aggregation","score":0.8009999990463257},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.8930000066757202},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.8299999833106995},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.7310000061988831},{"id":"https://openalex.org/keywords/treatment-strategy","display_name":"treatment options","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C2777739294","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tauopathy","level":4,"score":0.9718490839004517},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6441291570663452},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5785588622093201},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.5144894123077393},{"id":"https://openalex.org/C3017833866","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tau pathology","level":4,"score":0.4897198975086212},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39716023206710815},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.39611995220184326},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.26542913913726807},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.2402258813381195},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1567663550376892}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024801","descriptor_name":"Tauopathies","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D024801","descriptor_name":"Tauopathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D024801","descriptor_name":"Tauopathies","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.tips.2017.03.011","doi":"https://doi.org/10.1016/j.tips.2017.03.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tips.2017.03.011","pdf_url":null,"source":{"id":"https://openalex.org/S31167473","display_name":"Trends in Pharmacological Sciences","issn_l":"0165-6147","issn":["0165-6147","1873-3735"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Pharmacological Sciences","raw_type":"journal-article"},{"id":"pmid:28455089","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28455089","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in pharmacological sciences","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4973276","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5476494","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5476494","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5476494","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Trends Pharmacol Sci","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4973276","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5476494","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1690238294","display_name":"Mechanisms and Consequences of Heterochromatin Loss in Tauopathies","funder_award_id":"R00NS088429","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5039640931","display_name":"Mechanisms of tau- and aging-induced neurological dysfunction: Focus on the nucleus","funder_award_id":"R01AG057896","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000913486","display_name":"San Antonio Claude D. Pepper Older Americans Independence Center","funder_award_id":"P30AG044271","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":117,"referenced_works":["https://openalex.org/W349712691","https://openalex.org/W383165372","https://openalex.org/W640206224","https://openalex.org/W1511517753","https://openalex.org/W1575367484","https://openalex.org/W1590917599","https://openalex.org/W1764460837","https://openalex.org/W1791762140","https://openalex.org/W1858579514","https://openalex.org/W1955207589","https://openalex.org/W1966398396","https://openalex.org/W1971010506","https://openalex.org/W1974760231","https://openalex.org/W1975040221","https://openalex.org/W1978116973","https://openalex.org/W1981393982","https://openalex.org/W1989208474","https://openalex.org/W1989280457","https://openalex.org/W1989723790","https://openalex.org/W1995144868","https://openalex.org/W1995737263","https://openalex.org/W1997198091","https://openalex.org/W1997820676","https://openalex.org/W2000158949","https://openalex.org/W2001599368","https://openalex.org/W2003275051","https://openalex.org/W2004371219","https://openalex.org/W2006520473","https://openalex.org/W2006588853","https://openalex.org/W2006955217","https://openalex.org/W2007787335","https://openalex.org/W2011134915","https://openalex.org/W2017443057","https://openalex.org/W2018908557","https://openalex.org/W2019036379","https://openalex.org/W2020311418","https://openalex.org/W2021354284","https://openalex.org/W2021933220","https://openalex.org/W2022916608","https://openalex.org/W2023316908","https://openalex.org/W2025722577","https://openalex.org/W2029457316","https://openalex.org/W2031472414","https://openalex.org/W2032665165","https://openalex.org/W2047159195","https://openalex.org/W2049599293","https://openalex.org/W2049676706","https://openalex.org/W2053082937","https://openalex.org/W2055468625","https://openalex.org/W2055476783","https://openalex.org/W2059215870","https://openalex.org/W2064587868","https://openalex.org/W2068011527","https://openalex.org/W2072875478","https://openalex.org/W2077903929","https://openalex.org/W2077905824","https://openalex.org/W2081051305","https://openalex.org/W2082429191","https://openalex.org/W2082970812","https://openalex.org/W2083337622","https://openalex.org/W2084979315","https://openalex.org/W2086477221","https://openalex.org/W2088637758","https://openalex.org/W2095963715","https://openalex.org/W2098463163","https://openalex.org/W2099340107","https://openalex.org/W2118101413","https://openalex.org/W2121713269","https://openalex.org/W2124201582","https://openalex.org/W2130295086","https://openalex.org/W2131001963","https://openalex.org/W2134157741","https://openalex.org/W2136922708","https://openalex.org/W2141370620","https://openalex.org/W2141839336","https://openalex.org/W2153284686","https://openalex.org/W2161260889","https://openalex.org/W2172007938","https://openalex.org/W2185034389","https://openalex.org/W2190404250","https://openalex.org/W2203120038","https://openalex.org/W2215958284","https://openalex.org/W2217184110","https://openalex.org/W2220065337","https://openalex.org/W2257271597","https://openalex.org/W2257327272","https://openalex.org/W2279268939","https://openalex.org/W2284769570","https://openalex.org/W2290598353","https://openalex.org/W2315843281","https://openalex.org/W2320404255","https://openalex.org/W2327032644","https://openalex.org/W2327547544","https://openalex.org/W2338404539","https://openalex.org/W2338601774","https://openalex.org/W2342553225","https://openalex.org/W2345948651","https://openalex.org/W2429762803","https://openalex.org/W2472346278","https://openalex.org/W2479496252","https://openalex.org/W2514362821","https://openalex.org/W2514975062","https://openalex.org/W2519516239","https://openalex.org/W2523775282","https://openalex.org/W2526775532","https://openalex.org/W2528875402","https://openalex.org/W2531274513","https://openalex.org/W2541361002","https://openalex.org/W2548465653","https://openalex.org/W2551564313","https://openalex.org/W2553119477","https://openalex.org/W2555852498","https://openalex.org/W2559946394","https://openalex.org/W2560158394","https://openalex.org/W2582711285","https://openalex.org/W4235092975","https://openalex.org/W6728463345"],"related_works":["https://openalex.org/W3108256620","https://openalex.org/W4401374903","https://openalex.org/W2004371219","https://openalex.org/W2742194272","https://openalex.org/W4223629343","https://openalex.org/W2771269710","https://openalex.org/W4387402298","https://openalex.org/W4319316995","https://openalex.org/W2739629672","https://openalex.org/W4387002823"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":32},{"year":2024,"cited_by_count":24},{"year":2023,"cited_by_count":34},{"year":2022,"cited_by_count":35},{"year":2021,"cited_by_count":43},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-05-05T00:00:00"}
