{"id":"https://openalex.org/W2607841801","doi":"https://doi.org/10.1111/dom.12985","title":"Postprandial renal haemodynamic effect of lixisenatide vs once\u2010daily insulin\u2010glulisine in patients with type 2 diabetes on insulin\u2010glargine: An 8\u2010week, randomised, open\u2010label trial","display_name":"Postprandial renal haemodynamic effect of lixisenatide vs once\u2010daily insulin\u2010glulisine in patients with type 2 diabetes on insulin\u2010glargine: An 8\u2010week, randomised, open\u2010label trial","publication_year":2017,"publication_date":"2017-04-27","ids":{"openalex":"https://openalex.org/W2607841801","doi":"https://doi.org/10.1111/dom.12985","mag":"2607841801","pmid":"https://pubmed.ncbi.nlm.nih.gov/28449402"},"language":"en","primary_location":{"id":"doi:10.1111/dom.12985","doi":"https://doi.org/10.1111/dom.12985","is_oa":true,"landing_page_url":"https://doi.org/10.1111/dom.12985","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dom.12985","source":{"id":"https://openalex.org/S148394532","display_name":"Diabetes Obesity and Metabolism","issn_l":"1462-8902","issn":["1462-8902","1463-1326"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, Obesity and Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dom.12985","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067721247","display_name":"Lennart Tonneijck","orcid":"https://orcid.org/0000-0001-5637-910X","observed_orcids":["https://orcid.org/0000-0001-5637-910X"]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Lennart Tonneijck","raw_affiliation_strings":["Department of Internal Medicine, Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-5637-910X","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084278641","display_name":"Marcel H.A. Muskiet","orcid":"https://orcid.org/0000-0003-4116-555X","observed_orcids":["https://orcid.org/0000-0003-4116-555X"]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marcel H. A. Muskiet","raw_affiliation_strings":["Department of Internal Medicine, Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091895526","display_name":"Mark M. Smits","orcid":"https://orcid.org/0000-0001-8236-8842","observed_orcids":["https://orcid.org/0000-0001-8236-8842"]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Mark M. Smits","raw_affiliation_strings":["Department of Internal Medicine, Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016447558","display_name":"Trynke Hoekstra","orcid":"https://orcid.org/0000-0002-0535-0056","observed_orcids":["https://orcid.org/0000-0002-0535-0056"]},"institutions":[{"id":"https://openalex.org/I4210124285","display_name":"Amsterdam Public Health","ror":"https://ror.org/0258apj61","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210124285"]},{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Trynke Hoekstra","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands","Department of Health Sciences and the EMGO Institute for Health and Care Research, VU University Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]},{"raw_affiliation_string":"Department of Health Sciences and the EMGO Institute for Health and Care Research, VU University Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210124285","https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028760009","display_name":"Mark H.H. Kramer","orcid":"https://orcid.org/0000-0001-7996-0466","observed_orcids":["https://orcid.org/0000-0001-7996-0466"]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Mark H. H. Kramer","raw_affiliation_strings":["Department of Internal Medicine, Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046295598","display_name":"A.H. Jan Danser","orcid":"https://orcid.org/0000-0002-5052-3585","observed_orcids":["https://orcid.org/0000-0002-5052-3585"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A. H. Jan Danser","raw_affiliation_strings":["Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I913958620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109335776","display_name":"Micha\u00ebla Diamant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Michaela Diamant","raw_affiliation_strings":["Department of Internal Medicine, Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062438369","display_name":"Jaap A. Joles","orcid":"https://orcid.org/0000-0003-2565-242X","observed_orcids":["https://orcid.org/0000-0003-2565-242X"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jaap A. Joles","raw_affiliation_strings":["Department of Nephrology and Hypertension, University Medical Center, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Hypertension, University Medical Center, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067127165","display_name":"Dani\u00ebl H. van Raalte","orcid":"https://orcid.org/0000-0003-2894-6124","observed_orcids":["https://orcid.org/0000-0003-2894-6124"]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Dani\u00ebl H. van Raalte","raw_affiliation_strings":["Department of Internal Medicine, Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-2894-6124","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5067721247"],"corresponding_institution_ids":["https://openalex.org/I911458345"],"apc_list":{"value":5380,"currency":"USD","value_usd":5380},"apc_paid":null,"fwci":5.6348,"has_fulltext":true,"cited_by_count":64,"citation_normalized_percentile":{"value":0.9699505,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"19","issue":"12","first_page":"1669","last_page":"1680"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.03709999844431877,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lixisenatide","display_name":"lixisenatide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/insulin-glulisine","display_name":"insulin glulisine","score":0.9229999780654907},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8460000157356262},{"id":"https://openalex.org/keywords/glomerular-hyperfiltration","display_name":"glomerular hyperfiltration","score":0.8500000238418579},{"id":"https://openalex.org/keywords/glomerular-filtration-rate","display_name":"glomerular filtration rate","score":0.7519999742507935},{"id":"https://openalex.org/keywords/effective-renal-plasma-flow","display_name":"effective renal plasma flow","score":0.984000027179718},{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.8320000171661377},{"id":"https://openalex.org/keywords/insulin-glargine","display_name":"insulin glargine","score":0.6470000147819519},{"id":"https://openalex.org/keywords/fractional-excretion-of-sodium","display_name":"fractional excretion of sodium","score":0.8270000219345093},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.6470000147819519},{"id":"https://openalex.org/keywords/body-weight","display_name":"body weight","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9543602466583252},{"id":"https://openalex.org/C2776442814","wikidata":"https://www.wikidata.org/wiki/Q6659956","display_name":"Lixisenatide","level":5,"score":0.9375749826431274},{"id":"https://openalex.org/C2778199505","wikidata":"https://www.wikidata.org/wiki/Q2992990","display_name":"Postprandial","level":3,"score":0.8427868485450745},{"id":"https://openalex.org/C2779920387","wikidata":"https://www.wikidata.org/wiki/Q417317","display_name":"Insulin glargine","level":4,"score":0.7229321599006653},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6901587247848511},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5441847443580627},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4355643391609192},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.3804309368133545},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36438167095184326},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.35161998867988586},{"id":"https://openalex.org/C2909524832","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Basal insulin","level":4,"score":0.22603347897529602}],"mesh":[{"descriptor_ui":"D000067757","descriptor_name":"Glucagon-Like Peptide-1 Receptor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000067758","descriptor_name":"Glucagon-Like Peptide-2 Receptor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069036","descriptor_name":"Insulin Glargine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000069036","descriptor_name":"Insulin Glargine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000097789","descriptor_name":"Glucagon-Like Peptide-1 Receptor Agonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009426","descriptor_name":"Netherlands","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014655","descriptor_name":"Vascular Resistance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019518","descriptor_name":"Postprandial Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050177","descriptor_name":"Overweight","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D050177","descriptor_name":"Overweight","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D050177","descriptor_name":"Overweight","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D051437","descriptor_name":"Renal Insufficiency","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D051437","descriptor_name":"Renal Insufficiency","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D051437","descriptor_name":"Renal Insufficiency","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false}],"locations_count":12,"locations":[{"id":"doi:10.1111/dom.12985","doi":"https://doi.org/10.1111/dom.12985","is_oa":true,"landing_page_url":"https://doi.org/10.1111/dom.12985","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dom.12985","source":{"id":"https://openalex.org/S148394532","display_name":"Diabetes Obesity and Metabolism","issn_l":"1462-8902","issn":["1462-8902","1463-1326"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, Obesity and Metabolism","raw_type":"journal-article"},{"id":"pmid:28449402","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28449402","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, obesity & metabolism","raw_type":"Clinical Trial, Phase IV"},{"id":"pmh:oai:pure.eur.nl:openaire_cris_publications/ce8ee351-0e45-4f1a-b11f-61a5050b17d6","doi":null,"is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/ce8ee351-0e45-4f1a-b11f-61a5050b17d6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tonneijck, L, Muskiet, MHA, Smits, MM, Hoekstra, T, Kramer, MHH, Danser, J, Diamant, M, Joles, JA & van Raalte, DH 2017, 'Postprandial renal haemodynamic effect of lixisenatide vs once-daily insulin-glulisine in patients with type 2 diabetes on insulin-glargine: An 8-week, randomised, open-label trial', Diabetes Obesity & Metabolism, vol. 19, no. 12, pp. 1669-1680. https://doi.org/10.1111/dom.12985","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:research.vu.nl:openaire/c410102d-bdd0-4978-ae16-791871d9c19b","doi":null,"is_oa":true,"landing_page_url":"https://research.vu.nl/en/publications/c410102d-bdd0-4978-ae16-791871d9c19b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401107","display_name":"VU Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I865915315","host_organization_name":"Vrije Universiteit Amsterdam","host_organization_lineage":["https://openalex.org/I865915315"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tonneijck, L, Muskiet, M H A, Smits, M M, Hoekstra, T, Kramer, M H H, Danser, A H J, Diamant, M, Joles, J A & van Raalte, D H 2017, 'Postprandial renal haemodynamic effect of lixisenatide vs once-daily insulin-glulisine in patients with type 2 diabetes on insulin-glargine: An 8-week, randomised, open-label trial', Diabetes, Obesity and Metabolism, vol. 19, no. 12, pp. 1669-1680. https://doi.org/10.1111/dom.12985","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/1a324ed9-49cc-47de-aefd-8110e73f5b65","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/1a324ed9-49cc-47de-aefd-8110e73f5b65","pdf_url":"https://pure.amsterdamumc.nl/ws/files/159007528/Postprandial-renal-haemodynamic-effect-of-lixisenatide-vs-once-daily-insulin-glulisine-in-patients-with-type-2-diabetes-.pdf","source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tonneijck, L, Muskiet, M H A, Smits, M M, Hoekstra, T, Kramer, M H H, Danser, A H J, Diamant, M, Joles, J A & van Raalte, D H 2017, 'Postprandial renal haemodynamic effect of lixisenatide vs once-daily insulin-glulisine in patients with type 2 diabetes on insulin-glargine : An 8-week, randomised, open-label trial', Diabetes, Obesity and Metabolism, vol. 19, no. 12, pp. 1669-1680. https://doi.org/10.1111/dom.12985","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:eur:oai:pure.eur.nl:publications/ce8ee351-0e45-4f1a-b11f-61a5050b17d6","doi":null,"is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/ce8ee351-0e45-4f1a-b11f-61a5050b17d6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Diabetes Obesity & Metabolism, 19(12), 1669 - 1680. Wiley-Blackwell Publishing Ltd","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dspace.library.uu.nl:1874/360322","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/360322","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/13d4da7a-4213-436c-85cb-7b240fb04d09","doi":null,"is_oa":false,"landing_page_url":"https://www.scopus.com/pages/publications/85026289827","pdf_url":null,"source":{"id":"https://openalex.org/S7407055350","display_name":"Amsterdam UMC (VU Amsterdam) - Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tonneijck, L, Muskiet, M H A, Smits, M M, Hoekstra, T, Kramer, M H H, Danser, A H J, Diamant, M, Joles, J A & van Raalte, D H 2017, 'Postprandial renal haemodynamic effect of lixisenatide vs once-daily insulin-glulisine in patients with type 2 diabetes on insulin-glargine : An 8-week, randomised, open-label trial', Diabetes, Obesity and Metabolism, vol. 19, no. 12, pp. 1669-1680. https://doi.org/10.1111/dom.12985","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/360322","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/360322","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Diabetes, Obesity & Metabolism, 19(12), 1669. Wiley-Blackwell","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/360322","doi":null,"is_oa":false,"landing_page_url":"http://dspace.library.uu.nl/handle/1874/360322","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Diabetes, Obesity & Metabolism, 19(12), 1669","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vu:oai:research.vu.nl:publications/c410102d-bdd0-4978-ae16-791871d9c19b","doi":null,"is_oa":false,"landing_page_url":"https://research.vu.nl/en/publications/c410102d-bdd0-4978-ae16-791871d9c19b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Diabetes, Obesity and Metabolism, 19(12), 1669 - 1680. Wiley-Blackwell","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vumc:oai:pure.atira.dk:publications/13d4da7a-4213-436c-85cb-7b240fb04d09","doi":null,"is_oa":false,"landing_page_url":"https://research.vumc.nl/en/publications/13d4da7a-4213-436c-85cb-7b240fb04d09","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Diabetes, Obesity and Metabolism, 19(12), 1669 - 1680. Wiley-Blackwell","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1111/dom.12985","doi":"https://doi.org/10.1111/dom.12985","is_oa":true,"landing_page_url":"https://doi.org/10.1111/dom.12985","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dom.12985","source":{"id":"https://openalex.org/S148394532","display_name":"Diabetes Obesity and Metabolism","issn_l":"1462-8902","issn":["1462-8902","1463-1326"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, Obesity and Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320321014","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2607841801.pdf","grobid_xml":"https://content.openalex.org/works/W2607841801.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1510097375","https://openalex.org/W1536061722","https://openalex.org/W1910083626","https://openalex.org/W1968897221","https://openalex.org/W1969068062","https://openalex.org/W1979288606","https://openalex.org/W2012029630","https://openalex.org/W2047793705","https://openalex.org/W2099221294","https://openalex.org/W2103274121","https://openalex.org/W2104688228","https://openalex.org/W2105771613","https://openalex.org/W2113094401","https://openalex.org/W2117340025","https://openalex.org/W2121198446","https://openalex.org/W2121310592","https://openalex.org/W2123786774","https://openalex.org/W2131176334","https://openalex.org/W2144210629","https://openalex.org/W2149802883","https://openalex.org/W2158742250","https://openalex.org/W2168234252","https://openalex.org/W2176491627","https://openalex.org/W2214858768","https://openalex.org/W2262517533","https://openalex.org/W2273849019","https://openalex.org/W2282578582","https://openalex.org/W2297560320","https://openalex.org/W2302058075","https://openalex.org/W2310697238","https://openalex.org/W2315065708","https://openalex.org/W2331767236","https://openalex.org/W2340643800","https://openalex.org/W2404273804","https://openalex.org/W2415080161","https://openalex.org/W2518652627","https://openalex.org/W2534632877","https://openalex.org/W2536045672","https://openalex.org/W2537726188","https://openalex.org/W2563017273","https://openalex.org/W2583476095"],"related_works":["https://openalex.org/W2808794046","https://openalex.org/W2898592605","https://openalex.org/W2943099799","https://openalex.org/W2607581455","https://openalex.org/W2045188930","https://openalex.org/W2128093058","https://openalex.org/W2103274121","https://openalex.org/W2396275270","https://openalex.org/W2031673150","https://openalex.org/W2909709263"],"abstract_inverted_index":{"Aim":[0],"To":[1],"determine":[2],"whether":[3],"lixisenatide,":[4],"a":[5,105,274],"prandial":[6],"short\u2010acting":[7],"glucagon\u2010like":[8],"peptide":[9],"receptor":[10],"agonist":[11],"(":[12,26,32,83,95,116,220],"GLP\u20101RA":[13,287],"),":[14],"ameliorates":[15],"postprandial":[16,214,238,253,294],"glomerular":[17,80],"hyperfiltration":[18],"in":[19,53,263,280],"patients":[20,56,264],"with":[21,30,43,57,63,144,218,225,257,265,298],"type":[22],"2":[23,92,156,167],"diabetes":[24],"mellitus":[25],"T2DM":[27,58,266],")":[28,85,97,118],"compared":[29,256,297],"insulin\u2010glulisine":[31],"iGlu":[33,50,145,200,226,258,299],").":[34],"Methods":[35],"Postprandial":[36],"renal":[37,113,126,175],"haemodynamic":[38,135],"effects":[39],"of":[40],"8\u2010week":[41],"treatment":[42,249,272],"lixisenatide":[44,147,219,228,248,271],"20":[45],"\u00b5g":[46],"vs":[47],"once\u2010daily":[48],"titrated":[49],"were":[51,119,137,196],"measured":[52],"35":[54],"overweight":[55],"inadequately":[59],"controlled":[60],"on":[61,130,285],"insulin\u2010glargine,":[62],"or":[64,174],"without":[65,267],"metformin":[66],"[mean":[67],"\u00b1":[68,72,77,87,206,210],"SD":[69],"age":[70],"62":[71],"7":[73],"years,":[74],"HbA1c":[75,202],"8.0%":[76],"0.9%,":[78],"estimated":[79,138],"filtration":[81],"rate":[82],"GFR":[84,108,151],"85":[86],"12":[88],"mL":[89,153,164],"/min/1.73":[90,154,165],"m":[91,155,166],",":[93,146,227,288],"median":[94],"IQR":[96],"urinary":[98,186],"albumin/creatinine":[99],"ratio":[100],"1.5":[101],"(0.9\u20103.0)":[102],"mg/mmol].":[103],"After":[104],"standardised":[106],"breakfast,":[107],"(primary":[109],"endpoint)":[110],"and":[111,123,185,194,199,208,236,292],"effective":[112],"plasma":[114],"flow":[115],"ERPF":[117,162],"determined":[120],"by":[121,204],"inulin":[122],"para\u2010aminohippuric":[124],"acid":[125],"clearance,":[127],"respectively,":[128,212],"based":[129],"timed":[131],"urine":[132],"sampling.":[133],"Intrarenal":[134],"functions":[136],"using":[139],"Gomez":[140],"equations.":[141],"Results":[142],"Compared":[143,224],"did":[148],"not":[149,251],"affect":[150,252],"[+0.1":[152],"(95%":[157],"CI":[158],"\u22129":[159],"to":[160,169,234,261,282],"9)],":[161],"[\u221217":[163],"(\u221261":[168],"26)],":[170],"other":[171],"(intra\u2010)renal":[172,254],"haemodynamics":[173,255],"damage":[176],"markers,":[177],"but":[178],"increased":[179,237],"fractional":[180],"sodium":[181],"excretion":[182],"[+0.25%":[183],"(0.09\u20100.41)]":[184],"pH":[187],"[+0.7":[188],"(0.3\u20101.2)].":[189],"Plasma":[190],"renin,":[191],"angiotensin\u2010":[192],"II":[193],"aldosterone":[195],"unchanged.":[197],"Lixisenatide":[198],"reduced":[201,229],"similarly,":[203],"0.8%":[205],"0.1%":[207],"0.6%":[209],"0.1%,":[211],"while":[213],"glucose":[215],"was":[216],"lower":[217],"P":[221],"=":[222],".002).":[223],"bodyweight":[230],"[\u22121.4":[231],"kg":[232],"(\u22122.5":[233],"\u22120.2)]":[235],"mean":[239],"arterial":[240],"pressure":[241,296],"[+9":[242],"mm":[243],"Hg":[244],"(4\u201014)].":[245],"Conclusion":[246],"Eight\u2010week":[247],"does":[250],"when":[259],"added":[260],"insulin\u2010glargine":[262],"overt":[268],"nephropathy.":[269],"Prolonged":[270],"has":[273],"sustained":[275],"natriuretic":[276],"effect,":[277],"which":[278],"is":[279],"contrast":[281],"previous":[283],"reports":[284],"long\u2010acting":[286],"reduces":[289],"body":[290],"weight":[291],"increases":[293],"blood":[295],".":[300],"Trial":[301],"registration":[302],":":[303],"ClinicalTrials.gov":[304],"identifier":[305],"NCT02276196":[306]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-05-05T00:00:00"}