{"id":"https://openalex.org/W2607657572","doi":"https://doi.org/10.1111/jgh.13812","title":"Zinc monotherapy for young children with presymptomatic Wilson disease: A multicenter study in Japan","display_name":"Zinc monotherapy for young children with presymptomatic Wilson disease: A multicenter study in Japan","publication_year":2017,"publication_date":"2017-04-28","ids":{"openalex":"https://openalex.org/W2607657572","doi":"https://doi.org/10.1111/jgh.13812","mag":"2607657572","pmid":"https://pubmed.ncbi.nlm.nih.gov/28452067"},"language":"en","primary_location":{"id":"doi:10.1111/jgh.13812","doi":"https://doi.org/10.1111/jgh.13812","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jgh.13812","pdf_url":null,"source":{"id":"https://openalex.org/S131037608","display_name":"Journal of Gastroenterology and Hepatology","issn_l":"0815-9319","issn":["0815-9319","1440-1746"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastroenterology and Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://kurume.repo.nii.ac.jp/record/704/files/37104B2921.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112436243","display_name":"Keisuke Eda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105296287","display_name":"Kurume University","ror":"https://ror.org/057xtrt18","country_code":"JP","type":"education","lineage":["https://openalex.org/I105296287"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keisuke Eda","raw_affiliation_strings":["Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Japan","institution_ids":["https://openalex.org/I105296287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083599951","display_name":"Tatsuki Mizuochi","orcid":"https://orcid.org/0000-0002-2943-7068","observed_orcids":["https://orcid.org/0000-0002-2943-7068"]},"institutions":[{"id":"https://openalex.org/I105296287","display_name":"Kurume University","ror":"https://ror.org/057xtrt18","country_code":"JP","type":"education","lineage":["https://openalex.org/I105296287"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tatsuki Mizuochi","raw_affiliation_strings":["Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Japan","institution_ids":["https://openalex.org/I105296287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001237318","display_name":"Itaru Iwama","orcid":"https://orcid.org/0000-0001-8677-8195","observed_orcids":["https://orcid.org/0000-0001-8677-8195"]},"institutions":[{"id":"https://openalex.org/I4210121081","display_name":"Okinawa Prefectural Chubu Hospital","ror":"https://ror.org/03mpa4w20","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210121081"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Itaru Iwama","raw_affiliation_strings":["Department of Pediatrics, Okinawa Chubu Hospital, Uruma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Okinawa Chubu Hospital, Uruma, Japan","institution_ids":["https://openalex.org/I4210121081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054121299","display_name":"Ayano Inui","orcid":"https://orcid.org/0000-0002-1973-4376","observed_orcids":["https://orcid.org/0000-0002-1973-4376"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ayano Inui","raw_affiliation_strings":["Department of Pediatric Hepatology and Gastroenterology, Saiseikai Yokohamashi Tobu Hospital, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Hepatology and Gastroenterology, Saiseikai Yokohamashi Tobu Hospital, Yokohama, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015236955","display_name":"Yuri Etani","orcid":"https://orcid.org/0000-0003-3005-4707","observed_orcids":["https://orcid.org/0000-0003-3005-4707"]},"institutions":[{"id":"https://openalex.org/I4210095711","display_name":"Osaka Women's and Children's Hospital","ror":"https://ror.org/00nx7n658","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210095711","https://openalex.org/I4405282797"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuri Etani","raw_affiliation_strings":["Department of Pediatric Gastroenterology, Nutrition, and Endocrinology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Gastroenterology, Nutrition, and Endocrinology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan","institution_ids":["https://openalex.org/I4210095711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022921244","display_name":"Mariko Araki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201954162","display_name":"University of Kochi","ror":"https://ror.org/02v1sf687","country_code":"JP","type":"education","lineage":["https://openalex.org/I201954162","https://openalex.org/I4405286278"]},{"id":"https://openalex.org/I77063589","display_name":"K\u014dchi University","ror":"https://ror.org/01xxp6985","country_code":"JP","type":"education","lineage":["https://openalex.org/I77063589"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mariko Araki","raw_affiliation_strings":["Department of Pediatrics, Kochi Medical School, Kochi University, Nankoku, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Kochi Medical School, Kochi University, Nankoku, Japan","institution_ids":["https://openalex.org/I201954162","https://openalex.org/I77063589"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081768903","display_name":"Shinya Hara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092859","display_name":"Toyota Memorial Hospital","ror":"https://ror.org/00hcz6468","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210092859"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinya Hara","raw_affiliation_strings":["Department of Pediatrics, Toyota Memorial Hospital, Toyota, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Toyota Memorial Hospital, Toyota, Japan","institution_ids":["https://openalex.org/I4210092859"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103195051","display_name":"Hideki Kumagai","orcid":"https://orcid.org/0000-0001-5309-8396","observed_orcids":["https://orcid.org/0000-0001-5309-8396"]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideki Kumagai","raw_affiliation_strings":["Department of Pediatrics, Jichi Medical University, Shimotsuke, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Jichi Medical University, Shimotsuke, Japan","institution_ids":["https://openalex.org/I146500386"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091352591","display_name":"Shin\u2010ichiro Hagiwara","orcid":"https://orcid.org/0000-0003-2713-1329","observed_orcids":["https://orcid.org/0000-0003-2713-1329"]},"institutions":[{"id":"https://openalex.org/I4210095856","display_name":"Saitama Children's Medical Center","ror":"https://ror.org/00smq1v26","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210095856"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shin\u2010Ichiro Hagiwara","raw_affiliation_strings":["Division of General Pediatrics, Saitama Children's Medical Center, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General Pediatrics, Saitama Children's Medical Center, Saitama, Japan","institution_ids":["https://openalex.org/I4210095856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083957581","display_name":"Kei Murayama","orcid":"https://orcid.org/0000-0002-3923-8636","observed_orcids":["https://orcid.org/0000-0002-3923-8636"]},"institutions":[{"id":"https://openalex.org/I4405253373","display_name":"Chiba Children's Hospital","ror":"https://ror.org/00khjyb83","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405253373"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kei Murayama","raw_affiliation_strings":["Department of Metabolism, Chiba Children's Hospital, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolism, Chiba Children's Hospital, Chiba, Japan","institution_ids":["https://openalex.org/I4405253373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061984117","display_name":"Jun Murakami","orcid":"https://orcid.org/0000-0001-9869-3383","observed_orcids":["https://orcid.org/0000-0001-9869-3383"]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Murakami","raw_affiliation_strings":["Division of Pediatrics and Perinatology, Faculty of Medicine, Tottori University, Yonago, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatrics and Perinatology, Faculty of Medicine, Tottori University, Yonago, Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Norikazu Shimizu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]},{"id":"https://openalex.org/I4210093329","display_name":"Toho University Ohashi Medical Center","ror":"https://ror.org/00mre2126","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210093329"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Norikazu Shimizu","raw_affiliation_strings":["Department of Pediatrics, Toho University School of Medicine, Ohashi Medical Center, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Toho University School of Medicine, Ohashi Medical Center, Tokyo, Japan","institution_ids":["https://openalex.org/I129634264","https://openalex.org/I4210093329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062222687","display_name":"Hiroko Kodama","orcid":"https://orcid.org/0000-0001-9612-0434","observed_orcids":["https://orcid.org/0000-0001-9612-0434"]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroko Kodama","raw_affiliation_strings":["Department of Pediatrics, Teikyo University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Teikyo University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060898319","display_name":"Ryosuke Yasuda","orcid":"https://orcid.org/0009-0009-3882-202X","observed_orcids":["https://orcid.org/0009-0009-3882-202X"]},"institutions":[{"id":"https://openalex.org/I105296287","display_name":"Kurume University","ror":"https://ror.org/057xtrt18","country_code":"JP","type":"education","lineage":["https://openalex.org/I105296287"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryosuke Yasuda","raw_affiliation_strings":["Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Japan","institution_ids":["https://openalex.org/I105296287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014240623","display_name":"Yugo Takaki","orcid":"https://orcid.org/0000-0002-3191-0192","observed_orcids":["https://orcid.org/0000-0002-3191-0192"]},"institutions":[{"id":"https://openalex.org/I105296287","display_name":"Kurume University","ror":"https://ror.org/057xtrt18","country_code":"JP","type":"education","lineage":["https://openalex.org/I105296287"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yugo Takaki","raw_affiliation_strings":["Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Japan","institution_ids":["https://openalex.org/I105296287"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042383489","display_name":"Yushiro Yamashita","orcid":"https://orcid.org/0000-0001-8677-3183","observed_orcids":["https://orcid.org/0000-0001-8677-3183"]},"institutions":[{"id":"https://openalex.org/I105296287","display_name":"Kurume University","ror":"https://ror.org/057xtrt18","country_code":"JP","type":"education","lineage":["https://openalex.org/I105296287"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yushiro Yamashita","raw_affiliation_strings":["Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Japan","institution_ids":["https://openalex.org/I105296287"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5083599951"],"corresponding_institution_ids":["https://openalex.org/I105296287"],"apc_list":{"value":4620,"currency":"USD","value_usd":4620},"apc_paid":null,"fwci":2.4012,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.87306432,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"33","issue":"1","first_page":"264","last_page":"269"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wilson-s-disease","display_name":"Wilson's disease","score":0.9399999976158142},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.7829999923706055},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.8029999732971191},{"id":"https://openalex.org/keywords/urinary-copper-excretion","display_name":"urinary copper excretion","score":0.7570000290870667},{"id":"https://openalex.org/keywords/aminotransferases","display_name":"transaminases","score":0.8650000095367432},{"id":"https://openalex.org/keywords/gamma-glutamyl-transferase","display_name":"gamma-glutamyl transferase","score":0.8180000185966492},{"id":"https://openalex.org/keywords/treatment-efficacy-and-safety","display_name":"treatment efficacy and safety","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8862633109092712},{"id":"https://openalex.org/C2778606649","wikidata":"https://www.wikidata.org/wiki/Q305481","display_name":"Alanine transaminase","level":2,"score":0.6003608703613281},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5894553661346436},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.5780009031295776},{"id":"https://openalex.org/C2776877979","wikidata":"https://www.wikidata.org/wiki/Q424288","display_name":"Transaminase","level":3,"score":0.5723775625228882},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5456429719924927},{"id":"https://openalex.org/C2776231509","wikidata":"https://www.wikidata.org/wiki/Q117121","display_name":"Wilson's disease","level":3,"score":0.5193513631820679},{"id":"https://openalex.org/C2779679107","wikidata":"https://www.wikidata.org/wiki/Q412474","display_name":"Aspartate transaminase","level":4,"score":0.4815935790538788},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4327335059642792},{"id":"https://openalex.org/C535196362","wikidata":"https://www.wikidata.org/wiki/Q758","display_name":"Zinc","level":2,"score":0.42816871404647827},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.40268272161483765},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3228986859321594},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.10846671462059021},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0829915702342987},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006527","descriptor_name":"Hepatolenticular Degeneration","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/jgh.13812","doi":"https://doi.org/10.1111/jgh.13812","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jgh.13812","pdf_url":null,"source":{"id":"https://openalex.org/S131037608","display_name":"Journal of Gastroenterology and Hepatology","issn_l":"0815-9319","issn":["0815-9319","1440-1746"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastroenterology and Hepatology","raw_type":"journal-article"},{"id":"pmid:28452067","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28452067","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gastroenterology and hepatology","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:01236:0003785749","doi":null,"is_oa":true,"landing_page_url":"https://kurume.repo.nii.ac.jp/records/704","pdf_url":"https://kurume.repo.nii.ac.jp/record/704/files/37104B2921.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"}],"best_oa_location":{"id":"pmh:oai:irdb.nii.ac.jp:01236:0003785749","doi":null,"is_oa":true,"landing_page_url":"https://kurume.repo.nii.ac.jp/records/704","pdf_url":"https://kurume.repo.nii.ac.jp/record/704/files/37104B2921.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G8877954402","display_name":null,"funder_award_id":"C15K09704","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2607657572.pdf","grobid_xml":"https://content.openalex.org/works/W2607657572.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W159935040","https://openalex.org/W1991140368","https://openalex.org/W1996610030","https://openalex.org/W2002803484","https://openalex.org/W2020657276","https://openalex.org/W2033653810","https://openalex.org/W2074605066","https://openalex.org/W2079522949","https://openalex.org/W2080058827","https://openalex.org/W2082677827","https://openalex.org/W2091516044","https://openalex.org/W2108765785","https://openalex.org/W2111658457","https://openalex.org/W2120805372","https://openalex.org/W2248606527","https://openalex.org/W2312434633","https://openalex.org/W4210926331","https://openalex.org/W4211041131"],"related_works":["https://openalex.org/W2312434633","https://openalex.org/W4254822018","https://openalex.org/W2073302179","https://openalex.org/W3134318877","https://openalex.org/W2091516044","https://openalex.org/W2002803484","https://openalex.org/W2420017384","https://openalex.org/W2074605066","https://openalex.org/W2248606527","https://openalex.org/W2108765785"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"AIM:":[2],"Few":[3],"studies":[4],"of":[5,24,57,84,97,123,146,164,186,237],"zinc":[6,25,53,147,187],"monotherapy":[7,26,54,188,197],"for":[8,27,33,120,189,242],"presymptomatic":[9,48,193],"Wilson":[10,49,194],"disease":[11,50],"have":[12],"focused":[13],"on":[14],"young":[15,190],"children.":[16],"We":[17,37],"therefore":[18],"evaluated":[19],"long-term":[20],"efficacy":[21],"and":[22,30,39,74,86,108,114,117,132,154,169,201,216,223,226],"safety":[23],"such":[28],"children":[29,42,191],"established":[31],"benchmarks":[32],"maintenance":[34],"therapy.":[35],"METHODS:":[36],"retrospectively":[38],"prospectively":[40],"examined":[41],"under":[43,89,111,138,209,227,244],"10":[44],"years":[45,96,140,246],"old":[46,141],"with":[47,192],"who":[51,142],"received":[52,143],"from":[55,92],"time":[56],"diagnosis":[58],"at":[59,105,159,173],"12":[60],"participating":[61],"pediatric":[62],"centers":[63],"in":[64],"Japan.":[65],"RESULTS:":[66],"Twenty-four":[67],"patients":[68,127,137,243],"met":[69],"entry":[70],"criteria.":[71],"Aspartate":[72],"aminotransferase":[73,76,153,156],"alanine":[75,155],"decreased":[77,103,158],"significantly":[78,104,157],"beginning":[79],"1":[80,93,116,160,222],"month":[81,161],"after":[82,162],"initiation":[83,163],"treatment":[85],"usually":[87,109],"remained":[88,110],"50":[90,144,210,238],"U/L":[91,211],"to":[94,129],"8":[95],"treatment.":[98],"Twenty":[99],"four-hour":[100],"urinary":[101,171,218],"copper":[102,172,219],"6":[106,139,174,245],"months":[107],"75":[112,228],"\u03bcg/day":[113,229],"between":[115,221],"3":[118,224],"\u03bcg/kg/day":[119,225],"the":[121,124,182],"remainder":[122],"study.":[125],"All":[126],"continued":[128],"take":[130],"zinc,":[131],"none":[133],"became":[134],"symptomatic.":[135],"In":[136],"mg/day":[145,239],"as":[148,166],"an":[149],"initial":[150,235],"dose,":[151],"aspartate":[152],"treatment,":[165],"did":[167],"\u03b3-glutamyltransferase":[168],"24-h":[170,217],"months.":[175],"CONCLUSIONS:":[176],"To":[177],"our":[178],"knowledge,":[179],"this":[180],"is":[181,214,230,240],"first":[183],"multicenter":[184],"study":[185],"disease.":[195],"Such":[196],"proved":[198],"highly":[199],"effective":[200],"safe.":[202],"Maintaining":[203],"normal":[204],"transaminase":[205],"values":[206,208],"(or":[207],"when":[212],"normalization":[213],"difficult)":[215],"excretion":[220],"a":[231],"reasonable":[232],"goal.":[233],"An":[234],"dose":[236],"appropriate":[241],"old.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2017-05-05T00:00:00"}
