{"id":"https://openalex.org/W2607478261","doi":"https://doi.org/10.18632/oncotarget.17341","title":"Updated meta-analysis of the role ofAPOE\u03b52/\u03b53/\u03b54 alleles in frontotemporal lobar degeneration","display_name":"Updated meta-analysis of the role ofAPOE\u03b52/\u03b53/\u03b54 alleles in frontotemporal lobar degeneration","publication_year":2017,"publication_date":"2017-04-21","ids":{"openalex":"https://openalex.org/W2607478261","doi":"https://doi.org/10.18632/oncotarget.17341","mag":"2607478261","pmid":"https://pubmed.ncbi.nlm.nih.gov/28487499","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5546436"},"language":"en","primary_location":{"id":"doi:10.18632/oncotarget.17341","doi":"https://doi.org/10.18632/oncotarget.17341","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.17341","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=17341&path%5B%5D=55492","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=17341&path%5B%5D=55492","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Wen-Hua Su","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102371","display_name":"Tianjin Huanhu Hospital","ror":"https://ror.org/00q6wbs64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210102371"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen-Hua Su","raw_affiliation_strings":["Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China","Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China","institution_ids":["https://openalex.org/I4210102371"]},{"raw_affiliation_string":"Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin, China","institution_ids":["https://openalex.org/I4210102371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101962620","display_name":"Zhihong Shi","orcid":"https://orcid.org/0000-0002-5743-5158","observed_orcids":["https://orcid.org/0000-0002-5743-5158"]},"institutions":[{"id":"https://openalex.org/I4210102371","display_name":"Tianjin Huanhu Hospital","ror":"https://ror.org/00q6wbs64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210102371"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-Hong Shi","raw_affiliation_strings":["Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China","Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China","institution_ids":["https://openalex.org/I4210102371"]},{"raw_affiliation_string":"Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin, China","institution_ids":["https://openalex.org/I4210102371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027284462","display_name":"Shuling Liu","orcid":"https://orcid.org/0000-0003-2754-6049","observed_orcids":["https://orcid.org/0000-0003-2754-6049"]},"institutions":[{"id":"https://openalex.org/I4210102371","display_name":"Tianjin Huanhu Hospital","ror":"https://ror.org/00q6wbs64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210102371"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shu-Ling Liu","raw_affiliation_strings":["Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China","Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China","institution_ids":["https://openalex.org/I4210102371"]},{"raw_affiliation_string":"Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin, China","institution_ids":["https://openalex.org/I4210102371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100395118","display_name":"Xiaodan Wang","orcid":"https://orcid.org/0000-0003-1675-3552","observed_orcids":["https://orcid.org/0000-0003-1675-3552"]},"institutions":[{"id":"https://openalex.org/I4210102371","display_name":"Tianjin Huanhu Hospital","ror":"https://ror.org/00q6wbs64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210102371"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Dan Wang","raw_affiliation_strings":["Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China","Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China","institution_ids":["https://openalex.org/I4210102371"]},{"raw_affiliation_string":"Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin, China","institution_ids":["https://openalex.org/I4210102371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088964405","display_name":"Shuai Liu","orcid":"https://orcid.org/0000-0001-6984-7814","observed_orcids":["https://orcid.org/0000-0001-6984-7814"]},"institutions":[{"id":"https://openalex.org/I4210102371","display_name":"Tianjin Huanhu Hospital","ror":"https://ror.org/00q6wbs64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210102371"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuai Liu","raw_affiliation_strings":["Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China","Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China","institution_ids":["https://openalex.org/I4210102371"]},{"raw_affiliation_string":"Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin, China","institution_ids":["https://openalex.org/I4210102371"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101571684","display_name":"Yong Ji","orcid":"https://orcid.org/0000-0002-8558-947X","observed_orcids":["https://orcid.org/0000-0002-8558-947X"]},"institutions":[{"id":"https://openalex.org/I4210102371","display_name":"Tianjin Huanhu Hospital","ror":"https://ror.org/00q6wbs64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210102371"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Ji","raw_affiliation_strings":["Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China","Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China","institution_ids":["https://openalex.org/I4210102371"]},{"raw_affiliation_string":"Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin, China","institution_ids":["https://openalex.org/I4210102371"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210102371"],"apc_list":null,"apc_paid":null,"fwci":0.1438,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.14896009,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"8","issue":"27","first_page":"43721","last_page":"43732"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.5313000082969666,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.5313000082969666,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.45210000872612,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.8949999809265137},{"id":"https://openalex.org/keywords/apoe-epsilon2-allele","display_name":"APOE \u03b52 allele","score":0.968999981880188},{"id":"https://openalex.org/keywords/apoe-epsilon3-allele","display_name":"APOE \u03b53 allele","score":0.7680000066757202},{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.8840000033378601},{"id":"https://openalex.org/keywords/frontotemporal-lobar-degeneration","display_name":"frontotemporal lobar degeneration","score":0.9980000257492065},{"id":"https://openalex.org/keywords/behavioral-variant-frontotemporal-dementia","display_name":"behavioral variant frontotemporal dementia","score":0.9509999752044678},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.6449999809265137},{"id":"https://openalex.org/keywords/case-control-association-studies","display_name":"case-control association","score":0.5529999732971191},{"id":"https://openalex.org/keywords/hardy-weinberg-equilibrium","display_name":"Hardy-Weinberg equilibrium","score":0.828000009059906},{"id":"https://openalex.org/keywords/genetic-models","display_name":"genetic models","score":0.3190000057220459},{"id":"https://openalex.org/keywords/subpopulations","display_name":"subpopulations","score":0.4300000071525574},{"id":"https://openalex.org/keywords/genetic-heterogeneity","display_name":"genetic heterogeneity","score":0.3930000066757202},{"id":"https://openalex.org/keywords/publication-bias","display_name":"publication bias","score":0.5099999904632568},{"id":"https://openalex.org/keywords/study-quality-bias","display_name":"study quality bias","score":0.41999998688697815}],"concepts":[{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.6535437703132629},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6509137749671936},{"id":"https://openalex.org/C2776939681","wikidata":"https://www.wikidata.org/wiki/Q18579","display_name":"Frontotemporal lobar degeneration","level":5,"score":0.5623403191566467},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5417209267616272},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.5151640176773071},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.4138033092021942},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4122692346572876},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40885424613952637},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3364660143852234},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.32404717803001404},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3073693811893463},{"id":"https://openalex.org/C2778641062","wikidata":"https://www.wikidata.org/wiki/Q18592","display_name":"Frontotemporal dementia","level":4,"score":0.17738059163093567},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15563344955444336},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1442493498325348},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.08976268768310547},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017594","descriptor_name":"Publication Bias","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053318","descriptor_name":"Apolipoprotein E3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053327","descriptor_name":"Apolipoprotein E4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053329","descriptor_name":"Apolipoprotein E2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057174","descriptor_name":"Frontotemporal Lobar Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.18632/oncotarget.17341","doi":"https://doi.org/10.18632/oncotarget.17341","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.17341","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=17341&path%5B%5D=55492","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4460629","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5546436","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5546436","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5546436","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Text"},{"id":"pmid:28487499","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28487499","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.18632/oncotarget.17341","doi":"https://doi.org/10.18632/oncotarget.17341","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.17341","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=17341&path%5B%5D=55492","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[{"id":"https://openalex.org/G1674534921","display_name":null,"funder_award_id":"81571057","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2299680010","display_name":null,"funder_award_id":"81300947","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3879138094","display_name":null,"funder_award_id":"81571057 and81300947","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G483322908","display_name":null,"funder_award_id":"13JCYBJC21300","funder_id":"https://openalex.org/F4320323993","funder_display_name":"Natural Science Foundation of Tianjin City"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323993","display_name":"Natural Science Foundation of Tianjin City","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2607478261.pdf","grobid_xml":"https://content.openalex.org/works/W2607478261.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W162167673","https://openalex.org/W246286872","https://openalex.org/W1479985867","https://openalex.org/W1482549097","https://openalex.org/W1482569350","https://openalex.org/W1562496202","https://openalex.org/W1626695651","https://openalex.org/W1733093963","https://openalex.org/W1965085108","https://openalex.org/W1972969270","https://openalex.org/W1975768665","https://openalex.org/W1982312358","https://openalex.org/W1989117089","https://openalex.org/W1995220469","https://openalex.org/W1997016283","https://openalex.org/W1999781602","https://openalex.org/W2002168925","https://openalex.org/W2002714610","https://openalex.org/W2005198393","https://openalex.org/W2007556408","https://openalex.org/W2017661902","https://openalex.org/W2018260001","https://openalex.org/W2025284633","https://openalex.org/W2030042395","https://openalex.org/W2031580888","https://openalex.org/W2032352894","https://openalex.org/W2035403720","https://openalex.org/W2043759922","https://openalex.org/W2051212378","https://openalex.org/W2056197709","https://openalex.org/W2063051154","https://openalex.org/W2065617421","https://openalex.org/W2066123530","https://openalex.org/W2067439875","https://openalex.org/W2075467558","https://openalex.org/W2082945994","https://openalex.org/W2082973072","https://openalex.org/W2084739843","https://openalex.org/W2091527371","https://openalex.org/W2095623404","https://openalex.org/W2101585932","https://openalex.org/W2104842812","https://openalex.org/W2105969458","https://openalex.org/W2106900897","https://openalex.org/W2107372864","https://openalex.org/W2109274553","https://openalex.org/W2112499304","https://openalex.org/W2114008352","https://openalex.org/W2119556701","https://openalex.org/W2121782248","https://openalex.org/W2122231795","https://openalex.org/W2123226252","https://openalex.org/W2133296173","https://openalex.org/W2134058827","https://openalex.org/W2139644711","https://openalex.org/W2142697531","https://openalex.org/W2143427233","https://openalex.org/W2143847000","https://openalex.org/W2152748843","https://openalex.org/W2156098321","https://openalex.org/W2156998090","https://openalex.org/W2161935657","https://openalex.org/W2221230808","https://openalex.org/W2276443256","https://openalex.org/W2328089541","https://openalex.org/W2404568684","https://openalex.org/W2416854880","https://openalex.org/W2443339653","https://openalex.org/W2478364026","https://openalex.org/W4294215472"],"related_works":["https://openalex.org/W2075467558","https://openalex.org/W2104842812","https://openalex.org/W7204928439","https://openalex.org/W2066123530","https://openalex.org/W2031580888","https://openalex.org/W2122231795","https://openalex.org/W2025284633","https://openalex.org/W2043759922","https://openalex.org/W2051212378","https://openalex.org/W2018260001"],"abstract_inverted_index":{"//":[0],"Wen-Hua":[1],"Su":[2],"1,":[3,8,13,18,23,28],"2":[4,9,14,19,24,29,39],",":[5,10,15,20],"Zhi-Hong":[6],"Shi":[7],"Shu-Ling":[11],"Liu":[12,22],"Xiao-Dan":[16],"Wang":[17],"Shuai":[21],"and":[25,46,111,116,124,134,198,228,246,256,260,268],"Yong":[26,56],"Ji":[27],"1":[30],"Department":[31],"of":[32,43,88,92,113,218],"Neurology,":[33],"Tianjin":[34,40,49],"Huanhu":[35,50],"Hospital,":[36,51],"Tianjin,":[37,52],"China":[38,53],"Key":[41],"Laboratory":[42],"Cerebral":[44],"Vascular":[45],"Neurodegenerative":[47],"Diseases,":[48],"Correspondence":[54],"to:":[55],"Ji,":[57],"email:":[58],"jiyongtianjin@163.com":[59],"Keywords:":[60],"APOE,":[61],"FTLD,":[62],"allele,":[63,156,160,164],"genotype,":[64],"meta-analysis":[65,83],"Received:":[66],"January":[67],"17,":[68],"2017":[69,73,77],"Accepted:":[70],"April":[71,75],"11,":[72],"Published:":[74],"21,":[76],"ABSTRACT":[78],"We":[79],"performed":[80],"an":[81],"updated":[82],"to":[84,132],"assess":[85],"the":[86,89,208,219,242],"role":[87],"\u03b52/\u03b53/\u03b54":[90],"alleles":[91],"Apolipoprotein":[93],"E":[94],"gene":[95],"(APOE)":[96],"in":[97,149,252,290],"frontotemporal":[98,231],"lobar":[99],"degeneration":[100],"(FTLD).":[101],"The":[102],"relevant":[103],"articles":[104],"were":[105,127],"retrieved":[106],"from":[107],"PubMed,":[108],"CENTRAL,":[109],"EMBASE":[110],"Web":[112],"Science":[114],"databases,":[115],"51":[117],"eligible":[118],"case-control":[119],"studies":[120],"with":[121,145,292],"5123":[122],"cases":[123],"20566":[125],"controls":[126],"selected":[128],"after":[129],"screening":[130],"according":[131],"inclusion":[133],"exclusion":[135],"criteria.":[136],"Our":[137],"analysis":[138,191,270,275],"demonstrated":[139],"that":[140,272,282],"APOE":[141,196,243,283],"\u03b54":[142,157,161,165,197,284],"was":[143,237,276],"associated":[144],"increased":[146],"FTLD":[147,199,247],"risk":[148,288],"all":[150,181],"genetic":[151,254,287],"models":[152,255],"(\u03b54":[153],"vs.":[154,158,162,166,170,173,176,179],"\u03b53":[155],"\u03b52":[159,244],"\u03b52+\u03b53+\u03b54":[163,167],"carrier,":[168],"\u03b54\u03b54":[169,178],"\u03b53\u03b53,":[171,174,177],"\u03b53\u03b54":[172],"\u03b53\u03b54+\u03b54\u03b54":[175],"\u03b53\u03b53+\u03b53\u03b54,":[180],"P":[182,201,214,249],"<":[183,202],"0.01,":[184,203],"odds":[185],"ratio":[186],"[OR]":[187],">":[188,205,215,226,250],"1).":[189],"Subgroup":[190],"revealed":[192,264],"significant":[193,239],"association":[194,240],"between":[195,241],"(":[200,248],"OR":[204],"1)":[206],"for":[207],"Caucasian,":[209],"Italian,":[210],"population":[211],"based":[212],"(PB),":[213],"0.05":[216],"value":[217],"Hardy-Weinberg":[220],"Equilibrium":[221],"(HWE),":[222],"Newcastle-Ottawa":[223],"scale":[224],"score":[225],"6,":[227],"behavioral":[229],"variant":[230],"dementia":[232],"(bvFTD)":[233],"subgroups.":[234],"However,":[235],"there":[236],"no":[238,265],"allele":[245],"0.05)":[251],"most":[253],"sub-group":[257],"analyses.":[258],"Begg\u2019s":[259],"Egger\u2019s":[261],"tests":[262],"also":[263],"publication":[266],"bias,":[267],"sensitivity":[269],"showed":[271],"our":[273,279],"data":[274],"robust.":[277],"Thus":[278],"meta-analyses":[280],"suggest":[281],"is":[285],"a":[286],"factor":[289],"patients":[291],"FTLD.":[293]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-04-28T00:00:00"}
