{"id":"https://openalex.org/W2607401042","doi":"https://doi.org/10.1097/moh.0000000000000358","title":"Epigenetic regulatory mutations and epigenetic therapy for multiple myeloma","display_name":"Epigenetic regulatory mutations and epigenetic therapy for multiple myeloma","publication_year":2017,"publication_date":"2017-04-22","ids":{"openalex":"https://openalex.org/W2607401042","doi":"https://doi.org/10.1097/moh.0000000000000358","mag":"2607401042","pmid":"https://pubmed.ncbi.nlm.nih.gov/28441149","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5767522"},"language":"en","primary_location":{"id":"doi:10.1097/moh.0000000000000358","doi":"https://doi.org/10.1097/moh.0000000000000358","is_oa":false,"landing_page_url":"https://doi.org/10.1097/moh.0000000000000358","pdf_url":null,"source":{"id":"https://openalex.org/S15004046","display_name":"Current Opinion in Hematology","issn_l":"1065-6251","issn":["1065-6251","1080-8213","1531-7048"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Hematology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5767522","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011132570","display_name":"Daphn\u00e9 Dup\u00e9r\u00e9-Richer","orcid":"https://orcid.org/0000-0003-2236-262X","observed_orcids":["https://orcid.org/0000-0003-2236-262X"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4390039331","display_name":"UF Health Cancer Center","ror":"https://ror.org/044vhe029","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144","https://openalex.org/I4390039331"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daphn\u00e9 Dup\u00e9r\u00e9-Richer","raw_affiliation_strings":["Department of Medicine, Division of Hematology-Oncology and The University of Florida Health Cancer Center University of Florida, Gainesville, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Hematology-Oncology and The University of Florida Health Cancer Center University of Florida, Gainesville, Florida, USA","institution_ids":["https://openalex.org/I33213144","https://openalex.org/I4390039331"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034992183","display_name":"Jonathan D. Licht","orcid":"https://orcid.org/0000-0002-3942-1369","observed_orcids":["https://orcid.org/0000-0002-3942-1369"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4390039331","display_name":"UF Health Cancer Center","ror":"https://ror.org/044vhe029","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144","https://openalex.org/I4390039331"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jonathan D. Licht","raw_affiliation_strings":["Department of Medicine, Division of Hematology-Oncology and The University of Florida Health Cancer Center University of Florida, Gainesville, Florida, USA","to Jonathan D. Licht, MD, Director, The University of Florida Health Cancer Center, The University of Florida, Cancer Genetics Research Complex, 2033 Mowry Road, Suite 145, Gainesville, FL 32610, USA. Tel: +1 352 273 8143; fax: +352 273 7969; e-mail: [email\u00a0protected]","e-mail: [email\u00a0protected]","fax: +352 273 7969","to Jonathan D. Licht, MD, Director, The University of Florida Health Cancer Center, The University of Florida, Cancer Genetics Research Complex, 2033 Mowry Road, Suite 145, Gainesville, FL 32610, USA. Tel: +1 352 273 8143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Hematology-Oncology and The University of Florida Health Cancer Center University of Florida, Gainesville, Florida, USA","institution_ids":["https://openalex.org/I33213144","https://openalex.org/I4390039331"]},{"raw_affiliation_string":"to Jonathan D. Licht, MD, Director, The University of Florida Health Cancer Center, The University of Florida, Cancer Genetics Research Complex, 2033 Mowry Road, Suite 145, Gainesville, FL 32610, USA. Tel: +1 352 273 8143; fax: +352 273 7969; e-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I33213144","https://openalex.org/I4390039331"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"fax: +352 273 7969","institution_ids":[]},{"raw_affiliation_string":"to Jonathan D. Licht, MD, Director, The University of Florida Health Cancer Center, The University of Florida, Cancer Genetics Research Complex, 2033 Mowry Road, Suite 145, Gainesville, FL 32610, USA. Tel: +1 352 273 8143","institution_ids":["https://openalex.org/I4390039331"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034992183"],"corresponding_institution_ids":["https://openalex.org/I33213144","https://openalex.org/I4390039331"],"apc_list":null,"apc_paid":null,"fwci":1.1637,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.75250358,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"24","issue":"4","first_page":"336","last_page":"344"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":1.0},{"id":"https://openalex.org/keywords/epigenetic-dysregulation","display_name":"epigenetic dysregulation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9509999752044678},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.8069999814033508},{"id":"https://openalex.org/keywords/epigenetic-therapy","display_name":"epigenetic therapy","score":0.8309999704360962},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7820000052452087},{"id":"https://openalex.org/keywords/immunomodulators","display_name":"immunomodulators","score":0.9570000171661377},{"id":"https://openalex.org/keywords/proteasome-inhibitors","display_name":"proteasome inhibitors","score":1.0}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.9433138370513916},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.6696956753730774},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6275806427001953},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5181530714035034},{"id":"https://openalex.org/C2780737395","wikidata":"https://www.wikidata.org/wiki/Q18353741","display_name":"Epigenetic therapy","level":5,"score":0.5149427056312561},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4761773943901062},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.45636647939682007},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.41861987113952637},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3894760310649872},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37363141775131226},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3549432158470154},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3400617241859436},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21069860458374023},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.18634480237960815},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18273749947547913}],"mesh":[{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011495","descriptor_name":"Histone-Lysine N-Methyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D042002","descriptor_name":"Chromatin Assembly and Disassembly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1097/moh.0000000000000358","doi":"https://doi.org/10.1097/moh.0000000000000358","is_oa":false,"landing_page_url":"https://doi.org/10.1097/moh.0000000000000358","pdf_url":null,"source":{"id":"https://openalex.org/S15004046","display_name":"Current Opinion in Hematology","issn_l":"1065-6251","issn":["1065-6251","1080-8213","1531-7048"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Hematology","raw_type":"journal-article"},{"id":"pmid:28441149","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28441149","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in hematology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4976371","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5767522","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5767522","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5767522","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Hematol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4976371","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5767522","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G35251022","display_name":"UTX, MLL AND PATHOGENIC DEREGULATION OF HISTONE METHYLATION IN MULTIPLE MYELOMA","funder_award_id":"R01CA180475","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5470963091","display_name":"The Role of MMSET in the Pathogenesis and Progression of Lymphoid Malignancy","funder_award_id":"R01CA195732","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":113,"referenced_works":["https://openalex.org/W81399563","https://openalex.org/W1500173675","https://openalex.org/W1523117612","https://openalex.org/W1601865702","https://openalex.org/W1832862155","https://openalex.org/W1890948742","https://openalex.org/W1907569406","https://openalex.org/W1966268694","https://openalex.org/W1969171402","https://openalex.org/W1972934671","https://openalex.org/W1977295792","https://openalex.org/W1978107331","https://openalex.org/W1978607217","https://openalex.org/W1981615602","https://openalex.org/W1982172799","https://openalex.org/W1986560938","https://openalex.org/W1988324497","https://openalex.org/W1991899579","https://openalex.org/W1995275377","https://openalex.org/W1998332918","https://openalex.org/W2001333511","https://openalex.org/W2009826707","https://openalex.org/W2010711123","https://openalex.org/W2011043347","https://openalex.org/W2015132841","https://openalex.org/W2017492512","https://openalex.org/W2020084014","https://openalex.org/W2024985626","https://openalex.org/W2025531396","https://openalex.org/W2032058375","https://openalex.org/W2032657745","https://openalex.org/W2033238287","https://openalex.org/W2034614265","https://openalex.org/W2039201797","https://openalex.org/W2042012963","https://openalex.org/W2045740132","https://openalex.org/W2048122601","https://openalex.org/W2052963850","https://openalex.org/W2053447630","https://openalex.org/W2054208176","https://openalex.org/W2058376960","https://openalex.org/W2058762628","https://openalex.org/W2083189092","https://openalex.org/W2084156359","https://openalex.org/W2086046991","https://openalex.org/W2086180957","https://openalex.org/W2088091102","https://openalex.org/W2090505632","https://openalex.org/W2090926709","https://openalex.org/W2091605994","https://openalex.org/W2096367061","https://openalex.org/W2097027640","https://openalex.org/W2099114692","https://openalex.org/W2100630390","https://openalex.org/W2101035019","https://openalex.org/W2105077884","https://openalex.org/W2109613178","https://openalex.org/W2110817748","https://openalex.org/W2114843025","https://openalex.org/W2120572492","https://openalex.org/W2120846234","https://openalex.org/W2125568224","https://openalex.org/W2127009065","https://openalex.org/W2127604631","https://openalex.org/W2128254777","https://openalex.org/W2128761802","https://openalex.org/W2129631172","https://openalex.org/W2130517158","https://openalex.org/W2132310381","https://openalex.org/W2132747713","https://openalex.org/W2142826475","https://openalex.org/W2144792857","https://openalex.org/W2146620343","https://openalex.org/W2147001911","https://openalex.org/W2156399444","https://openalex.org/W2159600984","https://openalex.org/W2159807221","https://openalex.org/W2161149476","https://openalex.org/W2163547433","https://openalex.org/W2166427186","https://openalex.org/W2168327939","https://openalex.org/W2169846247","https://openalex.org/W2173745138","https://openalex.org/W2190015925","https://openalex.org/W2254742941","https://openalex.org/W2267376195","https://openalex.org/W2282073262","https://openalex.org/W2291204775","https://openalex.org/W2300442403","https://openalex.org/W2311936801","https://openalex.org/W2320983896","https://openalex.org/W2326698965","https://openalex.org/W2343681268","https://openalex.org/W2346708996","https://openalex.org/W2402661058","https://openalex.org/W2465242437","https://openalex.org/W2481941722","https://openalex.org/W2511198553","https://openalex.org/W2511571730","https://openalex.org/W2520638688","https://openalex.org/W2537925564","https://openalex.org/W2542880571","https://openalex.org/W2551286426","https://openalex.org/W2562061013","https://openalex.org/W2566318589","https://openalex.org/W2568957191","https://openalex.org/W2582081516","https://openalex.org/W2587514273","https://openalex.org/W2587889130","https://openalex.org/W2592807826","https://openalex.org/W2980240469","https://openalex.org/W6731635791","https://openalex.org/W6733415995"],"related_works":["https://openalex.org/W2759493109","https://openalex.org/W2558687208","https://openalex.org/W2013320739","https://openalex.org/W7152494515","https://openalex.org/W2009805231","https://openalex.org/W4404766165","https://openalex.org/W2116446662","https://openalex.org/W4308124850","https://openalex.org/W2088474788","https://openalex.org/W3031864307"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"Next":[3],"generation":[4],"sequencing":[5],"and":[6,62,93,136],"large-scale":[7],"analysis":[8],"of":[9,18,37,52,59,65,87,100,142],"patient":[10],"specimens":[11],"has":[12],"created":[13],"a":[14,27,77],"more":[15,71],"complete":[16],"picture":[17],"multiple":[19],"myeloma":[20],"(MM)":[21],"revealing":[22],"that":[23,108],"epigenetic":[24,45,68,88,109],"deregulation":[25],"is":[26,54],"prominent":[28],"factor":[29],"in":[30,42,67,79,102,145],"MM":[31,38,53,130],"pathogenesis.":[32],"RECENT":[33],"FINDINGS:":[34],"Over":[35],"half":[36],"patients":[39],"have":[40,90],"mutations":[41,66],"genes":[43],"encoding":[44],"modifier":[46],"enzymes.":[47],"The":[48],"DNA":[49],"methylation":[50],"profile":[51],"related":[55],"to":[56,117,127],"the":[57,60,129],"stage":[58],"disease":[61,74,80],"certain":[63],"classes":[64],"modifiers":[69],"are":[70,96],"prevalent":[72],"upon":[73],"relapse,":[75],"suggesting":[76],"role":[78],"progression.":[81],"Many":[82],"small":[83],"molecules":[84],"targeting":[85,110],"regulators":[86],"machinery":[89],"been":[91],"developed":[92],"clinical":[94],"trials":[95],"underway":[97],"for":[98],"some":[99],"these":[101,121],"MM.":[103,119,146],"SUMMARY:":[104],"Recent":[105],"findings":[106],"suggest":[107],"drugs":[111,135],"could":[112],"be":[113],"an":[114],"important":[115],"strategy":[116],"cure":[118],"Combining":[120],"agents":[122],"along":[123],"with":[124],"other":[125],"strategies":[126],"affect":[128],"cell":[131],"such":[132],"as":[133],"immunomodulatory":[134],"proteasome":[137],"inhibitors":[138],"may":[139],"enhance":[140],"efficacy":[141],"combination":[143],"regimens":[144]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-04-28T00:00:00"}
