{"id":"https://openalex.org/W2607220177","doi":"https://doi.org/10.1117/12.2256621","title":"Visualization of drug distribution of topical minocycline in human facial skin with fluorescence microscopy (Conference Presentation)","display_name":"Visualization of drug distribution of topical minocycline in human facial skin with fluorescence microscopy (Conference Presentation)","publication_year":2017,"publication_date":"2017-04-19","ids":{"openalex":"https://openalex.org/W2607220177","doi":"https://doi.org/10.1117/12.2256621","mag":"2607220177"},"language":"en","primary_location":{"id":"doi:10.1117/12.2256621","doi":"https://doi.org/10.1117/12.2256621","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2256621","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Visualizing and Quantifying Drug Distribution in Tissue","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016755530","display_name":"Maiko Hermsmeier","orcid":"https://orcid.org/0000-0002-3355-5614","observed_orcids":["https://orcid.org/0000-0002-3355-5614"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maiko Hermsmeier","raw_affiliation_strings":["BioPharmX, Inc. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioPharmX, Inc. (United States)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057363694","display_name":"Tanvee Sawant","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tanvee Sawant","raw_affiliation_strings":["BioPharmX, Inc. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioPharmX, Inc. (United States)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019410125","display_name":"Diana Lac","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diana Lac","raw_affiliation_strings":["BioPharmX, Inc. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioPharmX, Inc. (United States)","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Akira Yamamoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akira Yamamoto","raw_affiliation_strings":["BioPharmX, Inc. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioPharmX, Inc. (United States)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100741536","display_name":"Xin Chen","orcid":"https://orcid.org/0000-0002-1920-8835","observed_orcids":["https://orcid.org/0000-0002-1920-8835"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xin Chen","raw_affiliation_strings":["BioPharmX, Inc. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioPharmX, Inc. (United States)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068433001","display_name":"Usha Nagavarapu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Usha Nagavarapu","raw_affiliation_strings":["BioPharmX, Inc. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioPharmX, Inc. (United States)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073936872","display_name":"Conor L. Evans","orcid":"https://orcid.org/0000-0003-2185-6505","observed_orcids":["https://orcid.org/0000-0003-2185-6505"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Conor L. Evans","raw_affiliation_strings":["Wellman Ctr. for Photomedicine (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellman Ctr. for Photomedicine (United States)","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049466135","display_name":"Kin Foong Chan","orcid":"https://orcid.org/0000-0003-0085-8210","observed_orcids":["https://orcid.org/0000-0003-0085-8210"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kin Foong Chan","raw_affiliation_strings":["BioPharmX, Inc. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioPharmX, Inc. (United States)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04672897,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"9","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.5684000253677368,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.5684000253677368,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11553","display_name":"Acne and Rosacea Treatments and Effects","score":0.42719998955726624,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acne-vulgaris","display_name":"acne","score":0.8619999885559082},{"id":"https://openalex.org/keywords/cutibacterium-acnes","display_name":"Propionibacterium acnes","score":0.9959999918937683},{"id":"https://openalex.org/keywords/fluorescence-microscopy","display_name":"fluorescence microscopy","score":0.6430000066757202},{"id":"https://openalex.org/keywords/drug-distribution","display_name":"drug distribution","score":0.7160000205039978},{"id":"https://openalex.org/keywords/facial-skin","display_name":"facial skin","score":0.875},{"id":"https://openalex.org/keywords/pilosebaceous-unit","display_name":"pilosebaceous unit","score":0.8790000081062317},{"id":"https://openalex.org/keywords/epidermis","display_name":"epidermis","score":0.8180000185966492},{"id":"https://openalex.org/keywords/stratum-corneum","display_name":"stratum corneum","score":0.9380000233650208},{"id":"https://openalex.org/keywords/dermis","display_name":"dermis","score":0.9409999847412109},{"id":"https://openalex.org/keywords/local-antibiotic-delivery","display_name":"local antibiotic delivery","score":0.6110000014305115},{"id":"https://openalex.org/keywords/therapeutic-dose","display_name":"therapeutic dose","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C2778275353","wikidata":"https://www.wikidata.org/wiki/Q415336","display_name":"Minocycline","level":3,"score":0.9641371369361877},{"id":"https://openalex.org/C2779900937","wikidata":"https://www.wikidata.org/wiki/Q2442109","display_name":"Propionibacterium acnes","level":3,"score":0.7970997095108032},{"id":"https://openalex.org/C2777673923","wikidata":"https://www.wikidata.org/wiki/Q79928","display_name":"Acne","level":2,"score":0.7930253744125366},{"id":"https://openalex.org/C2778370115","wikidata":"https://www.wikidata.org/wiki/Q2038676","display_name":"Stratum corneum","level":2,"score":0.6648972034454346},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4817235767841339},{"id":"https://openalex.org/C2777624698","wikidata":"https://www.wikidata.org/wiki/Q505531","display_name":"Dermis","level":2,"score":0.4797452688217163},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.42624345421791077},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.4093579947948456},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3273412585258484},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3250770568847656},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.31368541717529297},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.17704090476036072},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14820891618728638},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2256621","doi":"https://doi.org/10.1117/12.2256621","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2256621","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Visualizing and Quantifying Drug Distribution in Tissue","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2605800676","https://openalex.org/W2791491738","https://openalex.org/W2810036723","https://openalex.org/W3013485898","https://openalex.org/W2740659815","https://openalex.org/W2947662425","https://openalex.org/W3038379471","https://openalex.org/W4415813462","https://openalex.org/W2981331284","https://openalex.org/W4235917816"],"abstract_inverted_index":{"Minocycline":[0],"is":[1,57],"an":[2,17],"antibiotic":[3],"regularly":[4],"prescribed":[5],"to":[6,35,41,65,85,132],"treat":[7],"acne":[8],"vulgaris.":[9],"The":[10,111],"only":[11],"commercially":[12],"available":[13],"minocycline":[14,30,56,72,95,120],"comes":[15],"in":[16,24,70],"oral":[18],"dosage":[19],"form,":[20],"which":[21],"often":[22],"results":[23],"systemic":[25],"adverse":[26],"effects.":[27],"A":[28],"topical":[29,129],"composition":[31],"(BPX-01)":[32],"was":[33,63,82],"developed":[34],"provide":[36],"localized":[37],"and":[38,44,96,106,136],"targeted":[39],"delivery":[40],"the":[42,101],"epidermis":[43],"pilosebaceous":[45,107],"unit":[46,108],"where":[47],"acne-related":[48],"bacteria,":[49],"Propionibacterium":[50],"acnes":[51,135],"(P.":[52],"acnes),":[53],"reside.":[54],"As":[55],"a":[58,117],"known":[59],"fluorophore,":[60],"fluorescence":[61,98,113],"microscopy":[62],"performed":[64],"investigate":[66],"its":[67,97],"potential":[68],"use":[69],"visualizing":[71],"distribution":[73,93],"within":[74,100],"tissues.":[75],"BPX-01":[76,130],"with":[77],"various":[78],"concentrations":[79],"of":[80,94,119,128],"minocycline,":[81],"applied":[83],"topically":[84],"freshly":[86],"excised":[87],"human":[88],"facial":[89],"skin":[90],"specimens.":[91],"Spatial":[92],"intensity":[99,114],"stratum":[102],"corneum,":[103],"epidermis,":[104],"dermis,":[105],"were":[109],"assessed.":[110],"resulting":[112],"data":[115],"as":[116],"function":[118],"concentration":[121],"may":[122],"indicate":[123],"clinically":[124],"relevant":[125],"therapeutic":[126],"doses":[127],"needed":[131],"kill":[133],"P.":[134],"reduce":[137],"inflammation":[138],"for":[139],"successful":[140],"clinical":[141],"outcomes.":[142]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2017-04-28T00:00:00"}