{"id":"https://openalex.org/W2607199293","doi":"https://doi.org/10.17151/biosa.2016.15.2.3","title":"Different brain structures exhibit the same caffeine levels after the administration of a single dose of caffeine","display_name":"Different brain structures exhibit the same caffeine levels after the administration of a single dose of caffeine","publication_year":2016,"publication_date":"2016-07-01","ids":{"openalex":"https://openalex.org/W2607199293","doi":"https://doi.org/10.17151/biosa.2016.15.2.3","mag":"2607199293"},"language":"en","primary_location":{"id":"doi:10.17151/biosa.2016.15.2.3","doi":"https://doi.org/10.17151/biosa.2016.15.2.3","is_oa":true,"landing_page_url":"https://doi.org/10.17151/biosa.2016.15.2.3","pdf_url":null,"source":{"id":"https://openalex.org/S4210170995","display_name":"Biosalud","issn_l":"1657-9550","issn":["1657-9550","2462-960X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","publindex-c"],"host_organization":"https://openalex.org/P4310318884","host_organization_name":"University of Caldas","host_organization_lineage":["https://openalex.org/P4310318884"],"host_organization_lineage_names":["University of Caldas"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biosalud","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.17151/biosa.2016.15.2.3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079963567","display_name":"Mary Orrego Cardozo","orcid":"https://orcid.org/0000-0002-9416-2355","observed_orcids":["https://orcid.org/0000-0002-9416-2355"]},"institutions":[{"id":"https://openalex.org/I4210093237","display_name":"Universidad Autonoma de Manizales","ror":"https://ror.org/00jfare13","country_code":"CO","type":"education","lineage":["https://openalex.org/I4210093237"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Mary Orrego Cardozo","raw_affiliation_strings":["PhD Bioqu\u00edmica y Biolog\u00eda Molecular. Laboratorio de Neurofisiolog\u00eda. Universidad Aut\u00f3noma de Manizales. Manizales, Caldas. Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhD Bioqu\u00edmica y Biolog\u00eda Molecular. Laboratorio de Neurofisiolog\u00eda. Universidad Aut\u00f3noma de Manizales. Manizales, Caldas. Colombia","institution_ids":["https://openalex.org/I4210093237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042684144","display_name":"Alejandro Jim\u00e9nez-Rodr\u00edguez","orcid":"https://orcid.org/0000-0001-7172-1794","observed_orcids":["https://orcid.org/0000-0001-7172-1794"]},"institutions":[{"id":"https://openalex.org/I4210093237","display_name":"Universidad Autonoma de Manizales","ror":"https://ror.org/00jfare13","country_code":"CO","type":"education","lineage":["https://openalex.org/I4210093237"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Alejandro Jim\u00e9nez-Rodriguez","raw_affiliation_strings":["M.Sc. Matem\u00e1ticas Aplicadas. Laboratorio de Neurofisiolog\u00eda. Universidad Aut\u00f3noma de Manizales. Manizales, Caldas. Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.Sc. Matem\u00e1ticas Aplicadas. Laboratorio de Neurofisiolog\u00eda. Universidad Aut\u00f3noma de Manizales. Manizales, Caldas. Colombia","institution_ids":["https://openalex.org/I4210093237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018009853","display_name":"Alejandro Osorio-Forero","orcid":"https://orcid.org/0000-0003-4341-4206","observed_orcids":["https://orcid.org/0000-0003-4341-4206"]},"institutions":[{"id":"https://openalex.org/I4210093237","display_name":"Universidad Autonoma de Manizales","ror":"https://ror.org/00jfare13","country_code":"CO","type":"education","lineage":["https://openalex.org/I4210093237"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Alejandro Osorio-Forero","raw_affiliation_strings":["Ingenier\u00eda Biom\u00e9dica. Laboratorio de Neurofisiolog\u00eda. Universidad Aut\u00f3noma de Manizales. Manizales, Caldas. Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ingenier\u00eda Biom\u00e9dica. Laboratorio de Neurofisiolog\u00eda. Universidad Aut\u00f3noma de Manizales. Manizales, Caldas. Colombia","institution_ids":["https://openalex.org/I4210093237"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Francia Restrepo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093237","display_name":"Universidad Autonoma de Manizales","ror":"https://ror.org/00jfare13","country_code":"CO","type":"education","lineage":["https://openalex.org/I4210093237"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Francia Restrepo","raw_affiliation_strings":["PhD. Ciencias sociales, ni\u00f1ez y juventud. Laboratorio de Neurofisiolog\u00eda. Universidad Aut\u00f3noma de Manizales. Manizales, Caldas. Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhD. Ciencias sociales, ni\u00f1ez y juventud. Laboratorio de Neurofisiolog\u00eda. Universidad Aut\u00f3noma de Manizales. Manizales, Caldas. Colombia","institution_ids":["https://openalex.org/I4210093237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102962023","display_name":"Juan Miguel Arias Jim\u00e9nez","orcid":"https://orcid.org/0000-0002-6067-7238","observed_orcids":["https://orcid.org/0000-0002-6067-7238"]},"institutions":[{"id":"https://openalex.org/I4210093237","display_name":"Universidad Autonoma de Manizales","ror":"https://ror.org/00jfare13","country_code":"CO","type":"education","lineage":["https://openalex.org/I4210093237"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Juan Miguel Arias","raw_affiliation_strings":["MSc, Psicolog\u00eda Evolucionaria y Comparativa. Laboratorio de Neurofisiolog\u00eda. Universidad Aut\u00f3noma de Manizales. Manizales, Caldas. Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MSc, Psicolog\u00eda Evolucionaria y Comparativa. Laboratorio de Neurofisiolog\u00eda. Universidad Aut\u00f3noma de Manizales. Manizales, Caldas. Colombia","institution_ids":["https://openalex.org/I4210093237"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001287563","display_name":"Lukas Tamayo-Orrego","orcid":"https://orcid.org/0000-0001-7041-4848","observed_orcids":["https://orcid.org/0000-0001-7041-4848"]},"institutions":[{"id":"https://openalex.org/I4210093237","display_name":"Universidad Autonoma de Manizales","ror":"https://ror.org/00jfare13","country_code":"CO","type":"education","lineage":["https://openalex.org/I4210093237"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Lukas Tamayo-Orrego","raw_affiliation_strings":["M\u00e9dico Cirujano. Laboratorio de Neurofisiolog\u00eda. Universidad Aut\u00f3noma de Manizales. Manizales, Caldas. Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M\u00e9dico Cirujano. Laboratorio de Neurofisiolog\u00eda. Universidad Aut\u00f3noma de Manizales. Manizales, Caldas. Colombia","institution_ids":["https://openalex.org/I4210093237"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210093237"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"15","issue":"2","first_page":"20","last_page":"27"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11264","display_name":"Coffee research and impacts","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11264","display_name":"Coffee research and impacts","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caffeine","display_name":"caffeine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/brain-pharmacokinetics","display_name":"brain pharmacokinetics","score":0.7889999747276306},{"id":"https://openalex.org/keywords/regional-brain-distribution","display_name":"brain regional distribution","score":0.7390000224113464},{"id":"https://openalex.org/keywords/plasma-caffeine-concentration","display_name":"plasma caffeine concentration","score":0.6650000214576721},{"id":"https://openalex.org/keywords/cerebral-cortex","display_name":"cerebral cortex","score":0.9259999990463257},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.996999979019165},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":1.0},{"id":"https://openalex.org/keywords/cerebellum","display_name":"cerebellum","score":1.0},{"id":"https://openalex.org/keywords/brainstem","display_name":"brainstem","score":1.0},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C2778500429","wikidata":"https://www.wikidata.org/wiki/Q60235","display_name":"Caffeine","level":2,"score":0.9689921736717224},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.6913996934890747},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.569878101348877},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.5297083854675293},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.49736884236335754},{"id":"https://openalex.org/C551621295","wikidata":"https://www.wikidata.org/wiki/Q182228","display_name":"Brainstem","level":2,"score":0.47399818897247314},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.466743528842926},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46004417538642883},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.41294994950294495},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4042777419090271},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.380334734916687},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35356706380844116},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.280849814414978},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.1632838249206543},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.14042645692825317},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.13927915692329407}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.17151/biosa.2016.15.2.3","doi":"https://doi.org/10.17151/biosa.2016.15.2.3","is_oa":true,"landing_page_url":"https://doi.org/10.17151/biosa.2016.15.2.3","pdf_url":null,"source":{"id":"https://openalex.org/S4210170995","display_name":"Biosalud","issn_l":"1657-9550","issn":["1657-9550","2462-960X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","publindex-c"],"host_organization":"https://openalex.org/P4310318884","host_organization_name":"University of Caldas","host_organization_lineage":["https://openalex.org/P4310318884"],"host_organization_lineage_names":["University of Caldas"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biosalud","raw_type":"journal-article"},{"id":"pmh:oai:repositorio.ucaldas.edu.co:ucaldas/16022","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.ucaldas.edu.co/handle/ucaldas/16022","pdf_url":null,"source":{"id":"https://openalex.org/S7407055400","display_name":"Repositorio Universidad de Caldas","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://revistasojs.ucaldas.edu.co/index.php/biosalud/article/view/3749","raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":{"id":"doi:10.17151/biosa.2016.15.2.3","doi":"https://doi.org/10.17151/biosa.2016.15.2.3","is_oa":true,"landing_page_url":"https://doi.org/10.17151/biosa.2016.15.2.3","pdf_url":null,"source":{"id":"https://openalex.org/S4210170995","display_name":"Biosalud","issn_l":"1657-9550","issn":["1657-9550","2462-960X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","publindex-c"],"host_organization":"https://openalex.org/P4310318884","host_organization_name":"University of Caldas","host_organization_lineage":["https://openalex.org/P4310318884"],"host_organization_lineage_names":["University of Caldas"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biosalud","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1514696983","https://openalex.org/W1515108121","https://openalex.org/W1551195480","https://openalex.org/W1626302529","https://openalex.org/W1964725046","https://openalex.org/W1968554828","https://openalex.org/W1969880468","https://openalex.org/W2037008026","https://openalex.org/W2038571859","https://openalex.org/W2043276067","https://openalex.org/W2049677583","https://openalex.org/W2052637521","https://openalex.org/W2058766183","https://openalex.org/W2066191917","https://openalex.org/W2069693955","https://openalex.org/W2074057073","https://openalex.org/W2076754464","https://openalex.org/W2097533515","https://openalex.org/W2098492930","https://openalex.org/W2136717001","https://openalex.org/W2147870248","https://openalex.org/W2172295889"],"related_works":["https://openalex.org/W1969880468","https://openalex.org/W2292761431","https://openalex.org/W2087533981","https://openalex.org/W7018685491","https://openalex.org/W2098492930","https://openalex.org/W2566195316","https://openalex.org/W2052637521","https://openalex.org/W2023782592","https://openalex.org/W1981813007","https://openalex.org/W2066191917"],"abstract_inverted_index":{"Caffeine":[0,144,163],"is":[1,20,250],"a":[2,92,108],"highly":[3],"consumed":[4],"stimulant":[5],"of":[6,26,63,91,96,112,116,133,192,264],"the":[7,23,30,41,50,69,89,147,168,173,188,197,221,233,248,257,262],"nervous":[8],"system.":[9],"Although":[10],"caffeine":[11,38,47,70,182,193,202,212,228,245,265],"has":[12],"diverse":[13],"effects":[14,263],"on":[15,266,273],"different":[16,75,86,267],"brain":[17,43,59,76,151,174,178,186,225,236,268,277],"functions,":[18],"little":[19],"known":[21],"about":[22],"specific":[24,58],"pharmacokinetics":[25],"this":[27,64],"substance":[28],"in":[29,40,49,56,72,146,167,196,232,247,256],"brain.":[31,258],"For":[32,184],"instance,":[33],"most":[34],"studies":[35,208],"that":[36,209,261],"assessed":[37],"distribution":[39],"rat":[42],"have":[44],"only":[45],"measured":[46,154],"levels":[48,145,164,191],"cortex":[51,215],"and":[52,74,83,121,131,140,149,157,216,235,240,279],"striatum":[53],"but":[54,218],"not":[55,271],"more":[57],"areas.Aims:":[60],"The":[61,204],"purpose":[62],"work":[65],"was":[66,160],"to":[67,102,171,223],"measure":[68],"concentration":[71,190,213,229,246],"blood":[73,148,249],"regions":[77,179],"(i.e.":[78],"cortex,":[79,136],"striatum,":[80,137,217],"hippocampus,":[81,138],"cerebellum":[82,139],"brainstem)":[84],"at":[85],"times":[87,253],"after":[88,124,201,243],"administration":[90],"single":[93,109],"intraperitoneal":[94,110],"dose":[95,111],"caffeine.Methods:":[97],"Adult":[98],"Wistar":[99],"rats":[100],"(250":[101],"300":[103],"gr)":[104],"were":[105,127,142,153,165,194],"injected":[106],"with":[107],"30":[113],"mg/":[114],"Kg":[115],"caffeine.":[117],"20,":[118],"40,":[119,238],"60":[120,239],"80":[122,241],"minutes":[123,200,242],"administration,":[125,244],"subjects":[126],"sacrificed":[128],"by":[129,155,283],"decapitation":[130],"samples":[132],"plasma,":[134],"cerebral":[135],"brainstem":[141],"obtained.":[143],"each":[150],"structure":[152],"RP-HPLC":[156],"statistical":[158],"analysis":[159],"performed.":[161],"Results:":[162],"higher":[166,254],"plasma":[169,234],"compared":[170],"all":[172,185],"structures":[175],"studied.":[176],"Different":[177],"displayed":[180],"similar":[181,211],"concentrations.":[183],"regions,":[187],"maximal":[189],"reached":[195],"first":[198],"40":[199],"administration.Conclusions:":[203],"results":[205,222],"support":[206],"previous":[207],"show":[210],"between":[214,276],"also":[219],"extend":[220],"other":[224],"structures.":[226,237],"Furthermore,":[227],"increases":[230],"similarly":[231],"almost":[251],"two":[252],"than":[255],"This":[259],"suggests":[260],"functions":[269],"do":[270],"depend":[272],"pharmacokinetic":[274],"differences":[275],"areas":[278],"are":[280],"rather":[281],"explained":[282],"pharmacodynamics.":[284]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-04-28T00:00:00"}
