{"id":"https://openalex.org/W2607159183","doi":null,"title":"Fanconi anemia: The role of FANCD2 protein","display_name":"Fanconi anemia: The role of FANCD2 protein","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2607159183","mag":"2607159183"},"language":"en","primary_location":{"id":"mag:2607159183","doi":null,"is_oa":false,"landing_page_url":"https://www.muni.cz/vyzkum/publikace/792877","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050579239","display_name":"Veronika Altmannov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Veronika Altmannov\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5079626347","display_name":"Lum\u00edr Krej\u010d\u00ed","orcid":"https://orcid.org/0000-0002-4732-1405","observed_orcids":["https://orcid.org/0000-0002-4732-1405"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lum\u00edr Krej\u010d\u00ed","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4732-1405","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.28981193,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fanconi-anemia","display_name":"Fanconi anemia","score":1.0},{"id":"https://openalex.org/keywords/fancd2","display_name":"FANCD2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/monoubiquitination","display_name":"monoubiquitination","score":0.9110000133514404},{"id":"https://openalex.org/keywords/fa-core-complex","display_name":"FA core complex","score":0.8920000195503235},{"id":"https://openalex.org/keywords/fanconi-anemia-pathway","display_name":"Fanconi anemia pathway","score":0.9449999928474426},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.8140000104904175},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.7390000224113464},{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.652999997138977},{"id":"https://openalex.org/keywords/brca2","display_name":"BRCA2","score":0.9670000076293945},{"id":"https://openalex.org/keywords/chromosome-breakage","display_name":"chromosome breakage","score":0.6389999985694885},{"id":"https://openalex.org/keywords/bone-marrow-failure","display_name":"bone marrow failure","score":0.8669999837875366},{"id":"https://openalex.org/keywords/cancer-susceptibility","display_name":"cancer susceptibility","score":0.7139999866485596},{"id":"https://openalex.org/keywords/complementation-groups","display_name":"complementation groups","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C2776653068","wikidata":"https://www.wikidata.org/wiki/Q17927069","display_name":"FANCD2","level":5,"score":0.9619526863098145},{"id":"https://openalex.org/C2778124228","wikidata":"https://www.wikidata.org/wiki/Q845779","display_name":"Fanconi anemia","level":4,"score":0.9492191076278687},{"id":"https://openalex.org/C2778993383","wikidata":"https://www.wikidata.org/wiki/Q17927056","display_name":"FANCA","level":5,"score":0.8997998833656311},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6286349296569824},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5926421880722046},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5532063841819763},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4897182285785675},{"id":"https://openalex.org/C2779012473","wikidata":"https://www.wikidata.org/wiki/Q3235015","display_name":"RAD51","level":4,"score":0.48153382539749146},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3888421654701233},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36137819290161133},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3556644916534424},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.338949054479599}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2607159183","doi":null,"is_oa":false,"landing_page_url":"https://www.muni.cz/vyzkum/publikace/792877","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2163773782","https://openalex.org/W1966730768","https://openalex.org/W1991841649","https://openalex.org/W2029164849","https://openalex.org/W1753969589","https://openalex.org/W2021277673","https://openalex.org/W163239075","https://openalex.org/W1679709701","https://openalex.org/W2017329539","https://openalex.org/W2153314251"],"abstract_inverted_index":{"Fanconi":[0,66],"anemia":[1],"belongs":[2],"to":[3,19,31,127,168,174],"a":[4,106],"group":[5],"of":[6,42,124,154,165,181],"rare":[7],"human":[8],"genetic\ndiseases":[9],"and":[10,21,38,60,102,134,146,159],"is":[11,113,156],"frequently":[12],"associated":[13,64],"with":[14,65,136],"bone":[15],"marrow":[16],"failure,\nhigh":[17],"predisposition":[18],"cancer":[20],"birth":[22],"defects.":[23],"The":[24,121,151],"cells":[25],"from\nFanconi":[26],"anemias":[27],"patients":[28],"are":[29],"hypersensitive":[30],"crosslinking\nagents":[32],"(e.g.":[33],"diepoxybutane":[34],"or":[35,85,90],"mitomycin":[36],"C),":[37],"show":[39],"an\nincreased":[40],"frequency":[41],"chromosome":[43],"breakage.":[44],"To":[45],"date,":[46],"thirteen\ncomplementations":[47],"groups":[48],"(FANCA,":[49],"B,":[50,97],"C,":[51],"D1,":[52],"D2,":[53],"E,":[54],"F,":[55,99],"G,":[56,100],"I,":[57],"J,":[58],"L,\nM,":[59],"N)":[61],"have":[62],"been":[63],"anemia.":[67],"It":[68],"has":[69],"been\nalso":[70],"demonstrated":[71],"that":[72],"all":[73],"proteins":[74,95,138],"encoded":[75],"by":[76],"FA":[77,84,94,182],"genes\ncooperate":[78],"in":[79,105],"common":[80],"pathway,":[81],"called":[82],"as":[83,143],"FA/BRCA":[86],"pathway.\nAfter":[87],"DNA":[88,128],"damage":[89],"during":[91],"S-phase,":[92],"eight":[93],"(A,":[96],"C,\nE,":[98],"L,":[101],"M)":[103],"asssemble":[104],"multisubunit":[107],"nuclear":[108,130],"complex\n(FA":[109],"core":[110],"complex),":[111],"which":[112],"required":[114],"for":[115],"monoubiquitination":[116],"of\nFANCD2":[117],"at":[118],"lysine":[119],"561.":[120],"monoubiquitinated":[122],"isoform":[123],"FANCD2\nis":[125],"targeted":[126],"damage-induced":[129],"foci":[131],"where":[132],"it\ncolocalizes":[133],"interacts":[135],"other":[137],"participating":[139],"in\nDNA":[140],"repair,":[141],"such":[142],"BRCA1,":[144],"RAD51":[145],"BRCA2":[147],"(also":[148],"identified":[149],"as\nFANCD1).":[150],"exact":[152],"role":[153],"FANCD2":[155],"still":[157],"unknown":[158],"hence":[160],"it\nis":[161],"the":[162,176],"major":[163],"goal":[164],"this":[166],"thesis":[167],"better":[169],"elucidate":[170],"its\nbiological":[171],"function,":[172],"thereby":[173],"further":[175],"understanding":[177],"of\nthe":[178],"whole":[179],"machinery":[180],"pathway.":[183]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2017-04-28T00:00:00"}