{"id":"https://openalex.org/W2607152166","doi":"https://doi.org/10.1182/blood.v128.22.4152.4152","title":"Outcomes Following Salvage Therapy in Primary Refractory Peripheral T-Cell Lymphoma (PTCL)","display_name":"Outcomes Following Salvage Therapy in Primary Refractory Peripheral T-Cell Lymphoma (PTCL)","publication_year":2016,"publication_date":"2016-12-02","ids":{"openalex":"https://openalex.org/W2607152166","doi":"https://doi.org/10.1182/blood.v128.22.4152.4152","mag":"2607152166"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v128.22.4152.4152","doi":"https://doi.org/10.1182/blood.v128.22.4152.4152","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v128.22.4152.4152","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046170235","display_name":"Janie Yue Zhang","orcid":"https://orcid.org/0000-0002-0459-2635","observed_orcids":["https://orcid.org/0000-0002-0459-2635"]},"institutions":[{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Janie Y Zhang","raw_affiliation_strings":["Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI","institution_ids":["https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080028512","display_name":"Robert Edward Briski","orcid":"https://orcid.org/0009-0008-7975-8223","observed_orcids":["https://orcid.org/0009-0008-7975-8223"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Briski","raw_affiliation_strings":["Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Health System, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Health System, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047177351","display_name":"Sumana Devata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sumana Devata","raw_affiliation_strings":["Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Health System, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Health System, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080366682","display_name":"Mark Stefan Kaminski","orcid":"https://orcid.org/0000-0002-8712-2953","observed_orcids":["https://orcid.org/0000-0002-8712-2953"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark S Kaminski","raw_affiliation_strings":["Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Health System, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Health System, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062534813","display_name":"Tycel Jovelle Phillips","orcid":"https://orcid.org/0000-0003-2143-9672","observed_orcids":["https://orcid.org/0000-0003-2143-9672"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tycel Phillips","raw_affiliation_strings":["Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Health System, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Health System, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048137432","display_name":"Tera Mayer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tera Mayer","raw_affiliation_strings":["Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Health System, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Health System, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078371069","display_name":"Nathanael G. Bailey","orcid":"https://orcid.org/0000-0002-6747-680X","observed_orcids":["https://orcid.org/0000-0002-6747-680X"]},"institutions":[{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathanael G Bailey","raw_affiliation_strings":["Department of Pathology, University of Michigan Health System, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Michigan Health System, Ann Arbor, MI","institution_ids":["https://openalex.org/I4210114445"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020537159","display_name":"Ryan A. Wilcox","orcid":"https://orcid.org/0000-0002-6420-0760","observed_orcids":["https://orcid.org/0000-0002-6420-0760"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan A Wilcox","raw_affiliation_strings":["Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Health System, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Health System, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5046170235","https://openalex.org/A5048137432","https://openalex.org/A5062534813"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21030157,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"128","issue":"22","first_page":"4152","last_page":"4152"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11811","display_name":"Cutaneous lymphoproliferative disorders research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12212","display_name":"CNS Lymphoma Diagnosis and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salvage-therapy","display_name":"salvage therapy","score":0.9449999928474426},{"id":"https://openalex.org/keywords/second-line-chemotherapy","display_name":"second-line chemotherapy","score":0.800000011920929},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7960000038146973},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.41200000047683716},{"id":"https://openalex.org/keywords/ice-regimen","display_name":"ICE regimen","score":0.4950000047683716},{"id":"https://openalex.org/keywords/dhap-regimen","display_name":"DHAP regimen","score":0.7400000095367432},{"id":"https://openalex.org/keywords/eshap-regimen","display_name":"ESHAP regimen","score":0.9110000133514404},{"id":"https://openalex.org/keywords/anthracycline-resistance","display_name":"anthracycline resistance","score":0.746999979019165},{"id":"https://openalex.org/keywords/angioimmunoblastic-t-cell-lymphoma","display_name":"angioimmunoblastic T-cell lymphoma","score":0.8659999966621399},{"id":"https://openalex.org/keywords/alk-positive-anaplastic-large-cell-lymphoma","display_name":"ALK-positive anaplastic large cell lymphoma","score":0.9789999723434448},{"id":"https://openalex.org/keywords/treatment-outcomes","display_name":"treatment outcomes","score":0.4659999907016754},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7210000157356262},{"id":"https://openalex.org/keywords/prognostic-score","display_name":"prognostic score","score":0.4320000112056732}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8474844694137573},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6997309327125549},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.6466838121414185},{"id":"https://openalex.org/C2780775027","wikidata":"https://www.wikidata.org/wiki/Q17141389","display_name":"Salvage therapy","level":3,"score":0.5435810089111328},{"id":"https://openalex.org/C2776802502","wikidata":"https://www.wikidata.org/wiki/Q417589","display_name":"Anthracycline","level":4,"score":0.5267942547798157},{"id":"https://openalex.org/C2779725641","wikidata":"https://www.wikidata.org/wiki/Q1076228","display_name":"CHOP","level":3,"score":0.5212702751159668},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.481748104095459},{"id":"https://openalex.org/C2777891184","wikidata":"https://www.wikidata.org/wiki/Q7168693","display_name":"Peripheral T-cell lymphoma","level":4,"score":0.47513988614082336},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.4617822766304016},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.43650782108306885},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.42258724570274353},{"id":"https://openalex.org/C2777872185","wikidata":"https://www.wikidata.org/wiki/Q486090","display_name":"Anaplastic large-cell lymphoma","level":3,"score":0.42111936211586},{"id":"https://openalex.org/C2778336483","wikidata":"https://www.wikidata.org/wiki/Q5090632","display_name":"Chemotherapy regimen","level":3,"score":0.42100751399993896},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.22641760110855103},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.11106395721435547},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.09946334362030029},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.07875436544418335},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v128.22.4152.4152","doi":"https://doi.org/10.1182/blood.v128.22.4152.4152","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v128.22.4152.4152","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2569253585","https://openalex.org/W3131095990","https://openalex.org/W1974203122","https://openalex.org/W2160382003","https://openalex.org/W2612557526","https://openalex.org/W2163510906","https://openalex.org/W170895960","https://openalex.org/W2393310406","https://openalex.org/W1972347678","https://openalex.org/W4379981814"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Resistance":[2],"to":[3,42,78,195,197,280,344,354,447,472,551,601,629],"conventional":[4,324],"anthracycline-based":[5,74],"regimens":[6,235,286,326,340,358,599],"(CHOP/CHOEP)":[7],"and":[8,21,52,63,170,200,261,287,327,455,549,555,578],"the":[9,30,53,81,179,315,494,579],"emergence":[10],"of":[11,26,32,102,110,152,154,182,229,245,263,293,374,435,465,484,500,504,545,561,573,581,627],"primary":[12,33,119,225,468,564],"refractory":[13,34,88,120,226,469,536,565],"disease":[14,92],"remains":[15,60],"a":[16,44,208,449,474,498,517,526,547,568],"clinical":[17,615],"challenge":[18],"in":[19,24,29,80,107,187,317,443,576,613,620],"PTCL,":[20,163],"is":[22,538,553],"observed":[23,106,190,319,442,593],"\u224825%":[25],"patients.":[27,111,184,622],"Outcomes":[28],"setting":[31],"disease,":[35,89,227],"particularly":[36],"for":[37,57,178,594],"those":[38,201,355,425],"patients":[39,59,68,135,158,192,230,246,264,282,288,321,375,417,444,466,487,512,562,595],"who":[40,71,193,202,270,283,289,322,418,426,445,488,513],"fail":[41],"achieve":[43,448,473,491,516],"remission":[45,210,450,475,492,518,530,548],"with":[46,69,118,394,401,451,467,493,519,531,540,556,563,606],"second-line":[47,371,477,604],"chemotherapy,":[48],"are":[49,585],"poorly":[50],"described":[51],"optimal":[54],"therapeutic":[55,583],"strategy":[56],"these":[58,183,511,621],"uncertain.":[61],"Patients":[62,269,335],"Methods:":[64],"We":[65],"identified":[66],"159":[67],"PTCL":[70,82,121,470,537,577],"received":[72,231,247,265,271,284,290,323],"multi-agent,":[73],"treatment":[75],"from":[76],"1988":[77],"2011":[79],"database":[83],"at":[84,116],"our":[85],"institution.":[86],"Primary":[87,535],"defined":[90],"as":[91],"progression":[93],"during":[94],"initial":[95,198,520],"therapy":[96,155,199,275,362,379,454,478,505],"or":[97,347,359,386,397,460,479,528],"relapse":[98],"within":[99,204,481],"6":[100,205],"months":[101,206,483],"its":[103],"completion,":[104],"was":[105,122,130,143,159,189,331,399,441,508,591],"58":[108],"(36%)":[109],"Results:":[112],"The":[113,149,543],"median":[114,150,433,499,607],"age":[115],"diagnosis":[117],"49":[123],"years":[124,132,145,437],"(range,":[125,161,506],"18.8-77.1).":[126],"Median":[127,139],"follow":[128],"up":[129],"2.7":[131],"among":[133,424],"surviving":[134],"(95%":[136,146,438],"CI,":[137,147,215,220,300,305,310,408,413,439],"1.2-6.3).":[138],"overall":[140],"survival":[141,589,608],"(OS)":[142],"1.1":[144],"0.7-1.9).":[148],"number":[151],"lines":[153],"underwent":[156,376,419,427],"by":[157,381],"3":[160,482],"1-9).":[162],"NOS":[164],"(n=24),":[165],"angioimmunoblastic":[166],"T-cell":[167],"lymphoma":[168,175],"(n=6),":[169],"ALK-positive":[171],"anaplastic":[172],"large":[173],"cell":[174,350],"(n=7)":[176,524],"accounted":[177],"majority":[180],"(63.8%)":[181],"No":[185,624],"difference":[186,316],"OS":[188,212,278,297,318,403,405,434],"between":[191,320],"failed":[194,446,471],"respond":[196],"relapsed":[203,480],"after":[207],"first":[209,452,495],"(median":[211,296,404],"0.9":[213],"[95%":[214,219,299,304,309,407,412],"0.6-1.9]":[216],"vs.":[217,302,307,364,366,410],"1.3":[218,308],"0.5-6.3],":[221],"p=0.6).":[222],"After":[223],"developing":[224],"48.3%":[228],"aggressive,":[232,337],"multi-agent":[233,338],"salvage":[234,274,325,339,453,496,521,598],"(ICE,":[236],"n=16;":[237],"DHAP,":[238],"n=3;":[239,258],"ESHAP,":[240],"n=6;":[241],"other,":[242,259],"n=3),":[243],"29.3%":[244],"other":[248,291,328,602],"systemic":[249,267,273,294,329,361,603],"therapies":[250,295,330],"(HDAC":[251],"inhibitor,":[252],"n=1;":[253],"gemcitabine-based":[254],"therapies,":[255],"n=5;":[256],"pralatrexate,":[257],"n=8),":[260],"22.4%":[262],"no":[266,272,360],"therapies.":[268],"had":[276],"reduced":[277],"compared":[279,353,600],"both":[281],"aggressive":[285],"types":[292],"0.3":[298],"0.2-1.1]":[301],"1.7":[303],"0.8-11.7]":[306],"0.4-8.6],":[311],"respectively,":[312,368],"p<0.001),":[313],"but":[314],"not":[332,457,490,515,592],"significant":[333,588],"(p=0.3).":[334],"receiving":[336,356,596],"were":[341],"more":[342],"likely":[343],"undergo":[345,458],"autologous":[346,382],"allogeneic":[348,387],"stem":[349],"transplantation":[351],"(SCT)":[352],"non-traditional":[357],"(53.6%":[363],"23.5%":[365],"0%,":[367],"p=0.0003).":[369],"Following":[370],"therapy,":[372,497,522],"32.8%":[373],"high":[377],"dose":[378],"followed":[380],"SCT":[383,388],"(ASCT)":[384],"(n=5)":[385],"(allo-SCT)":[389],"(n=15).":[390],"Not":[391],"surprisingly,":[392],"consolidation":[393],"either":[395],"ASCT":[396,459],"allo-SCT":[398,461],"associated":[400,539],"improved":[402,582],"2.3":[406],"0.9-11.4]":[409],"0.6":[411,436],"0.4-1.3],":[414],"p=0.0012).":[415],"Among":[416,486,510],"allo-SCT,":[420],"26.7%":[421],"(n=4)":[422],"relapsed;":[423],"ASCT,":[428],"60%":[429],"(n=3)":[430],"relapsed.":[431],"A":[432,587],"0.4-1.1)":[440],"did":[456,489,514],"(n=25).":[462],"Overall,":[463],"77.6%":[464],"following":[476],"transplant.":[485],"1":[501],"subsequent":[502],"line":[503],"0-7)":[507],"utilized.":[509],"20.6%":[523],"achieved":[525,567],"partial":[527],"complete":[529],"further":[532],"therapy.":[533],"Conclusion:":[534],"dismal":[541],"outcomes.":[542],"likelihood":[544],"achieving":[546],"proceeding":[550],"transplant":[552],"\u224830%":[554],"transplant,":[557],"only":[558],"11":[559],"(19%":[560],"disease)":[566],"durable":[569],"remission.":[570],"Improved":[571],"understanding":[572],"resistance":[574],"mechanisms":[575],"development":[580],"strategies":[584],"needed.":[586],"benefit":[590],"traditional":[597],"regimens,":[605],"<20":[609],"months.":[610],"Therefore,":[611],"participation":[612],"well-designed":[614],"trials":[616],"should":[617],"be":[618],"encouraged":[619],"Disclosures":[623],"relevant":[625],"conflicts":[626],"interest":[628],"declare.":[630]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}
