{"id":"https://openalex.org/W2607138232","doi":null,"title":"EDITORIAL: A REVIEW ANALYZING IN VIVO AND IN VITRO TESTING MODELS ON NERVE CONDUITS OF THE PERIPHERAL NERVOUS SYSTEM","display_name":"EDITORIAL: A REVIEW ANALYZING IN VIVO AND IN VITRO TESTING MODELS ON NERVE CONDUITS OF THE PERIPHERAL NERVOUS SYSTEM","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2607138232","mag":"2607138232"},"language":"en","primary_location":{"id":"pmh:oai:doaj.org/article:20b9204f360049ff889625d7e09cadd4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/20b9204f360049ff889625d7e09cadd4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Iraqi Journal of Medical Sciences, Vol 12, Iss 3 (2016)","raw_type":"article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/20b9204f360049ff889625d7e09cadd4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074165856","display_name":"Ali AlHamdi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ali AlHamdi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001152407","display_name":"Zain Bukamal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zain Bukamal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108584036","display_name":"Billy C.S. Leung","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Billy C.S. Leung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"3","first_page":"189","last_page":"196"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.8970000147819519,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.8970000147819519,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.05719999969005585,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.028699999675154686,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nerve-guidance-conduits","display_name":"nerve conduits","score":0.9959999918937683},{"id":"https://openalex.org/keywords/peripheral-nerve-regeneration","display_name":"peripheral nerve regeneration","score":0.8349999785423279},{"id":"https://openalex.org/keywords/nerve-gap-length","display_name":"nerve gap length","score":0.7120000123977661},{"id":"https://openalex.org/keywords/animal-models","display_name":"animal models","score":0.6320000290870667},{"id":"https://openalex.org/keywords/test-standardization","display_name":"test standardization","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8779356479644775},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6780859231948853},{"id":"https://openalex.org/C545314008","wikidata":"https://www.wikidata.org/wiki/Q169953","display_name":"Peripheral nervous system","level":3,"score":0.6780401468276978},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.6123146414756775},{"id":"https://openalex.org/C3018498973","wikidata":"https://www.wikidata.org/wiki/Q9620","display_name":"Peripheral nerve","level":2,"score":0.545593798160553},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4857073724269867},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4735780656337738},{"id":"https://openalex.org/C89836073","wikidata":"https://www.wikidata.org/wiki/Q1719631","display_name":"Electrical conduit","level":2,"score":0.4122149348258972},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.249393492937088},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.20732128620147705},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20295798778533936},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.08172711730003357},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.05134060978889465},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.03636574745178223},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0362510085105896},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:doaj.org/article:20b9204f360049ff889625d7e09cadd4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/20b9204f360049ff889625d7e09cadd4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Iraqi Journal of Medical Sciences, Vol 12, Iss 3 (2016)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:a89c0a29116a40f9a650cc7c5ff3f4b7","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a89c0a29116a40f9a650cc7c5ff3f4b7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Iraqi Journal of Medical Sciences, Vol 12, Iss 3 (2016)","raw_type":"article"},{"id":"mag:2607138232","doi":null,"is_oa":true,"landing_page_url":"http://www.iasj.net/iasj?func=fulltext&aId=97800","pdf_url":null,"source":{"id":"https://openalex.org/S2764762542","display_name":"Iraqi journal of Medical Sciences","issn_l":"1681-6579","issn":["1681-6579","2224-4719"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Iraqi journal of Medical Sciences","raw_type":null}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:20b9204f360049ff889625d7e09cadd4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/20b9204f360049ff889625d7e09cadd4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Iraqi Journal of Medical Sciences, Vol 12, Iss 3 (2016)","raw_type":"article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1960585860","https://openalex.org/W1972243157","https://openalex.org/W1973023067","https://openalex.org/W1978140670","https://openalex.org/W1986780297","https://openalex.org/W1995945082","https://openalex.org/W2031748271","https://openalex.org/W2032396933","https://openalex.org/W2033867839","https://openalex.org/W2039097074","https://openalex.org/W2044208672","https://openalex.org/W2044774878","https://openalex.org/W2049870142","https://openalex.org/W2050237982","https://openalex.org/W2056327878","https://openalex.org/W2071772085","https://openalex.org/W2086633422","https://openalex.org/W2100938404","https://openalex.org/W2107514110","https://openalex.org/W2108477112","https://openalex.org/W2147600405","https://openalex.org/W2150762909","https://openalex.org/W2157221308","https://openalex.org/W2164840952","https://openalex.org/W2312945397","https://openalex.org/W2313709378","https://openalex.org/W2412640690","https://openalex.org/W2741763908"],"related_works":["https://openalex.org/W3207843697","https://openalex.org/W2964493117","https://openalex.org/W2582287067","https://openalex.org/W2810534211","https://openalex.org/W2613268037","https://openalex.org/W2059063700","https://openalex.org/W2367525947","https://openalex.org/W2907324428","https://openalex.org/W3164496985","https://openalex.org/W2084857658"],"abstract_inverted_index":{"The":[0,99],"gold":[1],"standard":[2],"method":[3],"for":[4,53,76,155,163,178,183,195],"nerve":[5,35,77,92,157,167,201],"reconstruction":[6],"involve":[7],"the":[8,57,71,85,89,109,175,188],"use":[9],"of":[10,23,61,73,91,104,115,122],"autologous":[11],"graft,":[12],"however,":[13],"major":[14],"drawbacks":[15],"included":[16],"limited":[17],"availability,":[18],"donor-site":[19],"morbidities":[20],"and":[21,48,96,106,128,136,159,169,187],"requirement":[22],"multiple":[24],"surgeries.":[25],"Researchers":[26],"worldwide":[27],"had":[28,39,160],"aimed":[29],"to":[30,70,83,190],"produce":[31],"alternative":[32],"tissue-engineered":[33],"synthetic":[34],"conduits,":[36],"but":[37,148],"development":[38],"been":[40,150,161],"slow,":[41],"with":[42],"only":[43],"four":[44],"FDA":[45],"(US":[46],"Food":[47],"Drug":[49],"Administration)":[50],"approved":[51],"conduits":[52,93],"human":[54],"subjects":[55],"in":[56,88,94,97,108,145,152,166,184,192],"past":[58],"50":[59],"years":[60,154],"research.":[62],"This":[63,80,172],"slow":[64],"progress":[65],"may":[66],"potentially":[67],"be":[68],"related":[69],"lack":[72,103],"standardized":[74,181],"guideline":[75],"conduit":[78],"testing.":[79],"review":[81,100],"aims":[82],"summarize":[84],"methodologies":[86],"used":[87],"testing":[90,146,165,197,207],"vivo":[95,185],"vitro.":[98],"demonstrated":[101],"a":[102,179],"consensus":[105],"consistency":[107],"study":[110,173],"methodologies,":[111],"including":[112],"various":[113],"measures":[114],"functional":[116,156,196],"assessment,":[117],"over":[118],"8":[119],"different":[120],"types":[121],"animal":[123],"species,":[124],"17":[125],"peripheral":[126,205],"nerves":[127],"varied":[129],"gap":[130],"lengths":[131],"ranging":[132],"between":[133],"1":[134],"mm":[135],"90":[137],"mm.":[138],"In":[139],"vitro":[140,193],"models":[141],"demonstrate":[142],"more":[143,180],"consistencies":[144],"models,":[147],"have":[149],"discarded":[151],"recent":[153],"testing,":[158,186],"employed":[162],"preliminary":[164],"toxicity":[168],"compatibility":[170],"instead.":[171],"emphasizes":[174],"urgent":[176],"need":[177,189],"approach":[182],"re-utilize":[191],"studies":[194],"purposes.":[198],"Key":[199],"words:":[200],"conduits;":[202],"tissue":[203],"engineering;":[204],"nerves;":[206],"methodology":[208]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-04-28T00:00:00"}
