{"id":"https://openalex.org/W2607013750","doi":null,"title":"Pregnane X Receptor SUMOylation and De-SUMOylation","display_name":"Pregnane X Receptor SUMOylation and De-SUMOylation","publication_year":2014,"publication_date":"2014-05-31","ids":{"openalex":"https://openalex.org/W2607013750","mag":"2607013750"},"language":"en","primary_location":{"id":"pmh:oai:kuscholarworks.ku.edu:1808/21634","doi":null,"is_oa":false,"landing_page_url":"https://kuscholarworks.ku.edu/bitstreams/2d80e0d7-10e0-4074-b5f8-de526ca41e5d/download","pdf_url":null,"source":{"id":"https://openalex.org/S4306400421","display_name":"KU ScholarWorks (The University of Kansas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146416000","host_organization_name":"University of Kansas","host_organization_lineage":["https://openalex.org/I146416000"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100353205","display_name":"Chang Liu","orcid":"https://orcid.org/0000-0002-1232-8308","observed_orcids":["https://orcid.org/0000-0002-1232-8308"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Chang Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1232-8308","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5100353205"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8661999702453613,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8661999702453613,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.03889999911189079,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.014499999582767487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pregnane-x-receptor","display_name":"pregnane X receptor","score":0.9919999837875366},{"id":"https://openalex.org/keywords/sumoylation","display_name":"SUMOylation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/desumoylation","display_name":"deSUMOylation","score":0.9869999885559082},{"id":"https://openalex.org/keywords/sumo1","display_name":"SUMO1","score":0.9179999828338623},{"id":"https://openalex.org/keywords/sumo3","display_name":"SUMO3","score":1.0},{"id":"https://openalex.org/keywords/senp1","display_name":"SENP1","score":0.75},{"id":"https://openalex.org/keywords/senp2","display_name":"SENP2","score":1.0},{"id":"https://openalex.org/keywords/senp6","display_name":"SENP6","score":0.9980000257492065},{"id":"https://openalex.org/keywords/piasy","display_name":"PIASy","score":0.9679999947547913},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.7609999775886536},{"id":"https://openalex.org/keywords/ligand-binding-domain","display_name":"ligand-binding domain","score":0.8259999752044678},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.34200000762939453},{"id":"https://openalex.org/keywords/xenobiotic-metabolism","display_name":"xenobiotic metabolism","score":0.6579999923706055},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.8199999928474426},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5789999961853027},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.37599998712539673}],"concepts":[{"id":"https://openalex.org/C171350616","wikidata":"https://www.wikidata.org/wiki/Q61506","display_name":"SUMO protein","level":4,"score":0.9580378532409668},{"id":"https://openalex.org/C132040763","wikidata":"https://www.wikidata.org/wiki/Q409867","display_name":"Pregnane X receptor","level":5,"score":0.7979034781455994},{"id":"https://openalex.org/C2780655410","wikidata":"https://www.wikidata.org/wiki/Q2700511","display_name":"Pregnane","level":2,"score":0.6395718455314636},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37397852540016174},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2063087821006775},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.15098071098327637},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05093652009963989},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.0},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:kuscholarworks.ku.edu:1808/21634","doi":null,"is_oa":false,"landing_page_url":"https://kuscholarworks.ku.edu/bitstreams/2d80e0d7-10e0-4074-b5f8-de526ca41e5d/download","pdf_url":null,"source":{"id":"https://openalex.org/S4306400421","display_name":"KU ScholarWorks (The University of Kansas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146416000","host_organization_name":"University of Kansas","host_organization_lineage":["https://openalex.org/I146416000"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2607013750","doi":null,"is_oa":false,"landing_page_url":"https://kuscholarworks.ku.edu/handle/1808/21634","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":161,"referenced_works":["https://openalex.org/W129841773","https://openalex.org/W1511850932","https://openalex.org/W1522773084","https://openalex.org/W1533823218","https://openalex.org/W1545401674","https://openalex.org/W1646199134","https://openalex.org/W1665938856","https://openalex.org/W1717444875","https://openalex.org/W1874881634","https://openalex.org/W1878535762","https://openalex.org/W1925943257","https://openalex.org/W1926862327","https://openalex.org/W1965919485","https://openalex.org/W1966594267","https://openalex.org/W1969097053","https://openalex.org/W1972166544","https://openalex.org/W1975993759","https://openalex.org/W1976621212","https://openalex.org/W1978213778","https://openalex.org/W1979275431","https://openalex.org/W1981062818","https://openalex.org/W1981306061","https://openalex.org/W1981873124","https://openalex.org/W1984345984","https://openalex.org/W1984405912","https://openalex.org/W1985313012","https://openalex.org/W1985723042","https://openalex.org/W1987038822","https://openalex.org/W1987556650","https://openalex.org/W1988396057","https://openalex.org/W1988924112","https://openalex.org/W1990529844","https://openalex.org/W1990613292","https://openalex.org/W1992125440","https://openalex.org/W1994714941","https://openalex.org/W1995754186","https://openalex.org/W1996384706","https://openalex.org/W1999054610","https://openalex.org/W1999389473","https://openalex.org/W1999513011","https://openalex.org/W2001029086","https://openalex.org/W2004722555","https://openalex.org/W2005026027","https://openalex.org/W2005120097","https://openalex.org/W2006755193","https://openalex.org/W2007012438","https://openalex.org/W2007169317","https://openalex.org/W2008263033","https://openalex.org/W2009010832","https://openalex.org/W2011030044","https://openalex.org/W2011726280","https://openalex.org/W2012225201","https://openalex.org/W2014765226","https://openalex.org/W2015711200","https://openalex.org/W2020872262","https://openalex.org/W2021444563","https://openalex.org/W2024805148","https://openalex.org/W2026160870","https://openalex.org/W2026421562","https://openalex.org/W2027350291","https://openalex.org/W2030580012","https://openalex.org/W2030711777","https://openalex.org/W2032360849","https://openalex.org/W2032693719","https://openalex.org/W2032913694","https://openalex.org/W2035000881","https://openalex.org/W2038657917","https://openalex.org/W2040669411","https://openalex.org/W2040825545","https://openalex.org/W2042389934","https://openalex.org/W2044229112","https://openalex.org/W2045938951","https://openalex.org/W2046037983","https://openalex.org/W2047740672","https://openalex.org/W2047852384","https://openalex.org/W2048447345","https://openalex.org/W2049652810","https://openalex.org/W2053649017","https://openalex.org/W2054747029","https://openalex.org/W2054835199","https://openalex.org/W2056092077","https://openalex.org/W2057547177","https://openalex.org/W2057743013","https://openalex.org/W2058788882","https://openalex.org/W2067961925","https://openalex.org/W2068458442","https://openalex.org/W2070163476","https://openalex.org/W2072233737","https://openalex.org/W2073148985","https://openalex.org/W2074832304","https://openalex.org/W2074878443","https://openalex.org/W2074907054","https://openalex.org/W2076218188","https://openalex.org/W2076985436","https://openalex.org/W2077993951","https://openalex.org/W2078220726","https://openalex.org/W2078621117","https://openalex.org/W2081532782","https://openalex.org/W2083312621","https://openalex.org/W2083876166","https://openalex.org/W2084462922","https://openalex.org/W2087102845","https://openalex.org/W2087577664","https://openalex.org/W2089595695","https://openalex.org/W2091077559","https://openalex.org/W2091578636","https://openalex.org/W2092190477","https://openalex.org/W2092839327","https://openalex.org/W2094209629","https://openalex.org/W2096958727","https://openalex.org/W2097155763","https://openalex.org/W2098563852","https://openalex.org/W2099443464","https://openalex.org/W2099762457","https://openalex.org/W2100200896","https://openalex.org/W2100983536","https://openalex.org/W2103545212","https://openalex.org/W2106515170","https://openalex.org/W2106877484","https://openalex.org/W2107203311","https://openalex.org/W2107954651","https://openalex.org/W2109677414","https://openalex.org/W2114108429","https://openalex.org/W2114756989","https://openalex.org/W2115778133","https://openalex.org/W2116988305","https://openalex.org/W2119301405","https://openalex.org/W2120818622","https://openalex.org/W2127337885","https://openalex.org/W2127645257","https://openalex.org/W2128566951","https://openalex.org/W2128594838","https://openalex.org/W2129272244","https://openalex.org/W2129747400","https://openalex.org/W2132613286","https://openalex.org/W2132783954","https://openalex.org/W2132909109","https://openalex.org/W2134055375","https://openalex.org/W2134305526","https://openalex.org/W2137506791","https://openalex.org/W2140513365","https://openalex.org/W2142783300","https://openalex.org/W2143241514","https://openalex.org/W2143751039","https://openalex.org/W2146906769","https://openalex.org/W2147041834","https://openalex.org/W2147277158","https://openalex.org/W2148590099","https://openalex.org/W2155250843","https://openalex.org/W2156575042","https://openalex.org/W2156739133","https://openalex.org/W2157388608","https://openalex.org/W2158609797","https://openalex.org/W2161816485","https://openalex.org/W2163475448","https://openalex.org/W2172256092","https://openalex.org/W2178970217","https://openalex.org/W2182025195","https://openalex.org/W2217629220","https://openalex.org/W2330446798","https://openalex.org/W7097221462"],"related_works":["https://openalex.org/W2280968171","https://openalex.org/W2758253071","https://openalex.org/W1999389473","https://openalex.org/W2107187147","https://openalex.org/W2146407725","https://openalex.org/W2216875441","https://openalex.org/W4389026619","https://openalex.org/W1866058184","https://openalex.org/W1602201600","https://openalex.org/W4406057416"],"abstract_inverted_index":{"The":[0,180],"pregnane":[1],"x":[2],"receptor":[3,12],"(PXR,":[4],"NR1I2)":[5],"is":[6,20,80,132],"a":[7,26,267,292,374],"member":[8],"of":[9,15,28,64,76,116,190,198,215,252,304],"the":[10,44,61,74,83,96,106,136,184,199,213,250,258,302,310,319,324,336,340],"nuclear":[11],"(NR)":[13],"superfamily":[14],"ligand-activated":[16],"transcription":[17],"factors.":[18],"PXR":[19,56,78,97,117,131,146,173,200,216,263,322,328,356],"activated":[21,191],"by":[22,118,175],"numerous":[23],"lipophilic":[24],"compounds,":[25],"variety":[27],"drugs":[29],"and":[30,46,70,153,158,178,233,237,243,276,283,295,327,349,372,387],"drug":[31,66,370],"metabolites":[32],"in":[33,43,103,140,151,163,166,205,274,277,291,313,346,351,385],"clinical":[34],"use.":[35],"It":[36],"regulates":[37],"xenobiotic-inducible":[38],"cytochrome":[39],"P450":[40],"(CYP)":[41],"expression":[42,157,218],"liver":[45,104,348,386],"intestine":[47,350],"which":[48,339],"are":[49,285,360],"major":[50],"organs":[51],"for":[52,91,269,363,367,377],"xenobiotic":[53],"biotransformation.":[54],"While":[55],"has":[57,88],"been":[58,89],"identified":[59],"as":[60,266],"positive":[62],"regulator":[63],"many":[65],"metabolizing":[67],"enzymes":[68,226],"(DMEs)":[69],"membrane":[71],"transporter":[72],"proteins,":[73],"effect":[75],"certain":[77],"activators":[79],"to":[81,125,134,170,211,287,317,334,338,381],"repress":[82,382],"inflammatory":[84,137,383],"response.":[85],"Although":[86],"it":[87],"known":[90],"40":[92],"years":[93],"now":[94],"that":[95,114,130,183,261,297],"activator":[98],"rifampicin":[99],"inhibits":[100],"immunological":[101],"responses":[102],"cells,":[105],"mechanisms":[107,149,342],"remain":[108],"poorly":[109],"understood.":[110],"Previous":[111],"results":[112],"indicate":[113],"modification":[115],"small":[119],"ubiquitin-related":[120],"modifier":[121],"(SUMO)":[122],"likely":[123],"contributes":[124,316],"this":[126,143,314],"phenomenon.":[127],"We":[128],"hypothesize":[129],"SUMOylated":[133],"transrepress":[135],"response":[138],"genes":[139],"liver.":[141],"Here,":[142],"thesis":[144,315],"examines":[145],"SUMOylation/de-SUMOylation":[147],"reaction":[148],"using":[150,217],"vitro":[152,167,275],"cell-based":[154,278],"methods.":[155],"Bacterial":[156],"purification":[159],"systems":[160],"were":[161,209],"used":[162,210],"conjunction":[164],"with":[165,355],"SUMOylation":[168,174,197,325],"reactions":[169,371],"further":[171],"analyze":[172],"both":[176,241,281],"SUMO-1":[177,242,271],"SUMO-3.":[179],"data":[181,259],"reveal":[182],"E3":[185],"SUMO-protein":[186],"ligase":[187],"protein":[188,193],"inhibitor":[189],"STAT":[192],"y":[194],"(PIASy)":[195],"potentiated":[196],"ligand":[201],"binding":[202],"domain":[203],"(PXR-LBD)":[204],"vitro.":[206],"Cell-based":[207],"methods":[208],"characterize":[212],"de-SUMOylation":[214],"vectors":[219],"encoding":[220],"six":[221],"different":[222],"sentrin":[223],"protease":[224],"(SENP)":[225],"including":[227],"SENP1,":[228],"SENP2,":[229],"SENP3,":[230],"SENP5,":[231],"SENP6,":[232],"SENP7.":[234],"Both":[235],"SENP1":[236,282],"SENP2":[238,284],"effectively":[239],"de-conjugated":[240],"SUMO-3":[244,253,273],"from":[245],"PXR,":[246],"whereas":[247],"SENP6":[248,298],"inhibited":[249],"formation":[251,303],"chains":[254],"on":[255,306],"PXR.":[256,307],"Collectively,":[257],"suggest":[260],"(1)":[262],"can":[264],"serve":[265],"substrate":[268],"either":[270],"or":[272,300],"assays,":[279],"(2)":[280],"able":[286],"remove":[288],"SUMO":[289],"moieties":[290],"cellular":[293],"environment,":[294],"(3)":[296],"removes":[299],"prevents":[301],"SUMO-chains":[305],"Taken":[308],"together,":[309],"work":[311],"presented":[312],"understanding":[318],"interface":[320],"between":[321],"activators,":[323],"pathway":[326],"activity.":[329],"Future":[330],"efforts":[331],"should":[332],"seek":[333],"determine":[335],"extent":[337],"biochemical":[341],"described":[343],"here":[344],"function":[345],"human":[347],"patients":[352],"undergoing":[353],"therapy":[354],"activators.":[357],"These":[358],"studies":[359],"deemed":[361],"critical":[362],"safe":[364],"pharmacological":[365],"strategies":[366],"addressing":[368],"adverse":[369],"provide":[373],"new":[375],"paradigm":[376],"exploring":[378],"novel":[379],"approaches":[380],"signaling":[384],"intestine.":[388]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-04-28T00:00:00"}
