{"id":"https://openalex.org/W2606835151","doi":"https://doi.org/10.3892/ol.2017.6072","title":"Investigation of the relative biological effectiveness and uniform isobiological killing effects of irradiation with a clinical carbon SOBP beam on DNA repair deficient CHO cells","display_name":"Investigation of the relative biological effectiveness and uniform isobiological killing effects of irradiation with a clinical carbon SOBP beam on DNA repair deficient CHO cells","publication_year":2017,"publication_date":"2017-04-21","ids":{"openalex":"https://openalex.org/W2606835151","doi":"https://doi.org/10.3892/ol.2017.6072","mag":"2606835151","pmid":"https://pubmed.ncbi.nlm.nih.gov/28599495","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5453035"},"language":"en","primary_location":{"id":"doi:10.3892/ol.2017.6072","doi":"https://doi.org/10.3892/ol.2017.6072","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ol.2017.6072","pdf_url":"http://www.spandidos-publications.com/10.3892/ol.2017.6072/download","source":{"id":"https://openalex.org/S58832373","display_name":"Oncology Letters","issn_l":"1792-1074","issn":["1792-1074","1792-1082"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.spandidos-publications.com/10.3892/ol.2017.6072/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036598584","display_name":"Shigeaki Sunada","orcid":"https://orcid.org/0000-0002-9446-8522","observed_orcids":["https://orcid.org/0000-0002-9446-8522"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeaki Sunada","raw_affiliation_strings":["Department of Nuclear Engineering and Management, School of Engineering, The University of Tokyo, Tokyo 113-8656, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Engineering and Management, School of Engineering, The University of Tokyo, Tokyo 113-8656, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082720535","display_name":"Ian M. Cartwright","orcid":"https://orcid.org/0000-0003-3430-0143","observed_orcids":["https://orcid.org/0000-0003-3430-0143"]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian M. Cartwright","raw_affiliation_strings":["Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074581569","display_name":"Hirokazu Hirakawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114217","display_name":"National Institutes for Quantum Science and Technology","ror":"https://ror.org/020rbyg91","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217"]},{"id":"https://openalex.org/I4387155384","display_name":"National Institute of Radiological Sciences","ror":"https://ror.org/05szqz470","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4387155384"]},{"id":"https://openalex.org/I4405287617","display_name":"Institute for Radiological Science","ror":"https://ror.org/05pbkxj36","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217","https://openalex.org/I4405287617"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirokazu Hirakawa","raw_affiliation_strings":["Department of Basic Medical Sciences for Radiation Damage, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Medical Sciences for Radiation Damage, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan","institution_ids":["https://openalex.org/I4210114217","https://openalex.org/I4387155384","https://openalex.org/I4405287617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103755490","display_name":"Akira Fujimori","orcid":"https://orcid.org/0009-0009-2499-9369","observed_orcids":["https://orcid.org/0009-0009-2499-9369","https://orcid.org/0009-0006-1834-4989"]},"institutions":[{"id":"https://openalex.org/I4210114217","display_name":"National Institutes for Quantum Science and Technology","ror":"https://ror.org/020rbyg91","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217"]},{"id":"https://openalex.org/I4387155384","display_name":"National Institute of Radiological Sciences","ror":"https://ror.org/05szqz470","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4387155384"]},{"id":"https://openalex.org/I4405287617","display_name":"Institute for Radiological Science","ror":"https://ror.org/05pbkxj36","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217","https://openalex.org/I4405287617"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Fujimori","raw_affiliation_strings":["Department of Basic Medical Sciences for Radiation Damage, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Medical Sciences for Radiation Damage, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan","institution_ids":["https://openalex.org/I4210114217","https://openalex.org/I4387155384","https://openalex.org/I4405287617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022281989","display_name":"Mitsuru Uesaka","orcid":"https://orcid.org/0000-0003-2870-2103","observed_orcids":["https://orcid.org/0000-0003-2870-2103"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuru Uesaka","raw_affiliation_strings":["Department of Nuclear Engineering and Management, School of Engineering, The University of Tokyo, Tokyo 113-8656, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Engineering and Management, School of Engineering, The University of Tokyo, Tokyo 113-8656, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000770470","display_name":"Takamitsu A. Kato","orcid":"https://orcid.org/0000-0002-6263-600X","observed_orcids":["https://orcid.org/0000-0002-6263-600X"]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takamitsu A. Kato","raw_affiliation_strings":["Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA","institution_ids":["https://openalex.org/I92446798"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7244,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.65890826,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"13","issue":"6","first_page":"4911","last_page":"4916"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spread-out-bragg-peak","display_name":"spread-out Bragg peak","score":0.7409999966621399},{"id":"https://openalex.org/keywords/carbon-ion-radiotherapy","display_name":"carbon ion radiotherapy","score":0.8109999895095825},{"id":"https://openalex.org/keywords/relative-biological-effectiveness","display_name":"relative biological effectiveness","score":0.8709999918937683},{"id":"https://openalex.org/keywords/dna-repair-deficiency","display_name":"DNA repair deficiency","score":0.8289999961853027},{"id":"https://openalex.org/keywords/non-homologous-end-joining","display_name":"non-homologous end joining","score":0.8270000219345093},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.9620000123977661},{"id":"https://openalex.org/keywords/linear-energy-transfer","display_name":"linear energy transfer","score":0.7059999704360962},{"id":"https://openalex.org/keywords/cell-survival","display_name":"cell survival","score":0.4580000042915344},{"id":"https://openalex.org/keywords/cho-cells","display_name":"CHO cells","score":0.546999990940094},{"id":"https://openalex.org/keywords/radiosensitivity","display_name":"radiosensitivity","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C2781298738","wikidata":"https://www.wikidata.org/wiki/Q18041535","display_name":"Sobp","level":4,"score":0.9606418013572693},{"id":"https://openalex.org/C11928243","wikidata":"https://www.wikidata.org/wiki/Q1360981","display_name":"Relative biological effectiveness","level":3,"score":0.7615599632263184},{"id":"https://openalex.org/C2780944729","wikidata":"https://www.wikidata.org/wiki/Q897227","display_name":"Bragg peak","level":3,"score":0.7270475625991821},{"id":"https://openalex.org/C86611320","wikidata":"https://www.wikidata.org/wiki/Q1699996","display_name":"Linear energy transfer","level":3,"score":0.6625510454177856},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.5718915462493896},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.5496795773506165},{"id":"https://openalex.org/C206684579","wikidata":"https://www.wikidata.org/wiki/Q4387689","display_name":"Radiosensitivity","level":3,"score":0.5332180261611938},{"id":"https://openalex.org/C175656101","wikidata":"https://www.wikidata.org/wiki/Q56646","display_name":"Chinese hamster ovary cell","level":3,"score":0.45805251598358154},{"id":"https://openalex.org/C50774322","wikidata":"https://www.wikidata.org/wiki/Q644248","display_name":"Ion beam","level":3,"score":0.42788293957710266},{"id":"https://openalex.org/C54516573","wikidata":"https://www.wikidata.org/wiki/Q2294","display_name":"Proton","level":2,"score":0.4276803135871887},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39212724566459656},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3599855303764343},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3509562611579895},{"id":"https://openalex.org/C177322064","wikidata":"https://www.wikidata.org/wiki/Q750955","display_name":"Radiochemistry","level":1,"score":0.3327663540840149},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2841395437717438},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2564260959625244},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09517601132392883},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.09026950597763062},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3892/ol.2017.6072","doi":"https://doi.org/10.3892/ol.2017.6072","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ol.2017.6072","pdf_url":"http://www.spandidos-publications.com/10.3892/ol.2017.6072/download","source":{"id":"https://openalex.org/S58832373","display_name":"Oncology Letters","issn_l":"1792-1074","issn":["1792-1074","1792-1082"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Letters","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4313444","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5453035","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5453035","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5453035","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncol Lett","raw_type":"Text"},{"id":"pmid:28599495","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28599495","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology letters","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:01116:0003812415","doi":null,"is_oa":true,"landing_page_url":"https://repo.qst.go.jp/records/48812","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ONCOLOGY LETTERS","raw_type":"journal article"},{"id":"pmh:oai:repo.qst.go.jp:00033921","doi":null,"is_oa":true,"landing_page_url":"http://repo.qst.go.jp/?action=repository_uri&item_id=33921","pdf_url":null,"source":{"id":"https://openalex.org/S4377196694","display_name":"QST-Repository (National Institutes for Quantum and Radiological Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210114217","host_organization_name":"National Institutes for Quantum Science and Technology","host_organization_lineage":["https://openalex.org/I4210114217"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/ol.2017.6072","doi":"https://doi.org/10.3892/ol.2017.6072","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ol.2017.6072","pdf_url":"http://www.spandidos-publications.com/10.3892/ol.2017.6072/download","source":{"id":"https://openalex.org/S58832373","display_name":"Oncology Letters","issn_l":"1792-1074","issn":["1792-1074","1792-1082"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3792101444","display_name":null,"funder_award_id":"15H05935","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G3835219533","display_name":"\u52b9\u7387\u7684\u306a\u7d30\u80de\u8001\u5316\u4fc3\u9032\u306b\u3088\u308b\u304c\u3093\u6291\u5236\u6cd5\u306e\u57fa\u790e\u7814\u7a76","funder_award_id":"15J09331","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5078116074","display_name":null,"funder_award_id":"15H05935","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320322832","display_name":"University of Tokyo","ror":"https://ror.org/057zh3y96"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2606835151.pdf","grobid_xml":"https://content.openalex.org/works/W2606835151.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1498308778","https://openalex.org/W1575172090","https://openalex.org/W1842167960","https://openalex.org/W1970435786","https://openalex.org/W1982929565","https://openalex.org/W2003675334","https://openalex.org/W2005765181","https://openalex.org/W2012543899","https://openalex.org/W2018028783","https://openalex.org/W2035714015","https://openalex.org/W2036611623","https://openalex.org/W2036901351","https://openalex.org/W2063882035","https://openalex.org/W2088413560","https://openalex.org/W2091581874","https://openalex.org/W2100125421","https://openalex.org/W2111711907","https://openalex.org/W2134565827","https://openalex.org/W2139067293","https://openalex.org/W2140425310","https://openalex.org/W2141550359","https://openalex.org/W2159192512","https://openalex.org/W2166284889","https://openalex.org/W2319913415","https://openalex.org/W2462854298"],"related_works":["https://openalex.org/W2088005887","https://openalex.org/W2903111768","https://openalex.org/W7100113905","https://openalex.org/W7096835352","https://openalex.org/W3086162142","https://openalex.org/W2018028783","https://openalex.org/W4251028252","https://openalex.org/W2728820223","https://openalex.org/W4312117080","https://openalex.org/W7145742266"],"abstract_inverted_index":{"Spread-out":[0],"Bragg":[1,24],"peak":[2],"(SOBP)":[3],"C":[4,99,129,137,175,193,204,213,235,244,315],"ions":[5,100,105,138,149,176,194,214,236],"have":[6],"been":[7,39],"used":[8,119],"clinically":[9,46],"in":[10,55,108,254,274],"charged":[11],"particle":[12],"radiation":[13,336],"therapy":[14,317],"for":[15,232,241,260,291,314],"years.":[16],"An":[17,114],"SOBP":[18,34,128,256],"beam":[19,35,53,293],"consists":[20],"of":[21,30,65,127,136,278,321,330],"various":[22],"monoenergetic":[23],"peaks;":[25],"however,":[26],"the":[27,45,52,122,221,248,251,255,275,279,297,319,322,328],"biological":[28,132],"effect":[29],"irradiation":[31],"with":[32,97,162,199,210,296],"an":[33,311],"track":[36,54],"has":[37],"not":[38,186],"well-studied.":[40],"In":[41],"order":[42,109],"to":[43,51,110,120,172,190,327],"determine":[44],"prospective":[47],"molecular":[48],"targets,":[49],"radiosensitivity":[50],"DNA":[56],"repair":[57,301,305],"deficient":[58],"cell":[59,72,156,164,167,223,272],"lines":[60,168],"was":[61,118],"investigated.":[62],"A":[63],"total":[64],"four":[66],"distinct":[67,125],"Chinese":[68],"hamster":[69],"ovary":[70],"(CHO)":[71],"lines,":[73],"including":[74],"CHO10B2":[75],"(wild-type),":[76],"V3":[77,183,266],"(protein":[78],"kinase":[79],"DNA-activated":[80],"catalytic":[81],"polypeptide":[82],"deficient),":[83],"51D1":[84,207,268],"(RAD51":[85],"paralog":[86],"D":[87],"deficient)":[88],"and":[89,103,144,147,177,195,203,206,237,262,267,302,318],"PADR9":[90,226,263],"[poly(ADP-ribose)":[91],"polymerase":[92],"(PARP)":[93],"deficient],":[94],"were":[95,153,258],"irradiated":[96,209],"gamma-rays,":[98],"(290":[101],"MeV/n)":[102],"Fe":[104,148,180,196],"(500":[106],"MeV/n),":[107],"compare":[111],"cellular":[112],"lethality.":[113],"OptiCell\u2122":[115],"culture":[116],"system":[117],"evaluate":[121],"lethality":[123],"at":[124],"depths":[126],"ions.":[130,181,245],"Relative":[131],"effectiveness":[133],"(RBE)":[134],"values":[135,219,231,240],"(linear":[139],"energy":[140],"transfer":[141],"(LET),":[142],"13":[143,211,233],"70":[145,173,242],"keV/\u00b5m)":[146,152],"(LET,":[150],"200":[151,178],"calculated":[154],"from":[155],"survival":[157,252],"using":[158,247],"colony":[159],"formation":[160],"assay":[161],"standard":[163],"dishes.":[165],"All":[166],"exhibited":[169,215,228,270],"similar":[170],"sensitivity":[171,189],"keV/\u00b5m":[174,179,212,234,243],"Furthermore,":[182],"cells":[184,208,227,269],"did":[185],"exhibit":[187],"increased":[188],"high":[191,217,238],"LET":[192,201],"ions,":[197,205],"compared":[198,295],"low":[200,229],"gamma-rays":[202],"relatively":[216],"RBE":[218,230,239],"among":[220],"tested":[222],"lines.":[224],"Conversely,":[225,265],"Obtained":[246],"OptiCell":[249],"system,":[250],"fractions":[253],"region":[257,277],"uniform":[259],"wild-type":[261],"cells.":[264],"decreased":[271],"death":[273],"distal":[276],"SOBP.":[280],"These":[281],"results":[282,320],"indicated":[283],"that":[284],"PARP":[285,307],"is":[286],"a":[287,331],"more":[288,332],"effective":[289,333],"target":[290,313],"clinical":[292],"therapy,":[294],"non-homologous":[298],"end":[299],"joining":[300],"homologous":[303],"recombination":[304],"pathways.":[306],"deficiency":[308],"may":[309,325],"be":[310],"optimal":[312],"ion":[316,335],"present":[323],"study":[324],"contribute":[326],"development":[329],"heavy":[334],"therapy.":[337]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-04-28T00:00:00"}
