{"id":"https://openalex.org/W2606785697","doi":"https://doi.org/10.1016/j.toxlet.2017.03.025","title":"Metabolism of 14 C-octamethylcyclotetrasiloxane ([ 14 C]D 4 ) or 14 C-decamethylcyclopentasiloxane ([ 14 C]D 5 ) orally gavaged in rainbow trout ( Oncorhynchus mykiss )","display_name":"Metabolism of 14 C-octamethylcyclotetrasiloxane ([ 14 C]D 4 ) or 14 C-decamethylcyclopentasiloxane ([ 14 C]D 5 ) orally gavaged in rainbow trout ( Oncorhynchus mykiss )","publication_year":2017,"publication_date":"2017-04-21","ids":{"openalex":"https://openalex.org/W2606785697","doi":"https://doi.org/10.1016/j.toxlet.2017.03.025","mag":"2606785697","pmid":"https://pubmed.ncbi.nlm.nih.gov/28438492"},"language":"en","primary_location":{"id":"doi:10.1016/j.toxlet.2017.03.025","doi":"https://doi.org/10.1016/j.toxlet.2017.03.025","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.toxlet.2017.03.025","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0378427417301273/pdf","source":{"id":"https://openalex.org/S205878144","display_name":"Toxicology Letters","issn_l":"0378-4274","issn":["0378-4274","1879-3169"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0378427417301273/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110168922","display_name":"Jeanne Y. Domoradzki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jeanne Y. Domoradzki","raw_affiliation_strings":["Dow Corning Corporation, Midland, MI 48686, USA. Electronic address: jean.domoradzki@dowcorning.com","Dow Corning Corporation, Midland, MI 48686, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dow Corning Corporation, Midland, MI 48686, USA. Electronic address: jean.domoradzki@dowcorning.com","institution_ids":[]},{"raw_affiliation_string":"Dow Corning Corporation, Midland, MI 48686, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039621127","display_name":"Jacob M. Sushynski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jacob M. Sushynski","raw_affiliation_strings":["Dow Corning Corporation, Midland, MI 48686, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dow Corning Corporation, Midland, MI 48686, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027016685","display_name":"Lisa M. Thackery","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lisa M. Thackery","raw_affiliation_strings":["Dow Corning Corporation, Midland, MI 48686, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dow Corning Corporation, Midland, MI 48686, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003615852","display_name":"Timothy A. Springer","orcid":"https://orcid.org/0000-0001-6627-2904","observed_orcids":["https://orcid.org/0000-0001-6627-2904"]},"institutions":[{"id":"https://openalex.org/I4210129820","display_name":"Evans Analytical Group (United States)","ror":"https://ror.org/03f0b2d64","country_code":"US","type":"company","lineage":["https://openalex.org/I4210129820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy A. Springer","raw_affiliation_strings":["EAG Laboratories, Easton, MD 21601, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EAG Laboratories, Easton, MD 21601, USA","institution_ids":["https://openalex.org/I4210129820"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Timothy L. Ross","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129820","display_name":"Evans Analytical Group (United States)","ror":"https://ror.org/03f0b2d64","country_code":"US","type":"company","lineage":["https://openalex.org/I4210129820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy L. Ross","raw_affiliation_strings":["EAG Laboratories, Easton, MD 21601, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EAG Laboratories, Easton, MD 21601, USA","institution_ids":["https://openalex.org/I4210129820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016860218","display_name":"Kent B. Woodburn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kent B. Woodburn","raw_affiliation_strings":["Dow Corning Corporation, Midland, MI 48686, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dow Corning Corporation, Midland, MI 48686, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083136101","display_name":"Jeremy Durham","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeremy A. Durham","raw_affiliation_strings":["Dow Corning Corporation, Midland, MI 48686, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dow Corning Corporation, Midland, MI 48686, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071770917","display_name":"Debra A. McNett","orcid":"https://orcid.org/0000-0002-0426-5773","observed_orcids":["https://orcid.org/0000-0002-0426-5773"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Debra A. McNett","raw_affiliation_strings":["Dow Corning Corporation, Midland, MI 48686, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dow Corning Corporation, Midland, MI 48686, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110168922"],"corresponding_institution_ids":[],"apc_list":{"value":4270,"currency":"USD","value_usd":4270},"apc_paid":{"value":4270,"currency":"USD","value_usd":4270},"fwci":0.2947,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.54685263,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"279","issue":null,"first_page":"115","last_page":"124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.6044999957084656,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.6044999957084656,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.37059998512268066,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11869","display_name":"Per- and polyfluoroalkyl substances research","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/octamethylcyclotetrasiloxane","display_name":"octamethylcyclotetrasiloxane","score":0.9739999771118164},{"id":"https://openalex.org/keywords/decamethylcyclopentasiloxane","display_name":"decamethylcyclopentasiloxane","score":0.9959999918937683},{"id":"https://openalex.org/keywords/siloxanes","display_name":"siloxanes","score":0.8989999890327454},{"id":"https://openalex.org/keywords/d4","display_name":"D4","score":0.6380000114440918},{"id":"https://openalex.org/keywords/d5","display_name":"D5","score":0.9959999918937683},{"id":"https://openalex.org/keywords/rainbow-trout","display_name":"rainbow trout","score":0.972000002861023},{"id":"https://openalex.org/keywords/metabolism","display_name":"metabolism","score":0.6269999742507935},{"id":"https://openalex.org/keywords/bioaccumulation","display_name":"bioaccumulation","score":0.6079999804496765},{"id":"https://openalex.org/keywords/biomagnification","display_name":"biomagnification","score":0.8090000152587891},{"id":"https://openalex.org/keywords/elimination-half-life","display_name":"elimination half-life","score":0.6449999809265137},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.7350000143051147},{"id":"https://openalex.org/keywords/bile","display_name":"bile","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C2994167347","wikidata":"https://www.wikidata.org/wiki/Q187986","display_name":"Rainbow trout","level":3,"score":0.7601900100708008},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7361613512039185},{"id":"https://openalex.org/C71572567","wikidata":"https://www.wikidata.org/wiki/Q864231","display_name":"Bioaccumulation","level":2,"score":0.7297906279563904},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.6365887522697449},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.6346357464790344},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.607781171798706},{"id":"https://openalex.org/C2777118750","wikidata":"https://www.wikidata.org/wiki/Q2013804","display_name":"Octamethylcyclotetrasiloxane","level":2,"score":0.5285374522209167},{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.47593024373054504},{"id":"https://openalex.org/C2780473477","wikidata":"https://www.wikidata.org/wiki/Q3072135","display_name":"Toxicant","level":3,"score":0.46067744493484497},{"id":"https://openalex.org/C2779363728","wikidata":"https://www.wikidata.org/wiki/Q2258881","display_name":"Trout","level":3,"score":0.45261603593826294},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.4105185866355896},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40420907735824585},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4012991487979889},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.40053823590278625},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3347999155521393},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.296575665473938},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.2589854598045349},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17958199977874756},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.1760256290435791},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1656515896320343},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11270388960838318},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.08933556079864502},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.06558284163475037},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002247","descriptor_name":"Carbon Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004785","descriptor_name":"Environmental Pollutants","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004785","descriptor_name":"Environmental Pollutants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004785","descriptor_name":"Environmental Pollutants","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004785","descriptor_name":"Environmental Pollutants","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D011239","descriptor_name":"Prednisolone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D012833","descriptor_name":"Siloxanes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012833","descriptor_name":"Siloxanes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D017686","descriptor_name":"Oncorhynchus mykiss","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.toxlet.2017.03.025","doi":"https://doi.org/10.1016/j.toxlet.2017.03.025","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.toxlet.2017.03.025","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0378427417301273/pdf","source":{"id":"https://openalex.org/S205878144","display_name":"Toxicology Letters","issn_l":"0378-4274","issn":["0378-4274","1879-3169"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology Letters","raw_type":"journal-article"},{"id":"pmid:28438492","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28438492","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology letters","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.1016/j.toxlet.2017.03.025","doi":"https://doi.org/10.1016/j.toxlet.2017.03.025","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.toxlet.2017.03.025","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0378427417301273/pdf","source":{"id":"https://openalex.org/S205878144","display_name":"Toxicology Letters","issn_l":"0378-4274","issn":["0378-4274","1879-3169"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology Letters","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306107","display_name":"U.S. Environmental Protection Agency","ror":"https://ror.org/03tns0030"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2606785697.pdf","grobid_xml":"https://content.openalex.org/works/W2606785697.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1965152879","https://openalex.org/W1965903351","https://openalex.org/W1968036702","https://openalex.org/W1975732240","https://openalex.org/W1985824626","https://openalex.org/W2002308373","https://openalex.org/W2003306671","https://openalex.org/W2023398726","https://openalex.org/W2028451685","https://openalex.org/W2046476702","https://openalex.org/W2058244162","https://openalex.org/W2074017920","https://openalex.org/W2099205675","https://openalex.org/W2099219696","https://openalex.org/W2123182418","https://openalex.org/W2144699649","https://openalex.org/W2154380528","https://openalex.org/W2157707587","https://openalex.org/W2161525665","https://openalex.org/W2170269880","https://openalex.org/W2170482285","https://openalex.org/W2183525506","https://openalex.org/W2320680154","https://openalex.org/W2322675639","https://openalex.org/W4231586921"],"related_works":["https://openalex.org/W2003306671","https://openalex.org/W4399118986","https://openalex.org/W3012359665","https://openalex.org/W2087680759","https://openalex.org/W2754578766","https://openalex.org/W3164729555","https://openalex.org/W2154462752","https://openalex.org/W3140098741","https://openalex.org/W3184364331","https://openalex.org/W2027001678"],"abstract_inverted_index":{"Critical":[0],"factors":[1],"(uptake,":[2],"distribution,":[3],"metabolism":[4,41,178],"and":[5,15,36,73,87,105,109,112,114,119,133,146,164,171,185,193,201,246,265,317],"elimination)":[6],"for":[7,117,131,135,231],"understanding":[8],"the":[9,29,33,68,79,82,90,97,126,205,214,227,250,261,270,274,279,291,294,314],"bioaccumulation/biomagnification":[10],"potential":[11],"of":[12,32,81,89,99,125,160,169,182,198,204,211,249,269,281,306,320],"Octamethylcyclotetrasiloxane":[13],"(D4)":[14,72,163,184,200,245],"Decamethylcyclopentasiloxane":[16],"(D5)":[17,75,203,248],"siloxanes":[18],"in":[19,45,102,139,176,189,213,220,237,260,273,293,309],"fish":[20,215],"were":[21,144,234,257],"investigated":[22],"to":[23,254,278],"address":[24],"whether":[25],"these":[26],"chemicals":[27],"meet":[28],"\u201cB\u201d":[30],"criteria":[31],"Persistent,":[34],"Bioaccumulative,":[35],"Toxic":[37],"(PBT)":[38],"classification.":[39],"A":[40,122],"study":[42,83],"was":[43,63,76,93,137,219,229,252,276,296],"conducted":[44],"rainbow":[46],"trout":[47],"whereby":[48],"a":[49,58,196,286],"15":[50],"mg":[51],"[14C]D4/kg":[52],"bw":[53,56],"or":[54,150],"[14C]D5/kg":[55],"as":[57],"single":[59],"bolus":[60],"oral":[61],"dose":[62,92,101,128],"administered":[64,69],"via":[65,303,313],"gavage.":[66],"Of":[67],"dose,":[70],"79%":[71],"78%":[74],"recovered":[77,91,100,127],"by":[78,224],"end":[80],"(96-h).":[84],"Eighty-two":[85],"percent":[86],"25%":[88],"absorbed":[94,206],"based":[95],"on":[96],"percentage":[98],"carcass":[103],"(69%":[104],"17%),":[106],"tissues,":[107,190],"bile":[108,310],"blood":[110,142,152,173],"(12%":[111],"8%)":[113],"urine":[115,194,295],"(1%)":[116],"D4":[118,132,149,217],"D5,":[120],"respectively.":[121],"significant":[123],"portion":[124],"(i.e.":[129],"18%":[130],"75%":[134],"D5)":[136],"eliminated":[138],"feces.":[140],"Maximum":[141],"concentrations":[143,174],"1.6":[145],"1.4":[147],"\u03bcg":[148],"D5/g":[151],"at":[153],"24":[154],"h":[155,162,166],"post-dosing,":[156],"with":[157,298,311],"elimination":[158,284],"half-lives":[159],"39":[161],"70":[165],"(D5).":[167],"Modeling":[168],"parent":[170,240],"metabolite":[172],"resulted":[175],"estimated":[177],"rate":[179],"constants":[180],"(km(blood))":[181],"0.15":[183],"0.17":[186],"day\u22121(D5).":[187],"Metabolites":[188,233,256],"bile,":[191,225,243],"blood,":[192],"totaled":[195],"minimum":[197],"2%":[199],"14%":[202],"dose.":[207],"The":[208],"highest":[209],"concentration":[210],"14C-activity":[212,251,271,292],"following":[216],"administration":[218],"mesenteric":[221],"fat":[222],"followed":[223],"but":[226,289],"opposite":[228],"true":[230],"D5.":[232],"not":[235],"detected":[236,259,272],"fat,":[238],"only":[239],"chemical.":[241],"In":[242],"94%":[244],"99%":[247],"due":[253,277],"metabolites.":[255,282,299,322],"also":[258],"digestive":[262,315],"tract,":[263],"liver":[264,275],"gonads.":[266],"Approximately":[267],"40%":[268],"presence":[280],"Urinary":[283],"represented":[285],"minor":[287],"pathway,":[288],"all":[290],"associated":[297],"Clearance":[300],"may":[301],"occur":[302],"enterohepatic":[304],"circulation":[305],"metabolic":[307],"products":[308],"excretion":[312],"tract":[316],"urinary":[318],"clearance":[319],"polar":[321]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-04-28T00:00:00"}