{"id":"https://openalex.org/W26066121","doi":null,"title":"Propofol changes the cytoskeletal function in neurons : An experimental study in cortical cultures","display_name":"Propofol changes the cytoskeletal function in neurons : An experimental study in cortical cultures","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W26066121","mag":"26066121"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:liu-77219","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-77219","pdf_url":null,"source":{"id":"https://openalex.org/S4306400838","display_name":"DiVA (Linkoping University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102134673","host_organization_name":"Link\u00f6ping University","host_organization_lineage":["https://openalex.org/I102134673"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-77219","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061855591","display_name":"Dean Turina","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dean Turina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5061855591"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.02889999933540821,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propofol","display_name":"propofol","score":0.9980000257492065},{"id":"https://openalex.org/keywords/thiopental","display_name":"thiopental","score":1.0},{"id":"https://openalex.org/keywords/general-anesthesia","display_name":"general anesthesia","score":0.7360000014305115},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"cytoskeleton","score":0.7730000019073486},{"id":"https://openalex.org/keywords/neurite-retraction","display_name":"neurite retraction","score":0.996999979019165},{"id":"https://openalex.org/keywords/cortical-neurons","display_name":"cortical neurons","score":0.6650000214576721},{"id":"https://openalex.org/keywords/myosin-ii","display_name":"myosin II","score":0.8029999732971191},{"id":"https://openalex.org/keywords/rhoa","display_name":"RhoA","score":0.7590000033378601},{"id":"https://openalex.org/keywords/rok","display_name":"Rok","score":0.9020000100135803},{"id":"https://openalex.org/keywords/myosin-light-chain-phosphorylation","display_name":"myosin light chain phosphorylation","score":0.9829999804496765},{"id":"https://openalex.org/keywords/anterograde-transport","display_name":"anterograde transport","score":0.9599999785423279},{"id":"https://openalex.org/keywords/gaba-a-receptor","display_name":"GABAA receptor","score":0.9210000038146973},{"id":"https://openalex.org/keywords/orexin-a","display_name":"orexin-A","score":0.9879999756813049},{"id":"https://openalex.org/keywords/anesthetic-mechanisms","display_name":"anesthetic mechanisms","score":0.5109999775886536},{"id":"https://openalex.org/keywords/motor-proteins","display_name":"motor proteins","score":0.4320000112056732}],"concepts":[{"id":"https://openalex.org/C2776277131","wikidata":"https://www.wikidata.org/wiki/Q422740","display_name":"Propofol","level":2,"score":0.705736517906189},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.5437376499176025},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5250468254089355},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5107810497283936},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3639479875564575},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3632517457008362},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.341441810131073},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2790943384170532},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2764495611190796},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.1454475224018097},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11737188696861267}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:liu-77219","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-77219","pdf_url":null,"source":{"id":"https://openalex.org/S4306400838","display_name":"DiVA (Linkoping University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102134673","host_organization_name":"Link\u00f6ping University","host_organization_lineage":["https://openalex.org/I102134673"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:26066121","doi":null,"is_oa":false,"landing_page_url":"http://liu.diva-portal.org/smash/get/diva2:525640/FULLTEXT02.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:liu-77219","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-77219","pdf_url":null,"source":{"id":"https://openalex.org/S4306400838","display_name":"DiVA (Linkoping University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102134673","host_organization_name":"Link\u00f6ping University","host_organization_lineage":["https://openalex.org/I102134673"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":187,"referenced_works":["https://openalex.org/W255797560","https://openalex.org/W576610066","https://openalex.org/W1487622456","https://openalex.org/W1508109266","https://openalex.org/W1565010155","https://openalex.org/W1588401088","https://openalex.org/W1701778517","https://openalex.org/W1840025613","https://openalex.org/W1867653098","https://openalex.org/W1908131908","https://openalex.org/W1914381346","https://openalex.org/W1914409163","https://openalex.org/W1944127753","https://openalex.org/W1966087347","https://openalex.org/W1966090439","https://openalex.org/W1966197218","https://openalex.org/W1967916768","https://openalex.org/W1969146881","https://openalex.org/W1970083960","https://openalex.org/W1970429382","https://openalex.org/W1971388525","https://openalex.org/W1972223549","https://openalex.org/W1973501949","https://openalex.org/W1973977212","https://openalex.org/W1978348024","https://openalex.org/W1980056833","https://openalex.org/W1980401085","https://openalex.org/W1980521348","https://openalex.org/W1983336698","https://openalex.org/W1983832143","https://openalex.org/W1985963215","https://openalex.org/W1987878093","https://openalex.org/W1988185095","https://openalex.org/W1988202839","https://openalex.org/W1989497077","https://openalex.org/W1991781635","https://openalex.org/W1995071826","https://openalex.org/W1997310558","https://openalex.org/W1997899750","https://openalex.org/W1999362921","https://openalex.org/W1999889873","https://openalex.org/W2002001840","https://openalex.org/W2002774520","https://openalex.org/W2002980966","https://openalex.org/W2005829018","https://openalex.org/W2007197433","https://openalex.org/W2008691195","https://openalex.org/W2008908272","https://openalex.org/W2010825778","https://openalex.org/W2011526908","https://openalex.org/W2012418765","https://openalex.org/W2012982950","https://openalex.org/W2015193381","https://openalex.org/W2017237202","https://openalex.org/W2017269193","https://openalex.org/W2018709028","https://openalex.org/W2020080842","https://openalex.org/W2023491924","https://openalex.org/W2023505996","https://openalex.org/W2024348439","https://openalex.org/W2024677729","https://openalex.org/W2025256394","https://openalex.org/W2025621727","https://openalex.org/W2027740042","https://openalex.org/W2027858713","https://openalex.org/W2028401432","https://openalex.org/W2029060613","https://openalex.org/W2029854919","https://openalex.org/W2031483478","https://openalex.org/W2032084773","https://openalex.org/W2032150201","https://openalex.org/W2032247326","https://openalex.org/W2034059302","https://openalex.org/W2034480539","https://openalex.org/W2034485704","https://openalex.org/W2035252578","https://openalex.org/W2035504473","https://openalex.org/W2035847543","https://openalex.org/W2036394243","https://openalex.org/W2036880132","https://openalex.org/W2037373911","https://openalex.org/W2038954901","https://openalex.org/W2039205173","https://openalex.org/W2040380855","https://openalex.org/W2041168804","https://openalex.org/W2042256368","https://openalex.org/W2042856479","https://openalex.org/W2043533591","https://openalex.org/W2045565980","https://openalex.org/W2050393788","https://openalex.org/W2052534601","https://openalex.org/W2053659412","https://openalex.org/W2056289431","https://openalex.org/W2056792142","https://openalex.org/W2056979092","https://openalex.org/W2057227458","https://openalex.org/W2058185503","https://openalex.org/W2059131440","https://openalex.org/W2059364848","https://openalex.org/W2060262374","https://openalex.org/W2061910437","https://openalex.org/W2062104741","https://openalex.org/W2062116207","https://openalex.org/W2062347154","https://openalex.org/W2063586074","https://openalex.org/W2065331372","https://openalex.org/W2065477127","https://openalex.org/W2065702465","https://openalex.org/W2067025602","https://openalex.org/W2067080343","https://openalex.org/W2067605157","https://openalex.org/W2068837044","https://openalex.org/W2069110301","https://openalex.org/W2069570693","https://openalex.org/W2072555000","https://openalex.org/W2072827698","https://openalex.org/W2074671627","https://openalex.org/W2075439767","https://openalex.org/W2076465743","https://openalex.org/W2077015506","https://openalex.org/W2077056852","https://openalex.org/W2077993124","https://openalex.org/W2078314552","https://openalex.org/W2078486462","https://openalex.org/W2080858652","https://openalex.org/W2081141873","https://openalex.org/W2082848204","https://openalex.org/W2082903545","https://openalex.org/W2082965242","https://openalex.org/W2083104604","https://openalex.org/W2083217606","https://openalex.org/W2084236159","https://openalex.org/W2084323003","https://openalex.org/W2085877716","https://openalex.org/W2086475877","https://openalex.org/W2087748297","https://openalex.org/W2089280969","https://openalex.org/W2092273976","https://openalex.org/W2095535375","https://openalex.org/W2096104904","https://openalex.org/W2100231995","https://openalex.org/W2100728233","https://openalex.org/W2100837269","https://openalex.org/W2102247077","https://openalex.org/W2104389482","https://openalex.org/W2105954846","https://openalex.org/W2108697158","https://openalex.org/W2110158782","https://openalex.org/W2110690118","https://openalex.org/W2112164209","https://openalex.org/W2112639978","https://openalex.org/W2117406052","https://openalex.org/W2119295015","https://openalex.org/W2124508356","https://openalex.org/W2126764433","https://openalex.org/W2127562971","https://openalex.org/W2135801855","https://openalex.org/W2135826809","https://openalex.org/W2136037216","https://openalex.org/W2136325018","https://openalex.org/W2137626813","https://openalex.org/W2137779201","https://openalex.org/W2137796933","https://openalex.org/W2139367190","https://openalex.org/W2140594985","https://openalex.org/W2141226032","https://openalex.org/W2144196501","https://openalex.org/W2146375752","https://openalex.org/W2148347215","https://openalex.org/W2149164049","https://openalex.org/W2149456573","https://openalex.org/W2152211310","https://openalex.org/W2152959849","https://openalex.org/W2158372492","https://openalex.org/W2161870304","https://openalex.org/W2161957669","https://openalex.org/W2165419593","https://openalex.org/W2165793986","https://openalex.org/W2166277020","https://openalex.org/W2170019668","https://openalex.org/W2266799572","https://openalex.org/W2319407756","https://openalex.org/W2401059362","https://openalex.org/W2404852610","https://openalex.org/W2417577104","https://openalex.org/W2418359432","https://openalex.org/W2463329501"],"related_works":["https://openalex.org/W207080209","https://openalex.org/W206300910","https://openalex.org/W2122778155","https://openalex.org/W11444415","https://openalex.org/W2071769172","https://openalex.org/W2103729449","https://openalex.org/W1988202839","https://openalex.org/W2032084773","https://openalex.org/W2165793986","https://openalex.org/W2791596813"],"abstract_inverted_index":{"Every":[0],"day,":[1],"general":[2],"anaesthetics":[3,21,28,83],"are":[4,23,108],"given":[5,350],"to":[6,56,120,133,146,190,237,306,344,435],"a":[7,44,85,149,176,263,278,302,332,414,431],"large":[8],"number":[9],"of":[10,19,53,67,70,87,178,194,202,281,287,314,375,394],"patients":[11],"around":[12],"the":[13,16,30,68,88,96,121,131,179,192,199,249,255,288,311,315,336,371,382,391,395,459],"world":[14],"but":[15,38,185],"cellular":[17,140],"mechanisms":[18],"how":[20],"act":[22],"still":[24],"not":[25,103],"clear.":[26],"General":[27],"cause":[29,84,214],"intended":[31],"unconsciousness,":[32],"amnesia":[33],"and":[34,50,62,91,106,124,137,142,147,153,164,196,212,217,224,226,292,309,339,359,363,388,416,419,445,449],"immobility":[35],"in":[36,46,115,139,183,318,347,423,439],"patients,":[37],"also":[39,341,429],"side":[40],"effects":[41,193,221],"such":[42,58],"as":[43,59],"decrease":[45],"mean":[47],"arterial":[48],"pressure":[49],"arrhythmia,":[51],"both":[52,109],"which":[54,284,334,400],"contribute":[55],"complications":[57,74],"heart":[60],"damage":[61],"stroke.":[63],"With":[64],"more":[65],"knowledge":[66],"mechanism":[69],"anaesthetic":[71,111],"drugs,":[72],"these":[73,408],"could":[75],"be":[76,228],"reduced.":[77],"It":[78],"has":[79,340],"been":[80,342],"shown":[81,172,261,298,343,369],"that":[82,160,173,210,262,299,354,370,411],"disruption":[86],"thalamocortical":[89],"connectivity":[90],"brain":[92],"network":[93,97],"connectivity.":[94],"How":[95],"communication":[98],"is":[99,102,155,232,331,379,401],"disrupted":[100],"however":[101],"known.":[104],"Propofol":[105,387,428],"thiopental":[107,197,213,389],"intravenous":[110],"drugs":[112],"used":[113],"widely":[114],"clinical":[116],"anaesthesia.":[117],"They":[118],"bind":[119],"GABAA":[122,256,327],"receptor":[123],"enhance":[125],"its":[126,135],"function.":[127],"The":[128,320],"cytoskeleton":[129,180],"helps":[130],"cell":[132,151],"maintain":[134],"shape":[136],"participate":[138],"movement":[141],"transport.":[143],"Cellular":[144],"transport":[145,308,325,438],"from":[148,304,433],"neuron\u2019s":[150],"body":[152],"periphery":[154],"performed":[156],"by":[157,246,403],"motor":[158,250],"proteins":[159,165],"move":[161],"vesicles,":[162],"organelles":[163],"along":[166],"cytoskeletal":[167,200,397,450],"tracks.":[168],"We":[169,234,258,352],"have":[170,259,297,368],"previously":[171,260],"propofol":[174,195,211,231,300,321,358,412,444],"causes":[175,301,413,430],"reorganisation":[177],"protein":[181,251,398],"actin":[182,245,270,364],"neurons,":[184],"we":[186,243,296,367],"were":[187,222,235],"further":[188],"interested":[189],"study":[191],"on":[198],"function":[201],"cultured":[203,424],"cortical":[204,425],"rat":[205,426],"neurons.":[206,427],"Our":[207],"results":[208,409],"show":[209],"neurite":[215,240,273,361,377,421,447,456],"(axon":[216],"dendrite)":[218],"retraction.":[219],"Propofol\u2019s":[220],"time-":[223,415],"dose-dependent,":[225,417],"can":[227],"reversed":[229,402],"when":[230,349],"removed.":[233],"able":[236],"inhibit":[238],"propofolinduced":[239],"retraction":[241,274,362,378,422,448,457],"if":[242],"stabilised":[244],"blocking":[247],"either":[248],"myosin":[252,289],"II":[253],"or":[254],"receptor.":[257],"small":[264],"GTP-binding":[265],"protein,":[266],"RhoA,":[267,282],"inhibits":[268,454],"propofol-caused":[269],"reorganisation.":[271,365,451],"Propofol-induced":[272],"was":[275,326],"mediated":[276,380],"via":[277,381,458],"downstream":[279],"effector":[280],"ROK,":[283],"induces":[285],"phosphorylation":[286],"light":[290],"chain":[291],"increases":[293,310],"contractility.":[294],"Furthermore,":[295],"switch":[303,432],"anterograde":[305,434],"retrograde":[307,323,436],"average":[312],"velocity":[313],"moving":[316],"vesicles":[317],"neurites.":[319,440],"induced":[322],"vesicle":[324,437],"receptor-mediated.":[328],"Orexin":[329,441,452],"A":[330,356,373,442,453],"neuropeptide":[333],"regulates":[335],"sleep/awake":[337],"cycle":[338],"reduce":[345],"anaesthesia":[346],"animals":[348],"intracerebroventricularly.":[351],"found":[353],"orexin":[355,372,404],"reverses":[357,443],"thiopental-induced":[360,446],"Moreover,":[366],"inhibition":[374],"propofol-induced":[376,455],"PLD/PKC":[383,460],"intracellular":[384,461],"signalling":[385,462],"pathway.":[386,463],"decreased":[390],"tyrosine":[392],"phosphorilation":[393],"intermediate":[396],"vimentin":[399],"A.":[405],"Taken":[406],"together,":[407],"suggest":[410],"reversible":[418],"GABAAreceptor-mediated":[420]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}
