{"id":"https://openalex.org/W2606592012","doi":"https://doi.org/10.19163/2307-9266-2016-4-6-54-71","title":"Method development and validation for determination of antihemolytic activity of eculizumab (Soliris)","display_name":"Method development and validation for determination of antihemolytic activity of eculizumab (Soliris)","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2606592012","doi":"https://doi.org/10.19163/2307-9266-2016-4-6-54-71","mag":"2606592012"},"language":"en","primary_location":{"id":"doi:10.19163/2307-9266-2016-4-6-54-71","doi":"https://doi.org/10.19163/2307-9266-2016-4-6-54-71","is_oa":true,"landing_page_url":"https://doi.org/10.19163/2307-9266-2016-4-6-54-71","pdf_url":"https://www.pharmpharm.ru/jour/article/download/224/337","source":{"id":"https://openalex.org/S2737365290","display_name":"Pharmacy & Pharmacology","issn_l":"2307-9266","issn":["2307-9266","2413-2241"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-d","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312629","host_organization_name":"Pyatigorsk Medical and Pharmaceutical Institute - branch of Volgograd State Medical University","host_organization_lineage":["https://openalex.org/P4310312629"],"host_organization_lineage_names":["Pyatigorsk Medical and Pharmaceutical Institute - branch of Volgograd State Medical University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacy & Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.pharmpharm.ru/jour/article/download/224/337","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093546987","display_name":"E. Yu. Prudnikova","orcid":"https://orcid.org/0000-0002-7983-5312","observed_orcids":["https://orcid.org/0000-0002-7983-5312"]},"institutions":[{"id":"https://openalex.org/I4405272539","display_name":"Generium Pharmaceuticals (Russia)","ror":"https://ror.org/04anvdv29","country_code":"RU","type":"company","lineage":["https://openalex.org/I4405272539"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E. Yu. Prudnikova","raw_affiliation_strings":["International Biotechnology Center \u00abGenerium\u00bb , 601125 , Russia , Vladimir region , Volginskiy","\u041c\u0435\u0436\u0434\u0443\u043d\u0430\u0440\u043e\u0434\u043d\u044b\u0439 \u0431\u0438\u043e\u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0446\u0435\u043d\u0442\u0440 \u00ab\u0413\u0435\u043d\u0435\u0440\u0438\u0443\u043c\u00bb"],"raw_orcid":"https://orcid.org/0000-0002-7983-5312","affiliations":[{"raw_affiliation_string":"International Biotechnology Center \u00abGenerium\u00bb , 601125 , Russia , Vladimir region , Volginskiy","institution_ids":["https://openalex.org/I4405272539"]},{"raw_affiliation_string":"\u041c\u0435\u0436\u0434\u0443\u043d\u0430\u0440\u043e\u0434\u043d\u044b\u0439 \u0431\u0438\u043e\u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0446\u0435\u043d\u0442\u0440 \u00ab\u0413\u0435\u043d\u0435\u0440\u0438\u0443\u043c\u00bb","institution_ids":["https://openalex.org/I4405272539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002783437","display_name":"G. N. Poroshin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405272539","display_name":"Generium Pharmaceuticals (Russia)","ror":"https://ror.org/04anvdv29","country_code":"RU","type":"company","lineage":["https://openalex.org/I4405272539"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"G. N. Poroshin","raw_affiliation_strings":["International Biotechnology Center \u00abGenerium\u00bb , 601125 , Russia , Vladimir region , Volginskiy","\u041c\u0435\u0436\u0434\u0443\u043d\u0430\u0440\u043e\u0434\u043d\u044b\u0439 \u0431\u0438\u043e\u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0446\u0435\u043d\u0442\u0440 \u00ab\u0413\u0435\u043d\u0435\u0440\u0438\u0443\u043c\u00bb"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Biotechnology Center \u00abGenerium\u00bb , 601125 , Russia , Vladimir region , Volginskiy","institution_ids":["https://openalex.org/I4405272539"]},{"raw_affiliation_string":"\u041c\u0435\u0436\u0434\u0443\u043d\u0430\u0440\u043e\u0434\u043d\u044b\u0439 \u0431\u0438\u043e\u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0446\u0435\u043d\u0442\u0440 \u00ab\u0413\u0435\u043d\u0435\u0440\u0438\u0443\u043c\u00bb","institution_ids":["https://openalex.org/I4405272539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050180563","display_name":"N. K. Kudina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405272539","display_name":"Generium Pharmaceuticals (Russia)","ror":"https://ror.org/04anvdv29","country_code":"RU","type":"company","lineage":["https://openalex.org/I4405272539"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"N. K. Kudina","raw_affiliation_strings":["International Biotechnology Center \u00abGenerium\u00bb , 601125 , Russia , Vladimir region , Volginskiy","\u041c\u0435\u0436\u0434\u0443\u043d\u0430\u0440\u043e\u0434\u043d\u044b\u0439 \u0431\u0438\u043e\u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0446\u0435\u043d\u0442\u0440 \u00ab\u0413\u0435\u043d\u0435\u0440\u0438\u0443\u043c\u00bb"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Biotechnology Center \u00abGenerium\u00bb , 601125 , Russia , Vladimir region , Volginskiy","institution_ids":["https://openalex.org/I4405272539"]},{"raw_affiliation_string":"\u041c\u0435\u0436\u0434\u0443\u043d\u0430\u0440\u043e\u0434\u043d\u044b\u0439 \u0431\u0438\u043e\u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0446\u0435\u043d\u0442\u0440 \u00ab\u0413\u0435\u043d\u0435\u0440\u0438\u0443\u043c\u00bb","institution_ids":["https://openalex.org/I4405272539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060029889","display_name":"Ivan V. Lyagoskin","orcid":"https://orcid.org/0000-0002-9058-1106","observed_orcids":["https://orcid.org/0000-0002-9058-1106"]},"institutions":[{"id":"https://openalex.org/I4405272539","display_name":"Generium Pharmaceuticals (Russia)","ror":"https://ror.org/04anvdv29","country_code":"RU","type":"company","lineage":["https://openalex.org/I4405272539"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"I. V. Lyagoskin","raw_affiliation_strings":["International Biotechnology Center \u00abGenerium\u00bb , 601125 , Russia , Vladimir region , Volginskiy","\u041c\u0435\u0436\u0434\u0443\u043d\u0430\u0440\u043e\u0434\u043d\u044b\u0439 \u0431\u0438\u043e\u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0446\u0435\u043d\u0442\u0440 \u00ab\u0413\u0435\u043d\u0435\u0440\u0438\u0443\u043c\u00bb"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Biotechnology Center \u00abGenerium\u00bb , 601125 , Russia , Vladimir region , Volginskiy","institution_ids":["https://openalex.org/I4405272539"]},{"raw_affiliation_string":"\u041c\u0435\u0436\u0434\u0443\u043d\u0430\u0440\u043e\u0434\u043d\u044b\u0439 \u0431\u0438\u043e\u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0446\u0435\u043d\u0442\u0440 \u00ab\u0413\u0435\u043d\u0435\u0440\u0438\u0443\u043c\u00bb","institution_ids":["https://openalex.org/I4405272539"]}]},{"author_position":"middle","author":{"id":null,"display_name":"E. V. Sazonova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405272539","display_name":"Generium Pharmaceuticals (Russia)","ror":"https://ror.org/04anvdv29","country_code":"RU","type":"company","lineage":["https://openalex.org/I4405272539"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E. V. Sazonova","raw_affiliation_strings":["International Biotechnology Center \u00abGenerium\u00bb , 601125 , Russia , Vladimir region , Volginskiy","\u041c\u0435\u0436\u0434\u0443\u043d\u0430\u0440\u043e\u0434\u043d\u044b\u0439 \u0431\u0438\u043e\u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0446\u0435\u043d\u0442\u0440 \u00ab\u0413\u0435\u043d\u0435\u0440\u0438\u0443\u043c\u00bb"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Biotechnology Center \u00abGenerium\u00bb , 601125 , Russia , Vladimir region , Volginskiy","institution_ids":["https://openalex.org/I4405272539"]},{"raw_affiliation_string":"\u041c\u0435\u0436\u0434\u0443\u043d\u0430\u0440\u043e\u0434\u043d\u044b\u0439 \u0431\u0438\u043e\u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0446\u0435\u043d\u0442\u0440 \u00ab\u0413\u0435\u043d\u0435\u0440\u0438\u0443\u043c\u00bb","institution_ids":["https://openalex.org/I4405272539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027722529","display_name":"\u0410. \u042e. \u0412\u0438\u0448\u043d\u0435\u0432\u0441\u043a\u0438\u0439","orcid":"https://orcid.org/0000-0002-7865-9361","observed_orcids":["https://orcid.org/0000-0002-7865-9361"]},"institutions":[{"id":"https://openalex.org/I4405272539","display_name":"Generium Pharmaceuticals (Russia)","ror":"https://ror.org/04anvdv29","country_code":"RU","type":"company","lineage":["https://openalex.org/I4405272539"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. Yu. Vishnevskiy","raw_affiliation_strings":["International Biotechnology Center \u00abGenerium\u00bb, 601125, Russia, Vladimir region, Volginskiy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Biotechnology Center \u00abGenerium\u00bb, 601125, Russia, Vladimir region, Volginskiy","institution_ids":["https://openalex.org/I4405272539"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071080340","display_name":"S. G. Abbasova","orcid":"https://orcid.org/0000-0001-5841-7587","observed_orcids":["https://orcid.org/0000-0001-5841-7587"]},"institutions":[{"id":"https://openalex.org/I4405272539","display_name":"Generium Pharmaceuticals (Russia)","ror":"https://ror.org/04anvdv29","country_code":"RU","type":"company","lineage":["https://openalex.org/I4405272539"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"S. G. Abbasova","raw_affiliation_strings":["International Biotechnology Center \u00abGenerium\u00bb , 601125 , Russia , Vladimir region , Volginskiy","\u041c\u0435\u0436\u0434\u0443\u043d\u0430\u0440\u043e\u0434\u043d\u044b\u0439 \u0431\u0438\u043e\u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0446\u0435\u043d\u0442\u0440 \u00ab\u0413\u0435\u043d\u0435\u0440\u0438\u0443\u043c\u00bb"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Biotechnology Center \u00abGenerium\u00bb , 601125 , Russia , Vladimir region , Volginskiy","institution_ids":["https://openalex.org/I4405272539"]},{"raw_affiliation_string":"\u041c\u0435\u0436\u0434\u0443\u043d\u0430\u0440\u043e\u0434\u043d\u044b\u0439 \u0431\u0438\u043e\u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0446\u0435\u043d\u0442\u0440 \u00ab\u0413\u0435\u043d\u0435\u0440\u0438\u0443\u043c\u00bb","institution_ids":["https://openalex.org/I4405272539"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405272539"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"4","issue":"6","first_page":"54","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.5009999871253967,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.5009999871253967,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.461899995803833,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.021299999207258224,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eculizumab","display_name":"eculizumab","score":1.0},{"id":"https://openalex.org/keywords/antihemolytic-activity","display_name":"antihemolytic activity","score":0.9210000038146973},{"id":"https://openalex.org/keywords/method-validation","display_name":"method validation","score":0.7319999933242798},{"id":"https://openalex.org/keywords/bioanalytical-methods","display_name":"bioanalytical methods","score":0.7490000128746033},{"id":"https://openalex.org/keywords/complement-c5-inhibitor","display_name":"complement C5 inhibitor","score":0.6489999890327454},{"id":"https://openalex.org/keywords/human-serum-complement","display_name":"human serum complement","score":0.5759999752044678},{"id":"https://openalex.org/keywords/pharmaceutical-quality-control","display_name":"pharmaceutical quality control","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C137535248","wikidata":"https://www.wikidata.org/wiki/Q4914691","display_name":"Bioanalysis","level":2,"score":0.7649427056312561},{"id":"https://openalex.org/C154020017","wikidata":"https://www.wikidata.org/wiki/Q520171","display_name":"Repeatability","level":2,"score":0.7359808683395386},{"id":"https://openalex.org/C9893847","wikidata":"https://www.wikidata.org/wiki/Q1425625","display_name":"Reproducibility","level":2,"score":0.7212173342704773},{"id":"https://openalex.org/C2777991916","wikidata":"https://www.wikidata.org/wiki/Q421617","display_name":"Eculizumab","level":4,"score":0.6762447953224182},{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.4149574339389801},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.39364519715309143},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36059877276420593},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3321405053138733},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2683749794960022},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.23402640223503113},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.18870270252227783},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12485387921333313},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0785415768623352},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.0},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.19163/2307-9266-2016-4-6-54-71","doi":"https://doi.org/10.19163/2307-9266-2016-4-6-54-71","is_oa":true,"landing_page_url":"https://doi.org/10.19163/2307-9266-2016-4-6-54-71","pdf_url":"https://www.pharmpharm.ru/jour/article/download/224/337","source":{"id":"https://openalex.org/S2737365290","display_name":"Pharmacy & Pharmacology","issn_l":"2307-9266","issn":["2307-9266","2413-2241"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-d","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312629","host_organization_name":"Pyatigorsk Medical and Pharmaceutical Institute - branch of Volgograd State Medical University","host_organization_lineage":["https://openalex.org/P4310312629"],"host_organization_lineage_names":["Pyatigorsk Medical and Pharmaceutical Institute - branch of Volgograd State Medical University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacy & Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:128c2ea0036f46ee9feb019547551465","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/128c2ea0036f46ee9feb019547551465","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0424\u0430\u0440\u043c\u0430\u0446\u0438\u044f \u0438 \u0444\u0430\u0440\u043c\u0430\u043a\u043e\u043b\u043e\u0433\u0438\u044f (\u041f\u044f\u0442\u0438\u0433\u043e\u0440\u0441\u043a), Vol 4, Iss 6, Pp 54-71 (2017)","raw_type":"article"},{"id":"pmh:oai:oai.pmedpharm.elpub.ru:article/224","doi":null,"is_oa":true,"landing_page_url":"http://www.pharmpharm.ru/jour/article/view/224","pdf_url":null,"source":{"id":"https://openalex.org/S2737365290","display_name":"Pharmacy & Pharmacology","issn_l":"2307-9266","issn":["2307-9266","2413-2241"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-d","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312629","host_organization_name":"Pyatigorsk Medical and Pharmaceutical Institute - branch of Volgograd State Medical University","host_organization_lineage":["https://openalex.org/P4310312629"],"host_organization_lineage_names":["Pyatigorsk Medical and Pharmaceutical Institute - branch of Volgograd State Medical University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmacy & Pharmacology; \u0422\u043e\u043c 4, \u2116 6 (2016); 54-71","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.19163/2307-9266-2016-4-6-54-71","doi":"https://doi.org/10.19163/2307-9266-2016-4-6-54-71","is_oa":true,"landing_page_url":"https://doi.org/10.19163/2307-9266-2016-4-6-54-71","pdf_url":"https://www.pharmpharm.ru/jour/article/download/224/337","source":{"id":"https://openalex.org/S2737365290","display_name":"Pharmacy & Pharmacology","issn_l":"2307-9266","issn":["2307-9266","2413-2241"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-d","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312629","host_organization_name":"Pyatigorsk Medical and Pharmaceutical Institute - branch of Volgograd State Medical University","host_organization_lineage":["https://openalex.org/P4310312629"],"host_organization_lineage_names":["Pyatigorsk Medical and Pharmaceutical Institute - branch of Volgograd State Medical University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacy & Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2606592012.pdf","grobid_xml":"https://content.openalex.org/works/W2606592012.grobid-xml"},"referenced_works_count":8,"referenced_works":["https://openalex.org/W1999063686","https://openalex.org/W2004265876","https://openalex.org/W2069260705","https://openalex.org/W2145490488","https://openalex.org/W2152757679","https://openalex.org/W2158938961","https://openalex.org/W2519173411","https://openalex.org/W4213310623"],"related_works":["https://openalex.org/W3028018730","https://openalex.org/W2739914861","https://openalex.org/W4302969660","https://openalex.org/W2889416043","https://openalex.org/W7118004168","https://openalex.org/W2489021157","https://openalex.org/W2199641985","https://openalex.org/W2076689456","https://openalex.org/W3191511786","https://openalex.org/W4400332205"],"abstract_inverted_index":{"Bioanalytical":[0],"methods":[1,72],"are":[2],"applied":[3],"at":[4,14],"the":[5,15,64,76,79,121,124,180,196],"development":[6],"and":[7,22,32,36,109,126,146,162,225],"test":[8],"of":[9,17,30,38,54,60,70,75,78,88,97,101,123,131,177,179,191,195,216],"drugs":[10,226],"as":[11,13],"well":[12],"step":[16],"pharmaceutic":[18],"products":[19],"issue.":[20],"Drugs":[21],"excipients":[23],"quality":[24],"estimation":[25],"is":[26,41,46,57,73],"made":[27],"by":[28],"means":[29],"precise":[31],"reproducible":[33],"methods.":[34],"Accuracy":[35],"reproducibility":[37,142],"a":[39,93],"method":[40,55,94,125,181,197,207],"established":[42],"during":[43,153,171],"validation":[44,56,83],"which":[45],"obligatory":[47],"for":[48,63,95,167,182,213,221],"medicine":[49,81],"registration.":[50],"The":[51,86,155,193,205],"principal":[52],"task":[53],"experimental":[58],"evidence":[59,176],"its":[61,127],"suitability":[62,178],"objectives":[65],"to":[66,91,129,231],"be":[67,209],"achieved.":[68],"Validation":[69],"bioanalytical":[71],"one":[74],"elements":[77],"whole":[80],"production":[82],"[1,":[84],"2].":[85],"aim":[87],"research":[89],":":[90],"validate":[92],"determination":[96,218],"specific":[98,184,214,230],"anti-hemolytic":[99],"activity":[100,185,215],"eculizumab":[102,183],"developed":[103,206],"in":[104,189,202],"LCC":[105],"\u201cIBC":[106],"Generium\u201d.":[107],"Materials":[108],"methods:":[110],"eculizumab,":[111],"antibody-sensitized":[112],"chicken":[113],"erythrocytes,":[114],"complement-containing":[115],"human":[116,232],"serum.":[117],"Results.":[118],"We":[119],"demonstrated":[120],"specificity":[122],"correspondence":[128],"criteria":[130],"accuracy":[132],"(103.0\u00b11.4)%,":[133],"robustness":[134],"(CV":[135,139,143],"\u2013":[136,140,144,151],"11.5%),":[137],"repeatability":[138],"(4.9\u00b10.9)%),":[141],"(3.5\u00b10.4)%),":[145],"linearity":[147],"(k":[148],"-1.0275;":[149],"R2":[150],"0.9975)":[152],"validation.":[154,172,192],"system":[156],"validity":[157],"(equipment,":[158],"materials,":[159],"analytical":[160],"operations":[161],"analyzed":[163],"samples)":[164],"was":[165,187],"confirmed":[166],"true":[168],"results":[169,201],"obtaining":[170,199],"Results":[173],"discussion.":[174],"Experimental":[175],"assessment":[186],"obtained":[188],"course":[190],"simplicity":[194],"allows":[198],"accurate":[200],"other":[203,222],"laboratories.":[204],"can":[208],"used":[210],"not":[211],"only":[212],"Soliris":[217],"but":[219],"also":[220],"pharmaceutical":[223],"substances":[224],"based":[227],"on":[228],"antibodies":[229],"complement":[233],"C5.":[234]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2017-04-28T00:00:00"}