{"id":"https://openalex.org/W2606548969","doi":"https://doi.org/10.6084/m9.figshare.c.3743330_d1","title":"Additional file 1: Figure S1. of Interleukin-1 primes human mesenchymal stem cells towards an anti-inflammatory and pro-trophic phenotype in vitro","display_name":"Additional file 1: Figure S1. of Interleukin-1 primes human mesenchymal stem cells towards an anti-inflammatory and pro-trophic phenotype in vitro","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2606548969","doi":"https://doi.org/10.6084/m9.figshare.c.3743330_d1","mag":"2606548969"},"language":"en","primary_location":{"id":"doi:10.6084/m9.figshare.c.3743330_d1","doi":"https://doi.org/10.6084/m9.figshare.c.3743330_d1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.c.3743330_d1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Image"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.6084/m9.figshare.c.3743330_d1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080492530","display_name":"Elena Redondo\u2010Castro","orcid":"https://orcid.org/0000-0002-6717-9186","observed_orcids":["https://orcid.org/0000-0002-6717-9186"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Redondo-Castro, Elena","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080002760","display_name":"Catriona J. Cunningham","orcid":"https://orcid.org/0000-0002-9216-9414","observed_orcids":["https://orcid.org/0000-0002-9216-9414"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cunningham, Catriona","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042898061","display_name":"Jonjo Miller","orcid":"https://orcid.org/0000-0003-1815-6997","observed_orcids":["https://orcid.org/0000-0003-1815-6997"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonjo Miller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008676516","display_name":"Licia Martuscelli","orcid":"https://orcid.org/0000-0001-8320-7151","observed_orcids":["https://orcid.org/0000-0001-8320-7151"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martuscelli, Licia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074886911","display_name":"Aoulad-Ali Sarah","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aoulad-Ali, Sarah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001134449","display_name":"Nancy J. Rothwell","orcid":"https://orcid.org/0000-0002-3325-3149","observed_orcids":["https://orcid.org/0000-0002-3325-3149"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rothwell, Nancy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071497079","display_name":"Cay M. Kielty","orcid":"https://orcid.org/0000-0003-1610-6881","observed_orcids":["https://orcid.org/0000-0003-1610-6881"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kielty, Cay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006384918","display_name":"Stuart McRae Allan","orcid":"https://orcid.org/0000-0001-9646-4456","observed_orcids":["https://orcid.org/0000-0001-9646-4456"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Allan, Stuart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5075955348","display_name":"Emmanuel Pinteaux","orcid":"https://orcid.org/0000-0002-9986-4401","observed_orcids":["https://orcid.org/0000-0002-9986-4401"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pinteaux, Emmanuel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.9639999866485596},{"id":"https://openalex.org/keywords/interleukin-1-alpha","display_name":"interleukin-1 alpha","score":0.8209999799728394},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.9079999923706055},{"id":"https://openalex.org/keywords/anti-inflammatory-phenotype","display_name":"anti-inflammatory phenotype","score":0.7429999709129333},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.6970000267028809},{"id":"https://openalex.org/keywords/interleukin-1-receptor-antagonist","display_name":"interleukin-1 receptor antagonist","score":0.9589999914169312},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.9340000152587891},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9739999771118164},{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.9070000052452087},{"id":"https://openalex.org/keywords/donor-variability","display_name":"donor variability","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.8493056297302246},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6734020709991455},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5444123148918152},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.46628451347351074},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44881880283355713},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4316747486591339},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38291049003601074},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3352341651916504},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3200925588607788},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18762686848640442},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17374184727668762}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.6084/m9.figshare.c.3743330_d1","doi":"https://doi.org/10.6084/m9.figshare.c.3743330_d1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.c.3743330_d1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Image"},{"id":"doi:10.6084/m9.figshare.c.3743330_d1.v1","doi":"https://doi.org/10.6084/m9.figshare.c.3743330_d1.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.c.3743330_d1.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Image"},{"id":"mag:2606548969","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/Additional_file_1_Figure_S1_of_Interleukin-1_primes_human_mesenchymal_stem_cells_towards_an_anti-inflammatory_and_pro-trophic_phenotype_in_vitro/4880126","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.6084/m9.figshare.c.3743330_d1","doi":"https://doi.org/10.6084/m9.figshare.c.3743330_d1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.c.3743330_d1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Image"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2917389501","https://openalex.org/W2605750225","https://openalex.org/W4404828323","https://openalex.org/W58266109","https://openalex.org/W6902249381","https://openalex.org/W2147409266","https://openalex.org/W2048762993","https://openalex.org/W2897285377","https://openalex.org/W2089442121","https://openalex.org/W2166534114"],"abstract_inverted_index":{"Is":[0],"showing":[1,73],"levels":[2,65],"of":[3,18,34,39,51,66],"cytokines":[4],"secreted":[5],"by":[6,29],"MSCs":[7],"from":[8],"three":[9],"different":[10,69],"donors":[11,47,77],"after":[12,57],"IL-1\u03b1":[13],"or":[14],"IL-1\u03b2":[15],"treatment.":[16],"Secretion":[17],"VEGF":[19],"(A,":[20],"B)":[21],"and":[22,55],"NGF":[23],"(C,":[24],"D)":[25],"was":[26],"not":[27],"modified":[28],"any":[30,33],"treatments":[31,59],"in":[32,45,63,70,75],"the":[35,64],"donors,":[36],"but":[37],"secretion":[38],"IL-10":[40],"showed":[41],"a":[42],"non-significant":[43],"increase":[44],"some":[46,76],"(E,":[48],"F).":[49],"Levels":[50],"IL-1Ra":[52],"were":[53,68],"high":[54],"unchanged":[56],"IL-1":[58],"(G,":[60],"H).":[61],"Changes":[62],"BDNF":[67],"each":[71],"donor,":[72],"significance":[74],"(I,":[78],"J)":[79],"(n":[80],"=":[81],"3":[82],"experiments/donor).":[83],"*p":[84]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2017-04-28T00:00:00"}