{"id":"https://openalex.org/W2606353465","doi":"https://doi.org/10.1038/s41598-017-01186-5","title":"Small methyltransferase RlmH assembles a composite active site to methylate a ribosomal pseudouridine","display_name":"Small methyltransferase RlmH assembles a composite active site to methylate a ribosomal pseudouridine","publication_year":2017,"publication_date":"2017-04-11","ids":{"openalex":"https://openalex.org/W2606353465","doi":"https://doi.org/10.1038/s41598-017-01186-5","mag":"2606353465","pmid":"https://pubmed.ncbi.nlm.nih.gov/28428565","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5430550"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-017-01186-5","doi":"https://doi.org/10.1038/s41598-017-01186-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-017-01186-5","pdf_url":"https://www.nature.com/articles/s41598-017-01186-5.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-017-01186-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031606146","display_name":"Cha San Koh","orcid":"https://orcid.org/0000-0002-1579-0362","observed_orcids":["https://orcid.org/0000-0002-1579-0362"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cha San Koh","raw_affiliation_strings":["RNA Therapeutics Institute, University of Massachusetts Medical School, 368 Plantation St, Worcester, MA 01605, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RNA Therapeutics Institute, University of Massachusetts Medical School, 368 Plantation St, Worcester, MA 01605, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007195869","display_name":"Rohini Madireddy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rohini Madireddy","raw_affiliation_strings":["RNA Therapeutics Institute, University of Massachusetts Medical School, 368 Plantation St, Worcester, MA 01605, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RNA Therapeutics Institute, University of Massachusetts Medical School, 368 Plantation St, Worcester, MA 01605, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024479541","display_name":"Timothy Jason Beane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy J. Beane","raw_affiliation_strings":["RNA Therapeutics Institute, University of Massachusetts Medical School, 368 Plantation St, Worcester, MA 01605, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RNA Therapeutics Institute, University of Massachusetts Medical School, 368 Plantation St, Worcester, MA 01605, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020225652","display_name":"Phillip D. Zamore","orcid":"https://orcid.org/0000-0002-4505-9618","observed_orcids":["https://orcid.org/0000-0002-4505-9618"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Phillip D. Zamore","raw_affiliation_strings":["RNA Therapeutics Institute, Howard Hughes Medical Institute, University of Massachusetts Medical School, 368 Plantation St, Worcester, MA 01605, USA. phillip.zamore@umassmed.edu","RNA Therapeutics Institute, Howard Hughes Medical Institute, University of Massachusetts Medical School, 368 Plantation St, Worcester, MA 01605, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RNA Therapeutics Institute, Howard Hughes Medical Institute, University of Massachusetts Medical School, 368 Plantation St, Worcester, MA 01605, USA. phillip.zamore@umassmed.edu","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I166722992"]},{"raw_affiliation_string":"RNA Therapeutics Institute, Howard Hughes Medical Institute, University of Massachusetts Medical School, 368 Plantation St, Worcester, MA 01605, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I166722992"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086024663","display_name":"Andrei A. Korostelev","orcid":"https://orcid.org/0000-0003-1588-717X","observed_orcids":["https://orcid.org/0000-0003-1588-717X"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrei A. Korostelev","raw_affiliation_strings":["RNA Therapeutics Institute, University of Massachusetts Medical School, 368 Plantation St, Worcester, MA 01605, USA. andrei.korostelev@umassmed.edu","RNA Therapeutics Institute, University of Massachusetts Medical School, 368 Plantation St, Worcester, MA 01605, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RNA Therapeutics Institute, University of Massachusetts Medical School, 368 Plantation St, Worcester, MA 01605, USA. andrei.korostelev@umassmed.edu","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"RNA Therapeutics Institute, University of Massachusetts Medical School, 368 Plantation St, Worcester, MA 01605, USA","institution_ids":["https://openalex.org/I166722992"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5020225652","https://openalex.org/A5086024663"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I166722992"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.8925,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.69910616,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"7","issue":"1","first_page":"969","last_page":"969"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.5634999871253967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.5634999871253967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.4336000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-dimer","display_name":"protein dimer","score":0.5849999785423279},{"id":"https://openalex.org/keywords/sinefungin","display_name":"sinefungin","score":0.8669999837875366},{"id":"https://openalex.org/keywords/catalytic-residues","display_name":"catalytic residues","score":0.7250000238418579},{"id":"https://openalex.org/keywords/23s-rrna","display_name":"23S rRNA","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.8080099821090698},{"id":"https://openalex.org/C2779810333","wikidata":"https://www.wikidata.org/wiki/Q420445","display_name":"Pseudouridine","level":5,"score":0.7351524829864502},{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.5873997807502747},{"id":"https://openalex.org/C38062823","wikidata":"https://www.wikidata.org/wiki/Q3408228","display_name":"Ribosomal protein","level":5,"score":0.5414791703224182},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.531466543674469},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49381837248802185},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.47965601086616516},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.46595650911331177},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.45493894815444946},{"id":"https://openalex.org/C40749294","wikidata":"https://www.wikidata.org/wiki/Q4631553","display_name":"23S ribosomal RNA","level":5,"score":0.45149537920951843},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.44092386960983276},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4114808142185211},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3726304769515991},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.37256094813346863},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.30442988872528076},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.26738443970680237},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.15814423561096191},{"id":"https://openalex.org/C153957851","wikidata":"https://www.wikidata.org/wiki/Q201448","display_name":"Transfer RNA","level":4,"score":0.15429547429084778},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10699781775474548},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008780","descriptor_name":"Methyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008780","descriptor_name":"Methyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008780","descriptor_name":"Methyltransferases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011560","descriptor_name":"Pseudouridine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012338","descriptor_name":"RNA, Ribosomal, 23S","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012436","descriptor_name":"S-Adenosylmethionine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-017-01186-5","doi":"https://doi.org/10.1038/s41598-017-01186-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-017-01186-5","pdf_url":"https://www.nature.com/articles/s41598-017-01186-5.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5430550","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5430550","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:28428565","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28428565","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.umassmed.edu:oapubs-4143","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.umassmed.edu/oapubs/3136","pdf_url":null,"source":{"id":"https://openalex.org/S4306400883","display_name":"The Journal of the American Medical Association (JAMA) Network (American Medical Association)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173654999","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/I173654999"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications by UMass Chan Authors","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:d054ded6d21e412c86951938f4ea5fff","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d054ded6d21e412c86951938f4ea5fff","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-017-01186-5","doi":"https://doi.org/10.1038/s41598-017-01186-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-017-01186-5","pdf_url":"https://www.nature.com/articles/s41598-017-01186-5.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2629451145","display_name":"Molecular principles of translation termination","funder_award_id":"R01GM107465","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7447525703","display_name":"Structural bases for cellular stress responses mediated by stalled translation","funder_award_id":"R01GM106105","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7976641167","display_name":"Asymmetric flow FFF and Composition Gradient/Light Scattering System","funder_award_id":"S10RR023748","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G816945753","display_name":"Argonaute proteins and RNA silencing pathways","funder_award_id":"R37GM062862","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000063835","display_name":null,"funder_award_id":"GM62862","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320308380","display_name":"Yale University","ror":"https://ror.org/03v76x132"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320338284","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2606353465.pdf","grobid_xml":"https://content.openalex.org/works/W2606353465.grobid-xml"},"referenced_works_count":85,"referenced_works":["https://openalex.org/W1496844582","https://openalex.org/W1507889266","https://openalex.org/W1519266993","https://openalex.org/W1525289848","https://openalex.org/W1561290028","https://openalex.org/W1570444344","https://openalex.org/W1575664323","https://openalex.org/W1581165587","https://openalex.org/W1711482514","https://openalex.org/W1753285579","https://openalex.org/W1863063757","https://openalex.org/W1919801225","https://openalex.org/W1977503986","https://openalex.org/W1981977120","https://openalex.org/W1989067983","https://openalex.org/W1990868071","https://openalex.org/W1992657741","https://openalex.org/W1993888178","https://openalex.org/W2009347810","https://openalex.org/W2010257676","https://openalex.org/W2012291245","https://openalex.org/W2013195519","https://openalex.org/W2013800961","https://openalex.org/W2014802837","https://openalex.org/W2021012130","https://openalex.org/W2022754910","https://openalex.org/W2027173928","https://openalex.org/W2029921266","https://openalex.org/W2031782903","https://openalex.org/W2032757954","https://openalex.org/W2035503835","https://openalex.org/W2038840577","https://openalex.org/W2043989250","https://openalex.org/W2046889198","https://openalex.org/W2050329965","https://openalex.org/W2054511300","https://openalex.org/W2060344007","https://openalex.org/W2061523668","https://openalex.org/W2061649557","https://openalex.org/W2068106209","https://openalex.org/W2069927544","https://openalex.org/W2073149987","https://openalex.org/W2074722040","https://openalex.org/W2074910098","https://openalex.org/W2082388363","https://openalex.org/W2087233405","https://openalex.org/W2093041571","https://openalex.org/W2093471887","https://openalex.org/W2096064309","https://openalex.org/W2096520577","https://openalex.org/W2098586421","https://openalex.org/W2101404563","https://openalex.org/W2102459164","https://openalex.org/W2104107140","https://openalex.org/W2108921801","https://openalex.org/W2108959691","https://openalex.org/W2110680433","https://openalex.org/W2110808180","https://openalex.org/W2111967267","https://openalex.org/W2114622716","https://openalex.org/W2116275717","https://openalex.org/W2120287399","https://openalex.org/W2125047925","https://openalex.org/W2131064870","https://openalex.org/W2132925244","https://openalex.org/W2132926880","https://openalex.org/W2133168873","https://openalex.org/W2134201060","https://openalex.org/W2138377787","https://openalex.org/W2138463176","https://openalex.org/W2142125112","https://openalex.org/W2142672816","https://openalex.org/W2144081223","https://openalex.org/W2153689708","https://openalex.org/W2154714625","https://openalex.org/W2158714788","https://openalex.org/W2159211495","https://openalex.org/W2163341755","https://openalex.org/W2180229411","https://openalex.org/W2221000518","https://openalex.org/W2256584119","https://openalex.org/W2266719610","https://openalex.org/W2333064774","https://openalex.org/W2765633603","https://openalex.org/W4248872320"],"related_works":["https://openalex.org/W2081155341","https://openalex.org/W2035428982","https://openalex.org/W2760554947","https://openalex.org/W2028669847","https://openalex.org/W22923995","https://openalex.org/W2088543498","https://openalex.org/W2034407986","https://openalex.org/W2120287399","https://openalex.org/W2128027295","https://openalex.org/W2082388363"],"abstract_inverted_index":{"Eubacterial":[0],"ribosomal":[1,8,17],"large-subunit":[2],"methyltransferase":[3,60],"H":[4],"(RlmH)":[5],"methylates":[6],"23S":[7],"RNA":[9,32],"pseudouridine":[10],"1915":[11],"(\u03a81915),":[12],"which":[13,104],"lies":[14],"near":[15],"the":[16,24,31,50,59,73,81,85,90,101],"decoding":[18],"center.":[19],"The":[20,39],"smallest":[21],"member":[22],"of":[23,27,42,52,89],"SPOUT":[25],"superfamily":[26],"methyltransferases,":[28],"RlmH":[29,43,53],"lacks":[30],"recognition":[33],"domain":[34],"found":[35],"in":[36,72],"larger":[37],"methyltransferases.":[38],"catalytic":[40],"mechanism":[41,102],"enzyme":[44],"is":[45],"unknown.":[46],"Here,":[47],"we":[48],"describe":[49],"structures":[51],"bound":[54],"to":[55],"S-adenosyl-methionine":[56],"(SAM)":[57],"and":[58,65],"inhibitor":[61],"sinefungin.":[62],"Our":[63,98],"structural":[64],"biochemical":[66],"studies":[67],"reveal":[68],"catalytically":[69],"essential":[70,95],"residues":[71,94],"dimer-mediated":[74],"asymmetrical":[75],"active":[76],"site.":[77],"One":[78],"monomer":[79,92],"provides":[80,93],"SAM-binding":[82],"site,":[83],"whereas":[84],"conserved":[86],"C-terminal":[87],"tail":[88],"second":[91],"for":[96],"catalysis.":[97],"findings":[99],"elucidate":[100],"by":[103],"a":[105,110],"small":[106],"protein":[107],"dimer":[108],"assembles":[109],"functionally":[111],"asymmetric":[112],"architecture.":[113]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-04-28T00:00:00"}