{"id":"https://openalex.org/W2606349786","doi":"https://doi.org/10.1161/hypertensionaha.117.09156","title":"Physiological and Pathological Roles in Human Adrenal of the Glomeruli-Defining Matrix Protein NPNT (Nephronectin)","display_name":"Physiological and Pathological Roles in Human Adrenal of the Glomeruli-Defining Matrix Protein NPNT (Nephronectin)","publication_year":2017,"publication_date":"2017-04-18","ids":{"openalex":"https://openalex.org/W2606349786","doi":"https://doi.org/10.1161/hypertensionaha.117.09156","mag":"2606349786","pmid":"https://pubmed.ncbi.nlm.nih.gov/28416583","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5424579"},"language":"en","primary_location":{"id":"doi:10.1161/hypertensionaha.117.09156","doi":"https://doi.org/10.1161/hypertensionaha.117.09156","is_oa":true,"landing_page_url":"https://doi.org/10.1161/hypertensionaha.117.09156","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1161/hypertensionaha.117.09156","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061242453","display_name":"Ada Ee Der Teo","orcid":"https://orcid.org/0000-0002-8832-0409","observed_orcids":["https://orcid.org/0000-0002-8832-0409"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]},{"id":"https://openalex.org/I368840534","display_name":"University of Mississippi","ror":"https://ror.org/02teq1165","country_code":"US","type":"education","lineage":["https://openalex.org/I368840534","https://openalex.org/I4210141039"]},{"id":"https://openalex.org/I4210089716","display_name":"MRC Cancer Unit","ror":"https://ror.org/015nth639","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210089716","https://openalex.org/I4210106569","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210106569","display_name":"Hutchison/MRC Research Centre","ror":"https://ror.org/01ajt3179","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210106569","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210116691","display_name":"Wellcome/MRC Institute of Metabolic Science","ror":"https://ror.org/0264dxb48","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I4210087105","https://openalex.org/I4210116691","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210144720","display_name":"G.V. (Sonny) Montgomery VA Medical Center","ror":"https://ror.org/040qrra89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138636","https://openalex.org/I4210144720"]},{"id":"https://openalex.org/I4210149920","display_name":"William Harvey Research Institute","ror":"https://ror.org/0574dzy90","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4210149920"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"id":"https://openalex.org/I4389425352","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I34931013","https://openalex.org/I4389425352"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Ada Ee Der Teo","raw_affiliation_strings":["From the Clinical Pharmacology Unit, Centre for Clinical Investigation, Addenbrooke\u2019s Hospital (A.E.D.T., S.G., J.Z., M.J.B.), Tissue Bank, Department of Histopathology, Addenbrooke\u2019s Hospital (W.Z.), NIHR Cambridge Biomedical Research Centre, Addenbrooke\u2019s Hospital (M.G.), MRC Cancer Unit, Hutchison/MRC Research Centre (T.I.J.), and Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science (M.G.), University of Cambridge, United Kingdom; Centre for Clinical Pharmacology,","Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, United Kingdom (J.Z., M.J.B.)","Division of Endocrinology, Department of Medicine, The University of Mississippi Medical Centre, Jackson (C.E.G.-S.)","Research and Medicine Services, G.V. (Sonny) Montgomery VA Medical Centre, Jackson, MS (C.E.G.-S.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Clinical Pharmacology Unit, Centre for Clinical Investigation, Addenbrooke\u2019s Hospital (A.E.D.T., S.G., J.Z., M.J.B.), Tissue Bank, Department of Histopathology, Addenbrooke\u2019s Hospital (W.Z.), NIHR Cambridge Biomedical Research Centre, Addenbrooke\u2019s Hospital (M.G.), MRC Cancer Unit, Hutchison/MRC Research Centre (T.I.J.), and Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science (M.G.), University of Cambridge, United Kingdom; Centre for Clinical Pharmacology,","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210089716","https://openalex.org/I4210106569","https://openalex.org/I4210116691","https://openalex.org/I4210156194","https://openalex.org/I4389425352"]},{"raw_affiliation_string":"Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, United Kingdom (J.Z., M.J.B.)","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"]},{"raw_affiliation_string":"Division of Endocrinology, Department of Medicine, The University of Mississippi Medical Centre, Jackson (C.E.G.-S.)","institution_ids":["https://openalex.org/I29606459","https://openalex.org/I368840534"]},{"raw_affiliation_string":"Research and Medicine Services, G.V. (Sonny) Montgomery VA Medical Centre, Jackson, MS (C.E.G.-S.)","institution_ids":["https://openalex.org/I4210144720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101454503","display_name":"Sumedha Garg","orcid":"https://orcid.org/0000-0002-4375-8968","observed_orcids":["https://orcid.org/0000-0002-4375-8968"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]},{"id":"https://openalex.org/I368840534","display_name":"University of Mississippi","ror":"https://ror.org/02teq1165","country_code":"US","type":"education","lineage":["https://openalex.org/I368840534","https://openalex.org/I4210141039"]},{"id":"https://openalex.org/I4210089716","display_name":"MRC Cancer Unit","ror":"https://ror.org/015nth639","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210089716","https://openalex.org/I4210106569","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210106569","display_name":"Hutchison/MRC Research Centre","ror":"https://ror.org/01ajt3179","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210106569","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210116691","display_name":"Wellcome/MRC Institute of Metabolic Science","ror":"https://ror.org/0264dxb48","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I4210087105","https://openalex.org/I4210116691","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210144720","display_name":"G.V. (Sonny) Montgomery VA Medical Center","ror":"https://ror.org/040qrra89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138636","https://openalex.org/I4210144720"]},{"id":"https://openalex.org/I4210149920","display_name":"William Harvey Research Institute","ror":"https://ror.org/0574dzy90","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4210149920"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"id":"https://openalex.org/I4389425352","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I34931013","https://openalex.org/I4389425352"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Sumedha Garg","raw_affiliation_strings":["From the Clinical Pharmacology Unit, Centre for Clinical Investigation, Addenbrooke\u2019s Hospital (A.E.D.T., S.G., J.Z., M.J.B.), Tissue Bank, Department of Histopathology, Addenbrooke\u2019s Hospital (W.Z.), NIHR Cambridge Biomedical Research Centre, Addenbrooke\u2019s Hospital (M.G.), MRC Cancer Unit, Hutchison/MRC Research Centre (T.I.J.), and Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science (M.G.), University of Cambridge, United Kingdom; Centre for Clinical Pharmacology,","Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, United Kingdom (J.Z., M.J.B.)","Division of Endocrinology, Department of Medicine, The University of Mississippi Medical Centre, Jackson (C.E.G.-S.)","Research and Medicine Services, G.V. (Sonny) Montgomery VA Medical Centre, Jackson, MS (C.E.G.-S.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Clinical Pharmacology Unit, Centre for Clinical Investigation, Addenbrooke\u2019s Hospital (A.E.D.T., S.G., J.Z., M.J.B.), Tissue Bank, Department of Histopathology, Addenbrooke\u2019s Hospital (W.Z.), NIHR Cambridge Biomedical Research Centre, Addenbrooke\u2019s Hospital (M.G.), MRC Cancer Unit, Hutchison/MRC Research Centre (T.I.J.), and Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science (M.G.), University of Cambridge, United Kingdom; Centre for Clinical Pharmacology,","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210089716","https://openalex.org/I4210106569","https://openalex.org/I4210116691","https://openalex.org/I4210156194","https://openalex.org/I4389425352"]},{"raw_affiliation_string":"Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, United Kingdom (J.Z., M.J.B.)","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"]},{"raw_affiliation_string":"Division of Endocrinology, Department of Medicine, The University of Mississippi Medical Centre, Jackson (C.E.G.-S.)","institution_ids":["https://openalex.org/I29606459","https://openalex.org/I368840534"]},{"raw_affiliation_string":"Research and Medicine Services, G.V. (Sonny) Montgomery VA Medical Centre, Jackson, MS (C.E.G.-S.)","institution_ids":["https://openalex.org/I4210144720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061018385","display_name":"Timothy Isaac Johnson","orcid":"https://orcid.org/0000-0002-1606-8849","observed_orcids":["https://orcid.org/0000-0002-1606-8849"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]},{"id":"https://openalex.org/I368840534","display_name":"University of Mississippi","ror":"https://ror.org/02teq1165","country_code":"US","type":"education","lineage":["https://openalex.org/I368840534","https://openalex.org/I4210141039"]},{"id":"https://openalex.org/I4210089716","display_name":"MRC Cancer Unit","ror":"https://ror.org/015nth639","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210089716","https://openalex.org/I4210106569","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210106569","display_name":"Hutchison/MRC Research Centre","ror":"https://ror.org/01ajt3179","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210106569","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210116691","display_name":"Wellcome/MRC Institute of Metabolic Science","ror":"https://ror.org/0264dxb48","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I4210087105","https://openalex.org/I4210116691","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210144720","display_name":"G.V. (Sonny) Montgomery VA Medical Center","ror":"https://ror.org/040qrra89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138636","https://openalex.org/I4210144720"]},{"id":"https://openalex.org/I4210149920","display_name":"William Harvey Research Institute","ror":"https://ror.org/0574dzy90","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4210149920"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"id":"https://openalex.org/I4389425352","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I34931013","https://openalex.org/I4389425352"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Timothy Isaac Johnson","raw_affiliation_strings":["From the Clinical Pharmacology Unit, Centre for Clinical Investigation, Addenbrooke\u2019s Hospital (A.E.D.T., S.G., J.Z., M.J.B.), Tissue Bank, Department of Histopathology, Addenbrooke\u2019s Hospital (W.Z.), NIHR Cambridge Biomedical Research Centre, Addenbrooke\u2019s Hospital (M.G.), MRC Cancer Unit, Hutchison/MRC Research Centre (T.I.J.), and Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science (M.G.), University of Cambridge, United Kingdom; Centre for Clinical Pharmacology,","Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, United Kingdom (J.Z., M.J.B.)","Division of Endocrinology, Department of Medicine, The University of Mississippi Medical Centre, Jackson (C.E.G.-S.)","Research and Medicine Services, G.V. (Sonny) Montgomery VA Medical Centre, Jackson, MS (C.E.G.-S.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Clinical Pharmacology Unit, Centre for Clinical Investigation, Addenbrooke\u2019s Hospital (A.E.D.T., S.G., J.Z., M.J.B.), Tissue Bank, Department of Histopathology, Addenbrooke\u2019s Hospital (W.Z.), NIHR Cambridge Biomedical Research Centre, Addenbrooke\u2019s Hospital (M.G.), MRC Cancer Unit, Hutchison/MRC Research Centre (T.I.J.), and Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science (M.G.), University of Cambridge, United Kingdom; Centre for Clinical Pharmacology,","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210089716","https://openalex.org/I4210106569","https://openalex.org/I4210116691","https://openalex.org/I4210156194","https://openalex.org/I4389425352"]},{"raw_affiliation_string":"Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, United Kingdom (J.Z., M.J.B.)","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"]},{"raw_affiliation_string":"Division of Endocrinology, Department of Medicine, The University of Mississippi Medical Centre, Jackson (C.E.G.-S.)","institution_ids":["https://openalex.org/I29606459","https://openalex.org/I368840534"]},{"raw_affiliation_string":"Research and Medicine Services, G.V. (Sonny) Montgomery VA Medical Centre, Jackson, MS (C.E.G.-S.)","institution_ids":["https://openalex.org/I4210144720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082659522","display_name":"Wanfeng Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]},{"id":"https://openalex.org/I368840534","display_name":"University of Mississippi","ror":"https://ror.org/02teq1165","country_code":"US","type":"education","lineage":["https://openalex.org/I368840534","https://openalex.org/I4210141039"]},{"id":"https://openalex.org/I4210089716","display_name":"MRC Cancer Unit","ror":"https://ror.org/015nth639","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210089716","https://openalex.org/I4210106569","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210106569","display_name":"Hutchison/MRC Research Centre","ror":"https://ror.org/01ajt3179","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210106569","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210116691","display_name":"Wellcome/MRC Institute of Metabolic Science","ror":"https://ror.org/0264dxb48","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I4210087105","https://openalex.org/I4210116691","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210144720","display_name":"G.V. (Sonny) Montgomery VA Medical Center","ror":"https://ror.org/040qrra89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138636","https://openalex.org/I4210144720"]},{"id":"https://openalex.org/I4210149920","display_name":"William Harvey Research Institute","ror":"https://ror.org/0574dzy90","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4210149920"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"id":"https://openalex.org/I4389425352","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I34931013","https://openalex.org/I4389425352"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Wanfeng Zhao","raw_affiliation_strings":["From the Clinical Pharmacology Unit, Centre for Clinical Investigation, Addenbrooke\u2019s Hospital (A.E.D.T., S.G., J.Z., M.J.B.), Tissue Bank, Department of Histopathology, Addenbrooke\u2019s Hospital (W.Z.), NIHR Cambridge Biomedical Research Centre, Addenbrooke\u2019s Hospital (M.G.), MRC Cancer Unit, Hutchison/MRC Research Centre (T.I.J.), and Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science (M.G.), University of Cambridge, United Kingdom; Centre for Clinical Pharmacology,","Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, United Kingdom (J.Z., M.J.B.)","Division of Endocrinology, Department of Medicine, The University of Mississippi Medical Centre, Jackson (C.E.G.-S.)","Research and Medicine Services, G.V. (Sonny) Montgomery VA Medical Centre, Jackson, MS (C.E.G.-S.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Clinical Pharmacology Unit, Centre for Clinical Investigation, Addenbrooke\u2019s Hospital (A.E.D.T., S.G., J.Z., M.J.B.), Tissue Bank, Department of Histopathology, Addenbrooke\u2019s Hospital (W.Z.), NIHR Cambridge Biomedical Research Centre, Addenbrooke\u2019s Hospital (M.G.), MRC Cancer Unit, Hutchison/MRC Research Centre (T.I.J.), and Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science (M.G.), University of Cambridge, United Kingdom; Centre for Clinical Pharmacology,","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210089716","https://openalex.org/I4210106569","https://openalex.org/I4210116691","https://openalex.org/I4210156194","https://openalex.org/I4389425352"]},{"raw_affiliation_string":"Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, United Kingdom (J.Z., M.J.B.)","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"]},{"raw_affiliation_string":"Division of Endocrinology, Department of Medicine, The University of Mississippi Medical Centre, Jackson (C.E.G.-S.)","institution_ids":["https://openalex.org/I29606459","https://openalex.org/I368840534"]},{"raw_affiliation_string":"Research and Medicine Services, G.V. (Sonny) Montgomery VA Medical Centre, Jackson, MS (C.E.G.-S.)","institution_ids":["https://openalex.org/I4210144720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101637587","display_name":"Junhua Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]},{"id":"https://openalex.org/I368840534","display_name":"University of Mississippi","ror":"https://ror.org/02teq1165","country_code":"US","type":"education","lineage":["https://openalex.org/I368840534","https://openalex.org/I4210141039"]},{"id":"https://openalex.org/I4210089716","display_name":"MRC Cancer Unit","ror":"https://ror.org/015nth639","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210089716","https://openalex.org/I4210106569","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210106569","display_name":"Hutchison/MRC Research Centre","ror":"https://ror.org/01ajt3179","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210106569","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210116691","display_name":"Wellcome/MRC Institute of Metabolic Science","ror":"https://ror.org/0264dxb48","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I4210087105","https://openalex.org/I4210116691","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210144720","display_name":"G.V. (Sonny) Montgomery VA Medical Center","ror":"https://ror.org/040qrra89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138636","https://openalex.org/I4210144720"]},{"id":"https://openalex.org/I4210149920","display_name":"William Harvey Research Institute","ror":"https://ror.org/0574dzy90","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4210149920"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"id":"https://openalex.org/I4389425352","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I34931013","https://openalex.org/I4389425352"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Junhua Zhou","raw_affiliation_strings":["From the Clinical Pharmacology Unit, Centre for Clinical Investigation, Addenbrooke\u2019s Hospital (A.E.D.T., S.G., J.Z., M.J.B.), Tissue Bank, Department of Histopathology, Addenbrooke\u2019s Hospital (W.Z.), NIHR Cambridge Biomedical Research Centre, Addenbrooke\u2019s Hospital (M.G.), MRC Cancer Unit, Hutchison/MRC Research Centre (T.I.J.), and Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science (M.G.), University of Cambridge, United Kingdom; Centre for Clinical Pharmacology,","Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, United Kingdom (J.Z., M.J.B.)","Division of Endocrinology, Department of Medicine, The University of Mississippi Medical Centre, Jackson (C.E.G.-S.)","Research and Medicine Services, G.V. (Sonny) Montgomery VA Medical Centre, Jackson, MS (C.E.G.-S.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Clinical Pharmacology Unit, Centre for Clinical Investigation, Addenbrooke\u2019s Hospital (A.E.D.T., S.G., J.Z., M.J.B.), Tissue Bank, Department of Histopathology, Addenbrooke\u2019s Hospital (W.Z.), NIHR Cambridge Biomedical Research Centre, Addenbrooke\u2019s Hospital (M.G.), MRC Cancer Unit, Hutchison/MRC Research Centre (T.I.J.), and Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science (M.G.), University of Cambridge, United Kingdom; Centre for Clinical Pharmacology,","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210089716","https://openalex.org/I4210106569","https://openalex.org/I4210116691","https://openalex.org/I4210156194","https://openalex.org/I4389425352"]},{"raw_affiliation_string":"Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, United Kingdom (J.Z., M.J.B.)","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"]},{"raw_affiliation_string":"Division of Endocrinology, Department of Medicine, The University of Mississippi Medical Centre, Jackson (C.E.G.-S.)","institution_ids":["https://openalex.org/I29606459","https://openalex.org/I368840534"]},{"raw_affiliation_string":"Research and Medicine Services, G.V. (Sonny) Montgomery VA Medical Centre, Jackson, MS (C.E.G.-S.)","institution_ids":["https://openalex.org/I4210144720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024989958","display_name":"Celso E. G\u00f3mez-S\u00e1nchez","orcid":"https://orcid.org/0000-0002-9882-2082","observed_orcids":["https://orcid.org/0000-0002-9882-2082"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]},{"id":"https://openalex.org/I368840534","display_name":"University of Mississippi","ror":"https://ror.org/02teq1165","country_code":"US","type":"education","lineage":["https://openalex.org/I368840534","https://openalex.org/I4210141039"]},{"id":"https://openalex.org/I4210089716","display_name":"MRC Cancer Unit","ror":"https://ror.org/015nth639","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210089716","https://openalex.org/I4210106569","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210106569","display_name":"Hutchison/MRC Research Centre","ror":"https://ror.org/01ajt3179","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210106569","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210116691","display_name":"Wellcome/MRC Institute of Metabolic Science","ror":"https://ror.org/0264dxb48","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I4210087105","https://openalex.org/I4210116691","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210144720","display_name":"G.V. (Sonny) Montgomery VA Medical Center","ror":"https://ror.org/040qrra89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138636","https://openalex.org/I4210144720"]},{"id":"https://openalex.org/I4210149920","display_name":"William Harvey Research Institute","ror":"https://ror.org/0574dzy90","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4210149920"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"id":"https://openalex.org/I4389425352","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I34931013","https://openalex.org/I4389425352"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Celso Enrique Gomez-Sanchez","raw_affiliation_strings":["From the Clinical Pharmacology Unit, Centre for Clinical Investigation, Addenbrooke\u2019s Hospital (A.E.D.T., S.G., J.Z., M.J.B.), Tissue Bank, Department of Histopathology, Addenbrooke\u2019s Hospital (W.Z.), NIHR Cambridge Biomedical Research Centre, Addenbrooke\u2019s Hospital (M.G.), MRC Cancer Unit, Hutchison/MRC Research Centre (T.I.J.), and Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science (M.G.), University of Cambridge, United Kingdom; Centre for Clinical Pharmacology,","Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, United Kingdom (J.Z., M.J.B.)","Division of Endocrinology, Department of Medicine, The University of Mississippi Medical Centre, Jackson (C.E.G.-S.)","Research and Medicine Services, G.V. (Sonny) Montgomery VA Medical Centre, Jackson, MS (C.E.G.-S.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Clinical Pharmacology Unit, Centre for Clinical Investigation, Addenbrooke\u2019s Hospital (A.E.D.T., S.G., J.Z., M.J.B.), Tissue Bank, Department of Histopathology, Addenbrooke\u2019s Hospital (W.Z.), NIHR Cambridge Biomedical Research Centre, Addenbrooke\u2019s Hospital (M.G.), MRC Cancer Unit, Hutchison/MRC Research Centre (T.I.J.), and Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science (M.G.), University of Cambridge, United Kingdom; Centre for Clinical Pharmacology,","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210089716","https://openalex.org/I4210106569","https://openalex.org/I4210116691","https://openalex.org/I4210156194","https://openalex.org/I4389425352"]},{"raw_affiliation_string":"Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, United Kingdom (J.Z., M.J.B.)","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"]},{"raw_affiliation_string":"Division of Endocrinology, Department of Medicine, The University of Mississippi Medical Centre, Jackson (C.E.G.-S.)","institution_ids":["https://openalex.org/I29606459","https://openalex.org/I368840534"]},{"raw_affiliation_string":"Research and Medicine Services, G.V. (Sonny) Montgomery VA Medical Centre, Jackson, MS (C.E.G.-S.)","institution_ids":["https://openalex.org/I4210144720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073106718","display_name":"Mark Gurnell","orcid":"https://orcid.org/0000-0001-5745-6832","observed_orcids":["https://orcid.org/0000-0001-5745-6832"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]},{"id":"https://openalex.org/I368840534","display_name":"University of Mississippi","ror":"https://ror.org/02teq1165","country_code":"US","type":"education","lineage":["https://openalex.org/I368840534","https://openalex.org/I4210141039"]},{"id":"https://openalex.org/I4210089716","display_name":"MRC Cancer Unit","ror":"https://ror.org/015nth639","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210089716","https://openalex.org/I4210106569","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210106569","display_name":"Hutchison/MRC Research Centre","ror":"https://ror.org/01ajt3179","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210106569","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210116691","display_name":"Wellcome/MRC Institute of Metabolic Science","ror":"https://ror.org/0264dxb48","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I4210087105","https://openalex.org/I4210116691","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210144720","display_name":"G.V. (Sonny) Montgomery VA Medical Center","ror":"https://ror.org/040qrra89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138636","https://openalex.org/I4210144720"]},{"id":"https://openalex.org/I4210149920","display_name":"William Harvey Research Institute","ror":"https://ror.org/0574dzy90","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4210149920"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"id":"https://openalex.org/I4389425352","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I34931013","https://openalex.org/I4389425352"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Mark Gurnell","raw_affiliation_strings":["From the Clinical Pharmacology Unit, Centre for Clinical Investigation, Addenbrooke\u2019s Hospital (A.E.D.T., S.G., J.Z., M.J.B.), Tissue Bank, Department of Histopathology, Addenbrooke\u2019s Hospital (W.Z.), NIHR Cambridge Biomedical Research Centre, Addenbrooke\u2019s Hospital (M.G.), MRC Cancer Unit, Hutchison/MRC Research Centre (T.I.J.), and Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science (M.G.), University of Cambridge, United Kingdom; Centre for Clinical Pharmacology,","Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, United Kingdom (J.Z., M.J.B.)","Division of Endocrinology, Department of Medicine, The University of Mississippi Medical Centre, Jackson (C.E.G.-S.)","Research and Medicine Services, G.V. (Sonny) Montgomery VA Medical Centre, Jackson, MS (C.E.G.-S.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Clinical Pharmacology Unit, Centre for Clinical Investigation, Addenbrooke\u2019s Hospital (A.E.D.T., S.G., J.Z., M.J.B.), Tissue Bank, Department of Histopathology, Addenbrooke\u2019s Hospital (W.Z.), NIHR Cambridge Biomedical Research Centre, Addenbrooke\u2019s Hospital (M.G.), MRC Cancer Unit, Hutchison/MRC Research Centre (T.I.J.), and Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science (M.G.), University of Cambridge, United Kingdom; Centre for Clinical Pharmacology,","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210089716","https://openalex.org/I4210106569","https://openalex.org/I4210116691","https://openalex.org/I4210156194","https://openalex.org/I4389425352"]},{"raw_affiliation_string":"Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, United Kingdom (J.Z., M.J.B.)","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"]},{"raw_affiliation_string":"Division of Endocrinology, Department of Medicine, The University of Mississippi Medical Centre, Jackson (C.E.G.-S.)","institution_ids":["https://openalex.org/I29606459","https://openalex.org/I368840534"]},{"raw_affiliation_string":"Research and Medicine Services, G.V. (Sonny) Montgomery VA Medical Centre, Jackson, MS (C.E.G.-S.)","institution_ids":["https://openalex.org/I4210144720"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108166805","display_name":"Morris Jonathan Brown","orcid":"https://orcid.org/0000-0001-8409-1082","observed_orcids":["https://orcid.org/0000-0001-8409-1082"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]},{"id":"https://openalex.org/I368840534","display_name":"University of Mississippi","ror":"https://ror.org/02teq1165","country_code":"US","type":"education","lineage":["https://openalex.org/I368840534","https://openalex.org/I4210141039"]},{"id":"https://openalex.org/I4210089716","display_name":"MRC Cancer Unit","ror":"https://ror.org/015nth639","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210089716","https://openalex.org/I4210106569","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210106569","display_name":"Hutchison/MRC Research Centre","ror":"https://ror.org/01ajt3179","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210106569","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210116691","display_name":"Wellcome/MRC Institute of Metabolic Science","ror":"https://ror.org/0264dxb48","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I4210087105","https://openalex.org/I4210116691","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210144720","display_name":"G.V. (Sonny) Montgomery VA Medical Center","ror":"https://ror.org/040qrra89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138636","https://openalex.org/I4210144720"]},{"id":"https://openalex.org/I4210149920","display_name":"William Harvey Research Institute","ror":"https://ror.org/0574dzy90","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4210149920"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"id":"https://openalex.org/I4389425352","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I34931013","https://openalex.org/I4389425352"]}],"countries":["GB","US"],"is_corresponding":true,"raw_author_name":"Morris Jonathan Brown","raw_affiliation_strings":["From the Clinical Pharmacology Unit, Centre for Clinical Investigation, Addenbrooke\u2019s Hospital (A.E.D.T., S.G., J.Z., M.J.B.), Tissue Bank, Department of Histopathology, Addenbrooke\u2019s Hospital (W.Z.), NIHR Cambridge Biomedical Research Centre, Addenbrooke\u2019s Hospital (M.G.), MRC Cancer Unit, Hutchison/MRC Research Centre (T.I.J.), and Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science (M.G.), University of Cambridge, United Kingdom; Centre for Clinical Pharmacology,","Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, United Kingdom (J.Z., M.J.B.)","Division of Endocrinology, Department of Medicine, The University of Mississippi Medical Centre, Jackson (C.E.G.-S.)","Research and Medicine Services, G.V. (Sonny) Montgomery VA Medical Centre, Jackson, MS (C.E.G.-S.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Clinical Pharmacology Unit, Centre for Clinical Investigation, Addenbrooke\u2019s Hospital (A.E.D.T., S.G., J.Z., M.J.B.), Tissue Bank, Department of Histopathology, Addenbrooke\u2019s Hospital (W.Z.), NIHR Cambridge Biomedical Research Centre, Addenbrooke\u2019s Hospital (M.G.), MRC Cancer Unit, Hutchison/MRC Research Centre (T.I.J.), and Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science (M.G.), University of Cambridge, United Kingdom; Centre for Clinical Pharmacology,","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210089716","https://openalex.org/I4210106569","https://openalex.org/I4210116691","https://openalex.org/I4210156194","https://openalex.org/I4389425352"]},{"raw_affiliation_string":"Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, United Kingdom (J.Z., M.J.B.)","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"]},{"raw_affiliation_string":"Division of Endocrinology, Department of Medicine, The University of Mississippi Medical Centre, Jackson (C.E.G.-S.)","institution_ids":["https://openalex.org/I29606459","https://openalex.org/I368840534"]},{"raw_affiliation_string":"Research and Medicine Services, G.V. (Sonny) Montgomery VA Medical Centre, Jackson, MS (C.E.G.-S.)","institution_ids":["https://openalex.org/I4210144720"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5108166805"],"corresponding_institution_ids":["https://openalex.org/I166337079","https://openalex.org/I241749","https://openalex.org/I29606459","https://openalex.org/I368840534","https://openalex.org/I4210089716","https://openalex.org/I4210106569","https://openalex.org/I4210116691","https://openalex.org/I4210144720","https://openalex.org/I4210149920","https://openalex.org/I4210156194","https://openalex.org/I4389425352"],"apc_list":null,"apc_paid":{"value":5351,"currency":"EUR","value_usd":5771},"fwci":1.7786,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.84307569,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"69","issue":"6","first_page":"1207","last_page":"1216"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nephronectin","display_name":"nephronectin","score":0.9490000009536743},{"id":"https://openalex.org/keywords/aldosterone-producing-adenoma","display_name":"aldosterone-producing adenoma","score":0.9750000238418579},{"id":"https://openalex.org/keywords/primary-aldosteronism","display_name":"primary aldosteronism","score":0.9459999799728394},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.7149999737739563},{"id":"https://openalex.org/keywords/ctnnb1-mutation","display_name":"CTNNB1 mutation","score":0.859000027179718},{"id":"https://openalex.org/keywords/integrins","display_name":"integrins","score":0.7400000095367432},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.75},{"id":"https://openalex.org/keywords/aldosterone-biosynthesis","display_name":"aldosterone biosynthesis","score":0.6240000128746033},{"id":"https://openalex.org/keywords/zona-fasciculata","display_name":"zona fasciculata","score":0.7760000228881836},{"id":"https://openalex.org/keywords/genotype-phenotype-correlation","display_name":"genotype-phenotype correlation","score":0.7360000014305115},{"id":"https://openalex.org/keywords/adrenocortical-cells","display_name":"adrenocortical cells","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C2780178468","wikidata":"https://www.wikidata.org/wiki/Q3551060","display_name":"Zona glomerulosa","level":4,"score":0.8848255276679993},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.8455284833908081},{"id":"https://openalex.org/C2778736161","wikidata":"https://www.wikidata.org/wiki/Q3301573","display_name":"Zona fasciculata","level":3,"score":0.8308067321777344},{"id":"https://openalex.org/C2780233176","wikidata":"https://www.wikidata.org/wiki/Q1939330","display_name":"Primary aldosteronism","level":3,"score":0.706702470779419},{"id":"https://openalex.org/C2780249997","wikidata":"https://www.wikidata.org/wiki/Q14904983","display_name":"Aldosterone synthase","level":4,"score":0.6154149770736694},{"id":"https://openalex.org/C155392382","wikidata":"https://www.wikidata.org/wiki/Q904925","display_name":"Steroid 11-beta-hydroxylase","level":4,"score":0.6139854192733765},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5498467087745667},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5102369785308838},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5072000026702881},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.46895021200180054},{"id":"https://openalex.org/C2780694816","wikidata":"https://www.wikidata.org/wiki/Q712294","display_name":"Adrenal gland","level":2,"score":0.4198249578475952},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2775999903678894},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20987865328788757},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1414027214050293},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.10226187109947205},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.09098654985427856},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.07906067371368408},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.06713074445724487},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000302","descriptor_name":"Adrenal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000306","descriptor_name":"Adrenal Cortex Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000306","descriptor_name":"Adrenal Cortex Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000306","descriptor_name":"Adrenal Cortex Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006929","descriptor_name":"Hyperaldosteronism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006929","descriptor_name":"Hyperaldosteronism","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006929","descriptor_name":"Hyperaldosteronism","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007678","descriptor_name":"Kidney Glomerulus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012380","descriptor_name":"Role","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015384","descriptor_name":"Zona Glomerulosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019405","descriptor_name":"Cytochrome P-450 CYP11B2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1161/hypertensionaha.117.09156","doi":"https://doi.org/10.1161/hypertensionaha.117.09156","is_oa":true,"landing_page_url":"https://doi.org/10.1161/hypertensionaha.117.09156","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5424579","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5424579","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"Text"},{"id":"pmid:28416583","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28416583","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension (Dallas, Tex. : 1979)","raw_type":"Journal Article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/264580","doi":null,"is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/264580","pdf_url":"https://www.repository.cam.ac.uk/bitstreams/2a729477-fe3b-4b15-8a80-63b65748ed9e/download","source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:qmro.qmul.ac.uk:123456789/35423","doi":null,"is_oa":true,"landing_page_url":"http://hyper.ahajournals.org/content/69/6/1207.long","pdf_url":null,"source":{"id":"https://openalex.org/S4306400530","display_name":"Queen Mary Research Online (Queen Mary University of London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I166337079","host_organization_name":"Queen Mary University of London","host_organization_lineage":["https://openalex.org/I166337079"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"doi:10.17863/cam.10142","doi":"https://doi.org/10.17863/cam.10142","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.10142","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1161/hypertensionaha.117.09156","doi":"https://doi.org/10.1161/hypertensionaha.117.09156","is_oa":true,"landing_page_url":"https://doi.org/10.1161/hypertensionaha.117.09156","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2200295899","display_name":"Interdisciplinary Training Programme for Clinicians in Translational Medicine and Therapeutics at the University of Cambridge: Support for the 2009 MPhil appointments.","funder_award_id":"085686","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G3584128611","display_name":"NIHR Senior Investigator Award","funder_award_id":"NF-SI-0512-10052","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G6180863481","display_name":"Do somatic mutations of an L-type Ca++ channel in aldosterone-producing adenomas of the adrenal indicate a novel mechanism and target for regulating aldosterone production?","funder_award_id":"FS/14/75/31134","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G9000230881","display_name":null,"funder_award_id":"085686/Z/08/J","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"},{"id":"https://openalex.org/F4320320696","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09"},{"id":"https://openalex.org/F4320321846","display_name":"Cambridge Overseas Trust","ror":"https://ror.org/05sprqy15"},{"id":"https://openalex.org/F4320336709","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349"},{"id":"https://openalex.org/F4320337282","display_name":"NIHR Sheffield Biomedical Research Centre","ror":"https://ror.org/055qwb732"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2606349786.pdf","grobid_xml":"https://content.openalex.org/works/W2606349786.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W69067651","https://openalex.org/W1968991432","https://openalex.org/W1975839423","https://openalex.org/W1981486350","https://openalex.org/W1996133111","https://openalex.org/W2000483635","https://openalex.org/W2003456330","https://openalex.org/W2004602029","https://openalex.org/W2008821347","https://openalex.org/W2010209938","https://openalex.org/W2018439544","https://openalex.org/W2019200699","https://openalex.org/W2025273598","https://openalex.org/W2042963774","https://openalex.org/W2051696368","https://openalex.org/W2052720209","https://openalex.org/W2054770977","https://openalex.org/W2055035964","https://openalex.org/W2061341378","https://openalex.org/W2067525273","https://openalex.org/W2079676267","https://openalex.org/W2089400376","https://openalex.org/W2093249186","https://openalex.org/W2099370101","https://openalex.org/W2107964427","https://openalex.org/W2107999636","https://openalex.org/W2110132731","https://openalex.org/W2113014870","https://openalex.org/W2114004604","https://openalex.org/W2114544398","https://openalex.org/W2126616537","https://openalex.org/W2137022580","https://openalex.org/W2140657586","https://openalex.org/W2146167376","https://openalex.org/W2152585030","https://openalex.org/W2156172510","https://openalex.org/W2157610967","https://openalex.org/W2159980848","https://openalex.org/W2164356078","https://openalex.org/W2168778005","https://openalex.org/W2168924012","https://openalex.org/W2169670265","https://openalex.org/W2290633895","https://openalex.org/W2320400149","https://openalex.org/W2342974630","https://openalex.org/W2426108768","https://openalex.org/W2506027258","https://openalex.org/W2526402229","https://openalex.org/W2581452190"],"related_works":["https://openalex.org/W2781614213","https://openalex.org/W2503732152","https://openalex.org/W7097288139","https://openalex.org/W2406077598","https://openalex.org/W2536203224","https://openalex.org/W3159339395","https://openalex.org/W2519482469","https://openalex.org/W2100537280","https://openalex.org/W7212167056","https://openalex.org/W4315780424"],"abstract_inverted_index":{"Primary":[0],"aldosteronism":[1],"is":[2],"a":[3,65,72,111,208,214,249],"common":[4,39,209],"cause":[5],"of":[6,25,36,68,200,207,211],"hypertension,":[7],"which":[8,78,217,238],"becomes":[9],"refractory":[10],"if":[11],"undiagnosed,":[12],"but":[13,38,190],"potentially":[14],"curable":[15],"when":[16],"caused":[17],"by":[18,108,167,216],"an":[19,161],"aldosterone-producing":[20,118],"adenoma":[21],"(APA).":[22],"The":[23,51,198],"discovery":[24,199],"somatic":[26],"mutations":[27],"and":[28,57,101,124,157,171,187,192,213],"differences":[29],"in":[30,77,90,99,120,125,133,144,184,194,202],"clinical":[31],"presentations":[32],"led":[33],"to":[34,63,95,160,230],"recognition":[35,206],"small":[37],"zona":[40,48,152,154],"glomerulosa":[41],"(ZG)\u2013like":[42],"adenomas,":[43],"distinct":[44],"from":[45,150],"classical":[46],"large":[47],"fasciculata\u2013like":[49,155],"adenomas.":[50],"inverse":[52],"correlation":[53],"between":[54],"APA":[55,188],"size":[56],"aldosterone":[58,103,220],"synthase":[59],"expression":[60,131],"prompted":[61],"us":[62],"undertake":[64],"systematic":[66],"study":[67],"genotype\u2013phenotype":[69],"relationships.":[70],"After":[71],"microarray":[73],"comparing":[74],"tumor":[75],"subtypes,":[76],"NPNT":[79,105,147,163,172,181,201,242],"(":[80],"nephronectin":[81],")":[82],"was":[83,106,132,148,165,182],"the":[84,129,203],"most":[85],"highly":[86],"(>12-fold)":[87],"upregulated":[88],"gene":[89],"ZG-like":[91,127,134],"APAs,":[92,156],"we":[93],"aimed":[94],"determine":[96],"its":[97,244],"role":[98],"physiological":[100],"pathological":[102],"production.":[104,221],"identified":[107],"immunohistochemistry":[109],"as":[110],"secreted":[112],"matrix":[113],"protein":[114],"expressed":[115],"exclusively":[116],"around":[117],"glomeruli":[119],"normal":[121,151],"adrenal":[122,186,204],"ZG":[123,158],"aldosterone-dense":[126],"APAs;":[128],"highest":[130],"APAs":[135,212],"with":[136],"gain-of-function":[137],"CTNNB1":[138],"mutations,":[139],"whose":[140],"removal":[141],"cured":[142],"hypertension":[143],"our":[145],"patients.":[146],"absent":[149],"fasciculata,":[153],"adjacent":[159],"APA.":[162],"production":[164],"regulated":[166],"canonical":[168],"Wnt":[169,218],"pathway,":[170],"overexpression":[173],"or":[174,177,243],"silencing":[175],"increased":[176],"reduced":[178],"aldosterone,":[179],"respectively.":[180],"proadhesive":[183],"primary":[185],"cells":[189],"antiadhesive":[191],"antiapoptotic":[193],"immortalized":[195],"adrenocortical":[196],"cells.":[197],"helped":[205],"subtype":[210],"pathway":[215],"regulates":[219],"We":[222],"propose":[223],"that":[224],"this":[225],"arises":[226],"through":[227],"NPNT\u2019s":[228],"binding":[229],"cell-surface":[231],"integrins,":[232],"stimulating":[233],"cell\u2013cell":[234],"contact":[235],"within":[236],"glomeruli,":[237],"define":[239],"ZG.":[240],"Therefore,":[241],"cognate":[245],"integrin":[246],"could":[247],"present":[248],"novel":[250],"therapeutic":[251],"target.":[252]},"counts_by_year":[{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-04-28T00:00:00"}