{"id":"https://openalex.org/W2606156789","doi":"https://doi.org/10.1177/2047487317706585","title":"Matrix metalloproteinase-8 and tissue inhibitor of matrix metalloproteinase-1 predict incident cardiovascular disease events and all-cause mortality in a population-based cohort","display_name":"Matrix metalloproteinase-8 and tissue inhibitor of matrix metalloproteinase-1 predict incident cardiovascular disease events and all-cause mortality in a population-based cohort","publication_year":2017,"publication_date":"2017-04-21","ids":{"openalex":"https://openalex.org/W2606156789","doi":"https://doi.org/10.1177/2047487317706585","mag":"2606156789","pmid":"https://pubmed.ncbi.nlm.nih.gov/28429955"},"language":"en","primary_location":{"id":"doi:10.1177/2047487317706585","doi":"https://doi.org/10.1177/2047487317706585","is_oa":false,"landing_page_url":"https://doi.org/10.1177/2047487317706585","pdf_url":null,"source":{"id":"https://openalex.org/S201064403","display_name":"European Journal of Preventive Cardiology","issn_l":"2047-4873","issn":["2047-4873","2047-4881"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Preventive Cardiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10138/297791","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042976264","display_name":"Immi Kormi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Immi Kormi","raw_affiliation_strings":["Oral and Maxillofacial Department, Oulu University Hospital, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oral and Maxillofacial Department, Oulu University Hospital, Finland","institution_ids":["https://openalex.org/I2799272722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022794366","display_name":"Mikko T. Nieminen","orcid":"https://orcid.org/0000-0001-6427-3196","observed_orcids":["https://orcid.org/0000-0001-6427-3196"]},"institutions":[{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Mikko T Nieminen","raw_affiliation_strings":["Oral and Maxillofacial Diseases, Helsinki University Hospital, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oral and Maxillofacial Diseases, Helsinki University Hospital, Finland","institution_ids":["https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054656133","display_name":"Aki Samuli Havulinna","orcid":"https://orcid.org/0000-0002-4787-8959","observed_orcids":["https://orcid.org/0000-0002-4787-8959"]},"institutions":[{"id":"https://openalex.org/I39624965","display_name":"Finnish Institute for Health and Welfare","ror":"https://ror.org/03tf0c761","country_code":"FI","type":"government","lineage":["https://openalex.org/I39624965"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Aki S Havulinna","raw_affiliation_strings":["National Institute for Health and Welfare, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Health and Welfare, Finland","institution_ids":["https://openalex.org/I39624965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046127730","display_name":"Tanja Zeller","orcid":"https://orcid.org/0000-0003-3379-2641","observed_orcids":["https://orcid.org/0000-0003-3379-2641"]},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tanja Zeller","raw_affiliation_strings":["Clinic for General and Interventional Cardiology, University Heart Center Hamburg, Germany","German Center for Cardiovascular Research (DZHK e.V), Partner Site Hamburg/L\u00fcbeck/Kiel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic for General and Interventional Cardiology, University Heart Center Hamburg, Germany","institution_ids":["https://openalex.org/I159176309"]},{"raw_affiliation_string":"German Center for Cardiovascular Research (DZHK e.V), Partner Site Hamburg/L\u00fcbeck/Kiel, Germany","institution_ids":["https://openalex.org/I4210127591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030454575","display_name":"Stefan Blankenberg","orcid":"https://orcid.org/0000-0001-6488-2362","observed_orcids":["https://orcid.org/0000-0001-6488-2362"]},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Blankenberg","raw_affiliation_strings":["Clinic for General and Interventional Cardiology, University Heart Center Hamburg, Germany","German Center for Cardiovascular Research (DZHK e.V), Partner Site Hamburg/L\u00fcbeck/Kiel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic for General and Interventional Cardiology, University Heart Center Hamburg, Germany","institution_ids":["https://openalex.org/I159176309"]},{"raw_affiliation_string":"German Center for Cardiovascular Research (DZHK e.V), Partner Site Hamburg/L\u00fcbeck/Kiel, Germany","institution_ids":["https://openalex.org/I4210127591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045826730","display_name":"Taina I. Tervahartiala","orcid":"https://orcid.org/0000-0001-8817-896X","observed_orcids":["https://orcid.org/0000-0001-8817-896X"]},"institutions":[{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Taina Tervahartiala","raw_affiliation_strings":["Oral and Maxillofacial Diseases, Helsinki University Hospital, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oral and Maxillofacial Diseases, Helsinki University Hospital, Finland","institution_ids":["https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065156977","display_name":"Timo A. Sorsa","orcid":"https://orcid.org/0000-0001-7914-3052","observed_orcids":["https://orcid.org/0000-0001-7914-3052"]},"institutions":[{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["FI","SE"],"is_corresponding":false,"raw_author_name":"Timo Sorsa","raw_affiliation_strings":["Division of Periodontology, Karolinska Institutet, Sweden","Oral and Maxillofacial Diseases, Helsinki University Hospital, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Periodontology, Karolinska Institutet, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Oral and Maxillofacial Diseases, Helsinki University Hospital, Finland","institution_ids":["https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066237154","display_name":"Veikko V Salomaa","orcid":"https://orcid.org/0000-0001-7563-5324","observed_orcids":["https://orcid.org/0000-0001-7563-5324"]},"institutions":[{"id":"https://openalex.org/I39624965","display_name":"Finnish Institute for Health and Welfare","ror":"https://ror.org/03tf0c761","country_code":"FI","type":"government","lineage":["https://openalex.org/I39624965"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Veikko Salomaa","raw_affiliation_strings":["National Institute for Health and Welfare, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Health and Welfare, Finland","institution_ids":["https://openalex.org/I39624965"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058684324","display_name":"Pirkko J. Pussinen","orcid":"https://orcid.org/0000-0003-3563-1876","observed_orcids":["https://orcid.org/0000-0003-3563-1876"]},"institutions":[{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Pirkko J Pussinen","raw_affiliation_strings":["Oral and Maxillofacial Diseases, Helsinki University Hospital, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oral and Maxillofacial Diseases, Helsinki University Hospital, Finland","institution_ids":["https://openalex.org/I2800394112"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5058684324"],"corresponding_institution_ids":["https://openalex.org/I2800394112"],"apc_list":{"value":3355,"currency":"EUR","value_usd":3792},"apc_paid":null,"fwci":1.9424,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.84706762,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"24","issue":"11","first_page":"1136","last_page":"1144"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.014499999582767487,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/matrix-metalloproteinase-8","display_name":"matrix metalloproteinase-8","score":1.0},{"id":"https://openalex.org/keywords/timp-1","display_name":"TIMP-1","score":0.9750000238418579},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.5509999990463257},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.8859999775886536},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9190000295639038},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.8690000176429749},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.9869999885559082},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.9129999876022339},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":1.0},{"id":"https://openalex.org/keywords/extracellular-matrix-degradation","display_name":"extracellular matrix degradation","score":0.75},{"id":"https://openalex.org/keywords/atherogenesis","display_name":"atherogenesis","score":0.7749999761581421},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7889999747276306},{"id":"https://openalex.org/keywords/risk-reclassification","display_name":"risk reclassification","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8627075552940369},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.7213766574859619},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5885974764823914},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5539824962615967},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.46699798107147217},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4425148665904999},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.4380713999271393},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.4233365058898926},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.32495254278182983},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3235146999359131},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.1941225826740265},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.050010889768600464},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D002423","descriptor_name":"Cause of Death","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D005060","descriptor_name":"Europe","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008163","descriptor_name":"Luminescent Measurements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011159","descriptor_name":"Population Surveillance","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019715","descriptor_name":"Tissue Inhibitor of Metalloproteinase-1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D020784","descriptor_name":"Matrix Metalloproteinase 8","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1177/2047487317706585","doi":"https://doi.org/10.1177/2047487317706585","is_oa":false,"landing_page_url":"https://doi.org/10.1177/2047487317706585","pdf_url":null,"source":{"id":"https://openalex.org/S201064403","display_name":"European Journal of Preventive Cardiology","issn_l":"2047-4873","issn":["2047-4873","2047-4881"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Preventive Cardiology","raw_type":"journal-article"},{"id":"pmid:28429955","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28429955","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of preventive cardiology","raw_type":"Journal Article"},{"id":"pmh:oai:helda.helsinki.fi:10138/297791","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/297791","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:www.julkari.fi:10024/134927","doi":null,"is_oa":false,"landing_page_url":"http://www.julkari.fi/handle/10024/134927","pdf_url":null,"source":{"id":"https://openalex.org/S4306402058","display_name":"STM:n Hallinnonalan avoin julkaisuarkisto (Julkari)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"WOS","raw_type":"A1"}],"best_oa_location":{"id":"pmh:oai:helda.helsinki.fi:10138/297791","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/297791","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1520348292","https://openalex.org/W1549645780","https://openalex.org/W1552425692","https://openalex.org/W1596038729","https://openalex.org/W1705441511","https://openalex.org/W1756478057","https://openalex.org/W1984970871","https://openalex.org/W1991767791","https://openalex.org/W1992113107","https://openalex.org/W1994030389","https://openalex.org/W1996726306","https://openalex.org/W1996854958","https://openalex.org/W2012154384","https://openalex.org/W2018905179","https://openalex.org/W2019140140","https://openalex.org/W2042687123","https://openalex.org/W2044477396","https://openalex.org/W2045742923","https://openalex.org/W2045870074","https://openalex.org/W2047489942","https://openalex.org/W2063614970","https://openalex.org/W2066963386","https://openalex.org/W2069967133","https://openalex.org/W2072182685","https://openalex.org/W2087314212","https://openalex.org/W2093845784","https://openalex.org/W2094470310","https://openalex.org/W2097579313","https://openalex.org/W2100990071","https://openalex.org/W2101485098","https://openalex.org/W2106319388","https://openalex.org/W2111258565","https://openalex.org/W2114490800","https://openalex.org/W2125540101","https://openalex.org/W2126861624","https://openalex.org/W2127841529","https://openalex.org/W2128335879","https://openalex.org/W2130162835","https://openalex.org/W2130172749","https://openalex.org/W2135178819","https://openalex.org/W2142795630","https://openalex.org/W2143241981","https://openalex.org/W2148092884","https://openalex.org/W2155602568","https://openalex.org/W2161574055","https://openalex.org/W2163989722","https://openalex.org/W2165670510","https://openalex.org/W2180741588","https://openalex.org/W2198646327","https://openalex.org/W2300456711","https://openalex.org/W2332656577"],"related_works":["https://openalex.org/W2523544971","https://openalex.org/W2126861624","https://openalex.org/W7100342889","https://openalex.org/W7098527607","https://openalex.org/W2163989722","https://openalex.org/W2100990071","https://openalex.org/W2739166542","https://openalex.org/W45940124","https://openalex.org/W2142795630","https://openalex.org/W2072553979"],"abstract_inverted_index":{"Background":[0],"Extracellular":[1],"matrix":[2,38,43,49,54,150,167,204,209,224,243,253,269,275],"degrading":[3],"proteases":[4],"and":[5,14,24,60,88,122,132,152,183,185,196,239,249,271,287],"their":[6],"regulators":[7],"play":[8],"an":[9],"important":[10],"role":[11],"in":[12],"atherogenesis":[13],"subsequent":[15],"plaque":[16],"rupture":[17],"leading":[18],"to":[19,137,226],"acute":[20,118],"cardiovascular":[21,66,77,112,192,284],"manifestations.":[22],"Design":[23],"methods":[25],"In":[26],"this":[27],"prospective":[28],"cohort":[29,72],"study,":[30],"we":[31],"investigated":[32],"the":[33,46,95,109,139,143,173,189,203,215,227],"prognostic":[34],"value":[35],"of":[36,42,48,53,105,142,149,208,223,234,252,274,282],"circulating":[37],"metalloproteinase-8,":[39],"tissue":[40,51,147,206,221,250,272],"inhibitor":[41,52,148,207,222,251,273],"metalloproteinase-1":[44,55,151,210,225,254,276],"concentrations,":[45],"ratio":[47,211],"metalloproteinase-8/":[50,205],"and,":[56],"for":[57,64,162,175,191,202,217,265],"comparison,":[58],"myeloperoxidase":[59,186],"C-reactive":[61,153],"protein":[62,154],"concentrations":[63,155],"incident":[65,283],"disease":[67,78,113,179,193,285],"endpoints.":[68,165],"The":[69,81,103,198],"population-based":[70],"FINRISK97":[71],"comprised":[73],"7928":[74],"persons":[75],"without":[76],"at":[79],"baseline.":[80],"baseline":[82],"survey":[83],"included":[84],"a":[85,92,176],"clinical":[86,140,261],"examination":[87],"blood":[89],"sampling.":[90],"During":[91],"13-year":[93],"follow-up":[94],"endpoints":[96],"were":[97,125,135,156],"ascertained":[98],"through":[99],"national":[100],"healthcare":[101],"registers.":[102],"associations":[104],"measured":[106],"biomarkers":[107,281],"with":[108,159,172,188,214],"endpoints,":[110],"including":[111],"event,":[114,180],"coronary":[115,177],"artery":[116,178],"disease,":[117],"myocardial":[119,181,218,235],"infarction,":[120],"stroke":[121,195],"all-cause":[123],"death,":[124,184],"analysed":[126],"using":[127],"Cox":[128],"regression":[129],"models.":[130],"Discrimination":[131],"reclassification":[133,263],"models":[134],"used":[136],"evaluate":[138],"implications":[141],"biomarkers.":[144],"Results":[145],"Serum":[146,268],"associated":[157,171],"significantly":[158],"increased":[160],"risk":[161,174,190,216,229,232],"all":[163],"studied":[164],"Additionally,":[166],"metalloproteinase-8":[168,244,270],"concentration":[169,187],"was":[170,212],"infarction":[182,236],"events,":[194],"death.":[197,266,288],"only":[199],"significant":[200,260],"association":[201],"observed":[213],"infarction.":[219],"Adding":[220],"established":[228],"profile":[230],"improved":[231],"discrimination":[233],"(":[237],"p=0.039)":[238],"death":[240],"(0.001).":[241],"Both":[242],"(5.2%,":[245],"p":[246,256],"<":[247,257],"0.001)":[248,258],"(12.9%,":[255],"provided":[259],"net":[262],"improvement":[264],"Conclusions":[267],"can":[277],"be":[278],"considered":[279],"as":[280],"events":[286]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2017-04-28T00:00:00"}
