{"id":"https://openalex.org/W2606131944","doi":"https://doi.org/10.7554/elife.23932","title":"Single-molecule visualization of fast polymerase turnover in the bacterial replisome","display_name":"Single-molecule visualization of fast polymerase turnover in the bacterial replisome","publication_year":2017,"publication_date":"2017-04-22","ids":{"openalex":"https://openalex.org/W2606131944","doi":"https://doi.org/10.7554/elife.23932","mag":"2606131944","pmid":"https://pubmed.ncbi.nlm.nih.gov/28432790","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5419744"},"language":"en","primary_location":{"id":"doi:10.7554/elife.23932","doi":"https://doi.org/10.7554/elife.23932","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.23932","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.23932","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073253236","display_name":"Jacob S. Lewis","orcid":"https://orcid.org/0000-0002-9945-6133","observed_orcids":["https://orcid.org/0000-0002-9945-6133"]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]},{"id":"https://openalex.org/I4210091629","display_name":"Illawarra Health and Medical Research Institute","ror":"https://ror.org/00dt9qb91","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210091629"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jacob S Lewis","raw_affiliation_strings":["Centre for Medical and Molecular Bioscience, University of Wollongong, Wollongong, Australia","Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, Australia"],"raw_orcid":"https://orcid.org/0000-0002-9945-6133","affiliations":[{"raw_affiliation_string":"Centre for Medical and Molecular Bioscience, University of Wollongong, Wollongong, Australia","institution_ids":["https://openalex.org/I204824540"]},{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, Australia","institution_ids":["https://openalex.org/I204824540","https://openalex.org/I4210091629"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039468934","display_name":"Lisanne M. Spenkelink","orcid":"https://orcid.org/0000-0002-5511-8757","observed_orcids":["https://orcid.org/0000-0002-5511-8757"]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]},{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]},{"id":"https://openalex.org/I4210091629","display_name":"Illawarra Health and Medical Research Institute","ror":"https://ror.org/00dt9qb91","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210091629"]},{"id":"https://openalex.org/I4405280116","display_name":"Zernike Institute for Advanced Materials","ror":"https://ror.org/02fc7pq83","country_code":"NL","type":"facility","lineage":["https://openalex.org/I169381384","https://openalex.org/I4405280116"]}],"countries":["AU","NL"],"is_corresponding":false,"raw_author_name":"Lisanne M Spenkelink","raw_affiliation_strings":["Centre for Medical and Molecular Bioscience, University of Wollongong, Wollongong, Australia","Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, Australia","Zernike Institute for Advanced Materials, University of Groningen, Groningen, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-5511-8757","affiliations":[{"raw_affiliation_string":"Centre for Medical and Molecular Bioscience, University of Wollongong, Wollongong, Australia","institution_ids":["https://openalex.org/I204824540"]},{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, Australia","institution_ids":["https://openalex.org/I204824540","https://openalex.org/I4210091629"]},{"raw_affiliation_string":"Zernike Institute for Advanced Materials, University of Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I169381384","https://openalex.org/I4405280116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064106093","display_name":"Slobodan Jergic","orcid":"https://orcid.org/0000-0001-5252-0815","observed_orcids":["https://orcid.org/0000-0001-5252-0815"]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]},{"id":"https://openalex.org/I4210091629","display_name":"Illawarra Health and Medical Research Institute","ror":"https://ror.org/00dt9qb91","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210091629"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Slobodan Jergic","raw_affiliation_strings":["Centre for Medical and Molecular Bioscience, University of Wollongong, Wollongong, Australia","Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Medical and Molecular Bioscience, University of Wollongong, Wollongong, Australia","institution_ids":["https://openalex.org/I204824540"]},{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, Australia","institution_ids":["https://openalex.org/I204824540","https://openalex.org/I4210091629"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009865471","display_name":"Elizabeth A. Wood","orcid":"https://orcid.org/0000-0002-7769-8481","observed_orcids":["https://orcid.org/0000-0002-7769-8481"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth A Wood","raw_affiliation_strings":["Department of Biochemistry, University of Wisconsin-Madison, Madison, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Wisconsin-Madison, Madison, United States","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039426525","display_name":"Enrico Monachino","orcid":"https://orcid.org/0000-0002-2032-2950","observed_orcids":["https://orcid.org/0000-0002-2032-2950"]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]},{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]},{"id":"https://openalex.org/I4210091629","display_name":"Illawarra Health and Medical Research Institute","ror":"https://ror.org/00dt9qb91","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210091629"]},{"id":"https://openalex.org/I4405280116","display_name":"Zernike Institute for Advanced Materials","ror":"https://ror.org/02fc7pq83","country_code":"NL","type":"facility","lineage":["https://openalex.org/I169381384","https://openalex.org/I4405280116"]}],"countries":["AU","NL"],"is_corresponding":false,"raw_author_name":"Enrico Monachino","raw_affiliation_strings":["Centre for Medical and Molecular Bioscience, University of Wollongong, Wollongong, Australia","Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, Australia","Zernike Institute for Advanced Materials, University of Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Medical and Molecular Bioscience, University of Wollongong, Wollongong, Australia","institution_ids":["https://openalex.org/I204824540"]},{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, Australia","institution_ids":["https://openalex.org/I204824540","https://openalex.org/I4210091629"]},{"raw_affiliation_string":"Zernike Institute for Advanced Materials, University of Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I169381384","https://openalex.org/I4405280116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016793933","display_name":"Nicholas P Horan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]},{"id":"https://openalex.org/I4210091629","display_name":"Illawarra Health and Medical Research Institute","ror":"https://ror.org/00dt9qb91","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210091629"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Nicholas P Horan","raw_affiliation_strings":["Centre for Medical and Molecular Bioscience, University of Wollongong, Wollongong, Australia","Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Medical and Molecular Bioscience, University of Wollongong, Wollongong, Australia","institution_ids":["https://openalex.org/I204824540"]},{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, Australia","institution_ids":["https://openalex.org/I204824540","https://openalex.org/I4210091629"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036678986","display_name":"Karl E. Duderstadt","orcid":"https://orcid.org/0000-0002-1279-7841","observed_orcids":["https://orcid.org/0000-0002-1279-7841"]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]},{"id":"https://openalex.org/I4210150093","display_name":"Max Planck Institute of Biochemistry","ror":"https://ror.org/04py35477","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]},{"id":"https://openalex.org/I4405280116","display_name":"Zernike Institute for Advanced Materials","ror":"https://ror.org/02fc7pq83","country_code":"NL","type":"facility","lineage":["https://openalex.org/I169381384","https://openalex.org/I4405280116"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE","NL"],"is_corresponding":false,"raw_author_name":"Karl E Duderstadt","raw_affiliation_strings":["Max Planck Institute of Biochemistry, Martinsried, Germany","Physik Department, Technishche Universit\u00e4t M\u00fcnchen, Garching, Germany","Zernike Institute for Advanced Materials, University of Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute of Biochemistry, Martinsried, Germany","institution_ids":["https://openalex.org/I4210150093"]},{"raw_affiliation_string":"Physik Department, Technishche Universit\u00e4t M\u00fcnchen, Garching, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Zernike Institute for Advanced Materials, University of Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I169381384","https://openalex.org/I4405280116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080771015","display_name":"Michael M. Cox","orcid":"https://orcid.org/0000-0003-3606-5722","observed_orcids":["https://orcid.org/0000-0003-3606-5722"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael M Cox","raw_affiliation_strings":["Department of Biochemistry, University of Wisconsin-Madison, Madison, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Wisconsin-Madison, Madison, United States","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056379010","display_name":"Andrew Robinson","orcid":"https://orcid.org/0000-0002-3544-0976","observed_orcids":["https://orcid.org/0000-0002-3544-0976"]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]},{"id":"https://openalex.org/I4210091629","display_name":"Illawarra Health and Medical Research Institute","ror":"https://ror.org/00dt9qb91","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210091629"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Andrew Robinson","raw_affiliation_strings":["Centre for Medical and Molecular Bioscience, University of Wollongong, Wollongong, Australia","Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Medical and Molecular Bioscience, University of Wollongong, Wollongong, Australia","institution_ids":["https://openalex.org/I204824540"]},{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, Australia","institution_ids":["https://openalex.org/I204824540","https://openalex.org/I4210091629"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011359890","display_name":"Nicholas E. Dixon","orcid":"https://orcid.org/0000-0002-5958-6945","observed_orcids":["https://orcid.org/0000-0002-5958-6945"]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]},{"id":"https://openalex.org/I4210091629","display_name":"Illawarra Health and Medical Research Institute","ror":"https://ror.org/00dt9qb91","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210091629"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Nicholas E Dixon","raw_affiliation_strings":["Centre for Medical and Molecular Bioscience, University of Wollongong, Wollongong, Australia","Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, Australia"],"raw_orcid":"https://orcid.org/0000-0002-5958-6945","affiliations":[{"raw_affiliation_string":"Centre for Medical and Molecular Bioscience, University of Wollongong, Wollongong, Australia","institution_ids":["https://openalex.org/I204824540"]},{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, Australia","institution_ids":["https://openalex.org/I204824540","https://openalex.org/I4210091629"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075591359","display_name":"Antoine M. van Oijen","orcid":"https://orcid.org/0000-0002-1794-5161","observed_orcids":["https://orcid.org/0000-0002-1794-5161"]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]},{"id":"https://openalex.org/I4210091629","display_name":"Illawarra Health and Medical Research Institute","ror":"https://ror.org/00dt9qb91","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210091629"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Antoine M van Oijen","raw_affiliation_strings":["Centre for Medical and Molecular Bioscience, University of Wollongong, Wollongong, Australia","Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, Australia"],"raw_orcid":"https://orcid.org/0000-0002-1794-5161","affiliations":[{"raw_affiliation_string":"Centre for Medical and Molecular Bioscience, University of Wollongong, Wollongong, Australia","institution_ids":["https://openalex.org/I204824540"]},{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, Australia","institution_ids":["https://openalex.org/I204824540","https://openalex.org/I4210091629"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5075591359"],"corresponding_institution_ids":["https://openalex.org/I204824540","https://openalex.org/I4210091629"],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":6.4295,"has_fulltext":true,"cited_by_count":120,"citation_normalized_percentile":{"value":0.97810992,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"6","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.6747999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.6747999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.23800000548362732,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.024800000712275505,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/replisome","display_name":"replisome","score":0.8379999995231628},{"id":"https://openalex.org/keywords/clamp-loader","display_name":"clamp loader","score":0.6420000195503235},{"id":"https://openalex.org/keywords/dna-replication","display_name":"DNA replication","score":0.6660000085830688},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9240000247955322},{"id":"https://openalex.org/keywords/single-molecule-imaging","display_name":"single-molecule imaging","score":0.6930000185966492},{"id":"https://openalex.org/keywords/live-cell-imaging","display_name":"live-cell imaging","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C149187182","wikidata":"https://www.wikidata.org/wiki/Q22325217","display_name":"Replisome","level":5,"score":0.9694739580154419},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.8106129169464111},{"id":"https://openalex.org/C131140672","wikidata":"https://www.wikidata.org/wiki/Q2031164","display_name":"Processivity","level":4,"score":0.748855710029602},{"id":"https://openalex.org/C31254050","wikidata":"https://www.wikidata.org/wiki/Q22328799","display_name":"DNA clamp","level":5,"score":0.6974326372146606},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.6762364506721497},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6058484315872192},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.5904996991157532},{"id":"https://openalex.org/C88354546","wikidata":"https://www.wikidata.org/wiki/Q3502973","display_name":"DNA polymerase II","level":5,"score":0.5799766778945923},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5720042586326599},{"id":"https://openalex.org/C76535049","wikidata":"https://www.wikidata.org/wiki/Q3487941","display_name":"DNA polymerase delta","level":5,"score":0.5286256074905396},{"id":"https://openalex.org/C164965036","wikidata":"https://www.wikidata.org/wiki/Q2529148","display_name":"DNA polymerase I","level":5,"score":0.42612963914871216},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4045524597167969},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3658522069454193},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.34292152523994446},{"id":"https://openalex.org/C58167604","wikidata":"https://www.wikidata.org/wiki/Q5121654","display_name":"Circular bacterial chromosome","level":4,"score":0.18810498714447021},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.1604710817337036},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14329150319099426},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.0765247642993927}],"mesh":[{"descriptor_ui":"D000072760","descriptor_name":"Single Molecule Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004258","descriptor_name":"DNA Polymerase III","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.7554/elife.23932","doi":"https://doi.org/10.7554/elife.23932","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.23932","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},{"id":"pmid:28432790","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28432790","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5419744","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5419744/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Text"},{"id":"pmh:oai:pure.rug.nl:openaire/6b5d1784-7c47-426f-a764-c7750a8ae79e","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/6b5d1784-7c47-426f-a764-c7750a8ae79e","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lewis, J S, Spenkelink, L M, Jergic, S, Wood, E A, Monachino, E, Horan, N P, Duderstadt, K E, Cox, M M, Robinson, A, Dixon, N E & van Oijen, A M 2017, 'Single-molecule visualization of fast polymerase turnover in the bacterial replisome', eLife, vol. 6, 23932. https://doi.org/10.7554/eLife.23932","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.mpg.de:item_2446262","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11858/00-001M-0000-002D-5339-1","pdf_url":"https://hdl.handle.net/11858/00-001M-0000-002D-533C-C","source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:ro.uow.edu.au:ihmri-2113","doi":null,"is_oa":false,"landing_page_url":"https://ro.uow.edu.au/ihmri/1087","pdf_url":null,"source":{"id":"https://openalex.org/S4306400510","display_name":"Research Online (University of Wollongong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204824540","host_organization_name":"University of Wollongong","host_organization_lineage":["https://openalex.org/I204824540"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Illawarra Health and Medical Research Institute","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:146175f49fcc48049bc88b2ce1fc710c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/146175f49fcc48049bc88b2ce1fc710c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, Vol 6 (2017)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/27781263","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/journal_contribution/Single-molecule_visualization_of_fast_polymerase_turnover_in_the_bacterial_replisome/27781263","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:rug:oai:pure.rug.nl:publications/6b5d1784-7c47-426f-a764-c7750a8ae79e","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/6b5d1784-7c47-426f-a764-c7750a8ae79e","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, 6:23932. ELIFE SCIENCES PUBLICATIONS LTD","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.7554/elife.23932","doi":"https://doi.org/10.7554/elife.23932","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.23932","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4722312262","display_name":"Functional Dissection of the Bacterial Replisome","funder_award_id":"DP150100956","funder_id":"https://openalex.org/F4320334704","funder_display_name":"Australian Research Council"},{"id":"https://openalex.org/G5085209918","display_name":null,"funder_award_id":"12CMCE03","funder_id":"https://openalex.org/F4320320925","funder_display_name":"Stichting voor Fundamenteel Onderzoek der Materie"},{"id":"https://openalex.org/G7165872653","display_name":"Mechanisms and applications of recombinational DNA repair","funder_award_id":"U01GM032335","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7399874518","display_name":"The Biochemistry of Genetic Recombination/RecA Protein","funder_award_id":"R01GM032335","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8108170852","display_name":"Under the hood: single-molecule studies of multi-protein machines","funder_award_id":"FL140100027","funder_id":"https://openalex.org/F4320334704","funder_display_name":"Australian Research Council"},{"id":"https://openalex.org/G9000243287","display_name":null,"funder_award_id":"GM32335","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320315885","display_name":"Australian Government","ror":"https://ror.org/0314h5y94"},{"id":"https://openalex.org/F4320320925","display_name":"Stichting voor Fundamenteel Onderzoek der Materie","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334704","display_name":"Australian Research Council","ror":"https://ror.org/05mmh0f86"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2606131944.pdf","grobid_xml":"https://content.openalex.org/works/W2606131944.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1493097357","https://openalex.org/W1548610738","https://openalex.org/W1586315068","https://openalex.org/W1606519018","https://openalex.org/W1652360688","https://openalex.org/W1964549900","https://openalex.org/W1964736292","https://openalex.org/W1975997119","https://openalex.org/W1987717977","https://openalex.org/W1999350701","https://openalex.org/W1999428731","https://openalex.org/W2007362519","https://openalex.org/W2007637828","https://openalex.org/W2024220597","https://openalex.org/W2033224916","https://openalex.org/W2033870603","https://openalex.org/W2043736118","https://openalex.org/W2047582152","https://openalex.org/W2050865906","https://openalex.org/W2052508338","https://openalex.org/W2070181970","https://openalex.org/W2080058516","https://openalex.org/W2081581884","https://openalex.org/W2082840763","https://openalex.org/W2094006139","https://openalex.org/W2106285580","https://openalex.org/W2108539496","https://openalex.org/W2110095772","https://openalex.org/W2120468791","https://openalex.org/W2124041751","https://openalex.org/W2125996824","https://openalex.org/W2138180167","https://openalex.org/W2148593566","https://openalex.org/W2152780402","https://openalex.org/W2163634904","https://openalex.org/W2196633663","https://openalex.org/W2237687273","https://openalex.org/W2319364552","https://openalex.org/W2343166714","https://openalex.org/W2410925476","https://openalex.org/W2553282670","https://openalex.org/W2602490333","https://openalex.org/W4240412933"],"related_works":["https://openalex.org/W7165488265","https://openalex.org/W2602490333","https://openalex.org/W2053693072","https://openalex.org/W42506871","https://openalex.org/W2194888552","https://openalex.org/W1977803144","https://openalex.org/W75099420","https://openalex.org/W2002709421","https://openalex.org/W1975997119","https://openalex.org/W4416424295"],"abstract_inverted_index":{"The":[0],"Escherichia":[1],"coli":[2],"DNA":[3,19,33,91],"replication":[4],"machinery":[5],"has":[6],"been":[7],"used":[8],"as":[9],"a":[10,126,131],"road":[11],"map":[12],"to":[13,73,99],"uncover":[14],"design":[15],"rules":[16],"that":[17,52,75],"enable":[18],"duplication":[20],"with":[21,69],"high":[22],"efficiency":[23],"and":[24,121,135],"fidelity.":[25],"Although":[26],"the":[27,31,42,49,53,61,76,82,94,102,147],"enzymatic":[28],"activities":[29],"of":[30,104,139],"replicative":[32],"Pol":[34,54,77,105],"III":[35,55],"are":[36,44],"well":[37],"understood,":[38],"its":[39],"dynamics":[40],"within":[41,60],"replisome":[43,95],"not.":[45],"Here,":[46],"we":[47],"test":[48],"accepted":[50],"view":[51],"holoenzyme":[56],"remains":[57],"stably":[58],"associated":[59],"replisome.":[62],"We":[63,109],"use":[64],"in":[65,101,107,114,146],"vitro":[66],"single-molecule":[67],"assays":[68],"fluorescently":[70],"labeled":[71,118],"polymerases":[72],"demonstrate":[74],"III*":[78,106],"complex":[79],"(holoenzyme":[80],"lacking":[81],"\u03b22":[83],"sliding":[84],"clamp),":[85],"is":[86,96],"rapidly":[87],"exchanged":[88],"during":[89],"processive":[90],"replication.":[92],"Nevertheless,":[93],"highly":[97],"resistant":[98],"dilution":[100],"absence":[103],"solution.":[108],"further":[110],"show":[111],"similar":[112],"exchange":[113,128],"live":[115],"cells":[116],"containing":[117],"clamp":[119],"loader":[120],"polymerase.":[122],"These":[123],"observations":[124],"suggest":[125],"concentration-dependent":[127],"mechanism":[129],"providing":[130],"balance":[132],"between":[133],"stability":[134],"plasticity,":[136],"facilitating":[137],"replacement":[138],"replisomal":[140],"components":[141],"dependent":[142],"on":[143],"their":[144],"availability":[145],"environment.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":8}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2017-04-28T00:00:00"}