{"id":"https://openalex.org/W2606130024","doi":null,"title":"Binding and Entry Mechanisms of Adenovirus in Polarized Epithelial Cells","display_name":"Binding and Entry Mechanisms of Adenovirus in Polarized Epithelial Cells","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2606130024","mag":"2606130024"},"language":"en","primary_location":{"id":"pmh:oai:corescholar.libraries.wright.edu:etd_all-2584","doi":null,"is_oa":true,"landing_page_url":"https://corescholar.libraries.wright.edu/etd_all/1444","pdf_url":"https://corescholar.libraries.wright.edu/cgi/viewcontent.cgi?article=2584&context=etd_all","source":{"id":"https://openalex.org/S2737205702","display_name":"Journal of Bioresource Management","issn_l":"2309-3854","issn":["2309-3854"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","erih-plus"],"host_organization":"https://openalex.org/P4310316536","host_organization_name":"Bioresource Research Center (BRC), Islamabad","host_organization_lineage":["https://openalex.org/P4310316536"],"host_organization_lineage_names":["Bioresource Research Center (BRC), Islamabad"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Browse all Theses and Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://corescholar.libraries.wright.edu/cgi/viewcontent.cgi?article=2584&context=etd_all","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012587234","display_name":"Trisha L. Brockman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19648265","display_name":"Wright State University","ror":"https://ror.org/04qk6pt94","country_code":"US","type":"education","lineage":["https://openalex.org/I19648265"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Trisha L. Brockman","raw_affiliation_strings":["Wright State University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wright State University;","institution_ids":["https://openalex.org/I19648265"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012587234"],"corresponding_institution_ids":["https://openalex.org/I19648265"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.2851097,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.017100000753998756,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenovirus","display_name":"adenovirus","score":0.8059999942779541},{"id":"https://openalex.org/keywords/coxsackie-adenovirus-receptor","display_name":"coxsackievirus and adenovirus receptor","score":0.9570000171661377}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5145482420921326},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.444646954536438},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.392924040555954},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.39249804615974426},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.274486780166626}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:corescholar.libraries.wright.edu:etd_all-2584","doi":null,"is_oa":true,"landing_page_url":"https://corescholar.libraries.wright.edu/etd_all/1444","pdf_url":"https://corescholar.libraries.wright.edu/cgi/viewcontent.cgi?article=2584&context=etd_all","source":{"id":"https://openalex.org/S2737205702","display_name":"Journal of Bioresource Management","issn_l":"2309-3854","issn":["2309-3854"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","erih-plus"],"host_organization":"https://openalex.org/P4310316536","host_organization_name":"Bioresource Research Center (BRC), Islamabad","host_organization_lineage":["https://openalex.org/P4310316536"],"host_organization_lineage_names":["Bioresource Research Center (BRC), Islamabad"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Browse all Theses and Dissertations","raw_type":"text"},{"id":"pmh:oai:etd.ohiolink.edu:wright1410214584","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=wright1410214584","pdf_url":null,"source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=wright1410214584","raw_type":"text"},{"id":"mag:2606130024","doi":null,"is_oa":false,"landing_page_url":"https://corescholar.libraries.wright.edu/etd_all/1444/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:corescholar.libraries.wright.edu:etd_all-2584","doi":null,"is_oa":true,"landing_page_url":"https://corescholar.libraries.wright.edu/etd_all/1444","pdf_url":"https://corescholar.libraries.wright.edu/cgi/viewcontent.cgi?article=2584&context=etd_all","source":{"id":"https://openalex.org/S2737205702","display_name":"Journal of Bioresource Management","issn_l":"2309-3854","issn":["2309-3854"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","erih-plus"],"host_organization":"https://openalex.org/P4310316536","host_organization_name":"Bioresource Research Center (BRC), Islamabad","host_organization_lineage":["https://openalex.org/P4310316536"],"host_organization_lineage_names":["Bioresource Research Center (BRC), Islamabad"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Browse all Theses and Dissertations","raw_type":"text"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2606130024.pdf","grobid_xml":"https://content.openalex.org/works/W2606130024.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4210570634","https://openalex.org/W7000329203","https://openalex.org/W2084894878","https://openalex.org/W7099796817","https://openalex.org/W2062855335","https://openalex.org/W2548234321","https://openalex.org/W2964848800","https://openalex.org/W6996162122","https://openalex.org/W2531611277","https://openalex.org/W7100406410"],"abstract_inverted_index":{"Adenovirus's":[0],"primary":[1],"receptor,":[2],"the":[3,45,86],"Coxsackievirus":[4],"and":[5,36,110,115],"adenovirus":[6,141],"receptor":[7],"(CAR),":[8],"has":[9],"two":[10],"transmembrane":[11],"isoforms":[12],"with":[13,99],"differential":[14],"localization":[15],"within":[16],"polarized":[17,93],"epithelial":[18],"cells":[19],"(CAREx7":[20],"(basolateral),":[21],"CAREx8":[22,108,116,132],"(apical)).":[23],"I":[24],"hypothesized":[25],"that":[26,146],"each":[27],"isoform":[28],"of":[29,47,88],"CAR":[30,48,154],"is":[31,37,49],"degraded":[32],"at":[33,134],"different":[34],"rates":[35],"regulated":[38],"by":[39],"Src-family":[40,127],"kinases.":[41],"Increasing":[42],"or":[43,72],"decreasing":[44],"concentration":[46],"predicted":[50],"to":[51,84,105],"directly":[52],"alter":[53],"adenoviral":[54,160],"entry.":[55],"To":[56],"test":[57,106],"this":[58],"hypothesis,":[59],"inducible":[60],"Madin":[61],"Darby":[62],"Canine":[63],"Kidney":[64],"(MDCK)":[65],"cell":[66],"lines":[67],"either":[68],"expressing":[69],"CAREx7,":[70],"CAREx8,":[71],"mCherry,":[73],"under":[74],"a":[75,92,151],"doxycycline-inducible":[76],"promoter":[77],"were":[78],"used":[79,104],"in":[80,153],"pulse-chase":[81],"structured":[82],"experiments":[83],"calculate":[85],"half-lives":[87,120],"these":[89],"proteins.":[90],"Alternatively,":[91],"model":[94],"lung":[95],"epithelium":[96],"(CaLu-3)":[97],"treated":[98],"Src-kinase":[100],"inhibitor,":[101],"PP2,":[102],"was":[103],"apical":[107],"expression":[109,133],"viral":[111],"transduction.":[112,142],"Though":[113],"CAREx7":[114],"did":[117,129,139],"have":[118],"varying":[119],"(5.1":[121],"h,":[122],"2.0":[123],"h":[124],"respectively),":[125],"inhibiting":[126],"kinases":[128],"not":[130,149],"decrease":[131],"early":[135],"time":[136],"points":[137],"but":[138,156],"diminish":[140],"These":[143],"data":[144],"confirm":[145],"Src":[147],"does":[148],"play":[150],"role":[152],"turnover,":[155],"remains":[157],"critical":[158],"for":[159],"infection.":[161]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2017-04-28T00:00:00"}