{"id":"https://openalex.org/W2606073047","doi":"https://doi.org/10.1073/pnas.1703066114","title":"Structure of a DNA glycosylase that unhooks interstrand cross-links","display_name":"Structure of a DNA glycosylase that unhooks interstrand cross-links","publication_year":2017,"publication_date":"2017-04-10","ids":{"openalex":"https://openalex.org/W2606073047","doi":"https://doi.org/10.1073/pnas.1703066114","mag":"2606073047","pmid":"https://pubmed.ncbi.nlm.nih.gov/28396405","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5410837"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1703066114","doi":"https://doi.org/10.1073/pnas.1703066114","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1703066114","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5410837","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050798041","display_name":"E.A. Mullins","orcid":"https://orcid.org/0000-0003-3834-1065","observed_orcids":["https://orcid.org/0000-0003-3834-1065"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elwood A. Mullins","raw_affiliation_strings":["Center for Structural Biology, Vanderbilt University, Nashville, TN 37232;","Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Structural Biology, Vanderbilt University, Nashville, TN 37232;","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232;","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009634965","display_name":"Garrett M. Warren","orcid":"https://orcid.org/0000-0002-9949-309X","observed_orcids":["https://orcid.org/0000-0002-9949-309X"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Garrett M. Warren","raw_affiliation_strings":["Center for Structural Biology, Vanderbilt University, Nashville, TN 37232;","Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Structural Biology, Vanderbilt University, Nashville, TN 37232;","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232;","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048506955","display_name":"Noah P. Bradley","orcid":"https://orcid.org/0000-0002-2701-3405","observed_orcids":["https://orcid.org/0000-0002-2701-3405"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noah P. Bradley","raw_affiliation_strings":["Center for Structural Biology, Vanderbilt University, Nashville, TN 37232;","Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Structural Biology, Vanderbilt University, Nashville, TN 37232;","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232;","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056500437","display_name":"Brandt F. Eichman","orcid":"https://orcid.org/0000-0002-0965-2297","observed_orcids":["https://orcid.org/0000-0002-0965-2297"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandt F. Eichman","raw_affiliation_strings":["Center for Structural Biology, Vanderbilt University, Nashville, TN 37232;","Department of Biochemistry, Vanderbilt University, Nashville, TN 37232","Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Structural Biology, Vanderbilt University, Nashville, TN 37232;","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Biochemistry, Vanderbilt University, Nashville, TN 37232","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232;","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":null,"apc_paid":null,"fwci":1.34,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.79033773,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"114","issue":"17","first_page":"4400","last_page":"4405"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.7997999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.7997999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.12449999898672104,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.03189999982714653,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-glycosylase","display_name":"DNA glycosylase","score":0.9409999847412109},{"id":"https://openalex.org/keywords/interstrand-crosslinks","display_name":"interstrand cross-links","score":0.9620000123977661},{"id":"https://openalex.org/keywords/base-excision-repair","display_name":"base excision repair","score":0.8799999952316284},{"id":"https://openalex.org/keywords/winged-helix-turn-helix","display_name":"winged helix-turn-helix","score":0.8629999756813049},{"id":"https://openalex.org/keywords/glutamine-residues","display_name":"glutamine residues","score":0.8489999771118164},{"id":"https://openalex.org/keywords/beta-hairpin","display_name":"beta-hairpin","score":0.9459999799728394},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.7879999876022339},{"id":"https://openalex.org/keywords/bacterial-dna-repair","display_name":"bacterial DNA repair","score":0.6610000133514404},{"id":"https://openalex.org/keywords/host-pathogen-interaction","display_name":"host-pathogen interaction","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C192396546","wikidata":"https://www.wikidata.org/wiki/Q413156","display_name":"DNA glycosylase","level":4,"score":0.9203385710716248},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.645767867565155},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6310120820999146},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5837023854255676},{"id":"https://openalex.org/C187206112","wikidata":"https://www.wikidata.org/wiki/Q3113091","display_name":"Base excision repair","level":4,"score":0.5808206796646118},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4960413873195648},{"id":"https://openalex.org/C104451858","wikidata":"https://www.wikidata.org/wiki/Q2714458","display_name":"Nucleotide excision repair","level":4,"score":0.4701671302318573},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4236266016960144},{"id":"https://openalex.org/C161223559","wikidata":"https://www.wikidata.org/wiki/Q138864","display_name":"Helicase","level":4,"score":0.41141822934150696},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3771055340766907},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14489862322807312},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.14483410120010376}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009281","descriptor_name":"Naphthalenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009281","descriptor_name":"Naphthalenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045647","descriptor_name":"DNA Glycosylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045647","descriptor_name":"DNA Glycosylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045647","descriptor_name":"DNA Glycosylases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.1703066114","doi":"https://doi.org/10.1073/pnas.1703066114","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1703066114","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5410837","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5410837","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:28396405","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28396405","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:osti.gov:1372258","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1372258","pdf_url":"https://www.osti.gov/servlets/purl/1372258","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5410837","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5410837","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G107546177","display_name":null,"funder_award_id":"DE- AC02-06-CH11357","funder_id":"https://openalex.org/F4320338284","funder_display_name":"Argonne National Laboratory"},{"id":"https://openalex.org/G1313983767","display_name":null,"funder_award_id":"DE-AC02","funder_id":"https://openalex.org/F4320338284","funder_display_name":"Argonne National Laboratory"},{"id":"https://openalex.org/G1664757510","display_name":null,"funder_award_id":"AC02\u201306CH11357","funder_id":"https://openalex.org/F4320338284","funder_display_name":"Argonne National Laboratory"},{"id":"https://openalex.org/G1762607292","display_name":null,"funder_award_id":"R01ES019625","funder_id":"https://openalex.org/F4320337544","funder_display_name":"Office of Extramural Research, National Institutes of Health"},{"id":"https://openalex.org/G1947107004","display_name":null,"funder_award_id":"085P1000817","funder_id":"https://openalex.org/F4320338284","funder_display_name":"Argonne National Laboratory"},{"id":"https://openalex.org/G2287611682","display_name":null,"funder_award_id":"AC02\u201006CH11357","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G262962599","display_name":null,"funder_award_id":"AC02\u201006CH11357","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G3075337988","display_name":null,"funder_award_id":"06CH11357","funder_id":"https://openalex.org/F4320338284","funder_display_name":"Argonne National Laboratory"},{"id":"https://openalex.org/G3329398301","display_name":null,"funder_award_id":"DE-AC02-06CH11357","funder_id":"https://openalex.org/F4320334038","funder_display_name":"Michigan Technology Tri-Corridor"},{"id":"https://openalex.org/G416541740","display_name":null,"funder_award_id":"085P1000817","funder_id":"https://openalex.org/F4320334038","funder_display_name":"Michigan Technology Tri-Corridor"},{"id":"https://openalex.org/G4231426273","display_name":"A New Structural Architecture for Recognition of DNA Damage","funder_award_id":"1517695","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4773269573","display_name":null,"funder_award_id":"085P1000817","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G498139845","display_name":null,"funder_award_id":"DE-AC02","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G513797252","display_name":null,"funder_award_id":"DE-AC02\u201306CH11357","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5607048534","display_name":null,"funder_award_id":"DE-AC02\u201306CH11357","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5906309288","display_name":null,"funder_award_id":"085P1000817","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G5975312287","display_name":null,"funder_award_id":"T32ES07028","funder_id":"https://openalex.org/F4320337544","funder_display_name":"Office of Extramural Research, National Institutes of Health"},{"id":"https://openalex.org/G6848031779","display_name":null,"funder_award_id":"06CH11357","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G6918803902","display_name":null,"funder_award_id":"06CH11357","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G7131236900","display_name":"Crystallographic Automation","funder_award_id":"S10RR026915","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G7147508703","display_name":null,"funder_award_id":"085P1000817","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8362364538","display_name":null,"funder_award_id":"085P1000817","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G859008934","display_name":"Mechanisms of selective excision and oxidative repair of alkylated DNA","funder_award_id":"R01ES019625","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000914247","display_name":"Training Program in Environmental Toxicology","funder_award_id":"T32ES007028","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G969889393","display_name":null,"funder_award_id":"DE-AC02-","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G993149817","display_name":null,"funder_award_id":"DE-AC02-06CH11357 ","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320309151","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320334038","display_name":"Michigan Technology Tri-Corridor","ror":null},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337544","display_name":"Office of Extramural Research, National Institutes of Health","ror":"https://ror.org/05aq6yn88"},{"id":"https://openalex.org/F4320338284","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1539796472","https://openalex.org/W1874262838","https://openalex.org/W1969435183","https://openalex.org/W1982266992","https://openalex.org/W1983172492","https://openalex.org/W1991144086","https://openalex.org/W1994390940","https://openalex.org/W1994677283","https://openalex.org/W1999235659","https://openalex.org/W2019102075","https://openalex.org/W2022058405","https://openalex.org/W2026273332","https://openalex.org/W2029257339","https://openalex.org/W2030519118","https://openalex.org/W2032230159","https://openalex.org/W2034438104","https://openalex.org/W2035072013","https://openalex.org/W2036430935","https://openalex.org/W2038507406","https://openalex.org/W2050635419","https://openalex.org/W2059988559","https://openalex.org/W2060553286","https://openalex.org/W2068599914","https://openalex.org/W2070441533","https://openalex.org/W2077967078","https://openalex.org/W2093444752","https://openalex.org/W2100077840","https://openalex.org/W2104327623","https://openalex.org/W2109345619","https://openalex.org/W2113904137","https://openalex.org/W2114622716","https://openalex.org/W2115208252","https://openalex.org/W2122339645","https://openalex.org/W2124026197","https://openalex.org/W2141451936","https://openalex.org/W2145200068","https://openalex.org/W2151157717","https://openalex.org/W2154111088","https://openalex.org/W2155041137","https://openalex.org/W2166801599","https://openalex.org/W2169821755","https://openalex.org/W2173668347","https://openalex.org/W2180229411","https://openalex.org/W2224056471","https://openalex.org/W2312408004","https://openalex.org/W2511055764","https://openalex.org/W2525711566","https://openalex.org/W2950361549","https://openalex.org/W2952670656","https://openalex.org/W2993467305","https://openalex.org/W3150407098"],"related_works":["https://openalex.org/W4417303064","https://openalex.org/W2107060906","https://openalex.org/W2187004792","https://openalex.org/W2000965284","https://openalex.org/W2002561391","https://openalex.org/W2025668322","https://openalex.org/W2766535134","https://openalex.org/W1874262838","https://openalex.org/W420856844","https://openalex.org/W7100663760"],"abstract_inverted_index":{"AlkZ":[0,25],"(previously":[1],"Orf1),":[2],"a":[3,19,27,38,57,73,93],"bacterial":[4],"DNA":[5,126],"glycosylase":[6],"that":[7,64],"protects":[8],"its":[9],"host":[10],"by":[11],"excising":[12],"ICLs":[13],"derived":[14],"from":[15],"azinomycin":[16],"B":[17],"(AZB),":[18],"potent":[20],"antimicrobial":[21],"and":[22,56],"antitumor":[23],"genotoxin.":[24],"adopts":[26],"unique":[28],"fold":[29,111],"in":[30,112,128],"which":[31],"three":[32],"tandem":[33],"winged":[34],"helix-turn-helix":[35],"motifs":[36],"scaffold":[37],"positively":[39],"charged":[40],"concave":[41],"surface":[42],"perfectly":[43],"shaped":[44],"for":[45,67,77,95,121],"duplex":[46],"DNA.":[47],"Through":[48],"mutational":[49],"analysis,":[50],"we":[51,71],"identified":[52],"two":[53],"glutamine":[54],"residues":[55],"\u03b2-hairpin":[58],"within":[59],"this":[60,79,109,115],"putative":[61],"DNA-binding":[62],"cleft":[63],"are":[65],"essential":[66],"catalytic":[68],"activity.":[69],"Additionally,":[70],"present":[72],"molecular":[74],"docking":[75],"model":[76],"how":[78],"active":[80],"site":[81],"can":[82],"unhook":[83],"either":[84],"or":[85],"both":[86],"sides":[87],"of":[88,99,103,108,125],"an":[89,122],"AZB":[90],"ICL,":[91],"providing":[92],"basis":[94],"understanding":[96],"the":[97,106,119],"mechanisms":[98],"base":[100],"excision":[101],"repair":[102,127],"ICLs.":[104],"Given":[105],"prevalence":[107],"protein":[110],"pathogenic":[113],"bacteria,":[114],"work":[116],"also":[117],"lays":[118],"foundation":[120],"emerging":[123],"role":[124],"bacteria-host":[129],"pathogenesis.":[130]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-04-28T00:00:00"}