{"id":"https://openalex.org/W2605873763","doi":"https://doi.org/10.22034/apjcp.2017.18.3.771","title":"Evaluation of Cytotoxic and Genotoxic Effects of Euphorbia Triaculeata Forssk. Extract","display_name":"Evaluation of Cytotoxic and Genotoxic Effects of Euphorbia Triaculeata Forssk. Extract","publication_year":2017,"publication_date":"2017-03-01","ids":{"openalex":"https://openalex.org/W2605873763","doi":"https://doi.org/10.22034/apjcp.2017.18.3.771","mag":"2605873763","pmid":"https://pubmed.ncbi.nlm.nih.gov/28441785","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5464498"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5464498","doi":"https://doi.org/10.22034/apjcp.2017.18.3.771","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5464498/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5464498/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pac J Cancer Prev","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5464498/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015654719","display_name":"Zarraq I A Al-Faifi","orcid":"https://orcid.org/0000-0002-2000-4784","observed_orcids":["https://orcid.org/0000-0002-2000-4784"]},"institutions":[{"id":"https://openalex.org/I91450128","display_name":"Jazan University","ror":"https://ror.org/02bjnq803","country_code":"SA","type":"education","lineage":["https://openalex.org/I91450128"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Zarraq I A Al-Faifi","raw_affiliation_strings":["Department of Biology, Faculty of Science, Jazan University, Saudi Arabia. Email: magdyaly@yahoo.com","Department of Biology, Faculty of Science, Jazan University, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Science, Jazan University, Saudi Arabia. Email: magdyaly@yahoo.com","institution_ids":["https://openalex.org/I91450128"]},{"raw_affiliation_string":"Department of Biology, Faculty of Science, Jazan University, Saudi Arabia","institution_ids":["https://openalex.org/I91450128"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090376337","display_name":"Yahya S. Masrahi","orcid":"https://orcid.org/0000-0002-0582-416X","observed_orcids":["https://orcid.org/0000-0002-0582-416X"]},"institutions":[{"id":"https://openalex.org/I91450128","display_name":"Jazan University","ror":"https://ror.org/02bjnq803","country_code":"SA","type":"education","lineage":["https://openalex.org/I91450128"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Yahya S Masrahi","raw_affiliation_strings":["Department of Biology, Faculty of Science, Jazan University, Jazan, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Science, Jazan University, Jazan, Saudi Arabia","institution_ids":["https://openalex.org/I91450128"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103264184","display_name":"Magdy Sayed Aly","orcid":"https://orcid.org/0000-0002-7086-925X","observed_orcids":["https://orcid.org/0000-0002-7086-925X"]},"institutions":[{"id":"https://openalex.org/I113643904","display_name":"Beni-Suef University","ror":"https://ror.org/05pn4yv70","country_code":"EG","type":"education","lineage":["https://openalex.org/I113643904"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Magdy Sayed Aly","raw_affiliation_strings":["Zoology Department, Faculty of Science Beni\u2010Suef University  Beni\u2010Suef Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zoology Department, Faculty of Science Beni\u2010Suef University  Beni\u2010Suef Egypt","institution_ids":["https://openalex.org/I113643904"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111714042","display_name":"Turki A. Al\u2010Turki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1284598098","display_name":"King Abdulaziz City for Science and Technology","ror":"https://ror.org/05tdz6m39","country_code":"SA","type":"facility","lineage":["https://openalex.org/I1284598098"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Turki A Al-Turki","raw_affiliation_strings":["Natural Resources and Environmental Research Institute, King Abdulaziz City for Science and Technology, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Resources and Environmental Research Institute, King Abdulaziz City for Science and Technology, Saudi Arabia","institution_ids":["https://openalex.org/I1284598098"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017583294","display_name":"Tarek Dardeer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Tarek Dardeer","raw_affiliation_strings":["Department of Zoology, Faculty of Science , Cairo University , Cairo , Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, Faculty of Science , Cairo University , Cairo , Egypt","institution_ids":["https://openalex.org/I145487455"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7418,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.6137,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"18","issue":"3","first_page":"771","last_page":"777"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.7085000276565552,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.7085000276565552,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.0934000015258789,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.07079999893903732,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plant-extract-cytotoxicity","display_name":"plant extract cytotoxicity","score":0.8949999809265137},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":0.9929999709129333},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8619999885559082},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.8790000081062317},{"id":"https://openalex.org/keywords/pc-3-cells","display_name":"PC-3 cells","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.9649999737739563},{"id":"https://openalex.org/keywords/methanol-extract","display_name":"methanol extract","score":0.8679999709129333},{"id":"https://openalex.org/keywords/jazan-region","display_name":"Jazan region","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C2780358455","wikidata":"https://www.wikidata.org/wiki/Q903780","display_name":"Comet assay","level":4,"score":0.8705776929855347},{"id":"https://openalex.org/C2779880300","wikidata":"https://www.wikidata.org/wiki/Q146567","display_name":"Euphorbia","level":2,"score":0.8671003580093384},{"id":"https://openalex.org/C2778959862","wikidata":"https://www.wikidata.org/wiki/Q1009245","display_name":"Genotoxicity","level":3,"score":0.862993061542511},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.7159236669540405},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.595790684223175},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.5951389670372009},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5311181545257568},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4690834581851959},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4450218975543976},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4441673159599304},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.441878080368042},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4360084533691406},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42083272337913513},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4150296747684479},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38765138387680054},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2752322554588318},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18992352485656738},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17485040426254272},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.08801838755607605},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:5464498","doi":"https://doi.org/10.22034/apjcp.2017.18.3.771","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5464498/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5464498/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pac J Cancer Prev","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:4465244","doi":"https://doi.org/10.22034/apjcp.2017.18.3.771","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5464498","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:28441785","doi":"https://doi.org/10.22034/apjcp.2017.18.3.771","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28441785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific journal of cancer prevention : APJCP","raw_type":"Journal Article"},{"id":"mag:2605873763","doi":"https://doi.org/10.22034/apjcp.2017.18.3.771","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28441785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5464498","doi":"https://doi.org/10.22034/apjcp.2017.18.3.771","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5464498/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5464498/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pac J Cancer Prev","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2605873763.pdf","grobid_xml":"https://content.openalex.org/works/W2605873763.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W118828521","https://openalex.org/W133197257","https://openalex.org/W207317070","https://openalex.org/W1965565026","https://openalex.org/W1995391021","https://openalex.org/W2000233847","https://openalex.org/W2026720315","https://openalex.org/W2042615004","https://openalex.org/W2064073012","https://openalex.org/W2077581164","https://openalex.org/W2078390666","https://openalex.org/W2092629964","https://openalex.org/W2096549907","https://openalex.org/W2099861412","https://openalex.org/W2104336168","https://openalex.org/W2126902508","https://openalex.org/W2136935358","https://openalex.org/W2144378097","https://openalex.org/W2153779146","https://openalex.org/W2163699185"],"related_works":["https://openalex.org/W2804166770","https://openalex.org/W2131727232","https://openalex.org/W4400344355","https://openalex.org/W2116339191","https://openalex.org/W1970318037","https://openalex.org/W2533743462","https://openalex.org/W2795731054","https://openalex.org/W7096511377","https://openalex.org/W6902310979","https://openalex.org/W7096945625"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"evaluate":[2],"the":[3,67,79,96,113,116,141,176,185,206,216,219],"cytotoxic":[4],"and":[5,49,71,95,126,178,215],"genotoxic":[6,121],"activity":[7],"of":[8,84,144,180,188,205,210,218,222],"Euphorbia":[9,85,117,147,181,211],"triaculeata":[10,86,118,148,182,212],"Forssk.":[11],"plant":[12,87,190,213],"extract":[13,88,119,149,166,191],"from":[14],"Jazan":[15],"region,":[16],"Saudi":[17],"Arabia,":[18],"in":[19,21,29,66,135],"an":[20],"vitro":[22],"cancer":[23,35,154],"model,":[24],"which":[25],"could":[26],"be":[27,194],"beneficial":[28],"anticancer":[30,74,208],"therapy":[31],"against":[32,123,153],"human":[33,43,57],"breast":[34,51],"cell":[36,40,46,53,60,68,133],"line":[37,41,47,54],"(MCF-7),":[38],"prostate":[39],"(PC-3),":[42],"hepatocellular":[44],"carcinoma":[45],"(HEPG2)":[48],"normal":[50],"epithelial":[52],"(MCF-10A).":[55],"The":[56,172],"foreskin":[58],"fibroblast":[59],"line,":[61],"(Hs68),":[62],"was":[63,89,98],"also":[64],"included":[65],"panel.":[69],"Doxorubicin":[70],"5-Flurouracil,":[72],"broad-spectrum":[73],"drugs,":[75],"were":[76],"used":[77],"as":[78],"positive":[80,158],"control.":[81],"Methods:":[82],"Cytotoxicity":[83],"investigated":[90],"by":[91,100,139,164,196],"employing":[92],"MTT":[93],"assay":[94],"genotoxicity":[97,179],"assessed":[99],"using":[101],"comet":[102,114],"assay.":[103],"Results:":[104],"Both":[105],"toxicity":[106,110,152,187],"tests":[107],"exhibited":[108,120,163],"significant":[109,151],"results.":[111],"In":[112],"assay,":[115],"effects":[122],"MCF-7":[124],"DNA":[125,145],"PC":[127],"3":[128],"but":[129],"not":[130],"on":[131,200],"HEPG2":[132],"lines":[134],"a":[136],"time-dependent":[137],"manner":[138],"increasing":[140],"mean":[142],"percentage":[143],"damage.":[146],"showed":[150],"cells.":[155],"Comparison":[156],"with":[157],"control":[159],"signifies":[160],"that":[161],"cytotoxicity":[162,177],"methanol":[165],"might":[167],"have":[168],"moderate":[169],"activity.":[170],"Conclusion:":[171],"present":[173],"work":[174],"confirmed":[175,195],"plant.":[183],"However,":[184],"observed":[186],"this":[189],"needs":[192],"to":[193],"additional":[197],"studies.":[198],"Based":[199],"our":[201],"results,":[202],"further":[203],"examination":[204],"potential":[207],"properties":[209],"species":[214],"identification":[217],"active":[220],"ingredients":[221],"these":[223],"extracts":[224],"is":[225],"warranted.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2017-04-28T00:00:00"}
