{"id":"https://openalex.org/W2605837907","doi":"https://doi.org/10.1111/acer.13403","title":"A Preliminary Investigation of the Effect of Acute Alcohol on Dopamine Transmission as Assessed by [11C]-(+)-PHNO","display_name":"A Preliminary Investigation of the Effect of Acute Alcohol on Dopamine Transmission as Assessed by [11C]-(+)-PHNO","publication_year":2017,"publication_date":"2017-04-19","ids":{"openalex":"https://openalex.org/W2605837907","doi":"https://doi.org/10.1111/acer.13403","mag":"2605837907","pmid":"https://pubmed.ncbi.nlm.nih.gov/28421623"},"language":"en","primary_location":{"id":"doi:10.1111/acer.13403","doi":"https://doi.org/10.1111/acer.13403","is_oa":false,"landing_page_url":"https://doi.org/10.1111/acer.13403","pdf_url":null,"source":{"id":"https://openalex.org/S115510430","display_name":"Alcoholism Clinical and Experimental Research","issn_l":"0145-6008","issn":["0145-6008","1530-0277","2993-7175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism: Clinical and Experimental Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023370089","display_name":"Thulasi Thiruchselvam","orcid":"https://orcid.org/0000-0001-9288-5528","observed_orcids":["https://orcid.org/0000-0001-9288-5528"]},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Thulasi Thiruchselvam","raw_affiliation_strings":["Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada"],"raw_orcid":"https://orcid.org/0000-0001-9288-5528","affiliations":[{"raw_affiliation_string":"Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1338135719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105357931","display_name":"Alan A. Wilson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Alan A. Wilson","raw_affiliation_strings":["Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1338135719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063108898","display_name":"Isabelle Boileau","orcid":"https://orcid.org/0000-0002-9901-1484","observed_orcids":["https://orcid.org/0000-0002-9901-1484"]},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Isabelle Boileau","raw_affiliation_strings":["Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1338135719"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067734183","display_name":"Bernard Le Foll","orcid":"https://orcid.org/0000-0002-6406-4973","observed_orcids":["https://orcid.org/0000-0002-6406-4973"]},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I4405280014","display_name":"Campbell Family Mental Health Research Institute","ror":"https://ror.org/02ab2j218","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1338135719","https://openalex.org/I4405280014"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Bernard Le Foll","raw_affiliation_strings":["Alcohol Research and Treatment Clinic, Addiction Medicine Services, Ambulatory Care and Structured Treatments, Centre for Addiction and Mental Health, Toronto, Ontario, Canada","Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada","Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada","Department of Pharmacology; University of Toronto; Toronto Ontario Canada. Division of Brain and Therapeutics; Department of Psychiatry; University of Toronto; Toronto Ontario Canada. Institute of Medical Sciences; University of Toronto; Toronto Ontario Canada","Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada","Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada","Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alcohol Research and Treatment Clinic, Addiction Medicine Services, Ambulatory Care and Structured Treatments, Centre for Addiction and Mental Health, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1338135719","https://openalex.org/I4405280014"]},{"raw_affiliation_string":"Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Pharmacology; University of Toronto; Toronto Ontario Canada. Division of Brain and Therapeutics; Department of Psychiatry; University of Toronto; Toronto Ontario Canada. Institute of Medical Sciences; University of Toronto; Toronto Ontario Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5067734183"],"corresponding_institution_ids":["https://openalex.org/I1338135719","https://openalex.org/I185261750","https://openalex.org/I4405280014"],"apc_list":{"value":4110,"currency":"USD","value_usd":4110},"apc_paid":null,"fwci":0.6683,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.61010343,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"41","issue":"6","first_page":"1112","last_page":"1119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dopaminergic-neurotransmission","display_name":"dopamine signaling","score":0.8429999947547913},{"id":"https://openalex.org/keywords/11c-phno","display_name":"[11C]-(+)-PHNO","score":0.9620000123977661},{"id":"https://openalex.org/keywords/dopamine-d3-receptor","display_name":"dopamine D3 receptor","score":0.6359999775886536},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.8830000162124634},{"id":"https://openalex.org/keywords/ventral-pallidum","display_name":"ventral pallidum","score":0.8889999985694885},{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"substantia nigra","score":0.9909999966621399},{"id":"https://openalex.org/keywords/globus-pallidus","display_name":"globus pallidus","score":0.9520000219345093},{"id":"https://openalex.org/keywords/blood-alcohol-concentration","display_name":"blood alcohol concentration","score":0.8610000014305115},{"id":"https://openalex.org/keywords/synaptic-dopamine","display_name":"synaptic dopamine","score":0.5630000233650208},{"id":"https://openalex.org/keywords/alcohol-challenge","display_name":"alcohol challenge","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.7340712547302246},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6694620847702026},{"id":"https://openalex.org/C60592354","wikidata":"https://www.wikidata.org/wiki/Q4914018","display_name":"Binding potential","level":3,"score":0.6526360511779785},{"id":"https://openalex.org/C2780278869","wikidata":"https://www.wikidata.org/wiki/Q1759633","display_name":"Globus pallidus","level":4,"score":0.6316002607345581},{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.5329020619392395},{"id":"https://openalex.org/C2776743251","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Ventral striatum","level":4,"score":0.5098980665206909},{"id":"https://openalex.org/C2778187257","wikidata":"https://www.wikidata.org/wiki/Q464210","display_name":"Basal ganglia","level":3,"score":0.5083317160606384},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.4963145852088928},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4513706862926483},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44867491722106934},{"id":"https://openalex.org/C199596767","wikidata":"https://www.wikidata.org/wiki/Q21110872","display_name":"Dopamine receptor D3","level":4,"score":0.42604804039001465},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3792043924331665},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37728723883628845},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.36423566937446594},{"id":"https://openalex.org/C44208683","wikidata":"https://www.wikidata.org/wiki/Q15335165","display_name":"Dopamine receptor D2","level":3,"score":0.3325362205505371},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32267481088638306},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2822731137275696},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.19696390628814697},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16942790150642395},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.1673010289669037}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000428","descriptor_name":"Alcohol Drinking","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002250","descriptor_name":"Carbon Radioisotopes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005917","descriptor_name":"Globus Pallidus","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D005917","descriptor_name":"Globus Pallidus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016037","descriptor_name":"Single-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017448","descriptor_name":"Receptors, Dopamine D2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017448","descriptor_name":"Receptors, Dopamine D2","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D018491","descriptor_name":"Dopamine Agonists","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D050637","descriptor_name":"Receptors, Dopamine D3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066328","descriptor_name":"Ventral Striatum","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D066328","descriptor_name":"Ventral Striatum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/acer.13403","doi":"https://doi.org/10.1111/acer.13403","is_oa":false,"landing_page_url":"https://doi.org/10.1111/acer.13403","pdf_url":null,"source":{"id":"https://openalex.org/S115510430","display_name":"Alcoholism Clinical and Experimental Research","issn_l":"0145-6008","issn":["0145-6008","1530-0277","2993-7175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism: Clinical and Experimental Research","raw_type":"journal-article"},{"id":"pmid:28421623","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28421623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism, clinical and experimental research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W27308961","https://openalex.org/W180673108","https://openalex.org/W1526855917","https://openalex.org/W1876475223","https://openalex.org/W1965411329","https://openalex.org/W1967314822","https://openalex.org/W1968394811","https://openalex.org/W1971840690","https://openalex.org/W1973324928","https://openalex.org/W1978563883","https://openalex.org/W1981420707","https://openalex.org/W1991622227","https://openalex.org/W1992576043","https://openalex.org/W2004205066","https://openalex.org/W2012028929","https://openalex.org/W2014500606","https://openalex.org/W2017709022","https://openalex.org/W2026718617","https://openalex.org/W2029710758","https://openalex.org/W2038018468","https://openalex.org/W2047359051","https://openalex.org/W2048458184","https://openalex.org/W2050894849","https://openalex.org/W2054230322","https://openalex.org/W2083868954","https://openalex.org/W2090592015","https://openalex.org/W2095369944","https://openalex.org/W2098540646","https://openalex.org/W2110608362","https://openalex.org/W2112278807","https://openalex.org/W2115610172","https://openalex.org/W2117141815","https://openalex.org/W2117671988","https://openalex.org/W2118061336","https://openalex.org/W2126586632","https://openalex.org/W2129775580","https://openalex.org/W2135492979","https://openalex.org/W2137197828","https://openalex.org/W2138137140","https://openalex.org/W2142649133","https://openalex.org/W2143199663","https://openalex.org/W2146892597","https://openalex.org/W2156410582","https://openalex.org/W2159570624","https://openalex.org/W2165398609","https://openalex.org/W2238680512","https://openalex.org/W2332676550","https://openalex.org/W2473277320","https://openalex.org/W2479327196","https://openalex.org/W3171418018","https://openalex.org/W7074234824"],"related_works":["https://openalex.org/W2728787538","https://openalex.org/W2018491268","https://openalex.org/W3188593305","https://openalex.org/W2188962661","https://openalex.org/W2111681636","https://openalex.org/W2460595118","https://openalex.org/W4405833598","https://openalex.org/W1983128152","https://openalex.org/W1971840690","https://openalex.org/W4388661971"],"abstract_inverted_index":{"Background":[0],"Previous":[1],"positron":[2],"emission":[3],"tomography":[4],"(PET)":[5],"studies":[6,24],"exploring":[7],"the":[8,68,98,127,131,137,152,164,178,182,218],"effect":[9,270],"of":[10,86,181,271,274],"acute":[11],"alcohol":[12,32,93,115,142,214,227,251,256,275],"on":[13,254,276],"dopamine":[14],"(DA)":[15],"levels":[16,29,257],"have":[17,80],"yielded":[18],"inconsistent":[19],"results,":[20],"with":[21,231],"only":[22],"some":[23],"suggesting":[25,258],"increased":[26],"synaptic":[27,44],"DA":[28,45,262,277],"after":[30],"an":[31],"challenge.":[33],"The":[34,84,269],"D2/D3":[35],"agonist":[36,219],"radiotracer,":[37,220],"[11C]-(+)-propyl-hexahydro-naphtho-oxazin":[38],"([11C]-(+)-PHNO),":[39],"has":[40],"greater":[41,200],"sensitivity":[42],"to":[43,90,211],"fluctuation":[46],"than":[47],"previously":[48,81],"used":[49],"antagonist":[50],"radiotracers":[51],"and":[52,100,116,129],"is":[53,228],"in":[54,62,75,97,101,118,126,130,150,175,177,203,234,237,247,261,281],"principle":[55],"more":[56],"suitable":[57],"for":[58,67],"imaging":[59],"alcohol-induced":[60],"changes":[61,74,174,233,246],"DA.":[63],"Its":[64],"high":[65],"affinity":[66],"D3":[69],"receptor":[70],"also":[71],"enables":[72],"measuring":[73],"D3-rich":[76,102,179],"brain":[77],"areas":[78,180],"which":[79],"been":[82],"unexplored.":[83],"aim":[85],"this":[87],"study":[88],"was":[89,209],"investigate":[91],"whether":[92],"reduces":[94],"[11C]-(+)-PHNO":[95,111,124,148,204,248],"binding":[96,125,149,176,205,236,249],"striatum":[99,128,154,159,166],"extra-striatal":[103,132,240],"areas.":[104],"Methods":[105],"Eight":[106],"healthy":[107],"drinkers":[108],"underwent":[109],"2":[110,138],"PET":[112],"scans":[113,208],"following":[114,250],"placebo":[117],"a":[119,282],"randomized,":[120],"single-blind,":[121],"crossover":[122],"design.":[123],"regions":[133],"were":[134,172],"compared":[135],"between":[136,207],"scans.":[139],"Results":[140],"Acute":[141],"administration":[143],"did":[144],"not":[145,229],"significantly":[146],"reduce":[147],"either":[151],"limbic":[153],"(d":[155,160,167,185,190,196],"=":[156,186],"0.64),":[157],"associative":[158],"<":[161,168,191,197],"0.20),":[162],"or":[163,193,239],"sensorimotor":[165],"0.15).":[169,198],"Similarly,":[170],"there":[171],"no":[173],"ventral":[183],"pallidum":[184],"0.53),":[187],"substantia":[188],"nigra":[189],"0.15),":[192],"globus":[194],"pallidus":[195],"However,":[199,242],"percent":[201],"change":[202],"(\u0394BPND)":[206],"related":[210],"lower":[212,266,272],"blood":[213,255],"levels.":[215],"Conclusions":[216],"Using":[217],"[11C]-(+)-PHNO,":[221],"our":[222],"preliminary":[223],"findings":[224],"suggest":[225],"that":[226,245,259],"associated":[230],"robust":[232],"tracer":[235],"striatal":[238],"regions.":[241],"we":[243],"found":[244],"are":[252],"dependent":[253],"increases":[260],"may":[263],"occur":[264],"at":[265],"stimulating":[267],"doses.":[268],"doses":[273],"warrants":[278],"further":[279],"investigation":[280],"larger":[283],"study.":[284]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-04-28T00:00:00"}