{"id":"https://openalex.org/W2605633151","doi":null,"title":"GEN\u00c9TICA MOLECULAR Y BIOGERONTOLOG\u00cdA EN LA ERA POSGEN\u00d3MICA: UN ENFOQUE EN LAS SIRTUINAS Molecular Genetics of Aging in the Postgenomic Era: A Focus on Sirtuins","display_name":"GEN\u00c9TICA MOLECULAR Y BIOGERONTOLOG\u00cdA EN LA ERA POSGEN\u00d3MICA: UN ENFOQUE EN LAS SIRTUINAS Molecular Genetics of Aging in the Postgenomic Era: A Focus on Sirtuins","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2605633151","mag":"2605633151"},"language":"es","primary_location":{"id":"mag:2605633151","doi":null,"is_oa":false,"landing_page_url":"https://www.redalyc.org/pdf/3190/319027888010.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Juan E. Castillo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Juan E. Castillo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirtuins","display_name":"sirtuins","score":0.9940000176429749},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6769999861717224},{"id":"https://openalex.org/keywords/biogerontology","display_name":"biogerontology","score":0.8090000152587891},{"id":"https://openalex.org/keywords/molecular-genetics","display_name":"molecular genetics","score":0.6320000290870667},{"id":"https://openalex.org/keywords/post-genomic-era","display_name":"post-genomic era","score":0.8460000157356262},{"id":"https://openalex.org/keywords/reverse-genetics","display_name":"reverse genetics","score":0.9010000228881836},{"id":"https://openalex.org/keywords/nad-dependent-deacetylase","display_name":"NAD+-dependent deacetylase","score":0.8220000267028809},{"id":"https://openalex.org/keywords/age-related-diseases","display_name":"age-related diseases","score":0.8090000152587891},{"id":"https://openalex.org/keywords/functional-genomics","display_name":"functional genomics","score":0.7490000128746033},{"id":"https://openalex.org/keywords/omics-technologies","display_name":"omics technologies","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5826118588447571},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.5098751783370972},{"id":"https://openalex.org/C204315192","wikidata":"https://www.wikidata.org/wiki/Q210506","display_name":"Molecular genetics","level":3,"score":0.5070738792419434},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.48396065831184387},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.4534303545951843},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.44209614396095276},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3631650507450104},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.33768564462661743},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33665597438812256}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2605633151","doi":null,"is_oa":false,"landing_page_url":"https://www.redalyc.org/pdf/3190/319027888010.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W1532331378","https://openalex.org/W1536757970","https://openalex.org/W1594856149","https://openalex.org/W1762535185","https://openalex.org/W1901983160","https://openalex.org/W1926757795","https://openalex.org/W1938310987","https://openalex.org/W1939917798","https://openalex.org/W1963554273","https://openalex.org/W1963578989","https://openalex.org/W1963629394","https://openalex.org/W1974890383","https://openalex.org/W1983550639","https://openalex.org/W1985308585","https://openalex.org/W1985834536","https://openalex.org/W1987240473","https://openalex.org/W1988037647","https://openalex.org/W1992595091","https://openalex.org/W2002138269","https://openalex.org/W2005789183","https://openalex.org/W2008862303","https://openalex.org/W2013742279","https://openalex.org/W2021432006","https://openalex.org/W2039278502","https://openalex.org/W2042716686","https://openalex.org/W2053812461","https://openalex.org/W2053878202","https://openalex.org/W2054857432","https://openalex.org/W2058947330","https://openalex.org/W2059750004","https://openalex.org/W2060768223","https://openalex.org/W2073701242","https://openalex.org/W2075043109","https://openalex.org/W2077685680","https://openalex.org/W2077884141","https://openalex.org/W2077985117","https://openalex.org/W2094807579","https://openalex.org/W2096796564","https://openalex.org/W2101580126","https://openalex.org/W2109291482","https://openalex.org/W2114217399","https://openalex.org/W2114803943","https://openalex.org/W2117208578","https://openalex.org/W2117473844","https://openalex.org/W2120956575","https://openalex.org/W2124595934","https://openalex.org/W2126466006","https://openalex.org/W2127230663","https://openalex.org/W2133015492","https://openalex.org/W2138270253","https://openalex.org/W2146739166","https://openalex.org/W2150018728","https://openalex.org/W2155245588","https://openalex.org/W2158153532","https://openalex.org/W2161709857","https://openalex.org/W2168834363","https://openalex.org/W2414915547","https://openalex.org/W2616798345","https://openalex.org/W2725447946","https://openalex.org/W2764167475","https://openalex.org/W7098997929"],"related_works":["https://openalex.org/W1531795411","https://openalex.org/W2110603711","https://openalex.org/W1571402215","https://openalex.org/W2175395047","https://openalex.org/W1605379174","https://openalex.org/W7139132321","https://openalex.org/W2759338320","https://openalex.org/W3046369469","https://openalex.org/W4416142395","https://openalex.org/W2088605334"],"abstract_inverted_index":{"The":[0],"way":[1],"to":[2,16,31,41,57,110,221],"study":[3,18],"genetics":[4,85,213],"has":[5,142],"notably":[6],"progressed":[7],"in":[8,79,112,145,219,230],"the":[9,17,24,32,42,49,59,69,74,81,88,96,99,103,116,121,131,139,146,152,156,181,225],"last":[10,38,147],"decades.":[11],"Their":[12],"origins":[13],"date":[14],"back":[15],"of":[19,26,34,44,61,64,71,83,118,120,134,138,155,187,224,227],"hereditary":[20],"features,":[21],"followed":[22],"by":[23],"discovery":[25],"genes":[27,179,229],"and":[28,48,51,76,102,124,150,166,171,175,198],"chromosomes":[29],"up":[30],"knowledge":[33],"DNA":[35,46],"structure.":[36],"This":[37],"event":[39],"led":[40],"development":[43],"recombinant":[45],"technology":[47],"massive":[50],"automated":[52],"sequencing,":[53],"which":[54,80,189],"allowed":[55],"later":[56],"determine":[58],"anatomy":[60],"genomes.":[62],"All":[63],"these":[65,178,228],"discoveries":[66],"have":[67,161,216],"pushed":[68],"evolution":[70],"biomedicine":[72],"towards":[73],"genomic":[75],"postgenomic":[77,157],"eras,":[78],"use":[82],"reverse":[84,212],"prevails":[86],"over":[87],"basic":[89],"or":[90],"direct":[91],"one.":[92],"Furthermore,":[93],"it":[94],"emerges":[95],"molecular":[97,167],"genetics,":[98],"functional":[100],"genomics":[101],"diverse":[104],"\u201comics\u201d":[105],"technologies":[106],"that":[107,129,141,169,199,215],"together":[108],"pretend":[109],"understand,":[111],"an":[113,183,201],"integrative":[114],"way,":[115],"function":[117],"all":[119],"genome":[122],"components":[123],"its":[125],"products.":[126],"Biogerontology,":[127],"discipline":[128],"studies":[130],"biological":[132],"mechanisms":[133],"aging,":[135],"is":[136],"one":[137],"fields":[140],"developed":[143],"notoriously":[144],"15":[148],"years":[149],"reflects":[151],"scientific":[153],"advances":[154],"era.":[158],"Currently,":[159],"there":[160],"been":[162,217],"identified":[163],"several":[164],"gerontogenes":[165],"pathways":[168],"modify":[170],"regulate":[172],"age-related":[173],"processes":[174],"diseases.":[176],"Among":[177],"are":[180],"sirtuins,":[182],"evolutionarily":[184],"preserved":[185],"family":[186],"genes,":[188],"codify":[190],"for":[191],"proteins":[192],"with":[193],"NAD+":[194],"dependent":[195],"deacetylase":[196],"activity":[197],"play":[200],"important":[202],"role":[203],"on":[204],"aging.":[205],"In":[206],"this":[207],"work,":[208],"we":[209],"review":[210],"different":[211],"approaches":[214],"used":[218],"order":[220],"identify":[222],"some":[223],"functions":[226],"mammals.":[231]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-04-28T00:00:00"}