{"id":"https://openalex.org/W2605576636","doi":"https://doi.org/10.1161/circresaha.116.310119","title":"Why Don\u2019t We Have Proven Treatments for HFpEF?","display_name":"Why Don\u2019t We Have Proven Treatments for HFpEF?","publication_year":2017,"publication_date":"2017-04-13","ids":{"openalex":"https://openalex.org/W2605576636","doi":"https://doi.org/10.1161/circresaha.116.310119","mag":"2605576636","pmid":"https://pubmed.ncbi.nlm.nih.gov/28408453","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5407384"},"language":"en","primary_location":{"id":"doi:10.1161/circresaha.116.310119","doi":"https://doi.org/10.1161/circresaha.116.310119","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circresaha.116.310119","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.116.310119","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.116.310119","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080760721","display_name":"Jason D. Roh","orcid":"https://orcid.org/0000-0002-6999-6868","observed_orcids":["https://orcid.org/0000-0002-6999-6868"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Roh","raw_affiliation_strings":["From the Department of Internal Medicine, Cardiovascular Division, Massachusetts General Hospital and Harvard Medical School, Boston","Jason Roh From the Department of Internal Medicine, Cardiovascular Division, Massachusetts General Hospital and Harvard Medical School, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine, Cardiovascular Division, Massachusetts General Hospital and Harvard Medical School, Boston","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Jason Roh From the Department of Internal Medicine, Cardiovascular Division, Massachusetts General Hospital and Harvard Medical School, Boston","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034785907","display_name":"Nicholas E. Houstis","orcid":"https://orcid.org/0000-0003-3812-2241","observed_orcids":["https://orcid.org/0000-0003-3812-2241"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas Houstis","raw_affiliation_strings":["From the Department of Internal Medicine, Cardiovascular Division, Massachusetts General Hospital and Harvard Medical School, Boston","Nicholas Houstis From the Department of Internal Medicine, Cardiovascular Division, Massachusetts General Hospital and Harvard Medical School, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine, Cardiovascular Division, Massachusetts General Hospital and Harvard Medical School, Boston","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Nicholas Houstis From the Department of Internal Medicine, Cardiovascular Division, Massachusetts General Hospital and Harvard Medical School, Boston","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050240892","display_name":"Anthony Rosenzweig","orcid":"https://orcid.org/0000-0001-6387-0386","observed_orcids":["https://orcid.org/0000-0001-6387-0386"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony Rosenzweig","raw_affiliation_strings":["From the Department of Internal Medicine, Cardiovascular Division, Massachusetts General Hospital and Harvard Medical School, Boston","Anthony Rosenzweig From the Department of Internal Medicine, Cardiovascular Division, Massachusetts General Hospital and Harvard Medical School, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine, Cardiovascular Division, Massachusetts General Hospital and Harvard Medical School, Boston","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Anthony Rosenzweig From the Department of Internal Medicine, Cardiovascular Division, Massachusetts General Hospital and Harvard Medical School, Boston","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":106,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"120","issue":"8","first_page":"1243","last_page":"1245"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.6118000149726868,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.6118000149726868,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.22300000488758087,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.045099999755620956,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-failure-with-preserved-ejection-fraction","display_name":"heart failure with preserved ejection fraction","score":1.0},{"id":"https://openalex.org/keywords/animal-models","display_name":"animal models","score":0.7310000061988831},{"id":"https://openalex.org/keywords/preclinical-model-validation","display_name":"preclinical model validation","score":0.7870000004768372},{"id":"https://openalex.org/keywords/therapeutic-target-discovery","display_name":"therapeutic target discovery","score":0.8299999833106995},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.5830000042915344},{"id":"https://openalex.org/keywords/unmet-medical-needs","display_name":"unmet medical needs","score":0.9179999828338623}],"concepts":[{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4625481963157654},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44975629448890686},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4314248859882355}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1161/circresaha.116.310119","doi":"https://doi.org/10.1161/circresaha.116.310119","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circresaha.116.310119","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.116.310119","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},{"id":"pmid:28408453","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28408453","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4827002","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5407384","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5407384","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5407384","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Circ Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1161/circresaha.116.310119","doi":"https://doi.org/10.1161/circresaha.116.310119","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circresaha.116.310119","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.116.310119","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1021751512","display_name":"Plasma miRNA predictors of adverse mechanical and electrical remodeling after MI","funder_award_id":"UH3TR000901","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G241504776","display_name":"Does Exercise Induce Cardiomyogenesis?","funder_award_id":"R01HL122987","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6840175052","display_name":"Micro-RNA regulation of the cardiac exercise response","funder_award_id":"R21HL114352","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8565366329","display_name":"The role of C/EBPbeta and CITED4 in the heart","funder_award_id":"R01HL110733","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G964799974","display_name":"Role of miR-222 in pathological hypertrophy and heart failure","funder_award_id":"R01HL135886","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2605576636.pdf","grobid_xml":"https://content.openalex.org/works/W2605576636.grobid-xml"},"referenced_works_count":8,"referenced_works":["https://openalex.org/W1994734582","https://openalex.org/W2057547167","https://openalex.org/W2116811197","https://openalex.org/W2137784332","https://openalex.org/W2149841172","https://openalex.org/W2157684603","https://openalex.org/W2265004792","https://openalex.org/W2306006469"],"related_works":["https://openalex.org/W4281776060","https://openalex.org/W4387578183","https://openalex.org/W4291003291","https://openalex.org/W2306006469","https://openalex.org/W4313397324","https://openalex.org/W4388976618","https://openalex.org/W4413600003","https://openalex.org/W2768843843","https://openalex.org/W3092662461","https://openalex.org/W2527933700"],"abstract_inverted_index":{"T":[0],"he":[1],"lack":[2],"of":[3,39,47,61,73],"effective":[4,80],"treatments":[5],"for":[6,79,95],"heart":[7,29,84],"failure":[8,30,85],"with":[9,31,86],"preserved":[10,32,87],"ejection":[11,33,88],"fraction":[12,34],"represents":[13],"a":[14],"large":[15],"and":[16,58,75],"growing":[17],"unmet":[18],"need":[19],"in":[20,28,83],"cardiology":[21],"today.A":[22],"critical":[23],"obstacle":[24],"to":[25,69],"therapeutic":[26,81],"innovation":[27],"has":[35],"been":[36],"the":[37,45,48],"absence":[38],"animal":[40],"models":[41,63],"that":[42,53],"accurately":[43],"recapitulate":[44],"complexities":[46],"human":[49],"disease.Here,":[50],"we":[51,67],"propose":[52],"more":[54],"comprehensive":[55],"multiorgan":[56],"system":[57],"functional":[59],"phenotyping":[60],"preclinical":[62],"is":[64],"essential":[65],"if":[66],"are":[68],"maximize":[70],"our":[71],"chances":[72],"discovering":[74],"validating":[76],"novel":[77],"targets":[78],"development":[82],"fraction.Why":[89],"Don't":[90],"We":[91],"Have":[92],"Proven":[93],"Treatments":[94],"HFpEF?":[96]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":22},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-04-28T00:00:00"}