{"id":"https://openalex.org/W2605484486","doi":"https://doi.org/10.1117/12.2252685","title":"PDT-based combinations in overcoming chemoresistance from stromal and heterotypic cellular communication (Conference Presentation)","display_name":"PDT-based combinations in overcoming chemoresistance from stromal and heterotypic cellular communication (Conference Presentation)","publication_year":2017,"publication_date":"2017-04-19","ids":{"openalex":"https://openalex.org/W2605484486","doi":"https://doi.org/10.1117/12.2252685","mag":"2605484486"},"language":"en","primary_location":{"id":"doi:10.1117/12.2252685","doi":"https://doi.org/10.1117/12.2252685","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2252685","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVI","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007170985","display_name":"Imran Rizvi","orcid":"https://orcid.org/0000-0001-9673-4700","observed_orcids":["https://orcid.org/0000-0001-9673-4700"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Imran Rizvi","raw_affiliation_strings":["Harvard Medical School (United States)","Massachusetts General Hospital (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School (United States)","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Massachusetts General Hospital (United States)","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009505184","display_name":"Anne\u2010Laure Bulin","orcid":"https://orcid.org/0000-0002-2644-8626","observed_orcids":["https://orcid.org/0000-0002-2644-8626"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne-Laure Bulin","raw_affiliation_strings":["Harvard Medical School (United States)","Massachusetts General Hospital (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School (United States)","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Massachusetts General Hospital (United States)","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023103421","display_name":"Sriram R. Anbil","orcid":"https://orcid.org/0000-0002-3368-2445","observed_orcids":["https://orcid.org/0000-0002-3368-2445"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sriram R. Anbil","raw_affiliation_strings":["Harvard Medical School (United States)","Howard Hughes Medical Institute (United States)","Univ. of Texas School of Medicine in San Antonio (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School (United States)","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Howard Hughes Medical Institute (United States)","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Univ. of Texas School of Medicine in San Antonio (United States)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084649158","display_name":"Emma A. Briars","orcid":"https://orcid.org/0000-0001-9350-5523","observed_orcids":["https://orcid.org/0000-0001-9350-5523"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emma A. Briars","raw_affiliation_strings":["Massachusetts General Hospital (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital (United States)","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Daniela Vecchio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniela Vecchio","raw_affiliation_strings":["Harvard Medical School (United States)","Massachusetts General Hospital (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School (United States)","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Massachusetts General Hospital (United States)","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107115177","display_name":"Jonathan P. Celli","orcid":"https://orcid.org/0000-0003-3560-0770","observed_orcids":["https://orcid.org/0000-0003-3560-0770"]},"institutions":[{"id":"https://openalex.org/I33434090","display_name":"University of Massachusetts Boston","ror":"https://ror.org/04ydmy275","country_code":"US","type":"education","lineage":["https://openalex.org/I33434090"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan P. Celli","raw_affiliation_strings":["Univ. of Massachusetts Boston (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Massachusetts Boston (United States)","institution_ids":["https://openalex.org/I33434090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002417486","display_name":"Mans Broekgaarden","orcid":"https://orcid.org/0000-0002-9516-5048","observed_orcids":["https://orcid.org/0000-0002-9516-5048"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mans Broekgaarden","raw_affiliation_strings":["Harvard Medical School (United States)","Massachusetts General Hospital (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School (United States)","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Massachusetts General Hospital (United States)","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058184923","display_name":"Tayyaba G. Hasan","orcid":"https://orcid.org/0000-0003-0871-6057","observed_orcids":["https://orcid.org/0000-0003-0871-6057"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tayyaba Hasan","raw_affiliation_strings":["Harvard Medical School (United States)","Massachusetts General Hospital (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School (United States)","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Massachusetts General Hospital (United States)","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"3","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":1.0},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.9599999785423279},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8029999732971191},{"id":"https://openalex.org/keywords/stromal-cells","display_name":"stromal cells","score":0.6029999852180481},{"id":"https://openalex.org/keywords/verteporfin","display_name":"verteporfin","score":0.9810000061988831},{"id":"https://openalex.org/keywords/chemotherapy-enhancement","display_name":"chemotherapy enhancement","score":0.5199999809265137},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9710000157356262},{"id":"https://openalex.org/keywords/three-dimensional-tumor-models","display_name":"3D tumor models","score":0.9229999780654907},{"id":"https://openalex.org/keywords/image-analysis","display_name":"image analysis","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.7645896077156067},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.49490684270858765},{"id":"https://openalex.org/C2781148688","wikidata":"https://www.wikidata.org/wiki/Q782318","display_name":"Verteporfin","level":4,"score":0.4406883418560028},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43888619542121887},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40429407358169556},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3982633650302887},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3261831998825073},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26397427916526794},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11986947059631348},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11079272627830505},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.09492918848991394},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.0},{"id":"https://openalex.org/C2781359195","wikidata":"https://www.wikidata.org/wiki/Q5105209","display_name":"Choroidal neovascularization","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2252685","doi":"https://doi.org/10.1117/12.2252685","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2252685","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVI","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2789684727","https://openalex.org/W2344564142","https://openalex.org/W2185405197","https://openalex.org/W2969013845","https://openalex.org/W4292328009","https://openalex.org/W4413992472","https://openalex.org/W2070495584","https://openalex.org/W4312210278","https://openalex.org/W4393442301","https://openalex.org/W2490881606"],"abstract_inverted_index":{"Targeting":[0],"the":[1,38,60,77,88,115],"molecular":[2,127],"and":[3,36,57,75,84,121,128,138],"cellular":[4],"cues":[5],"that":[6,63,69,113],"influence":[7],"treatment":[8,97],"resistance":[9,35],"in":[10,102,140],"tumors":[11],"is":[12,28],"critical":[13],"to":[14,33,52,58],"effectively":[15],"treating":[16],"unresponsive":[17],"populations":[18],"of":[19,25,40,90,95,117,131,135],"stubborn":[20],"disease.":[21],"The":[22,126],"informed":[23],"design":[24],"mechanism-based":[26],"combinations":[27,71,108],"emerging":[29],"as":[30,93],"increasingly":[31],"important":[32],"targeting":[34],"improving":[37],"efficacy":[39,137],"conventional":[41,55],"treatments,":[42],"while":[43],"minimizing":[44],"toxicity.":[45],"Photodynamic":[46],"therapy":[47],"(PDT)":[48],"has":[49],"been":[50],"shown":[51],"synergize":[53],"with":[54],"agents":[56],"overcome":[59],"evasion":[61],"pathways":[62],"cause":[64],"resistance.":[65],"Increasing":[66],"evidence":[67],"shows":[68],"PDT-based":[70,133],"cooperate":[72],"mechanistically":[73],"with,":[74],"improve":[76],"therapeutic":[78],"index":[79],"of,":[80],"traditional":[81],"chemotherapies.":[82],"These":[83],"other":[85],"findings":[86],"emphasize":[87],"importance":[89],"including":[91],"PDT":[92],"part":[94],"comprehensive":[96],"plans":[98],"for":[99,144],"cancer,":[100],"particularly":[101],"complex":[103,141],"disease":[104],"sites.":[105],"Identifying":[106],"effective":[107],"requires":[109],"a":[110],"multi-faceted":[111],"approach":[112],"includes":[114],"development":[116],"bioengineered":[118],"cancer":[119,146],"models":[120,143],"corresponding":[122],"image":[123],"analysis":[124],"tools.":[125],"phenotypic":[129],"basis":[130],"verteporfin-mediated":[132],"enhancement":[134],"chemotherapeutic":[136],"predictability":[139],"3D":[142],"ovarian":[145],"will":[147],"be":[148],"presented.":[149]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2017-04-28T00:00:00"}