{"id":"https://openalex.org/W2605403511","doi":null,"title":"One Step at a Time, Stem Cell Therapy for Traumatic Brain Injury Needs Two More Breakthroughs","display_name":"One Step at a Time, Stem Cell Therapy for Traumatic Brain Injury Needs Two More Breakthroughs","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2605403511","mag":"2605403511"},"language":"en","primary_location":{"id":"mag:2605403511","doi":null,"is_oa":false,"landing_page_url":"https://medcraveonline.com/JSRT/JSRT-01-00027.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024132933","display_name":"Terrace Lois","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Terrace Lois","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5024132933"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.8916000127792358,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.8916000127792358,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0284000001847744,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.02329999953508377,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.9399999976158142},{"id":"https://openalex.org/keywords/neural-stem-cells","display_name":"neural stem cells","score":0.8619999885559082},{"id":"https://openalex.org/keywords/stem-cell-therapy","display_name":"stem cell therapy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9350000023841858},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.9990000128746033},{"id":"https://openalex.org/keywords/clinical-translation","display_name":"clinical translation","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.8007456064224243},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.5830793380737305},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.5603781342506409},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5079887509346008},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4674426317214966},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.43338561058044434},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4006987512111664},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2801820635795593},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.19854390621185303},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.12933355569839478},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1280493140220642},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11993125081062317},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2605403511","doi":null,"is_oa":false,"landing_page_url":"https://medcraveonline.com/JSRT/JSRT-01-00027.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":87,"referenced_works":["https://openalex.org/W641701808","https://openalex.org/W1504471840","https://openalex.org/W1519879819","https://openalex.org/W1600024584","https://openalex.org/W1703312244","https://openalex.org/W1754067249","https://openalex.org/W1916408841","https://openalex.org/W1948118029","https://openalex.org/W1964793630","https://openalex.org/W1970692199","https://openalex.org/W1974432822","https://openalex.org/W1977718418","https://openalex.org/W1980214151","https://openalex.org/W1980654171","https://openalex.org/W1980902978","https://openalex.org/W1982780398","https://openalex.org/W1986144010","https://openalex.org/W1990514899","https://openalex.org/W2006862511","https://openalex.org/W2012020530","https://openalex.org/W2017282701","https://openalex.org/W2017688638","https://openalex.org/W2020539766","https://openalex.org/W2021899490","https://openalex.org/W2024096946","https://openalex.org/W2026288887","https://openalex.org/W2027764735","https://openalex.org/W2028662192","https://openalex.org/W2028832381","https://openalex.org/W2031284517","https://openalex.org/W2034419604","https://openalex.org/W2043393467","https://openalex.org/W2043416148","https://openalex.org/W2045490045","https://openalex.org/W2046263184","https://openalex.org/W2052249006","https://openalex.org/W2056202275","https://openalex.org/W2059066863","https://openalex.org/W2062977301","https://openalex.org/W2063590777","https://openalex.org/W2064147926","https://openalex.org/W2065562908","https://openalex.org/W2073546483","https://openalex.org/W2074142693","https://openalex.org/W2080474239","https://openalex.org/W2082512473","https://openalex.org/W2084652685","https://openalex.org/W2088742448","https://openalex.org/W2091203314","https://openalex.org/W2093745250","https://openalex.org/W2095457856","https://openalex.org/W2096019298","https://openalex.org/W2100755403","https://openalex.org/W2105083983","https://openalex.org/W2113360628","https://openalex.org/W2123837167","https://openalex.org/W2133821981","https://openalex.org/W2134585986","https://openalex.org/W2136677656","https://openalex.org/W2143762738","https://openalex.org/W2148450488","https://openalex.org/W2149033728","https://openalex.org/W2149625294","https://openalex.org/W2164715609","https://openalex.org/W2165915651","https://openalex.org/W2168044601","https://openalex.org/W2168120562","https://openalex.org/W2168767889","https://openalex.org/W2190625755","https://openalex.org/W2278939412","https://openalex.org/W2294659377","https://openalex.org/W2297402353","https://openalex.org/W2313137828","https://openalex.org/W2325155086","https://openalex.org/W2328664994","https://openalex.org/W2330954195","https://openalex.org/W2359079907","https://openalex.org/W2380796370","https://openalex.org/W2386633507","https://openalex.org/W2396404073","https://openalex.org/W2399160190","https://openalex.org/W2444477496","https://openalex.org/W2466450088","https://openalex.org/W2472248420","https://openalex.org/W2495662047","https://openalex.org/W2736091234","https://openalex.org/W4229823484"],"related_works":["https://openalex.org/W4229501981","https://openalex.org/W3030302033","https://openalex.org/W7096193554","https://openalex.org/W3010847690","https://openalex.org/W7116779645","https://openalex.org/W1990818777","https://openalex.org/W2392137873","https://openalex.org/W4406799520","https://openalex.org/W2313137828","https://openalex.org/W3166993375"],"abstract_inverted_index":{"Traumatic":[0],"brain":[1],"injuries":[2],"often":[3],"result":[4],"in":[5,7,49],"disability":[6],"survivors.":[8],"Unresolved":[9],"inflammation":[10],"and":[11,36,70],"ongoing":[12],"neurodegeneration":[13],"underlies":[14],"the":[15,40,44,50,62],"disability.":[16],"Human":[17],"neural":[18],"stem":[19],"cells":[20],"(NSCs)":[21],"are":[22],"attractive":[23],"candidates":[24],"that":[25,60,74],"can":[26],"address":[27],"both":[28],"issues":[29],"at":[30],"once.":[31],"Despite":[32],"several":[33],"preclinical":[34],"studies":[35],"start-up":[37],"companies":[38],"over":[39],"past":[41],"two":[42,58,72],"decades,":[43],"approach":[45],"is":[46],"not":[47],"yet":[48],"clinic.":[51],"In":[52],"this":[53],"mini":[54],"review,":[55],"I":[56],"present":[57],"steps":[59],"brought":[61],"NSCs":[63],"from":[64],"lab":[65],"to":[66,78],"Phase":[67],"I/II":[68],"trials":[69],"final":[71],"breakthroughs":[73],"may":[75],"be":[76],"necessary":[77],"facilitate":[79],"clinical":[80],"application.":[81]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-04-28T00:00:00"}
