{"id":"https://openalex.org/W2605388259","doi":null,"title":"Prediction of response to therapy in rheumatoid arthritis : Lost in validation","display_name":"Prediction of response to therapy in rheumatoid arthritis : Lost in validation","publication_year":2017,"publication_date":"2017-03-23","ids":{"openalex":"https://openalex.org/W2605388259","mag":"2605388259"},"language":"en","primary_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/347728","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/347728","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dspace.library.uu.nl/handle/1874/347728","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065873952","display_name":"Bart V. J. Cuppen","orcid":"https://orcid.org/0000-0002-7592-0915","observed_orcids":["https://orcid.org/0000-0002-7592-0915"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Bart V. J. Cuppen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7592-0915","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5065873952"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.9340000152587891},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6919999718666077},{"id":"https://openalex.org/keywords/biological-therapy","display_name":"biologic therapy","score":0.8159999847412109},{"id":"https://openalex.org/keywords/tumor-necrosis-factor-inhibitors","display_name":"tumor necrosis factor inhibitors","score":0.9020000100135803},{"id":"https://openalex.org/keywords/gpr15","display_name":"GPR15","score":0.9990000128746033},{"id":"https://openalex.org/keywords/omics","display_name":"omics","score":0.3919999897480011},{"id":"https://openalex.org/keywords/biomarker-validation","display_name":"biomarker validation","score":0.7559999823570251},{"id":"https://openalex.org/keywords/exposome","display_name":"exposome","score":0.5929999947547913},{"id":"https://openalex.org/keywords/treatment-non-responders","display_name":"treatment non-responders","score":0.49799999594688416},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.39899998903274536},{"id":"https://openalex.org/keywords/synovial-joint-inflammation","display_name":"synovial joint inflammation","score":0.546999990940094},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.33399999141693115},{"id":"https://openalex.org/keywords/metabolites","display_name":"metabolites","score":0.7089999914169312},{"id":"https://openalex.org/keywords/proteins","display_name":"proteins","score":0.453000009059906},{"id":"https://openalex.org/keywords/mrna","display_name":"mRNA","score":0.5830000042915344},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.6579999923706055},{"id":"https://openalex.org/keywords/pharmacogenomics","display_name":"pharmacogenomics","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.7710826396942139},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7654553651809692},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6229612231254578},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.608034610748291},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.56361323595047},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5463013648986816},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5151499509811401},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5036477446556091},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4591178297996521},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.43625566363334656},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3855913281440735},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3391525149345398},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09254133701324463},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:dspace.library.uu.nl:1874/347728","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/347728","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/347728","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/347728","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/347728","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl/handle/1874/347728","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:2605388259","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/347728","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/347728","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/347728","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":82,"referenced_works":["https://openalex.org/W156563279","https://openalex.org/W1588610010","https://openalex.org/W1588728586","https://openalex.org/W1761300068","https://openalex.org/W1959658355","https://openalex.org/W1964095605","https://openalex.org/W1965222184","https://openalex.org/W1966066948","https://openalex.org/W1975130349","https://openalex.org/W1989086252","https://openalex.org/W1990524824","https://openalex.org/W1994224528","https://openalex.org/W1994682257","https://openalex.org/W1997106678","https://openalex.org/W1997356858","https://openalex.org/W2007252822","https://openalex.org/W2007567206","https://openalex.org/W2007767383","https://openalex.org/W2024651299","https://openalex.org/W2027581444","https://openalex.org/W2030682849","https://openalex.org/W2030955639","https://openalex.org/W2036147078","https://openalex.org/W2038635884","https://openalex.org/W2040576381","https://openalex.org/W2042990492","https://openalex.org/W2044591801","https://openalex.org/W2046266567","https://openalex.org/W2051411536","https://openalex.org/W2053320649","https://openalex.org/W2060943696","https://openalex.org/W2071458924","https://openalex.org/W2079776874","https://openalex.org/W2082376914","https://openalex.org/W2082977560","https://openalex.org/W2086089919","https://openalex.org/W2092499482","https://openalex.org/W2092829005","https://openalex.org/W2093865787","https://openalex.org/W2097148639","https://openalex.org/W2100741073","https://openalex.org/W2103310388","https://openalex.org/W2113591602","https://openalex.org/W2113609304","https://openalex.org/W2115594073","https://openalex.org/W2116314748","https://openalex.org/W2121095925","https://openalex.org/W2124179809","https://openalex.org/W2124428679","https://openalex.org/W2128384929","https://openalex.org/W2129467077","https://openalex.org/W2134431449","https://openalex.org/W2136085913","https://openalex.org/W2136624067","https://openalex.org/W2141314333","https://openalex.org/W2141395406","https://openalex.org/W2141521401","https://openalex.org/W2142004396","https://openalex.org/W2142122490","https://openalex.org/W2142165059","https://openalex.org/W2143385588","https://openalex.org/W2147855010","https://openalex.org/W2153248563","https://openalex.org/W2154144521","https://openalex.org/W2159700028","https://openalex.org/W2160070058","https://openalex.org/W2160258689","https://openalex.org/W2161726277","https://openalex.org/W2163463767","https://openalex.org/W2164305413","https://openalex.org/W2165139489","https://openalex.org/W2166228239","https://openalex.org/W2169006386","https://openalex.org/W2169772272","https://openalex.org/W2262408306","https://openalex.org/W2322584872","https://openalex.org/W2410306672","https://openalex.org/W2413008123","https://openalex.org/W2511676423","https://openalex.org/W2517073520","https://openalex.org/W2523119278","https://openalex.org/W4308769923"],"related_works":["https://openalex.org/W2411098472","https://openalex.org/W2142165059","https://openalex.org/W156563279","https://openalex.org/W2217616236","https://openalex.org/W3043841327","https://openalex.org/W2413232407","https://openalex.org/W2511676423","https://openalex.org/W7005249744","https://openalex.org/W2622190533","https://openalex.org/W7027027114"],"abstract_inverted_index":{"Introduction":[0],"Rheumatoid":[1,95],"arthritis":[2],"(RA)":[3],"is":[4,102,320,356],"a":[5,16,144,215,248,261,412,491],"chronic,":[6],"disabling":[7],"disease":[8,29],"that":[9,68,203,295,323,352,394,428,472],"mainly":[10],"affects":[11],"the":[12,85,136,178,218,225,232,254,268,296,310,327,330,339,349,361,385,416,431,447,459],"synovial":[13],"joints.":[14],"With":[15],"large":[17],"arsenal":[18],"of":[19,41,47,125,156,208,228,251,264,267,298,300,326,354,363,374,415,421,430],"treatments":[20],"among":[21],"which":[22,107,147,436],"tumor":[23],"necrosis":[24],"factor-alpha":[25],"inhibitors":[26],"(TNFi\u2019s),":[27],"RA":[28,108,364,400],"activity":[30],"decreases":[31],"sufficiently":[32],"in":[33,52,94,106,127,135,183,199,231,247,260,288,345,359,390,399,435,457],"most":[34,340],"but":[35],"not":[36,280,293],"all":[37,141,149,200,482],"cases.":[38],"The":[39],"identification":[40],"responders":[42],"and":[43,57,87,90,121,131,154,168,191,222,335,338,369,418,443,450,461],"non-responders":[44],"before":[45],"initiation":[46],"therapy":[48,422],"would":[49],"therefore":[50,253,321],"aid":[51],"making":[53],"strategic":[54],"treatment":[55,113,182,397],"decisions":[56],"improve":[58],"clinical":[59,117,150,289],"outcomes.":[60],"Biomarker":[61],"research":[62],"frequently":[63],"identifies":[64],"new":[65,249],"potential":[66,174],"targets":[67,196,220,256],"predict":[69,177],"response,":[70],"yet":[71],"validation":[72],"across":[73],"multiple":[74],"cohorts":[75],"fails":[76],"so":[77],"far.":[78],"Methods":[79],"In":[80,158,275,407],"this":[81,276,346,466,488],"thesis,":[82],"data":[83,142],"from":[84],"Biologicals":[86],"Outcome":[88],"Compared":[89],"predicted":[91],"Utrecht":[92],"region":[93],"Arthritis\u201d":[96],"(BiOCURA)":[97],"study":[98],"was":[99],"used.":[100],"BiOCURA":[101],"an":[103,324],"observational":[104],"cohort,":[105],"patients":[109,163,376],"eligible":[110],"for":[111,173,217,309,396],"biological":[112,181],"according":[114],"to":[115,176,282,286,312,332,371,381,405,409],"regular":[116],"practice":[118],"were":[119,164,197,204,257,279],"enrolled":[120],"followed":[122],"after":[123],"start":[124],"treatment,":[126],"one":[128],"academic":[129],"hospital":[130],"seven":[132],"regional":[133],"hospitals":[134],"Netherlands.":[137],"Trained":[138],"nurses":[139],"gathered":[140],"during":[143],"dedicated":[145],"visit,":[146],"included":[148],"parameters,":[151],"joint":[152],"counts":[153],"collection":[155],"blood.":[157],"total,":[159],"more":[160],"than":[161],"400":[162],"included.":[165],"Within":[166],"serum":[167],"isolated":[169],"cells,":[170],"we":[171,278],"searched":[172],"biomarkers":[175,438],"respons":[179],"on":[180],"RA,":[184],"by":[185],"screening":[186],"DNA,":[187],"mRNA,":[188],"microRNA,":[189],"proteins":[190],"metabolites.":[192],"Results":[193],"Potential":[194],"interesting":[195],"identified":[198,255],"\u201comics\u201d":[201],"platforms":[202],"screened.":[205],"Technical":[206],"replication":[207],"these":[209,229],"results":[210,244],"with":[211],"specific":[212],"assays,":[213],"e.g.":[214],"qPCR":[216],"mRNA":[219],"SEMA6B":[221],"GPR15,":[223],"confirmed":[224],"predictive":[226],"value":[227],"markers":[230],"measured":[233,259,442],"patient":[234],"population.":[235],"Yet,":[236],"true":[237],"confirmation":[238],"can":[239,317,469,473,495],"only":[240],"be":[241,272,303,366,402,424,455,470,474],"established":[242],"when":[243],"are":[245,343,441],"replicated":[246],"set":[250],"patients,":[252],"subsequently":[258],"separate":[262],"selection":[263],"patients.":[265],"None":[266],"markers,":[269],"however,":[270],"could":[271],"validated.":[273],"Conclusion":[274],"thesis":[277],"able":[281],"identify":[283],"predictors,":[284,337],"ready":[285],"use":[287],"practice.":[290],"This":[291,426],"does":[292],"mean":[294],"possibility":[297,350],"prediction":[299,353],"response":[301,355,398,463],"should":[302],"ruled":[304],"out,":[305],"as":[306],"many":[307,437],"reasons":[308],"inability":[311],"find":[313,333],"biologically":[314],"relevant":[315,336,341],"predictors":[316,395],"co-exist.":[318],"It":[319],"conceivable":[322],"adaption":[325],"strategy":[328],"enables":[329],"field":[331],"reproducible":[334],"items":[342],"discussed":[344],"thesis.":[347],"However,":[348],"exists":[351],"too":[357,367],"difficult":[358],"practice:":[360],"biology":[362],"might":[365,423,445,452,489],"complex":[368],"variable":[370],"get":[372,410],"hold":[373],"and/or":[375],"may":[377],"respond":[378],"very":[379],"unpredictable":[380],"unknown":[382],"parameters":[383],"like":[384],"exposome.":[386],"Still,":[387],"leading":[388],"scientists":[389],"rheumatology":[391],"firmly":[392],"believe":[393],"will":[401],"available":[403],"someday":[404],"use.":[406],"order":[408],"there,":[411],"better":[413,454],"understanding":[414,458],"pathogenesis":[417],"pharmacological":[419,462],"effects":[420],"needed.":[425],"means":[427],"instead":[429],"current":[432],"\u2018shotgun":[433],"approach\u2019":[434],"at":[439],"once":[440],"some":[444],"hit":[446],"target,":[448],"energy":[449],"funding":[451],"possibly":[453],"spent":[456],"pathophysiology":[460],"mechanisms.":[464],"Using":[465],"knowledge,":[467],"hypotheses":[468],"made":[471],"specifically":[475],"tested,":[476],"while":[477],"also":[478],"taking":[479],"into":[480],"account":[481],"(biologically":[483],"possible)":[484],"influencing":[485],"factors.":[486],"Although":[487],"seem":[490],"step":[492],"backwards,":[493],"it":[494],"actually":[496],"help":[497],"us":[498],"forward.":[499]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2017-04-28T00:00:00"}