{"id":"https://openalex.org/W2605116010","doi":"https://doi.org/10.1200/jco.2014.32.15_suppl.7111","title":"A phase 2 study of IPI-926, an oral hedgehog inhibitor, in patients with myelofibrosis.","display_name":"A phase 2 study of IPI-926, an oral hedgehog inhibitor, in patients with myelofibrosis.","publication_year":2014,"publication_date":"2014-05-20","ids":{"openalex":"https://openalex.org/W2605116010","doi":"https://doi.org/10.1200/jco.2014.32.15_suppl.7111","mag":"2605116010"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2014.32.15_suppl.7111","doi":"https://doi.org/10.1200/jco.2014.32.15_suppl.7111","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2014.32.15_suppl.7111","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029750735","display_name":"Koji Sasaki","orcid":"https://orcid.org/0000-0002-9140-0610","observed_orcids":["https://orcid.org/0000-0002-9140-0610"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Koji Sasaki","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065621786","display_name":"Jason R. Gotlib","orcid":"https://orcid.org/0000-0001-8253-6156","observed_orcids":["https://orcid.org/0000-0001-8253-6156"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason R. Gotlib","raw_affiliation_strings":["Stanford University, School of Medicine, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University, School of Medicine, Stanford, CA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039057642","display_name":"Ruben A. Mesa","orcid":"https://orcid.org/0000-0001-5880-7972","observed_orcids":["https://orcid.org/0000-0001-5880-7972"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruben A. Mesa","raw_affiliation_strings":["Mayo Clinic, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Scottsdale, AZ","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000750846","display_name":"Farhad Ravandi","orcid":"https://orcid.org/0000-0002-7621-377X","observed_orcids":["https://orcid.org/0000-0002-7621-377X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Farhad Ravandi","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015101485","display_name":"J\u00f6rge E. Cortes","orcid":"https://orcid.org/0000-0002-8636-1071","observed_orcids":["https://orcid.org/0000-0002-8636-1071"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorge E. Cortes","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066471470","display_name":"Patrick Francis Kelly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108457","display_name":"Infinity Pharmaceuticals (United States)","ror":"https://ror.org/01sfsq511","country_code":"US","type":"company","lineage":["https://openalex.org/I4210108457"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick Francis Kelly","raw_affiliation_strings":["Infinity Pharmaceuticals, Inc., Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infinity Pharmaceuticals, Inc., Cambridge, MA","institution_ids":["https://openalex.org/I4210108457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005876566","display_name":"Jeffery Lorne Kutok","orcid":"https://orcid.org/0009-0009-9931-3106","observed_orcids":["https://orcid.org/0009-0009-9931-3106"]},"institutions":[{"id":"https://openalex.org/I4210108457","display_name":"Infinity Pharmaceuticals (United States)","ror":"https://ror.org/01sfsq511","country_code":"US","type":"company","lineage":["https://openalex.org/I4210108457"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Lorne Kutok","raw_affiliation_strings":["Infinity Pharmaceuticals, Inc., Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infinity Pharmaceuticals, Inc., Cambridge, MA","institution_ids":["https://openalex.org/I4210108457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090435894","display_name":"Hagop M. Kantarjian","orcid":"https://orcid.org/0000-0002-1908-3307","observed_orcids":["https://orcid.org/0000-0002-1908-3307"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hagop M. Kantarjian","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085521139","display_name":"Sr\u0111an Verstov\u0161ek","orcid":"https://orcid.org/0000-0002-6912-8569","observed_orcids":["https://orcid.org/0000-0002-6912-8569"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Srdan Verstovsek","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"15_suppl","first_page":"7111","last_page":"7111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hedgehog-pathway-inhibitors","display_name":"Hedgehog pathway inhibitors","score":0.699999988079071},{"id":"https://openalex.org/keywords/myelofibrosis","display_name":"myelofibrosis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/gli1","display_name":"Gli1","score":0.8220000267028809},{"id":"https://openalex.org/keywords/oral-small-molecule-inhibitor","display_name":"oral small-molecule inhibitor","score":0.5180000066757202},{"id":"https://openalex.org/keywords/spleen-size-reduction","display_name":"spleen size reduction","score":0.8920000195503235},{"id":"https://openalex.org/keywords/transfusion-independence","display_name":"transfusion independence","score":0.8889999985694885},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.5350000262260437},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.45100000500679016},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.3479999899864197},{"id":"https://openalex.org/keywords/primary-myelofibrosis","display_name":"primary myelofibrosis","score":0.7049999833106995},{"id":"https://openalex.org/keywords/secondary-myelofibrosis","display_name":"secondary myelofibrosis","score":0.7850000262260437},{"id":"https://openalex.org/keywords/desmoplastic-stroma","display_name":"desmoplastic stroma","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9008632898330688},{"id":"https://openalex.org/C2778539099","wikidata":"https://www.wikidata.org/wiki/Q6120","display_name":"Hedgehog","level":3,"score":0.7297521233558655},{"id":"https://openalex.org/C2780076729","wikidata":"https://www.wikidata.org/wiki/Q1752571","display_name":"Myelofibrosis","level":3,"score":0.6916078329086304},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4598385691642761},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.42347246408462524},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41499078273773193},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.1974506676197052},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.08018004894256592},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2014.32.15_suppl.7111","doi":"https://doi.org/10.1200/jco.2014.32.15_suppl.7111","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2014.32.15_suppl.7111","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2125975672","https://openalex.org/W2120010339","https://openalex.org/W2510676179","https://openalex.org/W2890501719","https://openalex.org/W2952512321","https://openalex.org/W2970355440","https://openalex.org/W1916873495","https://openalex.org/W2123303875","https://openalex.org/W2619953469","https://openalex.org/W2918169471"],"abstract_inverted_index":{"7111":[0],"Background:":[1],"Aberrant":[2],"expression":[3],"of":[4,21,31,60,92,127,142,151,223,228,333,348],"the":[5,19],"Hedgehog":[6],"(Hh)":[7],"signaling":[8],"pathway":[9,366],"initiates":[10],"cancer,":[11],"promotes":[12],"tumor":[13,23],"survival,":[14],"and":[15,56,94,167,208,260,329,342],"is":[16],"related":[17],"to":[18,87,102,112,116,205,215,311],"development":[20],"desmoplastic":[22],"stroma.":[24],"We":[25],"conducted":[26],"a":[27,57,83,89,125,140,356],"phase":[28],"2":[29,108],"study":[30],"IPI-926,":[32],"an":[33],"oral":[34],"Hh":[35,365],"inhibitor,":[36],"in":[37,71,178,189,235,239,244,253,264,283,286,296,301,314,317,358,368,374],"patients":[38,203],"(pts)":[39],"with":[40,46,99,139,196,247,256,370],"myelofibrosis":[41],"(MF);":[42],"NCT01371617.":[43,382],"Methods:":[44],"Pts":[45],"performance":[47],"status":[48],"\u22642,":[49],"adequate":[50],"organ":[51],"function,":[52],"no":[53,184,216],"active":[54],"infection,":[55],"life":[58],"expectancy":[59],"at":[61,106,320,327],"least":[62,107],"3":[63,249,258,305,321],"months,":[64],"received":[65],"160":[66],"mg":[67],"IPI-926":[68,349],"orally":[69],"daily":[70],"continuous":[72],"28-day":[73],"cycles.":[74],"Response":[75],"was":[76,134],"defined":[77],"by":[78,181,299,304],"IWG":[79],"consensus":[80],"criteria.":[81],"Using":[82],"Simon":[84],"2-Stage":[85],"method":[86],"differentiate":[88],"response":[90,217],"rate":[91],"\u226410%":[93],">30%:":[95],"\u224812":[96],"evaluable":[97],"pts":[98,114,121,175,266,280,293,308],"MF":[100,375],"were":[101,115,122,159,210,277,335],"be":[103,117,377],"enrolled;":[104],"if":[105],"responses":[109],"occurred,":[110],"up":[111],"35":[113],"enrolled.":[118],"Results:":[119],"14":[120],"treated":[123],"for":[124,199],"median":[126,141,152],"5.1":[128],"months":[129,274],"(range,":[130],"0.7-7.3).":[131],"Their":[132],"age":[133],"71":[135],"years":[136,144],"(range":[137,155],"55-82),":[138],"5.8":[143],"since":[145],"diagnosis;":[146],"4":[147,331],"had":[148,164,169,176,186,193,281,294,309],"palpable":[149],"spleen":[150,179],"10.5":[153],"cm":[154],"6-23),":[156],"6":[157,200,254],"(43%)":[158],"transfusion":[160,197],"dependent,":[161],"8":[162],"(57%)":[163],"primary":[165],"MF,":[166],"all":[168],"\u2265":[170],"intermediate-2":[171],"MF.":[172,359],"While":[173],"several":[174],"reduction":[177,282],"size":[180],"palpation":[182],"(<50%),":[183],"pt":[185,192],"significant":[187],"improvement":[188,195],"symptoms.":[190],"One":[191],"clinical":[194,343],"independence":[198],"months.":[201,322],"Two":[202],"progressed":[204],"acute":[206],"leukemia,":[207],"11":[209,236],"taken":[211],"off":[212],"therapy":[213,276],"due":[214],"and/or":[218],"side":[219],"effects.":[220],"Adverse":[221],"events":[222],"any":[224],"grade":[225],"(in":[226],">30%":[227],"patients)":[229],"included":[230],"elevated":[231],"AST":[232],"or":[233,262],"ALT":[234],"pts,":[237],"nausea":[238],"8,":[240],"increased":[241],"conjugated":[242],"bilirubin":[243],"7":[245],"(3":[246],"gr":[248,257],"toxicity),":[250,259],"decreased":[251],"appetite":[252],"(1":[255],"constipation":[261],"vomiting":[263],"5":[265],"each.":[267],"Correlative":[268],"studies":[269],"on":[270,275],"samples":[271],"after":[272,330],">3":[273],"analyzed:":[278],"2/8":[279],"GLI1":[284,297],"mRNA":[285],"bone":[287],"marrow":[288],"(BM)":[289],"aspirate":[290],"cells;":[291],"3/10":[292],"reductions":[295],"protein":[298],"immunohistochemistry":[300],"BM":[302,318],"biopsies":[303,319],"months;":[306],"4/10":[307],"minimal":[310],"modest":[312],"decreases":[313],"fiber-length":[315],"density":[316],"Serum":[323],"cytokine":[324],"levels":[325],"measured":[326],"baseline":[328],"weeks":[332],"treatment":[334],"not":[336,351],"qualitatively":[337],"different.":[338],"Conclusions:":[339],"The":[340,360],"safety":[341],"activity":[344,363],"(ORR":[345],"\u2264":[346],"10%)":[347],"did":[350],"support":[352],"continued":[353],"evaluation":[354],"as":[355],"monotherapy":[357],"preliminary":[361],"biologic":[362],"suggests":[364],"inhibitors":[367],"combination":[369],"other":[371],"novel":[372],"agents":[373],"should":[376],"considered.":[378],"Clinical":[379],"trial":[380],"information:":[381]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-04-14T00:00:00"}
