{"id":"https://openalex.org/W26050007","doi":"https://doi.org/10.1016/s0021-9258(18)56146-9","title":"RATIO OF SICKLE-CELL ANEMIA HEMOGLOBIN TO NORMAL HEMOGLOBIN IN SICKLEMICS","display_name":"RATIO OF SICKLE-CELL ANEMIA HEMOGLOBIN TO NORMAL HEMOGLOBIN IN SICKLEMICS","publication_year":1951,"publication_date":"1951-01-01","ids":{"openalex":"https://openalex.org/W26050007","doi":"https://doi.org/10.1016/s0021-9258(18)56146-9","mag":"26050007","pmid":"https://pubmed.ncbi.nlm.nih.gov/14814114"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(18)56146-9","doi":"https://doi.org/10.1016/s0021-9258(18)56146-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)56146-9","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(18)56146-9","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111640866","display_name":"Ibert C. Wells","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]},{"id":"https://openalex.org/I1318687432","display_name":"National Academy of Sciences","ror":"https://ror.org/038mfx688","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1318687432","https://openalex.org/I197604219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ibert C. Wells","raw_affiliation_strings":["(From the Gates and Crellin Laboratories of Chemistry,$ California Institute of Technology, Pasadena, California","National Academy of Sciences in Wash-ington,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(From the Gates and Crellin Laboratories of Chemistry,$ California Institute of Technology, Pasadena, California","institution_ids":["https://openalex.org/I122411786"]},{"raw_affiliation_string":"National Academy of Sciences in Wash-ington,","institution_ids":["https://openalex.org/I1318687432"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060330432","display_name":"Harvey A. Itano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]},{"id":"https://openalex.org/I1318687432","display_name":"National Academy of Sciences","ror":"https://ror.org/038mfx688","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1318687432","https://openalex.org/I197604219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harvey A. Itano","raw_affiliation_strings":["(From the Gates and Crellin Laboratories of Chemistry,$ California Institute of Technology, Pasadena, California","National Academy of Sciences in Wash-ington,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(From the Gates and Crellin Laboratories of Chemistry,$ California Institute of Technology, Pasadena, California","institution_ids":["https://openalex.org/I122411786"]},{"raw_affiliation_string":"National Academy of Sciences in Wash-ington,","institution_ids":["https://openalex.org/I1318687432"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":23.5702,"has_fulltext":false,"cited_by_count":93,"citation_normalized_percentile":{"value":0.99447514,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"188","issue":"1","first_page":"65","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sickle-cell-trait","display_name":"sickle cell trait","score":0.9139999747276306},{"id":"https://openalex.org/keywords/normal-hemoglobin","display_name":"normal hemoglobin","score":0.8009999990463257},{"id":"https://openalex.org/keywords/erythrocyte-sickling","display_name":"erythrocyte sickling","score":0.859000027179718},{"id":"https://openalex.org/keywords/oxygen-partial-pressure","display_name":"oxygen partial pressure","score":0.8320000171661377},{"id":"https://openalex.org/keywords/hemoglobin-synthesis","display_name":"hemoglobin synthesis","score":0.4129999876022339}],"concepts":[{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.8257599472999573},{"id":"https://openalex.org/C2777566322","wikidata":"https://www.wikidata.org/wiki/Q3536635","display_name":"Sickle cell trait","level":3,"score":0.7742601633071899},{"id":"https://openalex.org/C2778620579","wikidata":"https://www.wikidata.org/wiki/Q185034","display_name":"Sickle cell anemia","level":3,"score":0.5412980318069458},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.5330141186714172},{"id":"https://openalex.org/C3020314195","wikidata":"https://www.wikidata.org/wiki/Q185034","display_name":"Hemoglobin s","level":4,"score":0.4890170991420746},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45949769020080566},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4436340928077698},{"id":"https://openalex.org/C2908652662","wikidata":"https://www.wikidata.org/wiki/Q2496436","display_name":"Hemoglobin F","level":5,"score":0.43459299206733704},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3879736065864563},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3610813617706299},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34980469942092896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29493969678878784},{"id":"https://openalex.org/C2776317666","wikidata":"https://www.wikidata.org/wiki/Q2496436","display_name":"Fetal hemoglobin","level":4,"score":0.29173344373703003},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.27184879779815674},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.231779545545578},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12502622604370117},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.06564384698867798},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.04874122142791748}],"mesh":[{"descriptor_ui":"D000740","descriptor_name":"Anemia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004913","descriptor_name":"Erythrocytes, Abnormal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0021-9258(18)56146-9","doi":"https://doi.org/10.1016/s0021-9258(18)56146-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)56146-9","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:14814114","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14814114","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:authors.library.caltech.edu:10765","doi":null,"is_oa":false,"landing_page_url":"https://resolver.caltech.edu/CaltechAUTHORS:WELjbc51","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(18)56146-9","doi":"https://doi.org/10.1016/s0021-9258(18)56146-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)56146-9","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W14959226","https://openalex.org/W53442977","https://openalex.org/W63494502","https://openalex.org/W1506154845","https://openalex.org/W1597579132","https://openalex.org/W1604485965","https://openalex.org/W1757735653","https://openalex.org/W2027816595","https://openalex.org/W2041595751","https://openalex.org/W2046577012","https://openalex.org/W2084295229","https://openalex.org/W2105061763","https://openalex.org/W2335985065"],"related_works":["https://openalex.org/W2319320942","https://openalex.org/W2481042206","https://openalex.org/W1969447152","https://openalex.org/W2019389568","https://openalex.org/W2161211235","https://openalex.org/W1968418136","https://openalex.org/W2088234492","https://openalex.org/W1979944031","https://openalex.org/W2050867145","https://openalex.org/W1518410322"],"abstract_inverted_index":{"It":[0],"has":[1],"been":[2],"observed":[3],"that":[4,17,46],"all":[5],"of":[6,9,24,39,62,70,87,98,101,104,119,133,146,149],"the":[7,68,74,85,96,99,102,117,131,143,147],"erythrocytes":[8,35],"individuals":[10,67,115],"with":[11],"sickle-cell":[12,33,40,55,105,134],"trait":[13,34],"undergo":[14],"sickling":[15,31],"and":[16,54,116],"a":[18,59],"greater":[19],"reduction":[20],"in":[21,32,37,113],"partial":[22],"pressure":[23],"oxygen":[25],"is":[26],"required":[27],"to":[28,73,79,94,110],"produce":[29],"complete":[30],"than":[36],"those":[38],"anemics":[41],"(1).":[42],"These":[43],"observations":[44],"indicate":[45],"each":[47],"sicklemia":[48],"erythrocyte":[49],"contains":[50],"both":[51],"normal":[52,75,111],"hemoglobin":[53,76,107,112,150],"anemia":[56,106],"hemoglobin.":[57],"In":[58],"pooled":[60],"sample":[61],"blood":[63],"from":[64],"five":[65],"sicklemic":[66,114],"ratio":[69,103],"t,he":[71],"abnormal":[72],"was":[77,91],"found":[78],"be":[80],"39:61":[81],"(7).":[82],"\\n":[83],"\\nIn":[84],"light":[86,141],"this":[88,123],"knowledge":[89,132],"it":[90],"considered":[92],"pertinent":[93],"ascertain":[95],"extent":[97],"variation":[100],"(SCA":[108],"hemoglobin)":[109],"effect":[118],"various":[120],"factors":[121],"on":[122,142],"ratio.":[124],"Such":[125],"information":[126],"not":[127],"only":[128],"would":[129],"increase":[130],"disease":[135],"but":[136],"also":[137],"might":[138],"shed":[139],"some":[140],"general":[144],"problem":[145],"control":[148],"anabolism.":[151]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
