{"id":"https://openalex.org/W2604928552","doi":"https://doi.org/10.1158/1557-3125.dnarepair16-b12","title":"Abstract B12: Effect of Ganoderma lucidum on DNA damage and DNA repair in colorectal cancer cell lines","display_name":"Abstract B12: Effect of Ganoderma lucidum on DNA damage and DNA repair in colorectal cancer cell lines","publication_year":2017,"publication_date":"2017-04-01","ids":{"openalex":"https://openalex.org/W2604928552","doi":"https://doi.org/10.1158/1557-3125.dnarepair16-b12","mag":"2604928552"},"language":"en","primary_location":{"id":"doi:10.1158/1557-3125.dnarepair16-b12","doi":"https://doi.org/10.1158/1557-3125.dnarepair16-b12","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1557-3125.dnarepair16-b12","pdf_url":null,"source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058857861","display_name":"Alena Opattov\u00e1","orcid":"https://orcid.org/0000-0002-4508-6560","observed_orcids":["https://orcid.org/0000-0002-4508-6560"]},"institutions":[{"id":"https://openalex.org/I4210133092","display_name":"Czech Academy of Sciences, Institute of Experimental Medicine","ror":"https://ror.org/03hjekm25","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210133092"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Alena Opattova","raw_affiliation_strings":["1Institute of Experimental medicine, AS CR, Prague, Czech Republic,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute of Experimental medicine, AS CR, Prague, Czech Republic,","institution_ids":["https://openalex.org/I4210133092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073170551","display_name":"Andrea \u010cumov\u00e1","orcid":"https://orcid.org/0000-0003-2485-3895","observed_orcids":["https://orcid.org/0000-0003-2485-3895"]},"institutions":[{"id":"https://openalex.org/I4210133092","display_name":"Czech Academy of Sciences, Institute of Experimental Medicine","ror":"https://ror.org/03hjekm25","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210133092"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Andrea Cumova","raw_affiliation_strings":["1Institute of Experimental medicine, AS CR, Prague, Czech Republic,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute of Experimental medicine, AS CR, Prague, Czech Republic,","institution_ids":["https://openalex.org/I4210133092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084593874","display_name":"So\u0148a Vodenkov\u00e1","orcid":"https://orcid.org/0000-0003-0315-5668","observed_orcids":["https://orcid.org/0000-0003-0315-5668"]},"institutions":[{"id":"https://openalex.org/I4210133092","display_name":"Czech Academy of Sciences, Institute of Experimental Medicine","ror":"https://ror.org/03hjekm25","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210133092"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Sona Vodenkova","raw_affiliation_strings":["1Institute of Experimental medicine, AS CR, Prague, Czech Republic,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute of Experimental medicine, AS CR, Prague, Czech Republic,","institution_ids":["https://openalex.org/I4210133092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011223729","display_name":"Peter Ma\u010dinga","orcid":"https://orcid.org/0000-0003-3699-6914","observed_orcids":["https://orcid.org/0000-0003-3699-6914"]},"institutions":[{"id":"https://openalex.org/I4210127955","display_name":"Institute of Clinical and Experimental Medicine","ror":"https://ror.org/036zr1b90","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210127955"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Peter Macinga","raw_affiliation_strings":["2Institute for Clinical and Experimental Medicine, Prague, Czech Republic,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Institute for Clinical and Experimental Medicine, Prague, Czech Republic,","institution_ids":["https://openalex.org/I4210127955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061901309","display_name":"Jozef Horak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133092","display_name":"Czech Academy of Sciences, Institute of Experimental Medicine","ror":"https://ror.org/03hjekm25","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210133092"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Jozef Horak","raw_affiliation_strings":["1Institute of Experimental medicine, AS CR, Prague, Czech Republic,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute of Experimental medicine, AS CR, Prague, Czech Republic,","institution_ids":["https://openalex.org/I4210133092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113555877","display_name":"Daniel Sl\u00edva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Sliva","raw_affiliation_strings":["3Purdue Research Park, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Purdue Research Park, Indianapolis, IN","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004651940","display_name":"Pavel Vodi\u010dka","orcid":"https://orcid.org/0000-0003-2376-1243","observed_orcids":["https://orcid.org/0000-0003-2376-1243"]},"institutions":[{"id":"https://openalex.org/I4210133092","display_name":"Czech Academy of Sciences, Institute of Experimental Medicine","ror":"https://ror.org/03hjekm25","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210133092"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Pavel Vodicka","raw_affiliation_strings":["1Institute of Experimental medicine, AS CR, Prague, Czech Republic,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute of Experimental medicine, AS CR, Prague, Czech Republic,","institution_ids":["https://openalex.org/I4210133092"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"4_Supplement","first_page":"B12","last_page":"B12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ganoderma-lucidum","display_name":"Ganoderma lucidum","score":0.9869999885559082},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9829999804496765},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.8209999799728394},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.9710000157356262},{"id":"https://openalex.org/keywords/oxidative-dna-damage","display_name":"oxidative DNA damage","score":0.7749999761581421},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9760000109672546},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.6470000147819519},{"id":"https://openalex.org/keywords/superoxide-dismutase-1","display_name":"superoxide dismutase 1","score":0.9739999771118164},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":1.0},{"id":"https://openalex.org/keywords/base-excision-repair","display_name":"base excision repair","score":0.9649999737739563},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8299999833106995},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.9900000095367432},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":0.7250000238418579},{"id":"https://openalex.org/keywords/anticancer-natural-products","display_name":"anticancer natural products","score":0.6610000133514404},{"id":"https://openalex.org/keywords/p53-deficient-cells","display_name":"p53-deficient cells","score":0.753000020980835},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.7191613912582397},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.708337664604187},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6899041533470154},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.6069883704185486},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5333437919616699},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.48568281531333923},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.47837820649147034},{"id":"https://openalex.org/C2776618520","wikidata":"https://www.wikidata.org/wiki/Q1799774","display_name":"Ganoderma","level":3,"score":0.4759480953216553},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45875123143196106},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4326658546924591},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3338935971260071},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30466681718826294},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2964879274368286},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.24288123846054077},{"id":"https://openalex.org/C2992468417","wikidata":"https://www.wikidata.org/wiki/Q271098","display_name":"Ganoderma lucidum","level":2,"score":0.24092435836791992},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19106486439704895},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15093672275543213}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1557-3125.dnarepair16-b12","doi":"https://doi.org/10.1158/1557-3125.dnarepair16-b12","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1557-3125.dnarepair16-b12","pdf_url":null,"source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7132423462","https://openalex.org/W7132353114","https://openalex.org/W7132071147","https://openalex.org/W4386705385","https://openalex.org/W7132732868","https://openalex.org/W2106714330","https://openalex.org/W1993213808","https://openalex.org/W2015631723","https://openalex.org/W2623262747","https://openalex.org/W4400523154"],"abstract_inverted_index":{"Abstract":[0],"Colorectal":[1],"carcinoma":[2],"(CRC)":[3],"is":[4,61,176,202],"the":[5,13,38,107,129,205,264,276,317,405],"third":[6],"most":[7,17],"common":[8,18],"type":[9],"of":[10,20,27,37,46,69,78,85,95,106,131,146,166,185,191,199,207,242,251,301,316,332,359,387,404],"cancer":[11,21,161,167,221,237,303,337,398],"in":[12,24,83,180,219,235,290,335,396],"world":[14],"and":[15,33,44,48,57,71,115,120,150,163,215,248,298,327,365,393,414],"second":[16],"cause":[19],"related":[22],"deaths":[23],"Europe.":[25],"Countries":[26],"Central":[28],"Europe":[29],"(Czech":[30],"Republic,":[31],"Slovakia":[32],"Hungary)":[34],"have":[35],"one":[36],"highest":[39],"rates":[40],"both":[41],"for":[42,183,187,357],"incidence":[43],"mortality":[45],"CRC":[47,60],"this":[49],"disease":[50,64],"therefore":[51],"possesses":[52],"a":[53,62,93,177,354],"serious":[54],"health,":[55],"social":[56],"economic":[58],"problem.":[59],"complex":[63],"that":[65,231,311,343],"develops":[66],"as":[67],"consequence":[68],"environmental":[70],"health":[72],"risk":[73],"factors":[74],"with":[75,128],"particular":[76],"involvement":[77],"suboptimal":[79],"DNA":[80,86,118,140,148,151,213,216,267,279,325,346,391,394,410],"repair,":[81],"resulting":[82],"accumulation":[84,114,260],"damage.":[87],"Reactive":[88],"oxygen":[89],"species":[90],"(ROS)":[91],"represent":[92],"group":[94],"highly":[96],"reactive":[97],"molecules":[98],"tightly":[99],"controlled":[100],"by":[101,154,257,349],"cellular":[102,318],"antioxidant":[103,319],"system.":[104],"Disturbance":[105],"prooxidation\u2013antioxidation":[108],"homeostasis":[109],"can":[110],"lead":[111,158],"to":[112,117,138,159,164,169,203,323,329],"ROS":[113,259],"consequently":[116],"damage":[119,141,149,214,268,326,347,392],"apoptosis.":[121],"Many":[122],"natural":[123,155,350],"compounds":[124,156,351],"possess":[125],"anti-cancer":[126,360],"activities":[127],"generation":[130],"ROS.":[132],"Cancer":[133,427],"cells":[134,168,238],"are":[135],"more":[136],"sensitive":[137],"oxidative":[139,147,266,324,345],"than":[142],"non-malignant":[143],"cells.":[144],"Modulation":[145],"repair":[152,217,280,395],"pathways":[153],"may":[157,352],"selective":[160],"cell-death":[162],"sensitization":[165],"treatment.":[170,361],"Ganoderma":[171,208,388],"Lucidum":[172],"(GLC)":[173,210],"(Reishi,":[174],"Ling-Zhi)":[175],"mushroom":[178],"used":[179],"Chinese":[181],"medicine":[182],"thousands":[184],"years":[186],"prevention":[188],"or":[189,295],"therapy":[190],"many":[192],"different":[193],"disorders":[194],"including":[195],"cancer.":[196],"The":[197],"aim":[198],"our":[200],"study":[201],"define":[204],"effect":[206],"lucidum":[209,389],"extract":[211,313,334],"on":[212,390,409],"machinery":[218],"colorectal":[220,236,302,336,397],"cell":[222,291,304,338,399],"lines":[223,400],"(HTC116,":[224],"HCT116p53-/-,":[225],"HT29,":[226],"SW480).":[227],"Our":[228,308],"results":[229,309],"showed":[230],"6hrs":[232],"GLC":[233,273,312,333],"treatment":[234],"(0.5\u00b5g/\u00b5l)":[239],"inhibits":[240],"activity":[241,250,315],"superoxid":[243],"dismutase":[244],"1":[245],"(25%,":[246,306],"p<0.01)":[247,271],"enzymatic":[249],"glutathione":[252],"peroxidase":[253],"(20%,":[254],"p<0.01),":[255],"followed":[256],"abnormal":[258],"(1,5-fold,":[261],"p<0.05).":[262,307],"Furthermore":[263],"specific":[265,344],"increased":[269],"(10-fold,":[270],"after":[272],"treatment,":[274],"whereas":[275],"base":[277],"excision":[278],"process":[281],"was":[282],"supressed":[283],"(40%,":[284],"p<0.001).":[285],"Finally,":[286],"above":[287],"events":[288],"resulted":[289],"cycle":[292],"arrest":[293],"(HCT116)":[294],"apoptosis":[296],"(HCTp53-/-)":[297],"subsequent":[299],"decrease":[300],"survival":[305],"suggest":[310],"decreases":[314],"system,":[320],"which":[321],"leads":[322],"subsequently":[328],"genotoxic":[330],"effects":[331],"lines.":[339],"These":[340],"data":[341],"indicate":[342],"caused":[348],"become":[353],"potential":[355],"tool":[356],"improvement":[358],"Acknowledgement:":[362],"AMVIS":[363],"LH13061":[364],"GACR":[366],"15-14789S,":[367],"AZV":[368],"15-27580A":[369],"Citation":[370],"Format:":[371],"Alena":[372],"Opattova,":[373],"Andrea":[374],"Cumova,":[375],"Sona":[376],"Vodenkova,":[377],"Peter":[378],"Macinga,":[379],"Jozef":[380],"Horak,":[381],"Daniel":[382],"Sliva,":[383],"Pavel":[384],"Vodicka.":[385],"Effect":[386],"[abstract].":[401],"In:":[402],"Proceedings":[403],"AACR":[406],"Special":[407],"Conference":[408],"Repair:":[411],"Tumor":[412],"Development":[413],"Therapeutic":[415],"Response;":[416],"2016":[417],"Nov":[418],"2-5;":[419],"Montreal,":[420],"QC,":[421],"Canada.":[422],"Philadelphia":[423],"(PA):":[424],"AACR;":[425],"Mol":[426],"Res":[428],"2017;15(4_Suppl):Abstract":[429],"nr":[430],"B12.":[431]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-04-14T00:00:00"}
