{"id":"https://openalex.org/W2604822899","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.4037","title":"Response assessment parameters in esophageal cancer \u2013 conventional and novel techniques","display_name":"Response assessment parameters in esophageal cancer \u2013 conventional and novel techniques","publication_year":2004,"publication_date":"2004-07-15","ids":{"openalex":"https://openalex.org/W2604822899","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.4037","mag":"2604822899"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2004.22.14_suppl.4037","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.4037","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.22.14_suppl.4037","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103646719","display_name":"L. H. Schwartz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. H. Schwartz","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113654300","display_name":"J. Colville","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. A. C. Colville","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013556648","display_name":"L. Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Wang","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021013894","display_name":"Hedvig Hricak","orcid":"https://orcid.org/0000-0003-2240-9694","observed_orcids":["https://orcid.org/0000-0003-2240-9694"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Hricak","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035865205","display_name":"David H. Ilson","orcid":"https://orcid.org/0000-0003-0831-2247","observed_orcids":["https://orcid.org/0000-0003-0831-2247"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Ilson","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006913373","display_name":"Gary K. Schwartz","orcid":"https://orcid.org/0000-0003-1813-5061","observed_orcids":["https://orcid.org/0000-0003-1813-5061"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. K. Schwartz","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"14_suppl","first_page":"4037","last_page":"4037"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.8848000168800354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.8848000168800354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.04639999940991402,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.039900001138448715,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/esophageal-cancer","display_name":"esophageal cancer","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tumor-response-assessment","display_name":"tumor response assessment","score":0.8659999966621399},{"id":"https://openalex.org/keywords/recist","display_name":"RECIST","score":0.9049999713897705},{"id":"https://openalex.org/keywords/who-criteria","display_name":"WHO criteria","score":0.8809999823570251},{"id":"https://openalex.org/keywords/tumor-shape","display_name":"tumor shape","score":0.6729999780654907},{"id":"https://openalex.org/keywords/metastatic-lymphadenopathy","display_name":"metastatic lymphadenopathy","score":0.7929999828338623},{"id":"https://openalex.org/keywords/bryostatin-1","display_name":"bryostatin 1","score":0.8920000195503235},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.9940000176429749},{"id":"https://openalex.org/keywords/computed-tomography","display_name":"computed tomography","score":0.43799999356269836},{"id":"https://openalex.org/keywords/treatment-response-assessment","display_name":"treatment response assessment","score":0.3580000102519989}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9055381417274475},{"id":"https://openalex.org/C2779984678","wikidata":"https://www.wikidata.org/wiki/Q2145898","display_name":"Response Evaluation Criteria in Solid Tumors","level":4,"score":0.8043238520622253},{"id":"https://openalex.org/C2779742542","wikidata":"https://www.wikidata.org/wiki/Q372701","display_name":"Esophageal cancer","level":3,"score":0.609050989151001},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5707886219024658},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.5471587777137756},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.4964178204536438},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.4621508717536926},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44539809226989746},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.38766998052597046},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.35954663157463074},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.35215240716934204},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.2893248498439789}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1200/jco.2004.22.14_suppl.4037","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.4037","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.22.14_suppl.4037","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"doi:10.1200/jco.2004.22.90140.4037","doi":"https://doi.org/10.1200/jco.2004.22.90140.4037","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.22.90140.4037","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2116064106","https://openalex.org/W3198486837","https://openalex.org/W6939632182","https://openalex.org/W2370224196","https://openalex.org/W2966031595","https://openalex.org/W7139868071","https://openalex.org/W2793657801","https://openalex.org/W2376713328","https://openalex.org/W2273719746","https://openalex.org/W2084905853"],"abstract_inverted_index":{"4037":[0],"Background:":[1],"There":[2,198],"is":[3,41,68,78],"great":[4],"concern":[5],"that":[6,44,70],"response":[7,99,207,289,356],"assessment":[8,160,290,352],"utilizing":[9],"RECIST":[10,118,253,270,326],"may":[11,47,296],"not":[12],"be":[13,48,297,344,349],"equivalent":[14],"to":[15,52,89,301,343,364],"methodology":[16],"previously":[17],"employed":[18],"with":[19,124,163,240],"WHO":[20,224,268,292,324],"in":[21,31,50,61,108,112,129,140,204,232,260,278,288,299,304,317,334,351,357],"the":[22,53,57,71,101,233,258,261,263,265,274,276,302,311,315,319,321,330,332],"evaluation":[23,62],"of":[24,56,63,74,81,98,134,176,250,306,339,353],"esophageal":[25,126],"cancer,":[26],"as":[27,66,218,271,273,308,327,329],"has":[28],"been":[29],"seen":[30],"other":[32],"tumor":[33,168,178,279,335,355],"types":[34],"(Cancer":[35],"2003":[36],"Oct.":[37],"15;":[38],"98[8]:1611\u20139).":[39],"It":[40],"our":[42],"hypothesis":[43],"this":[45,91,141,340],"discordance":[46,266,322],"due":[49,298],"part":[51,300],"inaccurate":[54],"use":[55],"long":[58,85],"dimension":[59],"(RECIST)":[60,210],"metastatic":[64,125],"lymphadenopathy,":[65],"it":[67,107],"apparent":[69],"short":[72],"axis":[73],"a":[75,95,109,130,174,177,200,285],"lymph":[76],"node":[77],"more":[79],"predictive":[80],"malignancy":[82],"than":[83],"its":[84],"axis.":[86],"In":[87],"order":[88],"test":[90],"hypothesis,":[92],"we":[93],"developed":[94],"new":[96,171],"parameter":[97],"called":[100],"\u201cEccentricity":[102],"Factor\u201d":[103],"(EF)":[104],"and":[105,119,136,150,166,192,211,221,242,254,269,293,325],"evaluated":[106],"clinical":[110],"trial":[111,133],"which":[113,295],"responses":[114],"were":[115,138,146,152,225],"measured":[116,309],"by":[117,223,227,310],"WHO.":[120,255],"Methods:":[121],"23":[122],"patients":[123,216,239],"cancer":[127],"involved":[128],"phase":[131],"II":[132],"bryostatin-1":[135],"paclitaxel":[137],"included":[139],"retrospective":[142],"study.":[143],"93":[144],"lesions":[145],"assessed":[147],"at":[148],"baseline":[149],"these":[151],"subsequently":[153],"followed":[154],"on":[155],"serial":[156],"CT":[157],"scans.":[158],"Response":[159],"was":[161,180,199,235],"calculated":[162,181],"both":[164],"unidimensional":[165,209],"bidimensional":[167,212],"measurements.":[169,214],"A":[170],"parameter,":[172],"\u201cEF\u201d,":[173],"measure":[175],"shape":[179],"(EF":[182],"=":[183,188,194],"\u221a1-(LPD/MD)":[184],"2":[185],"where":[186],"LPD":[187],"largest":[189],"perpendicular":[190],"diameter,":[191],"MD":[193],"maximal":[195],"diameter).":[196],"Results:":[197],"26%":[201],"disagreement":[202,251],"rate":[203],"best":[205],"overall":[206,354],"between":[208,252,267,291,323],"(WHO)":[213],"3/23":[215],"categorized":[217],"each":[219],"PR":[220],"PD":[222],"SD":[226],"RECIST.":[228],"The":[229,256,313,337],"average":[230],"change":[231,259,277,303,316,333],"EF":[234],"0.45":[236],"for":[237,247],"those":[238],"agreement":[241],"significantly":[243],"greater":[244,257,264,275,314,320,331],"0.8":[245],"(p<0.001)":[246],"time":[248],"points":[249],"EF,":[262],"well":[272,328],"shape.":[280,336],"Conclusions:":[281],"These":[282],"results":[283],"indicate":[284],"significant":[286,361],"difference":[287],"RECIST,":[294],"eccentricity":[305],"tumors":[307],"EF.":[312],"eccentricity,":[318],"importance":[338],"factor":[341],"needs":[342],"prospectively":[345],"validated":[346],"but":[347],"could":[348],"critical":[350],"any":[358],"therapy.":[359],"No":[360],"financial":[362],"relationships":[363],"disclose.":[365]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2017-04-14T00:00:00"}