{"id":"https://openalex.org/W2604635794","doi":"https://doi.org/10.1038/s41598-017-00933-y","title":"Characteristics of the heme catabolic pathway in mild unconjugated hyperbilirubinemia and their associations with inflammation and disease prevention","display_name":"Characteristics of the heme catabolic pathway in mild unconjugated hyperbilirubinemia and their associations with inflammation and disease prevention","publication_year":2017,"publication_date":"2017-04-03","ids":{"openalex":"https://openalex.org/W2604635794","doi":"https://doi.org/10.1038/s41598-017-00933-y","mag":"2604635794","pmid":"https://pubmed.ncbi.nlm.nih.gov/28389660"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-017-00933-y","doi":"https://doi.org/10.1038/s41598-017-00933-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-017-00933-y","pdf_url":"https://www.nature.com/articles/s41598-017-00933-y.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-017-00933-y.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110047308","display_name":"Christine M\u00f6lzer","orcid":"https://orcid.org/0000-0002-8015-7774","observed_orcids":["https://orcid.org/0000-0002-8015-7774"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["AT","GB"],"is_corresponding":true,"raw_author_name":"Christine M\u00f6lzer","raw_affiliation_strings":["University of Aberdeen, School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, Foresterhill, Ashgrove Road West, AB25 2ZD, Aberdeen, UK. christine.moelzer@univie.ac.at","University of Vienna, Faculty of Life Sciences, Department of Nutritional Sciences, Althanstra\u00dfe 14 (UZA2), 1090, Vienna, Austria. christine.moelzer@univie.ac.at","University of Aberdeen, School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, Foresterhill, UK","University of Vienna, Faculty of Life Sciences, Department of Nutritional Sciences, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Aberdeen, School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, Foresterhill, Ashgrove Road West, AB25 2ZD, Aberdeen, UK. christine.moelzer@univie.ac.at","institution_ids":["https://openalex.org/I195460627"]},{"raw_affiliation_string":"University of Vienna, Faculty of Life Sciences, Department of Nutritional Sciences, Althanstra\u00dfe 14 (UZA2), 1090, Vienna, Austria. christine.moelzer@univie.ac.at","institution_ids":["https://openalex.org/I129774422"]},{"raw_affiliation_string":"University of Aberdeen, School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, Foresterhill, UK","institution_ids":["https://openalex.org/I195460627"]},{"raw_affiliation_string":"University of Vienna, Faculty of Life Sciences, Department of Nutritional Sciences, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002386478","display_name":"Marlies Wallner","orcid":"https://orcid.org/0000-0003-0644-0712","observed_orcids":["https://orcid.org/0000-0003-0644-0712"]},"institutions":[{"id":"https://openalex.org/I103365165","display_name":"FH JOANNEUM University of Applied Sciences","ror":"https://ror.org/03kkbqm48","country_code":"AT","type":"education","lineage":["https://openalex.org/I103365165"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Marlies Wallner","raw_affiliation_strings":["University of Applied Sciences, FH JOANNEUM, Institute of Dietetics and Nutrition, Alte Poststra\u00dfe, 149, 8020, Graz, Austria","University of Applied Sciences, FH JOANNEUM, Institute of Dietetics and Nutrition, Alte Poststra\u00dfe, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Applied Sciences, FH JOANNEUM, Institute of Dietetics and Nutrition, Alte Poststra\u00dfe, 149, 8020, Graz, Austria","institution_ids":["https://openalex.org/I103365165"]},{"raw_affiliation_string":"University of Applied Sciences, FH JOANNEUM, Institute of Dietetics and Nutrition, Alte Poststra\u00dfe, Austria","institution_ids":["https://openalex.org/I103365165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088103166","display_name":"Carina C. Kern","orcid":"https://orcid.org/0000-0001-5639-4529","observed_orcids":["https://orcid.org/0000-0001-5639-4529","https://orcid.org/0000-0003-1997-7527"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Carina Kern","raw_affiliation_strings":["Medical University of Vienna, Center for Physiology and Pharmacology, Institute of Pharmacology, W\u00e4hringerstra\u00dfe 13A, 1090, Vienna, Austria","Medical University of Vienna, Center for Physiology and Pharmacology, Institute of Pharmacology, Vienna, Austria"],"raw_orcid":"https://orcid.org/0000-0003-1997-7527","affiliations":[{"raw_affiliation_string":"Medical University of Vienna, Center for Physiology and Pharmacology, Institute of Pharmacology, W\u00e4hringerstra\u00dfe 13A, 1090, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Medical University of Vienna, Center for Physiology and Pharmacology, Institute of Pharmacology, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071161720","display_name":"Anela Tosevska","orcid":"https://orcid.org/0000-0002-0892-7068","observed_orcids":["https://orcid.org/0000-0002-0892-7068"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["AT","US"],"is_corresponding":false,"raw_author_name":"Anela Tosevska","raw_affiliation_strings":["Department of Molecular, Cell and Developmental Biology, UCLA, 610 Charles E. Young Drive East, Los Angeles, CA, 90095, USA","University of Vienna, Faculty of Life Sciences, Department of Nutritional Sciences, Althanstra\u00dfe 14 (UZA2), 1090, Vienna, Austria","Department of Molecular, Cell and Developmental Biology, UCLA, Los Angeles, USA","University of Vienna, Faculty of Life Sciences, Department of Nutritional Sciences, Vienna, Austria"],"raw_orcid":"https://orcid.org/0000-0002-0892-7068","affiliations":[{"raw_affiliation_string":"Department of Molecular, Cell and Developmental Biology, UCLA, 610 Charles E. Young Drive East, Los Angeles, CA, 90095, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"University of Vienna, Faculty of Life Sciences, Department of Nutritional Sciences, Althanstra\u00dfe 14 (UZA2), 1090, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]},{"raw_affiliation_string":"Department of Molecular, Cell and Developmental Biology, UCLA, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"University of Vienna, Faculty of Life Sciences, Department of Nutritional Sciences, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055640871","display_name":"Ren\u00e9 Zadnikar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]},{"id":"https://openalex.org/I4210162546","display_name":"University Hospital Innsbruck","ror":"https://ror.org/05wjv2104","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210162546"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Ren\u00e9 Zadnikar","raw_affiliation_strings":["Central Institute of Medical and Chemical Laboratory Diagnostics, University Clinics Innsbruck, 6020, Innsbruck, Austria","Central Institute of Medical and Chemical Laboratory Diagnostics, University Clinics Innsbruck, Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Institute of Medical and Chemical Laboratory Diagnostics, University Clinics Innsbruck, 6020, Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584","https://openalex.org/I4210162546"]},{"raw_affiliation_string":"Central Institute of Medical and Chemical Laboratory Diagnostics, University Clinics Innsbruck, Innsbruck, Austria","institution_ids":["https://openalex.org/I4210162546"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004292301","display_name":"Daniel Doberer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802328216","display_name":"Vienna General Hospital","ror":"https://ror.org/05f0zr486","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I2802328216"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Daniel Doberer","raw_affiliation_strings":["Medical University of Vienna, Department of Clinical Pharmacology, Vienna General Hospital, W\u00e4hringer G\u00fcrtel 18-20, 1090, Vienna, Austria","Medical University of Vienna, Department of Clinical Pharmacology, Vienna General Hospital, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of Vienna, Department of Clinical Pharmacology, Vienna General Hospital, W\u00e4hringer G\u00fcrtel 18-20, 1090, Vienna, Austria","institution_ids":["https://openalex.org/I2802328216","https://openalex.org/I76134821"]},{"raw_affiliation_string":"Medical University of Vienna, Department of Clinical Pharmacology, Vienna General Hospital, Vienna, Austria","institution_ids":["https://openalex.org/I2802328216","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079506605","display_name":"Rodrig Marculescu","orcid":"https://orcid.org/0000-0003-1772-6695","observed_orcids":["https://orcid.org/0000-0003-1772-6695"]},"institutions":[{"id":"https://openalex.org/I2802328216","display_name":"Vienna General Hospital","ror":"https://ror.org/05f0zr486","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I2802328216"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Rodrig Marculescu","raw_affiliation_strings":["Medical University of Vienna, Clinical Institute of Laboratory Medicine, Vienna General Hospital, W\u00e4hringer G\u00fcrtel 18-20, 1090, Vienna, Austria","Medical University of Vienna, Clinical Institute of Laboratory Medicine, Vienna General Hospital, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of Vienna, Clinical Institute of Laboratory Medicine, Vienna General Hospital, W\u00e4hringer G\u00fcrtel 18-20, 1090, Vienna, Austria","institution_ids":["https://openalex.org/I2802328216","https://openalex.org/I76134821"]},{"raw_affiliation_string":"Medical University of Vienna, Clinical Institute of Laboratory Medicine, Vienna General Hospital, Vienna, Austria","institution_ids":["https://openalex.org/I2802328216","https://openalex.org/I76134821"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101760386","display_name":"Karl\u2010Heinz Wagner","orcid":"https://orcid.org/0000-0002-1683-7265","observed_orcids":["https://orcid.org/0000-0002-1683-7265"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Karl-Heinz Wagner","raw_affiliation_strings":["University of Vienna, Faculty of Life Sciences, Department of Nutritional Sciences, Althanstra\u00dfe 14 (UZA2), 1090, Vienna, Austria","University of Vienna, Faculty of Life Sciences, Department of Nutritional Sciences, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Vienna, Faculty of Life Sciences, Department of Nutritional Sciences, Althanstra\u00dfe 14 (UZA2), 1090, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]},{"raw_affiliation_string":"University of Vienna, Faculty of Life Sciences, Department of Nutritional Sciences, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5110047308"],"corresponding_institution_ids":["https://openalex.org/I129774422","https://openalex.org/I195460627"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.7764,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.67954964,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"7","issue":"1","first_page":"755","last_page":"755"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.9326000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.9326000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.06499999761581421,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heme-degradation","display_name":"heme degradation","score":0.972000002861023},{"id":"https://openalex.org/keywords/gilbert-syndrome","display_name":"Gilbert syndrome","score":0.8479999899864197},{"id":"https://openalex.org/keywords/unconjugated-hyperbilirubinemia","display_name":"unconjugated hyperbilirubinemia","score":0.9850000143051147},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.7990000247955322},{"id":"https://openalex.org/keywords/biliverdin-reductase","display_name":"biliverdin reductase","score":0.8880000114440918},{"id":"https://openalex.org/keywords/ugt1a1-28-polymorphism","display_name":"UGT1A1*28 polymorphism","score":0.9089999794960022},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7950000166893005},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.8029999732971191},{"id":"https://openalex.org/keywords/interleukins","display_name":"interleukins","score":0.7160000205039978},{"id":"https://openalex.org/keywords/haptoglobin","display_name":"haptoglobin","score":0.8989999890327454},{"id":"https://openalex.org/keywords/hemopexin","display_name":"hemopexin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/iron-metabolism","display_name":"iron metabolism","score":0.7319999933242798},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9390000104904175},{"id":"https://openalex.org/keywords/disease-prevention","display_name":"disease prevention","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C206396517","wikidata":"https://www.wikidata.org/wiki/Q422025","display_name":"Haptoglobin","level":2,"score":0.7240011692047119},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.673519492149353},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.5705734491348267},{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.5657596588134766},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5444492101669312},{"id":"https://openalex.org/C2779219270","wikidata":"https://www.wikidata.org/wiki/Q419972","display_name":"Heme oxygenase","level":4,"score":0.5305792689323425},{"id":"https://openalex.org/C2776474381","wikidata":"https://www.wikidata.org/wiki/Q409414","display_name":"Hemopexin","level":4,"score":0.5037233233451843},{"id":"https://openalex.org/C2777513400","wikidata":"https://www.wikidata.org/wiki/Q104219","display_name":"Bilirubin","level":2,"score":0.4933830797672272},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47440052032470703},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.438579261302948},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4341951310634613},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3538997173309326},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3192046880722046},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18825748562812805},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13394102454185486},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.10887125134468079}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001663","descriptor_name":"Bilirubin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001663","descriptor_name":"Bilirubin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001663","descriptor_name":"Bilirubin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006418","descriptor_name":"Heme","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006418","descriptor_name":"Heme","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006418","descriptor_name":"Heme","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006932","descriptor_name":"Hyperbilirubinemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006932","descriptor_name":"Hyperbilirubinemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006932","descriptor_name":"Hyperbilirubinemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006932","descriptor_name":"Hyperbilirubinemia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006932","descriptor_name":"Hyperbilirubinemia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006932","descriptor_name":"Hyperbilirubinemia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006932","descriptor_name":"Hyperbilirubinemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006932","descriptor_name":"Hyperbilirubinemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006932","descriptor_name":"Hyperbilirubinemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006932","descriptor_name":"Hyperbilirubinemia","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006932","descriptor_name":"Hyperbilirubinemia","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006932","descriptor_name":"Hyperbilirubinemia","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018895","descriptor_name":"Microsatellite Repeats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018895","descriptor_name":"Microsatellite Repeats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018895","descriptor_name":"Microsatellite Repeats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051547","descriptor_name":"Heme Oxygenase-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051547","descriptor_name":"Heme Oxygenase-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051547","descriptor_name":"Heme Oxygenase-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1038/s41598-017-00933-y","doi":"https://doi.org/10.1038/s41598-017-00933-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-017-00933-y","pdf_url":"https://www.nature.com/articles/s41598-017-00933-y.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:28389660","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28389660","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5429724","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5429724","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:info:fedora/oai:univie.ac.at:o:784821","doi":null,"is_oa":true,"landing_page_url":"https://phaidra.univie.ac.at/o:784821","pdf_url":null,"source":{"id":"https://openalex.org/S4306401993","display_name":"Phaidra (Universit\u00e4t Wien)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I129774422","host_organization_name":"University of Vienna","host_organization_lineage":["https://openalex.org/I129774422"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN:2045-2322","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:8d5e141c6064459cb511c1c0b44ffaa8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8d5e141c6064459cb511c1c0b44ffaa8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)","raw_type":"article"},{"id":"pmh:oai:epub.fh-joanneum.at:10163148","doi":null,"is_oa":true,"landing_page_url":"https://resolver.obvsg.at/urn:nbn:at:at-ubmuw:3-43012","pdf_url":null,"source":{"id":"https://openalex.org/S7407055160","display_name":"FH JOANNEUM ePUB","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"mag:2956107662","doi":null,"is_oa":false,"landing_page_url":"https://uscholar.univie.ac.at/view/o:784821","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1038/s41598-017-00933-y","doi":"https://doi.org/10.1038/s41598-017-00933-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-017-00933-y","pdf_url":"https://www.nature.com/articles/s41598-017-00933-y.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.800000011920929,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G531632913","display_name":null,"funder_award_id":"14541","funder_id":"https://openalex.org/F4320322325","funder_display_name":"Oesterreichische Nationalbank"},{"id":"https://openalex.org/G5336726453","display_name":"Therapy of Ischemia-Reperfusion-Injury by Heme Oxygenase-1 Induction in Skeletal Muscle and Ischemic Kidney","funder_award_id":"LS07-031","funder_id":"https://openalex.org/F4320321003","funder_display_name":"Vienna Science and Technology Fund"},{"id":"https://openalex.org/G8591891142","display_name":null,"funder_award_id":"14541","funder_id":"https://openalex.org/F4320321691","funder_display_name":"Universit\u00e4t Wien"}],"funders":[{"id":"https://openalex.org/F4320321003","display_name":"Vienna Science and Technology Fund","ror":"https://ror.org/01f9mc681"},{"id":"https://openalex.org/F4320321691","display_name":"Universit\u00e4t Wien","ror":"https://ror.org/03prydq77"},{"id":"https://openalex.org/F4320322325","display_name":"Oesterreichische Nationalbank","ror":"https://ror.org/00nkcmy90"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2604635794.pdf","grobid_xml":"https://content.openalex.org/works/W2604635794.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W106654750","https://openalex.org/W1222888527","https://openalex.org/W1490906959","https://openalex.org/W1504634754","https://openalex.org/W1600690434","https://openalex.org/W1693967370","https://openalex.org/W1781110211","https://openalex.org/W1839483610","https://openalex.org/W1957363998","https://openalex.org/W1963514532","https://openalex.org/W1965546595","https://openalex.org/W1966582616","https://openalex.org/W1966831402","https://openalex.org/W1970294462","https://openalex.org/W1971953294","https://openalex.org/W1975231341","https://openalex.org/W1986223929","https://openalex.org/W1988130146","https://openalex.org/W1990024459","https://openalex.org/W1996958458","https://openalex.org/W1997351738","https://openalex.org/W2001382332","https://openalex.org/W2004283265","https://openalex.org/W2007104356","https://openalex.org/W2007580897","https://openalex.org/W2014288494","https://openalex.org/W2014458122","https://openalex.org/W2016958390","https://openalex.org/W2023320997","https://openalex.org/W2026858140","https://openalex.org/W2031276389","https://openalex.org/W2032048503","https://openalex.org/W2032159980","https://openalex.org/W2038172495","https://openalex.org/W2039445636","https://openalex.org/W2047319099","https://openalex.org/W2051431505","https://openalex.org/W2055208350","https://openalex.org/W2056762760","https://openalex.org/W2060071948","https://openalex.org/W2064642280","https://openalex.org/W2065284764","https://openalex.org/W2065580295","https://openalex.org/W2069666755","https://openalex.org/W2071307185","https://openalex.org/W2078609739","https://openalex.org/W2093344546","https://openalex.org/W2093915500","https://openalex.org/W2096044299","https://openalex.org/W2105807252","https://openalex.org/W2114100281","https://openalex.org/W2121701848","https://openalex.org/W2122256417","https://openalex.org/W2122538288","https://openalex.org/W2127613089","https://openalex.org/W2135103569","https://openalex.org/W2141041110","https://openalex.org/W2145530136","https://openalex.org/W2149167244","https://openalex.org/W2152483356","https://openalex.org/W2155658087","https://openalex.org/W2161414034","https://openalex.org/W2192574210","https://openalex.org/W2201180650","https://openalex.org/W2243987051","https://openalex.org/W2292099685","https://openalex.org/W2322536880","https://openalex.org/W2397935080","https://openalex.org/W2410809655","https://openalex.org/W2413969120","https://openalex.org/W2417242080","https://openalex.org/W2465702003","https://openalex.org/W2496386220","https://openalex.org/W2949633101","https://openalex.org/W2978297846"],"related_works":["https://openalex.org/W41094349","https://openalex.org/W2784223579","https://openalex.org/W1990008211","https://openalex.org/W2109592429","https://openalex.org/W1892238282","https://openalex.org/W3023803570","https://openalex.org/W2597283431","https://openalex.org/W4205513426","https://openalex.org/W1631638135","https://openalex.org/W2046770279"],"abstract_inverted_index":{"Abstract":[0],"Heme":[1],"catabolism":[2,45],"exerts":[3],"physiological":[4],"functions":[5],"that":[6,80],"impact":[7,92],"health":[8,25,37],"through":[9],"depressing":[10],"inflammation.":[11],"Upon":[12],"reactive":[13],"pathway":[14],"progression,":[15],"as":[16,112],"in":[17,43,145,163,182],"Gilbert\u2019s":[18],"Syndrome":[19],"(GS;":[20],"UGT1A1":[21,84],"*28":[22],"polymorphism),":[23],"aggravated":[24],"effects":[26],"have":[27],"been":[28],"determined.":[29],"Based":[30],"on":[31],"lower":[32,197],"inflammation":[33,130],"and":[34,57,69,107,155,160,162,199],"improved":[35],"metabolic":[36],"reported":[38],"for":[39,77],"GS,":[40,62],"inter-group":[41],"differences":[42],"heme":[44,118,141],"were":[46,71,75,110,124,132,178],"explored.":[47],"Therefore,":[48],"a":[49,189],"case-control":[50],"study":[51],"including":[52],"120":[53],"fasted,":[54],"healthy,":[55],"age-":[56],"gender":[58],"matched":[59],"subjects":[60],"with/without":[61],"was":[63,136],"conducted.":[64],"Genetic":[65],"expressions":[66],"of":[67,153],"HMOX-1":[68,89],"BLVRA":[70,168],"measured.":[72],"Additionally":[73],"participants":[74],"genotyped":[76],"those":[78],"polymorphisms":[79],"are":[81,200],"known":[82],"(":[83,88,167],"*28)":[85],"or":[86],"likely":[87],"microsatellites)":[90],"to":[91,191,204],"bilirubinemia.":[93],"Intracellular":[94],"interleukins":[95],"(IL-6,":[96],"IL-1\u03b2,":[97],"TNF\u03b1),":[98],"circulatory":[99],"C-reactive":[100],"protein":[101],"(CRP),":[102],"serum":[103],"amyloid":[104],"A":[105],"(SAA)":[106],"haptoglobin":[108],"(Hpt)":[109],"analysed":[111],"inflammatory":[113],"markers.":[114],"To":[115],"assess":[116],"intracellular":[117],"oxygenase":[119],"1":[120],"(HO-1)":[121],"isolated":[122],"PBMCs":[123],"used.":[125],"In":[126],"GS":[127,184,194],"vs.":[128],"C,":[129],"markers":[131],"significantly":[133],"decreased.":[134],"This":[135],"supported":[137],"by":[138],"an":[139],"altered":[140],"catabolism,":[142],"indirectly":[143],"reflecting":[144],"elevated":[146],"unconjugated":[147],"bilirubin":[148],"(UCB;":[149],"main":[150],"phenotypic":[151],"feature":[152],"GS)":[154],"iron,":[156],"decreased":[157],"hemopexin":[158],"(Hpx)":[159],"Hpt":[161],"up-regulated":[164],"biliverdin":[165],"reductase":[166],")":[169],"gene":[170],"expressions.":[171],"Moreover,":[172],"HMOX":[173],"(GT)":[174],"n":[175],"short":[176],"alleles":[177],"non-significantly":[179],"more":[180],"prominent":[181],"female":[183],"individuals.":[185],"Herewith,":[186],"we":[187],"propose":[188],"concept":[190],"elucidate":[192],"why":[193],"individuals":[195],"encounter":[196],"inflammation,":[198],"thus":[201],"less":[202],"prone":[203],"oxidative-stress":[205],"mediated":[206],"diseases.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}