{"id":"https://openalex.org/W2604635500","doi":"https://doi.org/10.1200/jco.2015.33.15_suppl.2058","title":"Tumor profiling on 1245 gliomas and paired tumor study on 19 high grade gliomas.","display_name":"Tumor profiling on 1245 gliomas and paired tumor study on 19 high grade gliomas.","publication_year":2015,"publication_date":"2015-05-20","ids":{"openalex":"https://openalex.org/W2604635500","doi":"https://doi.org/10.1200/jco.2015.33.15_suppl.2058","mag":"2604635500"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2015.33.15_suppl.2058","doi":"https://doi.org/10.1200/jco.2015.33.15_suppl.2058","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2015.33.15_suppl.2058","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080544645","display_name":"Joanne Xiu","orcid":"https://orcid.org/0000-0001-8744-5827","observed_orcids":["https://orcid.org/0000-0001-8744-5827"]},"institutions":[{"id":"https://openalex.org/I4210140103","display_name":"Caris Life Sciences (United States)","ror":"https://ror.org/04wh5hg83","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joanne Xiu","raw_affiliation_strings":["Caris Life Sciences, Phoenix, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Caris Life Sciences, Phoenix, AZ","institution_ids":["https://openalex.org/I4210140103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082951042","display_name":"David B. Spetzler","orcid":"https://orcid.org/0000-0002-9531-0970","observed_orcids":["https://orcid.org/0000-0002-9531-0970"]},"institutions":[{"id":"https://openalex.org/I4210140103","display_name":"Caris Life Sciences (United States)","ror":"https://ror.org/04wh5hg83","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Spetzler","raw_affiliation_strings":["Caris Life Sci, Paradise Valley, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Caris Life Sci, Paradise Valley, AZ","institution_ids":["https://openalex.org/I4210140103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112255389","display_name":"Ryan P Bender","orcid":"https://orcid.org/0009-0005-7505-1165","observed_orcids":["https://orcid.org/0009-0005-7505-1165"]},"institutions":[{"id":"https://openalex.org/I4210140103","display_name":"Caris Life Sciences (United States)","ror":"https://ror.org/04wh5hg83","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Bender","raw_affiliation_strings":["Caris Life Sciences, Phoenix, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Caris Life Sciences, Phoenix, AZ","institution_ids":["https://openalex.org/I4210140103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022366907","display_name":"Anatole Ghazalpour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140103","display_name":"Caris Life Sciences (United States)","ror":"https://ror.org/04wh5hg83","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anatole Ghazalpour","raw_affiliation_strings":["Caris Life Sciences, Phoenix, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Caris Life Sciences, Phoenix, AZ","institution_ids":["https://openalex.org/I4210140103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037644603","display_name":"Zoran Gatalica","orcid":"https://orcid.org/0000-0002-0747-4431","observed_orcids":["https://orcid.org/0000-0002-0747-4431"]},"institutions":[{"id":"https://openalex.org/I4210140103","display_name":"Caris Life Sciences (United States)","ror":"https://ror.org/04wh5hg83","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zoran Gatalica","raw_affiliation_strings":["Caris Life Sciences, Phoenix, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Caris Life Sciences, Phoenix, AZ","institution_ids":["https://openalex.org/I4210140103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077908907","display_name":"Sandeep K. Reddy","orcid":"https://orcid.org/0000-0002-1458-6853","observed_orcids":["https://orcid.org/0000-0002-1458-6853"]},"institutions":[{"id":"https://openalex.org/I4210140103","display_name":"Caris Life Sciences (United States)","ror":"https://ror.org/04wh5hg83","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandeep K. Reddy","raw_affiliation_strings":["Caris Life Sciences, Phoenix, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Caris Life Sciences, Phoenix, AZ","institution_ids":["https://openalex.org/I4210140103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062289529","display_name":"David Eric Piccioni","orcid":"https://orcid.org/0000-0001-6006-0126","observed_orcids":["https://orcid.org/0000-0001-6006-0126"]},"institutions":[{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Eric Piccioni","raw_affiliation_strings":["UC San Diego Moores Cancer Center, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UC San Diego Moores Cancer Center, San Diego, CA","institution_ids":["https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010077225","display_name":"Jethro Lisien Hu","orcid":"https://orcid.org/0000-0002-5450-7988","observed_orcids":["https://orcid.org/0000-0002-5450-7988"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jethro Lisien Hu","raw_affiliation_strings":["Cedars-Sinai, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai, Los Angeles, CA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070567202","display_name":"Michael Glantz","orcid":"https://orcid.org/0000-0003-4877-5094","observed_orcids":["https://orcid.org/0000-0003-4877-5094"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Glantz","raw_affiliation_strings":["Penn State - Milton S Hershey Medcl Ctr, Hinsdale, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Penn State - Milton S Hershey Medcl Ctr, Hinsdale, MA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063863193","display_name":"Santosh Kesari","orcid":"https://orcid.org/0000-0003-3772-6000","observed_orcids":["https://orcid.org/0000-0003-3772-6000"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Santosh Kesari","raw_affiliation_strings":["UC San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UC San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"15_suppl","first_page":"2058","last_page":"2058"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.8529999852180481},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.953000009059906},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5960000157356262},{"id":"https://openalex.org/keywords/egfr-amplification","display_name":"EGFR amplification","score":0.7070000171661377},{"id":"https://openalex.org/keywords/egfrviii","display_name":"EGFRvIII","score":0.9660000205039978},{"id":"https://openalex.org/keywords/mgmt-promoter-methylation","display_name":"MGMT promoter methylation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/pd-l1-expression","display_name":"PD-L1 expression","score":0.8740000128746033},{"id":"https://openalex.org/keywords/1p-19q-codeletion","display_name":"1p/19q codeletion","score":0.9470000267028809},{"id":"https://openalex.org/keywords/brca1-mutation","display_name":"BRCA1 mutation","score":0.7110000252723694},{"id":"https://openalex.org/keywords/brca2-mutation","display_name":"BRCA2 mutation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/egfr-t790m-mutation","display_name":"T790M mutation","score":0.7229999899864197},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.30399999022483826}],"concepts":[{"id":"https://openalex.org/C121313828","wikidata":"https://www.wikidata.org/wiki/Q17861998","display_name":"CISH","level":5,"score":0.7644902467727661},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.7154647707939148},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7071098685264587},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5941973924636841},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.560031533241272},{"id":"https://openalex.org/C2777542201","wikidata":"https://www.wikidata.org/wiki/Q1336182","display_name":"Fluorescence in situ hybridization","level":4,"score":0.5327088236808777},{"id":"https://openalex.org/C2776643354","wikidata":"https://www.wikidata.org/wiki/Q5113886","display_name":"Chromogenic in situ hybridization","level":5,"score":0.5091163516044617},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45964694023132324},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4122043251991272},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28086036443710327},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.26892513036727905},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25946229696273804},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22936999797821045},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17492884397506714},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.15045568346977234},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.08330512046813965},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2015.33.15_suppl.2058","doi":"https://doi.org/10.1200/jco.2015.33.15_suppl.2058","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2015.33.15_suppl.2058","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4699999988079071}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2288672745","https://openalex.org/W2906730748","https://openalex.org/W4404941195","https://openalex.org/W2810241784","https://openalex.org/W2890361221","https://openalex.org/W2587839783","https://openalex.org/W2267259665","https://openalex.org/W2609525038","https://openalex.org/W2037934734","https://openalex.org/W3032019628"],"abstract_inverted_index":{"2058":[0],"Background:":[1],"Gliomas":[2],"are":[3,336],"molecularly":[4],"heterogeneous":[5],"with":[6,58,298],"genetic":[7],"alterations":[8],"driving":[9,32],"the":[10,16,271,344,349,359],"growth":[11,34],"of":[12,26,42,100,125,187,205,210,230,249,321,332,346,362],"recurrences":[13],"different":[14],"from":[15,81,214],"initial":[17],"tumor.":[18],"Previous":[19],"reports":[20],"showed":[21,235],"molecular":[22],"changes":[23,39,89,245],"during":[24,40],"progression":[25,41],"lower":[27],"grade":[28,110,132,179,206,221,341],"gliomas":[29,44,322,342],"to":[30,260,357],"GBM,":[31],"tumor":[33,143,315,324,355],"and":[35,73,127,149,173,196,208,219,277,310,330],"treatment":[36],"resistance;":[37],"however":[38],"high-grade":[43],"have":[45],"not":[46],"been":[47],"systematically":[48],"reported.":[49],"Methods:":[50],"1245":[51],"glioma":[52],"tumors":[53,80,112,154,213],"(934":[54],"GBM)":[55,101],"were":[56,85,290],"tested":[57],"multiple":[59],"platforms":[60],"including":[61,193,264],"sequencing":[62],"(SEQ),":[63],"immunohistochemistry":[64],"(IHC),":[65],"fluorescent/chromogenic":[66],"in-situ":[67],"hybridization":[68],"(FISH/CISH),":[69],"fragment":[70],"analysis":[71],"(FA)":[72],"promoter":[74],"methylation":[75],"(Me)":[76],"assay.":[77],"Metachronous":[78],"paired":[79],"19":[82,215],"patients":[83],"(pts)":[84],"assessed":[86],"for":[87,351,354],"biomarker":[88,244],"over":[90,246],"time.":[91,247],"Results:":[92],"EGFRvIII":[93],"was":[94,104,121,128,145,150,169,174,201],"seen":[95,122,146,170,202],"exclusively":[96],"in":[97,107,123,131,147,153,171,176,203,223,292,327,339],"GBM":[98,108,177,218],"(16%":[99],"while":[102],"amplification":[103,265],"more":[105,129,151,243],"common":[106,130,152],"than":[109,178],"II-III":[111,133,207],"(56%":[113],"vs.":[114,135,159,181],"20%,":[115],"p":[116,137,161,183],"<":[117,138],"0.001).":[118,139],"MGMT":[119,156,254,328],"Me":[120,157,329],"47%":[124],"all,":[126],"(64%":[134],"42%,":[136],"PD-L1":[140],"expression":[141,165],"on":[142,166,270,317],"cells":[144],"27%":[148],"without":[155],"(36%":[158],"18%,":[160],"=":[162,184,267,275,282,288],"0.01).":[163],"PD-1":[164],"tumor-infiltrating":[167],"lymphocytes":[168],"48%":[172],"higher":[175],"II-III(54%":[180],"30%,":[182],"0.005).":[185],"38":[186],"48":[188],"sequenced":[189],"genes":[190],"had":[191,240],"mutations,":[192],"BRCA1":[194],"(8%)":[195],"BRCA2":[197],"(6%).":[198],"1p19q":[199],"co-deletion":[200],"26%":[204],"2.9%":[209],"GBM.":[211],"Paired":[212],"pts":[216],"(18":[217],"1":[220],"III":[222],"both":[224],"samples)":[225],"taken":[226],"at":[227,343],"an":[228],"average":[229],"469":[231],"days":[232],"apart":[233],"(91-1400)":[234],"that":[236],"17":[237],"pairs":[238,252],"(89%)":[239],"one":[241],"or":[242],"3":[248,293],"13":[250],"(23%)":[251],"lost":[253],"Me,":[255],"potentially":[256],"indicating":[257],"acquired":[258,291,302],"resistance":[259],"temozolomide.":[261],"EGFR":[262,331],"aberrations":[263],"(N":[266],"1),":[268],"mutations":[269],"extracellular":[272],"(EGFRvIII,":[273],"N":[274,281,287],"1)":[276,289],"intracellular":[278],"domains":[279],"(T790M,":[280],"1;":[283],"Exon":[284],"20":[285],"insertion":[286],"pairs.":[294],"One":[295],"pt,":[296],"presenting":[297],"a":[299,318,352],"PTEN":[300],"mutation,":[301],"three":[303],"additional":[304],"mutations:":[305],"cKIT":[306],"(E583K),":[307],"PTPN11":[308],"(A72T)":[309],"PIK3CA":[311],"(D434N).":[312],"Conclusions:":[313],"Multiplatform":[314],"profiling":[316,356],"large":[319],"cohort":[320],"confirms":[323],"heterogeneity.":[325],"Changes":[326],"potential":[333],"therapeutic":[334],"importance":[335],"frequently":[337],"observed":[338],"high":[340],"time":[345],"recurrence,":[347],"suggesting":[348],"need":[350],"re-biopsy":[353],"direct":[358],"next":[360],"line":[361],"therapy.":[363]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2017-04-14T00:00:00"}
