{"id":"https://openalex.org/W2604575601","doi":"https://doi.org/10.1016/j.juro.2017.02.686","title":"PD12-11 DECREASED VASCULAR ENDOTHELIAL GROWTH FACTOR IN RADIATION CYSTITIS","display_name":"PD12-11 DECREASED VASCULAR ENDOTHELIAL GROWTH FACTOR IN RADIATION CYSTITIS","publication_year":2017,"publication_date":"2017-04-01","ids":{"openalex":"https://openalex.org/W2604575601","doi":"https://doi.org/10.1016/j.juro.2017.02.686","mag":"2604575601"},"language":"en","primary_location":{"id":"doi:10.1016/j.juro.2017.02.686","doi":"https://doi.org/10.1016/j.juro.2017.02.686","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.juro.2017.02.686","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052870430","display_name":"Bernadette M. M. Zwaans","orcid":"https://orcid.org/0000-0002-4717-5751","observed_orcids":["https://orcid.org/0000-0002-4717-5751"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bernadette Zwaans","raw_affiliation_strings":["Royal Oak, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Oak, MI","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046773465","display_name":"Sarah N. Bartolone","orcid":"https://orcid.org/0000-0001-9040-7055","observed_orcids":["https://orcid.org/0000-0001-9040-7055"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarah Bartolone","raw_affiliation_strings":["Royal Oak, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Oak, MI","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017957745","display_name":"Heinz E. Nicolai","orcid":"https://orcid.org/0000-0002-1916-2291","observed_orcids":["https://orcid.org/0000-0002-1916-2291"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heinz Nicholai","raw_affiliation_strings":["Santiago de Chile, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Santiago de Chile, Chile","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076037136","display_name":"Michael B. Chancellor","orcid":"https://orcid.org/0000-0001-9480-8972","observed_orcids":["https://orcid.org/0000-0001-9480-8972"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Chancellor","raw_affiliation_strings":["Royal Oak, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Oak, MI","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057978911","display_name":"Laura E. Lamb","orcid":"https://orcid.org/0000-0003-0386-4165","observed_orcids":["https://orcid.org/0000-0003-0386-4165"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura Lamb","raw_affiliation_strings":["Royal Oak, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Oak, MI","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04097817,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"197","issue":"4S","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.5351999998092651,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.5351999998092651,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.21619999408721924,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.18639999628067017,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiation-cystitis","display_name":"radiation cystitis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pelvic-radiotherapy","display_name":"pelvic radiotherapy","score":0.6430000066757202},{"id":"https://openalex.org/keywords/urinary-biomarkers","display_name":"urinary biomarkers","score":0.7289999723434448},{"id":"https://openalex.org/keywords/cystitis","display_name":"cystitis","score":0.5509999990463257},{"id":"https://openalex.org/keywords/cytokines-and-chemokines","display_name":"cytokines and chemokines","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cancer-survivors","display_name":"cancer survivors","score":0.6700000166893005},{"id":"https://openalex.org/keywords/radiation-induced-bladder-injury","display_name":"radiation-induced bladder injury","score":0.5329999923706055},{"id":"https://openalex.org/keywords/bladder-hemorrhage","display_name":"bladder hemorrhage","score":0.5049999952316284},{"id":"https://openalex.org/keywords/bladder-fibrosis","display_name":"bladder fibrosis","score":0.4309999942779541},{"id":"https://openalex.org/keywords/bladder-cancer-metastasis","display_name":"bladder cancer metastasis","score":0.32499998807907104}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8814430832862854},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5920982360839844},{"id":"https://openalex.org/C133507102","wikidata":"https://www.wikidata.org/wiki/Q4712977","display_name":"Genitourinary system","level":2,"score":0.5244598388671875},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.4953547716140747},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.49463507533073425},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.4195253252983093},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33201146125793457},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2975877523422241},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2934865355491638},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.21863403916358948},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.10372361540794373}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.juro.2017.02.686","doi":"https://doi.org/10.1016/j.juro.2017.02.686","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.juro.2017.02.686","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2795497738","https://openalex.org/W4225528137","https://openalex.org/W2795838763","https://openalex.org/W4392097460","https://openalex.org/W2478037188","https://openalex.org/W3097930639","https://openalex.org/W3204904648","https://openalex.org/W3176363951","https://openalex.org/W3097047734","https://openalex.org/W2032236538"],"abstract_inverted_index":{"You":[0],"have":[1,127],"accessJournal":[2],"of":[3,6,104,123,153,181,201,211,316,342,368,396,403,411],"UrologyInfections/Inflammation/Cystic":[4],"Disease":[5],"the":[7,105,112,139,146,171,199,218,340,350,362,409,426],"Genitourinary":[8],"Tract:":[9],"Kidney":[10],"&":[11,440],"Bladder":[12,236,280],"I1":[13],"Apr":[14],"2017PD12-11":[15],"DECREASED":[16],"VASCULAR":[17],"ENDOTHELIAL":[18],"GROWTH":[19],"FACTOR":[20],"IN":[21],"RADIATION":[22],"CYSTITIS":[23],"Bernadette":[24,35,444],"Zwaans,":[25],"Sarah":[26,44,451],"Bartolone,":[27],"Heinz":[28,53,458],"Nicholai,":[29],"Michael":[30,62,465],"Chancellor,":[31],"and":[32,71,101,141,158,242,247,263,370],"Laura":[33,72,472],"Lamb":[34,74,473],"ZwaansBernadette":[36],"Zwaans":[37,445],"More":[38,47,56,65,75,446,453,460,467,474],"articles":[39,48,57,66,76,447,454,461,468,475],"by":[40,49,58,67,77,285,373,448,455,462,469,476],"this":[41,50,59,68,78,383,449,456,463,470,477],"author":[42,51,60,69,79,450,457,464,471,478],",":[43,52,61,70],"BartoloneSarah":[45],"Bartolone":[46,452],"NicholaiHeinz":[54],"Nicholai":[55,459],"ChancellorMichael":[63],"Chancellor":[64,466],"LambLaura":[73],"View":[80],"All":[81,480],"Author":[82],"Informationhttps://doi.org/10.1016/j.juro.2017.02.686AboutPDF":[83],"ToolsAdd":[84],"to":[85,111,187,198,217,333,349,424],"favoritesDownload":[86],"CitationsTrack":[87],"CitationsPermissionsReprints":[88],"ShareFacebookTwitterLinked":[89],"InEmail":[90],"INTRODUCTION":[91],"AND":[92],"OBJECTIVES":[93],"Radiation":[94,224,337],"cystitis":[95],"(RC)":[96],"is":[97,118,136,155,364,371],"a":[98,178,208,221,227,314,365,394,420],"severely":[99],"debilitating":[100],"inflammatory":[102,303],"condition":[103],"bladder":[106,219,291,351],"resulting":[107],"from":[108,272,327],"radiation":[109,130,214,231,356],"therapy":[110,338],"pelvic":[113,129,277,343],"area":[114],"for":[115,249,339],"which":[116,391],"there":[117],"no":[119],"curative":[120],"therapy.":[121],"5-10%":[122],"cancer":[124,273],"patients":[125],"who":[126],"received":[128,207,276],"will":[131],"develop":[132,354],"RC,":[133],"though":[134],"little":[135],"known":[137],"about":[138],"histological":[140,151],"molecular":[142,167,252],"changes":[143,168,256],"that":[144,169,192,229,275,352,376],"drive":[145,170],"disease":[147],"progression.":[148],"A":[149],"major":[150,366],"hallmark":[152,367],"RC":[154,176,195,329,369,413],"vascular":[156,172,258,374,427],"damage":[157,348],"hemorrhaging.":[159],"Therefore,":[160],"our":[161],"study":[162,384],"focuses":[163],"on":[164],"identifying":[165],"early":[166],"defect":[173,311,428],"observed":[174],"in":[175,233,257,268,295,302,325,331,408,429],"using":[177,220],"mouse":[179,386],"model":[180],"RC.":[182,430],"In":[183,254,382,399],"addition,":[184,255,400],"we":[185],"aim":[186],"identify":[188,194],"potential":[189,421],"urine":[190,270,326,363,410],"biomarkers":[191],"could":[193],"development":[196],"prior":[197],"appearance":[200],"symptoms.":[202],"METHODS":[203],"Female":[204],"C57BL/6":[205],"mice":[206],"single":[209],"dose":[210],"40":[212],"Gy":[213],"delivered":[215],"specifically":[216],"Small":[222],"Animal":[223],"Research":[225],"Platform,":[226],"technique":[228],"simulates":[230],"treatment":[232,341],"human":[234,269],"patients.":[235,414],"tissues":[237],"were":[238,266,405],"harvested":[239],"at":[240],"2":[241],"12":[243,288],"weeks":[244],"post":[245],"irradiation":[246,281],"processed":[248],"histology":[250],"or":[251],"analysis.":[253],"endothelial":[259],"growth":[260],"factor":[261],"(VEGF)":[262],"cytokine/chemokine":[264],"expression":[265,321],"analyzed":[267],"samples":[271],"survivors":[274],"radiation.":[278],"RESULTS":[279],"was":[282,293,299,322],"well":[283,380],"tolerated":[284],"mice.":[286],"By":[287],"weeks,":[289],"decreased":[290],"vascularization":[292,310,390],"detected":[294],"irradiated":[296,385],"animals":[297],"as":[298,419],"an":[300],"increase":[301],"cells":[304],"clustered":[305],"around":[306],"blood":[307],"vessels.":[308],"This":[309],"coincided":[312,392],"with":[313,393],"loss":[315,360,395],"VEGF":[317,320,397,404,418],"levels.":[318],"Decreased":[319],"also":[323,406],"identified":[324,407],"symptomatic":[328,412],"patients,":[330],"comparison":[332],"age-matched":[334],"controls.":[335],"CONCLUSIONS":[336],"tumors":[344],"can":[345,353],"cause":[346],"severe":[347],"into":[355],"(hemorrhagic)":[357],"cystitis.":[358],"Blood":[359],"through":[361],"caused":[372],"defects":[375],"are":[377],"currently":[378],"not":[379],"understood.":[381],"bladders":[387],"developed":[388],"reduced":[389],"expression.":[398],"low":[401],"levels":[402],"Our":[415],"findings":[416],"suggest":[417],"therapeutic":[422],"target":[423],"treat":[425],"\u00a9":[431],"2017FiguresReferencesRelatedDetails":[432],"Volume":[433],"197Issue":[434],"4SApril":[435],"2017Page:":[436],"e269-e270":[437],"Advertisement":[438,481,482],"Copyright":[439],"Permissions\u00a9":[441],"2017MetricsAuthor":[442],"Information":[443],"Expand":[479],"PDF":[483],"downloadLoading":[484],"...":[485]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2017-04-14T00:00:00"}
