{"id":"https://openalex.org/W2604502136","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.9727","title":"Role of PAI-1 and TAFI in the mediation of fibrinolytic deficit in cancer patients","display_name":"Role of PAI-1 and TAFI in the mediation of fibrinolytic deficit in cancer patients","publication_year":2004,"publication_date":"2004-07-15","ids":{"openalex":"https://openalex.org/W2604502136","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.9727","mag":"2604502136"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2004.22.14_suppl.9727","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.9727","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.22.14_suppl.9727","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049166006","display_name":"M. Florian-Kujawski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12387023","display_name":"Trakya University","ror":"https://ror.org/00xa0xn82","country_code":"TR","type":"education","lineage":["https://openalex.org/I12387023"]},{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]}],"countries":["TR","US"],"is_corresponding":false,"raw_author_name":"M. R. Florian-Kujawski","raw_affiliation_strings":["Loyola University Medical Center, Maywood, IL; Trakya University Medical School, Edirne, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loyola University Medical Center, Maywood, IL; Trakya University Medical School, Edirne, Turkey","institution_ids":["https://openalex.org/I12387023","https://openalex.org/I1304196042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064983817","display_name":"Debra Hoppensteadt","orcid":"https://orcid.org/0000-0001-9342-4213","observed_orcids":["https://orcid.org/0000-0001-9342-4213"]},"institutions":[{"id":"https://openalex.org/I12387023","display_name":"Trakya University","ror":"https://ror.org/00xa0xn82","country_code":"TR","type":"education","lineage":["https://openalex.org/I12387023"]},{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]}],"countries":["TR","US"],"is_corresponding":false,"raw_author_name":"D. Hoppensteadt","raw_affiliation_strings":["Loyola University Medical Center, Maywood, IL; Trakya University Medical School, Edirne, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loyola University Medical Center, Maywood, IL; Trakya University Medical School, Edirne, Turkey","institution_ids":["https://openalex.org/I12387023","https://openalex.org/I1304196042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113782370","display_name":"Omar Iqbal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12387023","display_name":"Trakya University","ror":"https://ror.org/00xa0xn82","country_code":"TR","type":"education","lineage":["https://openalex.org/I12387023"]},{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]}],"countries":["TR","US"],"is_corresponding":false,"raw_author_name":"O. Iqbal","raw_affiliation_strings":["Loyola University Medical Center, Maywood, IL; Trakya University Medical School, Edirne, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loyola University Medical Center, Maywood, IL; Trakya University Medical School, Edirne, Turkey","institution_ids":["https://openalex.org/I12387023","https://openalex.org/I1304196042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103083288","display_name":"M. Demir","orcid":"https://orcid.org/0000-0003-4961-4639","observed_orcids":["https://orcid.org/0000-0003-4961-4639"]},"institutions":[{"id":"https://openalex.org/I12387023","display_name":"Trakya University","ror":"https://ror.org/00xa0xn82","country_code":"TR","type":"education","lineage":["https://openalex.org/I12387023"]},{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]}],"countries":["TR","US"],"is_corresponding":false,"raw_author_name":"M. Demir","raw_affiliation_strings":["Loyola University Medical Center, Maywood, IL; Trakya University Medical School, Edirne, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loyola University Medical Center, Maywood, IL; Trakya University Medical School, Edirne, Turkey","institution_ids":["https://openalex.org/I12387023","https://openalex.org/I1304196042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070149200","display_name":"M. Tobu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12387023","display_name":"Trakya University","ror":"https://ror.org/00xa0xn82","country_code":"TR","type":"education","lineage":["https://openalex.org/I12387023"]},{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]}],"countries":["TR","US"],"is_corresponding":false,"raw_author_name":"M. Tobu","raw_affiliation_strings":["Loyola University Medical Center, Maywood, IL; Trakya University Medical School, Edirne, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loyola University Medical Center, Maywood, IL; Trakya University Medical School, Edirne, Turkey","institution_ids":["https://openalex.org/I12387023","https://openalex.org/I1304196042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113488600","display_name":"Daniel Fareed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12387023","display_name":"Trakya University","ror":"https://ror.org/00xa0xn82","country_code":"TR","type":"education","lineage":["https://openalex.org/I12387023"]},{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]}],"countries":["TR","US"],"is_corresponding":false,"raw_author_name":"D. Fareed","raw_affiliation_strings":["Loyola University Medical Center, Maywood, IL; Trakya University Medical School, Edirne, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loyola University Medical Center, Maywood, IL; Trakya University Medical School, Edirne, Turkey","institution_ids":["https://openalex.org/I12387023","https://openalex.org/I1304196042"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007859032","display_name":"Jawed Fareed","orcid":"https://orcid.org/0000-0003-3465-2499","observed_orcids":["https://orcid.org/0000-0003-3465-2499"]},"institutions":[{"id":"https://openalex.org/I12387023","display_name":"Trakya University","ror":"https://ror.org/00xa0xn82","country_code":"TR","type":"education","lineage":["https://openalex.org/I12387023"]},{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]}],"countries":["TR","US"],"is_corresponding":false,"raw_author_name":"J. Fareed","raw_affiliation_strings":["Loyola University Medical Center, Maywood, IL; Trakya University Medical School, Edirne, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loyola University Medical Center, Maywood, IL; Trakya University Medical School, Edirne, Turkey","institution_ids":["https://openalex.org/I12387023","https://openalex.org/I1304196042"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"14_suppl","first_page":"9727","last_page":"9727"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cancer-associated-thrombosis","display_name":"cancer-associated thrombosis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/fibrinolysis","display_name":"fibrinolysis","score":0.5730000138282776},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.3580000102519989},{"id":"https://openalex.org/keywords/cancer-patients","display_name":"cancer patients","score":0.47600001096725464},{"id":"https://openalex.org/keywords/thrombosis-risk-factors","display_name":"thrombosis risk factors","score":0.7009999752044678},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.5120000243186951},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.807245135307312},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6645562648773193},{"id":"https://openalex.org/C2780675426","wikidata":"https://www.wikidata.org/wiki/Q410485","display_name":"Plasminogen activator inhibitor-1","level":3,"score":0.653337299823761},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6214372515678406},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.571195125579834},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4373904764652252},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.41991856694221497},{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.41850173473358154},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.35880184173583984},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27545031905174255}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1200/jco.2004.22.14_suppl.9727","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.9727","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.22.14_suppl.9727","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"doi:10.1200/jco.2004.22.90140.9727","doi":"https://doi.org/10.1200/jco.2004.22.90140.9727","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.22.90140.9727","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2065586785","https://openalex.org/W2888895868","https://openalex.org/W2077985380","https://openalex.org/W2325070742","https://openalex.org/W2005281127","https://openalex.org/W2093997298","https://openalex.org/W2461328896","https://openalex.org/W2587076345","https://openalex.org/W3120638928","https://openalex.org/W2888971292"],"abstract_inverted_index":{"9727":[0],"Background:":[1],"Cancer":[2],"associated":[3],"thrombosis":[4,101],"is":[5,286],"known":[6],"to":[7,32,45,77,155,207,281,328],"have":[8,29],"a":[9,78,130,145],"multi-factorial":[10],"pathogenesis":[11],"involving":[12],"up":[13,290],"regulation":[14,19,247,291],"of":[15,20,52,71,87,199,248,262,292,301],"coagulation":[16],"factors,":[17],"down":[18],"inhibitors":[21],"and":[22,109,123,236,257,295],"endothelial":[23],"dysfunction.":[24],"More":[25],"recently,":[26],"cancer":[27,97,203,220,275],"patients":[28,98,221,276],"been":[30,42,65],"shown":[31],"exhibit":[33],"fibrinolytic":[34,60,72,283],"deficit":[35,73],"with":[36,99,234,318],"impaired":[37],"clot":[38],"lysis.":[39],"This":[40,244],"has":[41,63],"mostly":[43],"attributed":[44],"an":[46,68,289],"increase":[47,147],"in":[48,89,148,202,252,274],"the":[49,85,197,208,229,263,282,298,308],"circulating":[50],"levels":[51,150,162,188,231,259,310],"plasminogen":[53],"activator":[54],"inhibitor":[55,61],"1":[56,213],"(PAI-1).":[57],"Thrombin":[58],"activatable":[59],"(TAFI)":[62],"recently":[64],"identified":[66],"as":[67],"additional":[69],"mediator":[70],"that":[74,271],"transforms":[75],"fibrin":[76],"plamsin":[79],"resistant":[80],"variant.":[81],"Methods:":[82],"To":[83],"decipher":[84],"role":[86],"TAFI":[88,106,110,184,209,238],"this":[90,200,217,314],"process,":[91],"plasma":[92],"samples":[93,143],"obtained":[94],"from":[95,164],"170":[96],"symptomatic":[100],"were":[102,189,232,260],"analyzed":[103],"for":[104,118,135,214,219],"PAI-1,":[105],"functional":[107,131,187],"(F)":[108],"immunologic":[111],"(I).":[112],"An":[113],"ELISA":[114],"method":[115,132],"was":[116,133,173,222,242],"used":[117,134],"PAI-1":[119,149,230,256,294],"(Stago,":[120],"Stamford,":[121],"CT)":[122],"TAFI-I":[124,161,258,309],"(American":[125],"Diagnostic,":[126],"Greenwich,":[127],"CT),":[128],"while":[129],"TAFI-F":[136],"(Pentapharm,":[137],"Ltd.,":[138],"Basel":[139],"Switerland)":[140],"Results:":[141],"Baseline":[142],"exhibited":[144],"marked":[146],"(140":[151],"\u00b1":[152,158,169,178,193,224],"21)":[153],"compared":[154,233],"normal":[156,176,215],"(94":[157],"14).":[159],"The":[160,254,267],"ranged":[163],"56":[165],"\u2013183":[166],"%NHP":[167],"(123":[168],"28":[170],"%NHP)":[171,195],"which":[172,285],"higher":[174],"than":[175],"(85.1":[177],"14":[179],"%NHP;":[180],"n=":[181],"82).":[182],"Interestingly,":[183],"measured":[185],"by":[186,288],"disproportionately":[190,312],"lower":[191],"(85":[192],"26":[194],"suggesting":[196],"consumption":[198],"protease":[201],"patients.":[204],"In":[205],"contrast":[206],"I/F":[210],"ratio":[211,218],"approximately":[212],"individuals,":[216],"1.6":[223],"0.1":[225],"(5.6":[226],"\u20130.7).":[227],"When":[228],"F":[235],"I":[237],"levels,":[239],"no":[240],"correlation":[241],"evident.":[243],"suggests":[245],"independent":[246,261],"these":[249],"two":[250,299],"proteins":[251,320],"cancer.":[253],"increased":[255],"fibrinogen":[264],"levels.":[265],"Conclusions:":[266],"results":[268],"clearly":[269],"suggest":[270],"thrombotic":[272],"complications":[273],"may":[277,316],"be":[278],"partly":[279],"due":[280],"deficit,":[284],"modulated":[287],"both":[293],"TAFI.":[296],"Furthermore,":[297],"regulators":[300],"fibrinolysis":[302],"mediate":[303],"their":[304],"effects":[305],"independently.":[306],"Since":[307],"are":[311],"high,":[313],"enzyme":[315],"complex":[317],"endogenous":[319],"modulating":[321],"its":[322],"functionality.":[323],"No":[324],"significant":[325],"financial":[326],"relationships":[327],"disclose.":[329]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2017-04-14T00:00:00"}
