{"id":"https://openalex.org/W2604448249","doi":"https://doi.org/10.1016/j.juro.2017.02.677","title":"PD12-02 ANTIMICROBIAL GENE EXPRESSION AND UTI SUSCEPTIBILITY IS DEPENDENT ON IL-6/STAT3 SIGNALING","display_name":"PD12-02 ANTIMICROBIAL GENE EXPRESSION AND UTI SUSCEPTIBILITY IS DEPENDENT ON IL-6/STAT3 SIGNALING","publication_year":2017,"publication_date":"2017-04-01","ids":{"openalex":"https://openalex.org/W2604448249","doi":"https://doi.org/10.1016/j.juro.2017.02.677","mag":"2604448249"},"language":"en","primary_location":{"id":"doi:10.1016/j.juro.2017.02.677","doi":"https://doi.org/10.1016/j.juro.2017.02.677","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.juro.2017.02.677","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022804099","display_name":"Christina Barbara Ching","orcid":"https://orcid.org/0000-0002-3396-4215","observed_orcids":["https://orcid.org/0000-0002-3396-4215"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christina Ching","raw_affiliation_strings":["Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbus, OH","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102009713","display_name":"Sudipti Gupta","orcid":"https://orcid.org/0000-0001-7574-5064","observed_orcids":["https://orcid.org/0000-0001-7574-5064"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sudipti Gupta","raw_affiliation_strings":["Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbus, OH","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008462752","display_name":"Birong Li","orcid":"https://orcid.org/0000-0001-9214-3890","observed_orcids":["https://orcid.org/0000-0001-9214-3890"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Birong Li","raw_affiliation_strings":["Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbus, OH","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086229604","display_name":"Brian Becknell","orcid":"https://orcid.org/0000-0002-2750-4415","observed_orcids":["https://orcid.org/0000-0002-2750-4415"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian Becknell","raw_affiliation_strings":["Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbus, OH","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04086449,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"197","issue":"4S","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.026000000536441803,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urinary-tract-infection","display_name":"urinary tract infection","score":0.9419999718666077},{"id":"https://openalex.org/keywords/il-6-stat3-signaling","display_name":"IL-6/STAT3 signaling","score":0.8190000057220459},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.9660000205039978},{"id":"https://openalex.org/keywords/urothelial-cells","display_name":"urothelial cells","score":0.6809999942779541},{"id":"https://openalex.org/keywords/antimicrobial-gene-expression","display_name":"antimicrobial gene expression","score":0.7329999804496765},{"id":"https://openalex.org/keywords/uropathogenic-escherichia-coli","display_name":"uropathogenic Escherichia coli","score":0.6470000147819519},{"id":"https://openalex.org/keywords/il-6-neutralizing-antibody","display_name":"IL-6 neutralizing antibody","score":0.8690000176429749},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.47200000286102295},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.49399998784065247},{"id":"https://openalex.org/keywords/pyelonephritis","display_name":"pyelonephritis","score":0.7570000290870667},{"id":"https://openalex.org/keywords/renal-scarring","display_name":"renal scarring","score":0.7770000100135803},{"id":"https://openalex.org/keywords/c3h-hej-mice","display_name":"C3H/HeJ mice","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6868684887886047},{"id":"https://openalex.org/C133507102","wikidata":"https://www.wikidata.org/wiki/Q4712977","display_name":"Genitourinary system","level":2,"score":0.4993579387664795},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4909394085407257},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.46852773427963257},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.45731326937675476},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.44706466794013977},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.44522589445114136},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.4423619508743286},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.4365878105163574},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43492788076400757},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.43419700860977173},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4113794267177582},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.38887208700180054},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35314255952835083},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3371366262435913},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2564742863178253},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21587640047073364},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.09426748752593994},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06609755754470825}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.juro.2017.02.677","doi":"https://doi.org/10.1016/j.juro.2017.02.677","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.juro.2017.02.677","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2788447215","https://openalex.org/W2605267471","https://openalex.org/W2604663376","https://openalex.org/W4396989171","https://openalex.org/W4403833119","https://openalex.org/W4397041426","https://openalex.org/W7126248835","https://openalex.org/W2275207622","https://openalex.org/W4415474936","https://openalex.org/W7096487357"],"abstract_inverted_index":{"You":[0],"have":[1],"accessJournal":[2],"of":[3,6,94,111,148,215,238,281,290,303,342,354,419,425,431],"UrologyInfections/Inflammation/Cystic":[4],"Disease":[5],"the":[7,145,213,236,301,352,432],"Genitourinary":[8],"Tract:":[9],"Kidney":[10],"&":[11,457],"Bladder":[12,307],"I1":[13],"Apr":[14],"2017PD12-02":[15],"ANTIMICROBIAL":[16],"GENE":[17],"EXPRESSION":[18],"AND":[19,84],"UTI":[20,157,409],"SUSCEPTIBILITY":[21],"IS":[22],"DEPENDENT":[23],"ON":[24],"IL-6/STAT3":[25],"SIGNALING":[26],"Christina":[27,36,461],"Ching,":[28],"Sudipti":[29,45,468],"Gupta,":[30],"Birong":[31,54,475],"Li,":[32],"and":[33,63,113,118,156,173,178,186,221,228,285,292,316,325,348,366,384,392,397,400,414,427,444],"Brian":[34,64,482],"Becknell":[35,66,483],"ChingChristina":[37],"Ching":[38,462],"More":[39,48,57,67,463,470,477,484],"articles":[40,49,58,68,464,471,478,485],"by":[41,50,59,69,181,253,262,465,472,479,486],"this":[42,51,60,70,466,473,480,487],"author":[43,52,61,71,467,474,481,488],",":[44,53,62],"GuptaSudipti":[46],"Gupta":[47,469],"LiBirong":[55],"Li":[56,476],"BecknellBrian":[65],"View":[72],"All":[73,490],"Author":[74],"Informationhttps://doi.org/10.1016/j.juro.2017.02.677AboutPDF":[75],"ToolsAdd":[76],"to":[77,97,125,143,207,240,300,335,407,438,442],"favoritesDownload":[78],"CitationsTrack":[79],"CitationsPermissionsReprints":[80],"ShareFacebookTwitterLinked":[81],"InEmail":[82],"INTRODUCTION":[83],"OBJECTIVES":[85],"Urinary":[86],"tract":[87],"infections":[88],"(UTI)":[89],"are":[90,104],"a":[91,139,277,436],"significant":[92],"source":[93],"morbidity.":[95],"Due":[96],"rising":[98],"antibiotic":[99],"resistance":[100],"patterns,":[101],"alternate":[102],"treatments":[103],"needed.":[105],"Prior":[106],"work":[107],"has":[108,122],"demonstrated":[109],"induction":[110,280,330],"urine":[112],"serum":[114],"IL-6":[115,121,216,225,229,283,291,314,318,344,370,388,404,413],"in":[116,130,217,351,376,423],"pyelonephritis":[117,385],"renal":[119,381],"scarring.":[120],"been":[123],"linked":[124],"antimicrobial":[126],"peptide":[127],"(AMP)":[128],"production":[129,242],"other":[131],"organs":[132],"via":[133,243],"Stat3":[134,239,245,357,415],"phosphorylation":[135],"on":[136,152,256],"Tyr705.":[137],"As":[138],"result,":[140],"we":[141,275],"sought":[142],"evaluate":[144],"potential":[146],"role":[147],"IL-6/Stat3":[149,433],"induced":[150,345],"signaling":[151,199],"urothelial":[153,323,395,420],"AMP":[154,179,219,241,308,328,349,361,398,421,440],"expression":[155,180,289,350,441],"susceptibility.":[158,410],"METHODS":[159],"We":[160,211,234,249],"infected":[161,304],"6":[162],"week":[163],"old":[164],"female":[165],"C57BL/6J":[166],"or":[167,402],"C3H/HeOuJ":[168,208,377],"mice":[169,320],"transurethrally":[170],"with":[171,266,379],"UPEC":[172,222,273,337,382],"measured":[174,250],"IL-6,":[175],"phosphorylated":[176],"(p-)Stat3,":[177],"ELISA,":[182],"qRT-PCR,":[183],"Western":[184],"blotting,":[185],"immunofluorescence":[187],"microscopy.":[188],"The":[189],"requirement":[190],"for":[191,394],"Lipopolysaccharide":[192],"(Lps)":[193],"/":[194],"Toll-like":[195],"receptor":[196],"4":[197],"(Tlr4)":[198],"was":[200],"established":[201],"using":[202,224],"Lps-hyporesponsive":[203],"C3H/HeJ":[204],"mice,":[205,378],"compared":[206],"Lps-sensitive":[209],"controls.":[210],"evaluated":[212,261],"roles":[214],"p-Stat3,":[218],"production,":[220],"clearance":[223],"neutralizing":[226,371],"antibody":[227,372],"knock":[230],"out":[231],"(KO)":[232],"mice.":[233,248],"determined":[235],"contribution":[237],"tamoxifen-inducible":[244],"conditional":[246],"KO":[247,319],"bacterial":[251],"burden":[252],"serial":[254],"plating":[255],"LB":[257],"agar.":[258],"Results":[259],"were":[260],"Mann-Whitney":[263],"U":[264],"test":[265],"p":[267],"<0.05":[268],"being":[269],"significant.":[270],"RESULTS":[271],"Upon":[272],"infection,":[274],"observed":[276],"time":[278],"dependent":[279],"urinary":[282],"secretion":[284,315],"bladder":[286,305,346,360],"p-Stat3.":[287,317],"Sustained":[288],"p-Stat3":[293,324,347,374,396],"required":[294],"intact":[295],"Tlr4":[296],"signaling.":[297],"P-Stat3":[298],"localized":[299],"nuclei":[302],"urothelium.":[306],"mRNA":[309,329,362],"levels":[310,363,375],"increased":[311,380,408],"following":[312,331,367],"peak":[313],"exhibited":[321],"absent":[322],"severely":[326],"blunted":[327],"experimental":[332,368],"UTI,":[333],"leading":[334],"impaired":[336],"clearance.":[338],"Conversely,":[339],"intraperitoneal":[340],"administration":[341],"recombinant":[343],"absence":[353],"infection.":[355,428],"Conditional":[356],"deletion":[358],"reduced":[359,373],"at":[364],"baseline":[365],"UTI.":[369,447],"colonization":[383],"severity.":[386],"CONCLUSIONS":[387],"is":[389],"both":[390],"necessary":[391],"sufficient":[393],"transcription,":[399],"genetic":[401],"acquired":[403],"deficiency":[405],"leads":[406],"This":[411],"implicates":[412],"as":[416],"master":[417],"regulators":[418],"transcription":[422],"states":[424],"sterility":[426],"Therapeutic":[429],"manipulation":[430],"axis":[434],"provides":[435],"mechanism":[437],"alter":[439],"treat":[443],"even":[445],"prevent":[446],"\u00a9":[448],"2017FiguresReferencesRelatedDetails":[449],"Volume":[450],"197Issue":[451],"4SApril":[452],"2017Page:":[453],"e265-e266":[454],"Advertisement":[455,491,492],"Copyright":[456],"Permissions\u00a9":[458],"2017MetricsAuthor":[459],"Information":[460],"Expand":[489],"PDF":[493],"downloadLoading":[494],"...":[495]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2017-04-14T00:00:00"}
