{"id":"https://openalex.org/W2604375404","doi":"https://doi.org/10.1200/jco.2015.33.15_suppl.6060","title":"A randomized phase II trial of the MET inhibitor tivantinib + cetuximab versus cetuximab alone in patients with recurrent/metastatic head and neck cancer.","display_name":"A randomized phase II trial of the MET inhibitor tivantinib + cetuximab versus cetuximab alone in patients with recurrent/metastatic head and neck cancer.","publication_year":2015,"publication_date":"2015-05-20","ids":{"openalex":"https://openalex.org/W2604375404","doi":"https://doi.org/10.1200/jco.2015.33.15_suppl.6060","mag":"2604375404"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2015.33.15_suppl.6060","doi":"https://doi.org/10.1200/jco.2015.33.15_suppl.6060","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2015.33.15_suppl.6060","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063904421","display_name":"Everett E. Vokes","orcid":"https://orcid.org/0000-0002-8645-8068","observed_orcids":["https://orcid.org/0000-0002-8645-8068"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Everett E. Vokes","raw_affiliation_strings":["Department of Medicine, University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022036818","display_name":"Francis Paul Worden","orcid":"https://orcid.org/0000-0002-6632-4951","observed_orcids":["https://orcid.org/0000-0002-6632-4951"]},"institutions":[{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francis P. Worden","raw_affiliation_strings":["University of Michigan Comprehensive Cancer Center, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan Comprehensive Cancer Center, Ann Arbor, MI","institution_ids":["https://openalex.org/I4390039285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064319129","display_name":"Douglas R. Adkins","orcid":"https://orcid.org/0000-0003-3207-8227","observed_orcids":["https://orcid.org/0000-0003-3207-8227"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas Adkins","raw_affiliation_strings":["Washington University School of Medicine, St. Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073246708","display_name":"Julie E. Bauman","orcid":"https://orcid.org/0000-0002-1398-6636","observed_orcids":["https://orcid.org/0000-0002-1398-6636"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie E. Bauman","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109365554","display_name":"Dean W. Lim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dean Lim","raw_affiliation_strings":["City of Hope, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"City of Hope, Duarte, CA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008487747","display_name":"Ammar W. Sukari","orcid":"https://orcid.org/0000-0003-1968-0459","observed_orcids":["https://orcid.org/0000-0003-1968-0459"]},"institutions":[{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ammar Sukari","raw_affiliation_strings":["Karmanos Cancer Inst, Detriot, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karmanos Cancer Inst, Detriot, MI","institution_ids":["https://openalex.org/I4210090317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059357699","display_name":"Krishna Rao","orcid":"https://orcid.org/0000-0002-1788-264X","observed_orcids":["https://orcid.org/0000-0002-1788-264X"]},"institutions":[{"id":"https://openalex.org/I196729704","display_name":"SIU Medicine","ror":"https://ror.org/0232r4451","country_code":"US","type":"education","lineage":["https://openalex.org/I196729704","https://openalex.org/I2801502357"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krishna A. Rao","raw_affiliation_strings":["Southern Illinois Univ School of Medicine, Springfield, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Illinois Univ School of Medicine, Springfield, IL","institution_ids":["https://openalex.org/I196729704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103725465","display_name":"Stephanie Ann Wagner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283055418","display_name":"Indiana University Health","ror":"https://ror.org/01aaptx40","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283055418","https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Ann Wagner","raw_affiliation_strings":["Indiana Univ Health, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana Univ Health, Indianapolis, IN","institution_ids":["https://openalex.org/I1283055418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111795638","display_name":"Kelly Kevelin Curtis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly Kevelin Curtis","raw_affiliation_strings":["Mayo Clinic, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Scottsdale, AZ","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044795397","display_name":"Barbara Jennifer Gitlitz","orcid":"https://orcid.org/0009-0001-0107-3135","observed_orcids":["https://orcid.org/0009-0001-0107-3135"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara J. Gitlitz","raw_affiliation_strings":["University of Southern California Keck School of Medicine, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Southern California Keck School of Medicine, Los Angeles, CA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037908919","display_name":"Katharine Andress Rowe Price","orcid":"https://orcid.org/0000-0002-5738-1866","observed_orcids":["https://orcid.org/0000-0002-5738-1866"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katharine Andress Rowe Price","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047818279","display_name":"James Lloyd Wade","orcid":"https://orcid.org/0000-0002-3802-3860","observed_orcids":["https://orcid.org/0000-0002-3802-3860"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Lloyd Wade","raw_affiliation_strings":["Cancer Care Center of Decatur, Decatur, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Care Center of Decatur, Decatur, IL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055165247","display_name":"Victoria Meucci Villaflor","orcid":"https://orcid.org/0000-0002-9111-1034","observed_orcids":["https://orcid.org/0000-0002-9111-1034"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria Meucci Villaflor","raw_affiliation_strings":["University of Chicago Med Ctr, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago Med Ctr, Chicago, IL","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066535571","display_name":"Jonas A. de Souza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonas A. De Souza","raw_affiliation_strings":["University of Chicago Medicine, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago Medicine, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038171309","display_name":"Theodore G Karrison","orcid":"https://orcid.org/0009-0009-8641-5111","observed_orcids":["https://orcid.org/0009-0009-8641-5111"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theodore Karrison","raw_affiliation_strings":["The University of Chicago Medicine and Biological Sciences, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Chicago Medicine and Biological Sciences, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088131964","display_name":"Walter Michael Stadler","orcid":"https://orcid.org/0000-0002-0435-2527","observed_orcids":["https://orcid.org/0000-0002-0435-2527"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Walter Michael Stadler","raw_affiliation_strings":["University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008467612","display_name":"Tanguy Y. Seiwert","orcid":"https://orcid.org/0000-0001-7919-8272","observed_orcids":["https://orcid.org/0000-0001-7919-8272"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tanguy Y. Seiwert","raw_affiliation_strings":["The University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":13,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"15_suppl","first_page":"6060","last_page":"6060"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tivantinib","display_name":"tivantinib","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cetuximab","display_name":"cetuximab","score":0.9509999752044678},{"id":"https://openalex.org/keywords/met-inhibitors","display_name":"MET inhibitors","score":0.8840000033378601},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9430000185966492},{"id":"https://openalex.org/keywords/oropharyngeal-cancer","display_name":"oropharyngeal cancer","score":0.8980000019073486},{"id":"https://openalex.org/keywords/egfr-inhibitor-resistance","display_name":"EGFR inhibitor resistance","score":0.8190000057220459},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7450000047683716},{"id":"https://openalex.org/keywords/response-rate","display_name":"response rate","score":0.6850000023841858},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9240000247955322},{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.6899999976158142},{"id":"https://openalex.org/keywords/platinum-refractory-disease","display_name":"platinum-refractory disease","score":0.777999997138977},{"id":"https://openalex.org/keywords/oral-anticancer-drugs","display_name":"oral anticancer drugs","score":0.4440000057220459}],"concepts":[{"id":"https://openalex.org/C2779998722","wikidata":"https://www.wikidata.org/wiki/Q420296","display_name":"Cetuximab","level":4,"score":0.9412484169006348},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9304025769233704},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6566286087036133},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5375580191612244},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.5322019457817078},{"id":"https://openalex.org/C2780873365","wikidata":"https://www.wikidata.org/wiki/Q496812","display_name":"Leukopenia","level":3,"score":0.5117947459220886},{"id":"https://openalex.org/C2779984678","wikidata":"https://www.wikidata.org/wiki/Q2145898","display_name":"Response Evaluation Criteria in Solid Tumors","level":4,"score":0.46808916330337524},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46748727560043335},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4442009925842285},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.42600536346435547},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.41671621799468994},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.26802611351013184},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.15300634503364563}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2015.33.15_suppl.6060","doi":"https://doi.org/10.1200/jco.2015.33.15_suppl.6060","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2015.33.15_suppl.6060","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3006910168","https://openalex.org/W2120484846","https://openalex.org/W4361222620","https://openalex.org/W4402688043","https://openalex.org/W4220722432","https://openalex.org/W2093207065","https://openalex.org/W2946611948","https://openalex.org/W2097501495","https://openalex.org/W2902474333","https://openalex.org/W4306411248"],"abstract_inverted_index":{"6060":[0],"Background:":[1],"MET":[2,15,37],"signaling":[3],"has":[4],"been":[5],"proposed":[6],"as":[7],"a":[8,168,206],"mechanism":[9],"of":[10,217,232],"resistance":[11],"to":[12,264],"anti-EGFR":[13],"therapy.":[14],"expression":[16],"is":[17],"common":[18],"in":[19,42,50,129,146,157,164,167,177,188,212,228,268],"Head":[20],"and":[21,73,113,141,242],"Neck":[22],"Squamous":[23],"Cell":[24],"Carcinomas":[25],"(HNSCC)":[26],"(Seiwert":[27],"et":[28,250,255],"al,":[29],"Cancer":[30],"Res":[31],"2009).":[32],"We":[33],"compared":[34],"the":[35,70,76,126,130,147,154,213],"oral":[36],"inhibitor":[38],"tivantinib":[39],"(ARQ197)":[40],"(T)":[41],"combination":[43],"with":[44,47,53,205,245],"cetuximab":[45,262],"(C),":[46],"C":[48,77,94,148],"monotherapy,":[49],"patients":[51],"(pts)":[52],"recurrent/metastatic":[54],"(r/m)":[55],"HNSCC.":[56,173],"Methods:":[57],"78":[58],"cetuximab-na\u00efve":[59],"pts":[60,81,121,161,179,218,235],"after":[61],"platinum":[62],"failure":[63],"were":[64,83,202],"enrolled":[65],"from":[66],"2012-2014,":[67],"40":[68],"on":[69,75],"T+C":[71,131,214],"arm,":[72],"38":[74],"control":[78],"arm.":[79],"31":[80,170],"(40%)":[82],"HPV-positive/p16-positive":[84,158,171,269],"oropharyngeal":[85,159,270],"(OP)":[86],"cancers.":[87],"T":[88],"was":[89,101,108,133,162,180,191],"given":[90,227],"orally":[91],"360mg":[92],"BID,":[93],"500mg/m2":[95],"every":[96,103],"two":[97],"weeks.":[98,105],"Cross-sectional":[99],"imaging":[100],"performed":[102],"8":[104,197],"Primary":[106],"outcome":[107],"response":[109,127,155,175,240],"rate":[110,128,156,176,241],"(RECIST":[111],"1.1),":[112],"secondary":[114],"outcomes":[115],"included":[116],"survival.":[117,243],"Results:":[118],"In":[119],"75":[120],"currently":[122],"assessable":[123],"for":[124],"response,":[125],"arm":[132,150,215],"8.5%":[134,183],"(N":[135,143],"=":[136,144],"3,":[137],"including":[138,261],"one":[139],"CR),":[140],"5.3%":[142],"2)":[145],"alone":[149],"(NS).":[151,185,199],"Of":[152],"note":[153],"HNSCC":[160,234,271],"0%":[163],"both":[165,189],"arms":[166,190],"combined":[169],"OP":[172],"The":[174],"HPV-negative":[178],"12.5%":[181],"(T+C)/":[182],"(C)":[184],"Median":[186],"PFS":[187],"4":[192],"months":[193,198],"(NS),":[194],"median":[195],"OS":[196],"Both":[200],"treatments":[201],"well":[203],"tolerated":[204],"trend":[207],"towards":[208],"increased":[209],"hematological":[210],"toxicities":[211],"(12.5%":[216],"experience":[219],"grade":[220],"3":[221],"leukopenia).":[222],"Conclusions:":[223],"Tivantinib":[224],"+":[225],"Cetuximab":[226],"an":[229],"unselected":[230],"population":[231],"r/m":[233],"does":[236],"not":[237],"significantly":[238],"improve":[239],"Consistent":[244],"other":[246],"recent":[247],"reports":[248],"(Fayette":[249],"al":[251,256],"ESMO":[252,257],"2014;":[253],"Machiels":[254],"2014),":[258],"EGFR":[259],"inhibitors,":[260],"appear":[263],"be":[265],"less":[266],"active/inactive":[267],"patients.":[272],"Clinical":[273],"trial":[274],"information:":[275],"NCT01696955.":[276]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2017-04-14T00:00:00"}