{"id":"https://openalex.org/W2604306183","doi":null,"title":"Control of Cardiomyocyte Proliferation by p53/MDM2-Regulated microRNAs","display_name":"Control of Cardiomyocyte Proliferation by p53/MDM2-Regulated microRNAs","publication_year":2016,"publication_date":"2016-11-01","ids":{"openalex":"https://openalex.org/W2604306183","mag":"2604306183"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/76044","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/76044","pdf_url":"https://utoronto.scholaris.ca/bitstreams/e85de3f1-d6a3-4d63-a05f-309291ac225a/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/e85de3f1-d6a3-4d63-a05f-309291ac225a/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023507476","display_name":"Shanna Stanley-Hasnain","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Shanna Stanley-Hasnain","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5023507476"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiomyocyte-proliferation","display_name":"cardiomyocyte proliferation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/p53-mdm2-pathway","display_name":"MDM2-p53 pathway","score":0.8759999871253967},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.9470000267028809},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8769999742507935},{"id":"https://openalex.org/keywords/cardiac-regeneration","display_name":"cardiac regeneration","score":0.6079999804496765},{"id":"https://openalex.org/keywords/cell-cycle-re-entry","display_name":"cell cycle re-entry","score":0.8169999718666077},{"id":"https://openalex.org/keywords/microrna-expression-profiling","display_name":"miRNA expression profiling","score":0.6309999823570251},{"id":"https://openalex.org/keywords/cytokinesis","display_name":"cytokinesis","score":0.7630000114440918}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7970198392868042},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.7532442808151245},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6884084939956665},{"id":"https://openalex.org/C2776192174","wikidata":"https://www.wikidata.org/wiki/Q18028978","display_name":"Mdm2","level":3,"score":0.6633968353271484},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6551623940467834},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.6421027183532715},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.639625072479248},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6184325218200684},{"id":"https://openalex.org/C45472230","wikidata":"https://www.wikidata.org/wiki/Q1447198","display_name":"Cytokinesis","level":4,"score":0.6178303956985474},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.5182749629020691},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4018482565879822},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.29937034845352173},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.25371813774108887},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11336225271224976},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0828496515750885}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/76044","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/76044","pdf_url":"https://utoronto.scholaris.ca/bitstreams/e85de3f1-d6a3-4d63-a05f-309291ac225a/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2604306183","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/bitstream/1807/76044/1/Stanley-Hasnain_Shanna_201611_MSc_thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/76044","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/76044","pdf_url":"https://utoronto.scholaris.ca/bitstreams/e85de3f1-d6a3-4d63-a05f-309291ac225a/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2604306183.pdf","grobid_xml":"https://content.openalex.org/works/W2604306183.grobid-xml"},"referenced_works_count":322,"referenced_works":["https://openalex.org/W48627038","https://openalex.org/W51425027","https://openalex.org/W57303695","https://openalex.org/W93803930","https://openalex.org/W111180501","https://openalex.org/W150871787","https://openalex.org/W200312034","https://openalex.org/W203223851","https://openalex.org/W259517682","https://openalex.org/W328031845","https://openalex.org/W1500160778","https://openalex.org/W1520865249","https://openalex.org/W1522784058","https://openalex.org/W1523325879","https://openalex.org/W1549203021","https://openalex.org/W1566940064","https://openalex.org/W1576330810","https://openalex.org/W1622164773","https://openalex.org/W1623600373","https://openalex.org/W1631250427","https://openalex.org/W1774715425","https://openalex.org/W1780349187","https://openalex.org/W1792024194","https://openalex.org/W1801269983","https://openalex.org/W1810296391","https://openalex.org/W1880891411","https://openalex.org/W1892952192","https://openalex.org/W1897109812","https://openalex.org/W1908293148","https://openalex.org/W1922218222","https://openalex.org/W1925711681","https://openalex.org/W1928161708","https://openalex.org/W1929350761","https://openalex.org/W1965912619","https://openalex.org/W1966563415","https://openalex.org/W1966841369","https://openalex.org/W1966967749","https://openalex.org/W1967163876","https://openalex.org/W1968008181","https://openalex.org/W1968631483","https://openalex.org/W1968903659","https://openalex.org/W1969038150","https://openalex.org/W1969044026","https://openalex.org/W1970431885","https://openalex.org/W1971321550","https://openalex.org/W1971559763","https://openalex.org/W1971850212","https://openalex.org/W1972305847","https://openalex.org/W1972400547","https://openalex.org/W1972551831","https://openalex.org/W1974391793","https://openalex.org/W1974836748","https://openalex.org/W1975308625","https://openalex.org/W1976275744","https://openalex.org/W1978041489","https://openalex.org/W1978406914","https://openalex.org/W1981805884","https://openalex.org/W1982250275","https://openalex.org/W1982298196","https://openalex.org/W1982395176","https://openalex.org/W1985139403","https://openalex.org/W1985491895","https://openalex.org/W1985839640","https://openalex.org/W1986179131","https://openalex.org/W1989840855","https://openalex.org/W1990392771","https://openalex.org/W1991199800","https://openalex.org/W1991510903","https://openalex.org/W1992708996","https://openalex.org/W1993864973","https://openalex.org/W1994414532","https://openalex.org/W1994645662","https://openalex.org/W1995689125","https://openalex.org/W1995741673","https://openalex.org/W1998781040","https://openalex.org/W1999074203","https://openalex.org/W2000190195","https://openalex.org/W2000298831","https://openalex.org/W2000674381","https://openalex.org/W2003035943","https://openalex.org/W2003816656","https://openalex.org/W2003907692","https://openalex.org/W2004101246","https://openalex.org/W2006173503","https://openalex.org/W2006247279","https://openalex.org/W2009385353","https://openalex.org/W2009682316","https://openalex.org/W2009876051","https://openalex.org/W2011528645","https://openalex.org/W2012282774","https://openalex.org/W2013721931","https://openalex.org/W2014051371","https://openalex.org/W2014203167","https://openalex.org/W2014397238","https://openalex.org/W2015519364","https://openalex.org/W2015644748","https://openalex.org/W2016160656","https://openalex.org/W2016864528","https://openalex.org/W2017767253","https://openalex.org/W2018183883","https://openalex.org/W2021271642","https://openalex.org/W2021987504","https://openalex.org/W2022697772","https://openalex.org/W2024715737","https://openalex.org/W2024996523","https://openalex.org/W2026640071","https://openalex.org/W2027230549","https://openalex.org/W2030665161","https://openalex.org/W2031300692","https://openalex.org/W2032945651","https://openalex.org/W2033518550","https://openalex.org/W2034768496","https://openalex.org/W2035608099","https://openalex.org/W2036362283","https://openalex.org/W2036923470","https://openalex.org/W2037090973","https://openalex.org/W2038167014","https://openalex.org/W2038407368","https://openalex.org/W2039270476","https://openalex.org/W2040063578","https://openalex.org/W2042461504","https://openalex.org/W2043212568","https://openalex.org/W2043468746","https://openalex.org/W2044225275","https://openalex.org/W2044890627","https://openalex.org/W2045086385","https://openalex.org/W2045820284","https://openalex.org/W2046355810","https://openalex.org/W2046704452","https://openalex.org/W2047960154","https://openalex.org/W2048577371","https://openalex.org/W2051395985","https://openalex.org/W2051521992","https://openalex.org/W2051923420","https://openalex.org/W2052162735","https://openalex.org/W2052210687","https://openalex.org/W2054604628","https://openalex.org/W2056362544","https://openalex.org/W2056559034","https://openalex.org/W2057081140","https://openalex.org/W2057930930","https://openalex.org/W2058431890","https://openalex.org/W2058891255","https://openalex.org/W2059310361","https://openalex.org/W2059848983","https://openalex.org/W2060387110","https://openalex.org/W2060515857","https://openalex.org/W2061601254","https://openalex.org/W2062500929","https://openalex.org/W2063705496","https://openalex.org/W2064533570","https://openalex.org/W2066213138","https://openalex.org/W2066636886","https://openalex.org/W2067462064","https://openalex.org/W2067655540","https://openalex.org/W2068380542","https://openalex.org/W2068834948","https://openalex.org/W2069266255","https://openalex.org/W2070032322","https://openalex.org/W2071260674","https://openalex.org/W2071596792","https://openalex.org/W2071682538","https://openalex.org/W2073811662","https://openalex.org/W2074210527","https://openalex.org/W2074272236","https://openalex.org/W2074447982","https://openalex.org/W2075103447","https://openalex.org/W2075263617","https://openalex.org/W2076025570","https://openalex.org/W2076984671","https://openalex.org/W2077548113","https://openalex.org/W2079557738","https://openalex.org/W2079761894","https://openalex.org/W2080572933","https://openalex.org/W2080696342","https://openalex.org/W2083158631","https://openalex.org/W2083507043","https://openalex.org/W2083822954","https://openalex.org/W2084136291","https://openalex.org/W2084218374","https://openalex.org/W2085225921","https://openalex.org/W2088120691","https://openalex.org/W2088740611","https://openalex.org/W2088824478","https://openalex.org/W2089218510","https://openalex.org/W2090374150","https://openalex.org/W2090719210","https://openalex.org/W2091151265","https://openalex.org/W2091619435","https://openalex.org/W2093468083","https://openalex.org/W2094957750","https://openalex.org/W2095025374","https://openalex.org/W2095059099","https://openalex.org/W2095854314","https://openalex.org/W2095909899","https://openalex.org/W2096492016","https://openalex.org/W2097572806","https://openalex.org/W2097834438","https://openalex.org/W2097837136","https://openalex.org/W2099692224","https://openalex.org/W2099907467","https://openalex.org/W2100894466","https://openalex.org/W2101147082","https://openalex.org/W2102770794","https://openalex.org/W2102978602","https://openalex.org/W2103052577","https://openalex.org/W2104919376","https://openalex.org/W2105718763","https://openalex.org/W2106382473","https://openalex.org/W2106391242","https://openalex.org/W2106944257","https://openalex.org/W2107696376","https://openalex.org/W2108108415","https://openalex.org/W2109712459","https://openalex.org/W2110275759","https://openalex.org/W2111129606","https://openalex.org/W2111129864","https://openalex.org/W2111750793","https://openalex.org/W2112792041","https://openalex.org/W2112968535","https://openalex.org/W2113074426","https://openalex.org/W2114252625","https://openalex.org/W2116484480","https://openalex.org/W2117014680","https://openalex.org/W2117391818","https://openalex.org/W2118356006","https://openalex.org/W2118475358","https://openalex.org/W2119337308","https://openalex.org/W2120151624","https://openalex.org/W2120785595","https://openalex.org/W2121037409","https://openalex.org/W2121936157","https://openalex.org/W2122118690","https://openalex.org/W2123269327","https://openalex.org/W2124052729","https://openalex.org/W2125418482","https://openalex.org/W2125635123","https://openalex.org/W2126266722","https://openalex.org/W2126426563","https://openalex.org/W2126679757","https://openalex.org/W2128717251","https://openalex.org/W2128989640","https://openalex.org/W2131388056","https://openalex.org/W2131775349","https://openalex.org/W2132093971","https://openalex.org/W2132194692","https://openalex.org/W2132735690","https://openalex.org/W2133331423","https://openalex.org/W2135060727","https://openalex.org/W2135314242","https://openalex.org/W2135436658","https://openalex.org/W2136154089","https://openalex.org/W2136292643","https://openalex.org/W2137625135","https://openalex.org/W2138664009","https://openalex.org/W2139348309","https://openalex.org/W2139689863","https://openalex.org/W2140118545","https://openalex.org/W2140397640","https://openalex.org/W2140477106","https://openalex.org/W2141451721","https://openalex.org/W2144038313","https://openalex.org/W2144154026","https://openalex.org/W2145244611","https://openalex.org/W2145306368","https://openalex.org/W2145348333","https://openalex.org/W2147326690","https://openalex.org/W2148096101","https://openalex.org/W2148220540","https://openalex.org/W2149386535","https://openalex.org/W2151439322","https://openalex.org/W2151688951","https://openalex.org/W2151812144","https://openalex.org/W2154070925","https://openalex.org/W2154185968","https://openalex.org/W2155047386","https://openalex.org/W2155363874","https://openalex.org/W2156299289","https://openalex.org/W2156800444","https://openalex.org/W2156861743","https://openalex.org/W2159210918","https://openalex.org/W2160854466","https://openalex.org/W2160968516","https://openalex.org/W2161214109","https://openalex.org/W2161234257","https://openalex.org/W2161693225","https://openalex.org/W2162527129","https://openalex.org/W2162542267","https://openalex.org/W2163229196","https://openalex.org/W2164489545","https://openalex.org/W2166404409","https://openalex.org/W2167202160","https://openalex.org/W2169385603","https://openalex.org/W2169859308","https://openalex.org/W2170331239","https://openalex.org/W2170647698","https://openalex.org/W2171137764","https://openalex.org/W2171501507","https://openalex.org/W2173417615","https://openalex.org/W2176090022","https://openalex.org/W2180068288","https://openalex.org/W2191577401","https://openalex.org/W2201934892","https://openalex.org/W2240497454","https://openalex.org/W2258280387","https://openalex.org/W2260132547","https://openalex.org/W2265951579","https://openalex.org/W2267037238","https://openalex.org/W2275154191","https://openalex.org/W2322440948","https://openalex.org/W2333259794","https://openalex.org/W2335806396","https://openalex.org/W2341653829","https://openalex.org/W2345424530","https://openalex.org/W2405232734","https://openalex.org/W2408897851","https://openalex.org/W2413986065","https://openalex.org/W2428564903","https://openalex.org/W3128370515","https://openalex.org/W4238531085","https://openalex.org/W4255009698","https://openalex.org/W7099838577"],"related_works":["https://openalex.org/W2338414348","https://openalex.org/W6939606381","https://openalex.org/W6986996015","https://openalex.org/W2583286401","https://openalex.org/W4409171778","https://openalex.org/W2145178074","https://openalex.org/W3164276239","https://openalex.org/W1872333944","https://openalex.org/W2885451943","https://openalex.org/W2794119682"],"abstract_inverted_index":{"Defining":[0],"the":[1,12,21,27,67,103,128,146],"roadblocks":[2],"responsible":[3,139],"for":[4,109,140],"adult":[5],"cardiomyocyte":[6,34],"cell":[7,43,70,114,142],"cycle":[8,44,71,115,143],"arrest":[9,144],"lies":[10],"at":[11],"core":[13],"of":[14,20,39,62,69,76,79,118,130,136],"developing":[15],"cardiac":[16,84],"regenerative":[17],"therapies.":[18],"Inactivation":[19],"p53/MDM2":[22,86],"tumor":[23],"suppressor":[24],"circuitry":[25],"in":[26,33,42,54,102,113,122,145],"heart":[28],"caused":[29],"a":[30,133],"significant":[31],"increase":[32],"proliferation,":[35],"through":[36],"an":[37],"upregulation":[38],"factors":[40,47],"involved":[41,112],"re-entry.":[45],"These":[46],"may":[48],"be":[49],"regulated":[50],"by":[51],"microRNAs":[52],"(miRNAs),":[53],"quiescent":[55],"cardiomyocytes.":[56,77],"Therefore,":[57],"we":[58],"hypothesized":[59],"that":[60,99],"inactivation":[61],"p53/MDM2-regulated":[63,137],"miRNAs":[64,98,121,138],"could":[65],"promote":[66],"expression":[68,81],"activators":[72],"and":[73,92,107],"induce":[74],"proliferation":[75],"Comparison":[78],"miRNA":[80],"profiles":[82],"from":[83],"specific":[85],"double":[87],"knockout":[88],"(DKO)":[89],"mouse":[90],"hearts":[91,106],"wild":[93],"type":[94],"controls":[95],"revealed":[96],"11":[97,120],"were":[100],"downregulated":[101],"\"proliferative\"":[104],"DKO":[105],"enriched":[108],"mRNA":[110],"targets":[111],"regulation.":[116],"Knockdown":[117],"these":[119],"neonatal":[123],"rat":[124],"cardiomyocytes":[125],"significantly":[126],"increased":[127],"occurrence":[129],"cytokinesis,":[131],"revealing":[132],"novel":[134],"subset":[135],"maintaining":[141],"heart.":[147]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-04-14T00:00:00"}